Navigation Links
Scientists first to see trafficking of immune cells in beating heart
Date:7/11/2012

Blood flow to the heart often is interrupted during a heart attack or cardiac surgery. But when blood flow resumes, the heart may still falter. That's because collateral damage can occur as blood re-enters the heart, potentially slowing recovery and causing future cardiac troubles.

Researchers investigating this type of secondary heart damage have been stymied by the inability to see in real time how restoring blood flow leads to inflammation that can cause further injury. Now, working in mice, surgeons and scientists at Washington University School of Medicine in St. Louis, have captured the first images of a beating heart at a resolution so detailed they can track individual immune cells swarming into the heart muscle, causing inflammation.

The achievement is detailed in the July issue of the Journal of Clinical Investigation.

The researchers say that the imaging technique, called intravital two-photon imaging, is a powerful tool for understanding the inflammation that occurs when blood flow to the heart is temporarily stopped and later restarted.

"Inflammation is quite common after a heart attack, open-heart surgery, heart transplants and in atherosclerosis, and it can severely hamper recovery and lead to death," says senior author Daniel Kreisel, MD, PhD, a Washington University cardiothoracic surgeon who operates at Barnes-Jewish Hospital. "But little is known about how inflammation ramps up in the heart. Now that we have the ability to see all the cellular players involved, we can begin to think about new therapeutic targets for treatment."

Two-photon imaging has been used to image other organs in living mice but never the heart. Scientists had assumed that the flutter of the beating heart, which pulses about 500 times a minute in a mouse, would blur any images of individual cells.

"No one thought we could get clear images of cells inside the beating heart," says Wenjun Li, MD, research inst
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists develop new strategy to overcome drug-resistant childhood cancer
2. Damon Runyon Cancer Research Foundation grants fellowship awards to 21 top young scientists
3. Scientists at the Mainz University Medical Center gain new insights into Taspase1 function
4. Scientists develop mouse model that could lead to new therapies for liver cancer
5. Scientists Use Stem Cells to Mimic Huntingtons Disease
6. Scientists identify gene linked to facial, skull and cognitive impairment
7. Scientists discover new clues explaining tendon injury
8. Scientists identify new cancer stem cell mechanism
9. Finding brings scientists 1 step closer to Parkinsons drug
10. Even Some Scientists Are Math-Challenged
11. Danish scientists detect new immune alert signal
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists first to see trafficking of immune cells in beating heart
(Date:9/19/2014)... Frankfurt, Germany (PRWEB) September 19, 2014 ... today that its new ND® Infusion Catheter ... University of Frankfurt. , The study commenced on September ... Cardiology. The use of the new catheter demonstrated a ... commonly known as stem cells. “We are at the ...
(Date:9/19/2014)... QueenBeeTickets.com has the largest ticket inventory that ... tour set to begin on January 21 of 2015, discount ... the secure website. , Click Here to view ... QueenBeeTickets.com. , The Plain Spoken Tour has recently been announced, ... for a show coming to their local area. Presales have ...
(Date:9/19/2014)... and other adult family members living without minors in ... with young children or adolescents to eat family meals ... research suggests. , The study is the first large-scale ... a substantial amount of research has focused on health ... eating patterns have not been widely studied in adult-only ...
(Date:9/19/2014)... 2014 A McLean County ... (case 14-L-1175), following a failed hip replacement using a ... DePuy Orthopaedics Inc. and Johnson & Johnson over allegations ... Group, a nationally known personal injury law firm, represents ... in litigation involving defective hips. , According to the ...
(Date:9/19/2014)... 19, 2014 VogueQueen.com has ... that will make ladies more beautiful at their weddings. ... everyone can afford. The company’s new products are made ... offering great savings for all the global clients. ... extremely beautiful. I have ordered several items on its ...
Breaking Medicine News(10 mins):Health News:First-in-man procedure utilizes a new method of stem cell delivery 2Health News:First-in-man procedure utilizes a new method of stem cell delivery 3Health News:John Mellencamp Plain Spoken Tour Tickets: QueenBeeTickets.com Delights Customers with Discount Tickets for Mellencamp’s 80-City 2015 Concert Tour with Carlene Carter 2Health News:Even without kids, couples eat frequent family meals 2Health News:Even without kids, couples eat frequent family meals 3Health News:Even without kids, couples eat frequent family meals 4Health News:Flood Law Group Comments on Recent Hip Replacement Lawsuit 2Health News:VogueQueen.com’s New Line Of Cheap Wedding Dresses Aims To Attract Chic Ladies 2
... the World Federation for Mental Health reveals that patients ... life suffers because of their disease. ,Bipolar disorder ... elation and depression. Also known as manic-depressive illness that ... population. This is a chronic condition and most of ...
... been around now for almost 40 years for treatment ... it maybe useful in treating cancer as it has been ... This was reported by international team of scientists. Leslie Wilson, ... Santa Barbara, The results are published in online edition of ...
... Researchers have found that teenage girls living in temperate countries ... in life if they took supplements of Vitamin D in ... is low. The sun is important for formation of the ... ,The vitamin supplement would help to strengthen bones for later ...
... Losing one kilo of weight may be equivalent to losing ... from osteoarthritis of the knee. ,Researchers from the Wake ... of exercise and weight loss on the osteoarthritis of the ... 5% of the body weight in obese elderly patients can ...
... cancer is the most common and deadly cancer worldwide. About ... out of which // 85% will die before 2010. Habit ... is fastly increasing in low and middle income countries. The ... smoking related disease causes 5 million deaths a year. ...
... to a recent study researchers say the drug orlistat ... least a year without // major side effects in ... the intestines to absorb fat by up to 30 ... taking orlistat passes through the body without being digested ...
Cached Medicine News:Health News:Vitamin D Supplement in Teenage Girls essential in Winter months 2Health News:Aggressive Tobacco taxation policy can reduce cigarette smoking, 2
(Date:9/18/2014)... 2014 MiMedx Group, Inc. (NASDAQ: ... marketer of patent protected regenerative biomaterials and bioimplants ... it has entered into a distribution agreement with ... its dehydrated human amnion/chorion membrane ("dHACM") allograft products ... a private label basis. The MiMedx ...
(Date:9/18/2014)... 2014  Zacks.com announces the list of stocks featured ... Research analysts discuss the latest news and events impacting ... the blog include the Avanir Pharmaceuticals (Nasdaq: AVNR - ... Free Report ), Orexigen (Nasdaq: OREX - Free ... ) and Gilead (Nasdaq: GILD - Free Report ...
(Date:9/18/2014)... YORK and PLAINSBORO, N.J. ... announced today its support of the National Hemophilia ... Care , which provides support to people with ... physical and psychosocial challenges that can impede disease ... six modules, Communication With Your Provider About ...
Breaking Medicine Technology:MiMedx Signs Distribution Agreement With Zimmer 2MiMedx Signs Distribution Agreement With Zimmer 3The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 2The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 3The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 4The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 5The Zacks Analyst Blog Highlights: Avanir Pharmaceuticals, NPS Pharmaceuticals, Orexigen, Medivation and Gilead 6Novo Nordisk Supports National Hemophilia Foundation Initiative for "Collaborating in Care" Disease Management Program 2Novo Nordisk Supports National Hemophilia Foundation Initiative for "Collaborating in Care" Disease Management Program 3
... level of blood oxygenation can be an essential ... in the clinical setting is often desirable. In ... technology into easily used point-of-care devices, recent products ... values., ,HemoCue, Inc., Lake Forest, Calif., says that ...
... the context of many clinical laboratories, automated production in ... years. In automobile assembly, for example, automated lines fabricate ... The result has been vastly improved products, far fewer ... These days, only a handful of luxury and sports ...
Cached Medicine Technology:Hemoglobin Testing at the Point of Care 2Hemoglobin Testing at the Point of Care 3Lab Automation Networks Proliferating 2Lab Automation Networks Proliferating 3Lab Automation Networks Proliferating 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: