Navigation Links
Scientists find second site for prostate cancer gene
Date:9/2/2008

WINSTON-SALEM, N.C. Scientists at Wake Forest University School of Medicine and colleagues who are studying a prostate cancer gene called HNF1B have found a second independent site within the HNF1B gene on chromosome 17 (17q12) increasing the number of genetic variants that may contribute to risk of developing the disease.

After comparing the newly-discovered site with a previously discovered site in the same gene among two large groups of patients in Sweden and at Johns Hopkins Hospital in Baltimore, "these data strongly suggest that the two sites are genetically independent," said Jianfeng Xu, M.D., Dr. Ph.H., senior researcher on the study.

"We found another genetic variant associated with prostate cancer risk," Xu said. "The more genetic variants we discover, the better off we are. As we find more of these, it improves our ability to predict prostate cancer risk."

Xu, a professor of epidemiology and cancer biology and Director of the Center for Cancer Genomics, reported the results with 30 colleagues in the current on-line version of Nature Genetics.

The researchers conducted what they termed a "fine-mapping study" in the two groups, one called CAPS, from Sweden, that had 2,899 prostate cancer cases and 1,722 control participants, and the Johns Hopkins study that had 1,527 prostate cancer patients and 482 control participants.

They found two separate clusters of prostate-cancer-associated SNPs (single nucleotide polymorphisms), one in a region previously identified and one in a new region. The researchers then worked to see whether the genetic variants were associated with risk of developing the disease. They looked at the same locations in five other large studies of prostate cancer patients and found that prostate cancer risk was higher among men who had the genetic variants. Earlier this year, the same research group reported in the New England Journal of Medicine that genetic variants have
'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Track Hourly Changes in Alzheimers Protein
2. Early trigger for type-1 diabetes found in mice, Stanford scientists report
3. Scientists ID Pathway That Makes Antipsychotic Drugs Work
4. UT Southwestern scientists discover leptin can also aid type 1 diabetics
5. Chemical liberated by leaky gut may allow HIV to infect the brain, Einstein scientists find
6. By amplifying cell death signals, scientists make precancerous cells self-destruct
7. NIH scientists find a novel mechanism that controls the development of autoimmunity
8. Scientists use old enemy to K.O. cancer
9. Distinguished Cardiologists and Scientists Honored With 2008 International Academy of Cardiology Award
10. CSHL neuroscientists glimpse how the brain decides what to believe
11. Scientists measure connection between the built environment and obesity in baby boomers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... December 26, 2014 It is said that ... dress. Today, UWDress.com, the famous wedding dress supplier, shows ... a site-wide cocktail gown promotion. , UWDress.com’s navy cocktail ... and they come in high fashion styles. Simple dresses in ... on the occasion; they are specially designed for those who ...
(Date:12/26/2014)... December 26, 2014 Yisrayl Hawkins, Pastor at ... open letter in light of the Ferguson, Missouri unrest. Yisrayl ... civil unrest and explains why it has only increased. ... was even created. He says there is a very specific ... also says there is a set of rules, or Laws ...
(Date:12/26/2014)... 26, 2014 Plugin and template developers from ... 5 Plugin for Final Cut Pro X. , “TransPack Volume ... tool to pull off an industry professional look” Said Christina ... hands on TransPack Volume 5, a new level of professionalism ... set of over 50 Final Cut Pro X transitions featuring ...
(Date:12/26/2014)... India Network Foundation, a non-profit US based ... today a new version of “ EasySelect ”, a ... plan for their visiting parents. The technology tool is ... process when choosing an insurance plan by showing the ... few clicks. Many elderly Asian Indian parents often find ...
(Date:12/26/2014)... DW-InductionHeating.com (DaWei Induction Heating Co.) is a comprehensive high-tech ... marketing of a series of induction heating equipment. Today, ... of induction brazing equipments . , According to ... refers to the joining of two or more ... manager says that there are fundamental differences in the ...
Breaking Medicine News(10 mins):Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2Health News:Yisrayl Hawkins Pleads for Peace in Ferguson and Beyond in New Open Letter 2Health News:Today a new plugin was announced from Pixel Film Studios, TransPack Volume 5 for Final Cut Pro X 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 3Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2
... People suffering from fatty liver disease may be three times ... liver, according to a study by researchers at St. Michael,s ... the first to find a link between nonalcoholic fatty liver ... in the liver in non drinkers and stroke. ...
... Mass.Consumers may place a high value on information to predict ... of pocket to get it. In a national survey conducted ... indicated that they would take a hypothetical predictive test to ... or prostate cancer, or arthritis. On average, respondents were willing ...
... THURSDAY, Jan. 6 (HealthDay News) -- A blood test that ... may one day be used to detect Alzheimer,s and other ... in its infancy, being able to detect Alzheimer,s via antibodies ... the disease, researchers said. But the study,s lead author ...
... scientists holds promise for the future development of treatments ... potentially for Alzheimer,s disease and other memory-impairment diseases. ... psychology Michael Fanselow, have discovered what may be a ... disorders. The research is published Jan. 7 in the ...
... the University of Granada (UGR) warns of the need to ... autonomous communities to improve recycling and waste disposal. There is ... the Spanish Ministry of the Environment and Rural and Marine ... out a comparison of the clinical waste management regulations and ...
... and K.U.Leuven have succeeded in decoding a potential ... abnormal tumor blood vessels through HRG (histidine-rich glycoprotein) ... efficiency. In tumors, vessels formation is disturbed, leading ... cancer cells to escape to other parts of ...
Cached Medicine News:Health News:Most consumers want predictive tests to learn if a disease is in their future 2Health News:Most consumers want predictive tests to learn if a disease is in their future 3Health News:Early Steps Toward an Alzheimer's Blood Test 2Health News:Early Steps Toward an Alzheimer's Blood Test 3Health News:'Long-shot' discovery may lead to advances in treating anxiety, memory disorders 2Health News:'Long-shot' discovery may lead to advances in treating anxiety, memory disorders 3Health News:Clinical waste management needs specialized regulation 2Health News:VIB-K.U. Leuven scientists clear the way to alternative anti-angiogenic cancer therapy 2
(Date:12/24/2014)... 2014 /PRNewswire/  -- Tianyin Pharmaceutical Inc. (NYSE Amex: ... specializes in the patented biopharmaceutical, modernized traditional Chinese ... (API) released unaudited preliminary financial results for the ... Fiscal Year 2015 Ended September 30, 2014 Financial ... with $14.7 million in 1Q14 with gross margins ...
(Date:12/24/2014)... , Dec. 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... pharmacy, is proud to announce Jennifer Hagerman , ... Diplomat, will take office as the president of the ... induction ceremony will take place Feb. 28, 2015, at ... held at the Renaissance Center in Detroit, ...
(Date:12/24/2014)... Dec. 23, 2014  Advanced Medical Isotope Corporation ... primarily in the development of brachytherapy devices and ... announced that it has filed a de ... Administration ("FDA") for marketing clearance for its patented ... the U.S. Food, Drug and Cosmetic Act (the ...
Breaking Medicine Technology:TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 2TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 3TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 5TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 6TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 7TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 8TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 9TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 10TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 11TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 12Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 2Advanced Medical Isotope Corporation Files a "de novo" Submission for Y-90 RadioGel(TM) Device 3
... Ill., Sept. 30 Sagent Pharmaceuticals, Inc., a ... it has launched vinorelbine injection, USP, an anti-mitotic ... vinorelbine injection, USP in the United States approximated ... vinorelbine injection immediately. , "Sagent has launched six ...
... Ill., Sept. 30 Hospira, Inc. (NYSE: HSP ... today announced the acquisition of worldwide rights to a ... facility from PLIVA Hrvatska d.o.o. (Zagreb, Croatia) (ZSE: PLVA-R-A), ... vertical integration in biogenerics. Financial terms of the ...
Cached Medicine Technology:Sagent Pharmaceuticals Launches Vinorelbine Injection, USP 2Hospira Acquires Worldwide Rights to Biogeneric Version of Filgrastim and Manufacturing Facility From PLIVA 2Hospira Acquires Worldwide Rights to Biogeneric Version of Filgrastim and Manufacturing Facility From PLIVA 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: