Navigation Links
Scientists find promising new approach to preventing progression of breast cancer
Date:2/15/2013

LA JOLLA, CA February 15, 2013 Doctors currently struggle to determine whether a breast tumor is likely to shift into an aggressive, life-threatening modean issue with profound implications for treatment. Now a group from The Scripps Research Institute (TSRI) has identified a mechanism through which mitochondria, the powerhouses of a cell, control tumor aggressiveness. Based on their findings, the team developed a simple treatment that inhibits cancer progression and prolongs life when tested in mice.

The research team, which describes its results February 15, 2013, in an article published online ahead of print by The Journal of Clinical Investigation, hopes to proceed quickly to human clinical trials to test this new approach using drugs already in use for other conditions.

Looking at Clues

The TSRI laboratory of Associate Professor Brunhilde H. Felding studies cancer, especially the mechanisms that control metastasis, the spread of cancer from its primary site to distant organs in the body.

Past research suggested that mutations affecting mitochondria, which are key to energy production in cells, strongly influence whether a tumor becomes aggressive. But the mechanism was not clear.

"We decided to investigate a specific protein complex, called mitochondrial complex I, that critically determines the energy output of cellular respiration," said the study's first author, Antonio F. Santidrian, a research associate in Felding's laboratory. To do this, the group teamed up with Akemi and Takao Yagi at TSRI, who are leading experts in complex I research. Using unique reagents from the Yagi group, the Felding team discovered that the balance of key metabolic cofactors processed by complex Ispecifically, nicotinamide adenine dinucleotide (NAD+) and NADH, the form it takes after accepting a key electron in the energy production cyclewas disturbed in aggressive breast cancer cells.

Exciting Res
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Hopkins scientists create method to personalize chemotherapy drug selection
2. Spanish scientists develop a pioneering technique to effectively treat mucositis
3. Scientists find calcium is the initial trigger in our immune response to healing
4. Scientists should advance management of behavioral norms
5. Scientists advance the art of magic with a study of Penn and Tellers cups and balls illusion
6. CSHL scientists identify a new strategy for interfering with a potent cancer-causing gene
7. Scientists Find 24 New Genes Linked to Nearsightedness
8. NIH scientists discover promising target to block Staphylococcus infection
9. Scientists find key to growth of bad bacteria in inflammatory bowel disease
10. Scientists Explore How Zinc Fights Off Infection
11. Compound developed by scientists protects heart cells during and after attack
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists find promising new approach to preventing progression of breast cancer
(Date:8/29/2015)... ... August 29, 2015 , ... ... two inventors from Miller Place, N.Y. "I specialize in manual therapy, and my ... addition, it can be used for additional muscle dysfunction throughout the body." , ...
(Date:8/29/2015)... ... 2015 , ... Dr. Tim Novelli, DC., Founder and President of the Patriot ... of the chiropractic field in the military. All too often VA hospitals treat patients ... made available to the VA program over a decade ago, the reality is that ...
(Date:8/29/2015)... ... , ... ProDrop Particles includes over 40 particle backdrops designed for use in ... that users can shrink and stretch in the Final Cut Pro X timeline. Choose ... brightness, scale, speed, range, and flare attributes with intuitive controls found in the top-right ...
(Date:8/29/2015)... ... August 29, 2015 , ... The popular television program VOICES IN ... announced that it will be devoting an entire short segment to the subject of ... around the globe on a daily basis, but recent advancements in medical science may ...
(Date:8/28/2015)... ... August 28, 2015 , ... Joining a ... Memorial Hospital recently transitioned management companies to partner with Wound Care Advantage (WCA) ... outpatient wound center. , Transitioning wound care management providers can be a ...
Breaking Medicine News(10 mins):Health News:Inventors and InventHelp Clients Develops Tension Reliever (LGI-1951) 2Health News:The Patriot Project brings Chiropractic Care to the Armed Forces and their Families - Rapid Release Technology Joins the Effort to Recruit more Doctors to Pledge 2Health News:FCPX Effects Developer, Pixel Film Studios, Releases ProDrop Particles. 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 2Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 3Health News:Decatur County Memorial Hospital Transitions Wound Center Management To Wound Care Advantage and the Luvo Operating System 4
... Should physicians be banned from assisting in a lethal ... A recent ruling by the American Board of Anesthesiology ... punishment, and other medical boards may act similarly. An ... concludes that decertification of physicians participating in lethal ...
... HealthDay Reporter , THURSDAY, June 9 (HealthDay News) ... disease among kidney patients by as much as 25 percent, ... ever conducted. "People with kidney disease are at a ... Dr. Colin Baigent, a professor of epidemiology at the University ...
... in the Clinical Neuropsychologist (e-publication ahead of ... in the brain development of preschool children with symptoms ... the brain important for cognitive and motor control was ... Novel for its use of neuroimaging in very young, ...
... Sheffield,s School of Health and Related Research (ScHARR) has developed ... been accepted for use by the Department of Health. ... Jacques and James Fotheringham, were commissioned in January 2011 by ... index to look at deaths following a hospital admission. In ...
... , Bethesda, MD Vaccinating children around the world against ... past several decades. Now new opportunities exist to overcome remaining ... according articles in the June 2011 edition of Health ... from the Bill & Melinda Gates Foundation. Last ...
... into a wallet or pursebut it could mean the difference between ... stores personal medical data (e.g. information on existing medical conditions, allergies ... enabling the data to be accessed in just a few moments. ... have been trialled in the UK. This working prototype has ...
Cached Medicine News:Health News:Physician participation in lethal injection executions should not be banned, argue 2 ethicists 2Health News:Physician participation in lethal injection executions should not be banned, argue 2 ethicists 3Health News:Vytorin Lowers Heart Disease Risk in Large Study of Kidney Patients 2Health News:Vytorin Lowers Heart Disease Risk in Large Study of Kidney Patients 3Health News:Brain imaging study of preschoolers with ADHD detects brain differences linked to symptoms 2Health News:New hospital mortality rate index to be used across UK 2Health News:New hospital mortality rate index to be used across UK 3Health News:'Decade of vaccines' has potential to save lives, but challenges ahead 2Health News:'Decade of vaccines' has potential to save lives, but challenges ahead 3Health News:'Decade of vaccines' has potential to save lives, but challenges ahead 4Health News:MyCare -- the 'card' that could save your life 2
(Date:8/28/2015)... FRANCISCO , August 28, 2015 ... expected to reach USD 49.12 billion by 2020, growing ... according to a new report by Grand View Research, ... estimated CAGR of 49.7% from 2014 to 2020. ... Growing aging population along with rising incidences of chronic ...
(Date:8/27/2015)... 27, 2015  A recent study by Feucht ... compared the Arthrosurface HemiCAP® Wave implant, which is ... "onlay" design implant for isolated patellofemoral disease. While ... and pain scores, none of the patients in ... However, 53% of the patients in the "onlay" ...
(Date:8/27/2015)... -- Biosimilars are not generics and the Biologics ... Drug Administration (FDA) for recognizing that each biosimilar ... issued today. The FDA,s draft guidance on nonproprietary ... for biological products to bear a nonproprietary name ... the agency,s thinking that "there is a need ...
Breaking Medicine Technology:mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 2Study Demonstrates Dramatic Reduction in Progression of Osteoarthritis with the Arthrosurface "Inlay" Patellofemoral Implant Design Compared to Traditional "Onlay" Implant 3Biologics Prescribers Collaborative (BPC) Statement on FDA Draft Guidance entitled "Nonproprietary Naming of Biological Products" 2
... Oct. 12 Today at the annual AdvaMed ... provider of Good Promotional Practices software, announced a ... hotline and case management solutions. Together, the companies ... to help Life Sciences companies cope with the ...
... Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) today announced that ... general business update on Monday, October 12, 2009, at 8:00 ... parties may access a live webcast of the presentation on ... or by dialing 847-413-3362 and using the passcode 25577870#. ...
Cached Medicine Technology:Prolifiq and EthicsPoint Announce Partnership: 'Automatic Alerts' Help Life Sciences Engage in Good Promotional Practices 2Prolifiq and EthicsPoint Announce Partnership: 'Automatic Alerts' Help Life Sciences Engage in Good Promotional Practices 3
... knee system was designed to ... between all articulating surfaces and ... with wear in order to ... with normalized quadriceps and patellar ...
...
...
...
Medicine Products: