Navigation Links
Scientists find potential target for treating mitochondrial disorders
Date:3/27/2014

CAMBRIDGE, Mass. (March 27, 2014) Mitochondria, long known as "cellular power plants" for their generation of the key energy source adenosine triphosphate (ATP), are essential for proper cellular functions. Mitochondrial defects are often observed in a variety of diseases, including cancer, Alzheimer's disease, and Parkinson's disease, and are the hallmarks of a number of genetic mitochondrial disorders whose manifestations range from muscle weakness to organ failure. Despite a fairly strong understanding of the pathology of such genetic mitochondrial disorders, efforts to treat them have been largely ineffective.

But now, graduate student Walter Chen and postdoctoral researcher Kivanc Birsoy, both part of Whitehead Institute Member David Sabatini's lab, have unraveled how to rescue cells suffering from mitochondrial dysfunction, a finding that may lead to new therapies for this condition.

To find genetic mutations that would rescue the cells, Chen and Birsoy mimicked mitochondrial dysfunction in a haploid genetic system developed by former Whitehead Fellow Thijn Brummelkamp. After suppressing mitochondrial function using the drug antimycin, Chen and Birsoy saw that cells with mutations inactivating the gene ATPIF1 were protected against loss of mitochondrial function.

ATPIF1 is part of a backup system to save starving cells. When cells are deprived of oxygen and sugars, a mitochondrial complex that usually produces ATP, called ATP synthase, switches to consuming it, a state that can be harmful to an already starving cell. ATPIF1 interacts with ATP synthase to shut it down and prevent it from consuming the mitochondrion's dwindling ATP supply but, in the process, also worsens the mitochondrion's membrane potential

"In these diseases of mitochondrial dysfunction, in a sense, it's a false starvation situation for the cellthere are plenty of nutrients, but because there's a block in the mitochondria's normal function, the mito
'/>"/>

Contact: Nicole Giese Rura
rura@wi.mit.edu
617-258-6851
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists solving the mystery of human consciousness
2. Scientists uncover multiple faces of deadly breast cancer
3. Scientists identify major source of cells defense against oxidative stress
4. Scientists tailor cell surface targeting system to hit organelle ZIP codes
5. Scientists rewrite rulebook on breast cancer in landmark global study
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. NIH scientists link quickly spreading gene to Asian MRSA epidemic
8. Joslin scientists identify important mechanism that affects the aging process
9. Scripps Research scientists show how memory B cells stay in class to fight different infections
10. Scientists Map Melanomas Genome
11. A*STAR scientists discover switch to boost anti-viral response to fight infectious diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... By Karen Pallarito ... -- Imagine if doctors and hospitals got paid for providing ... consumers had better data for making informed health choices. ... health system is headed. The report, from the IMS ... of change" -- recent events expected to alter the delivery ...
(Date:9/23/2014)... 23, 2014 What information do ... National Quality Forum (NQF) released a report ( ... and an infographic ( http://bit.ly/1tX3lzA ) resulting from ... healthcare, how patients define affordability, and what information ... the best possible healthcare at the lowest possible ...
(Date:9/23/2014)... recent Oregon survey about an exercise DVD that adds ... of elementary school students found it had a high ... offered clear advantages for overly sedentary educational programs. , ... by the Healthy Youth Program of the Linus Pauling ... , Brain Breaks leads children in 5-7 minute segments ...
(Date:9/23/2014)... California (PRWEB) September 23, 2014 ... Oracle services market. Included are Oracle Managed ... Augmentation. Trevera supports all versions of Oracle E-Business ... point releases. , Trevera has announced a ... organizations that need help with their software technology ...
(Date:9/23/2014)... September 23, 2014 Risperdal lawsuits ( ... the country, Bernstein Liebhard LLP reports. According to an ... Florida on September 19th, the Court has dismissed fraud ... in that jurisdiction on behalf of a man who ... due to his use of Risperdal. In dismissing the ...
Breaking Medicine News(10 mins):Health News:Report Identifies Game Changers for U.S. Health Care 2Health News:Report Identifies Game Changers for U.S. Health Care 3Health News:Finding Affordable Care: Asking the Right Question is Key 2Health News:'Brain Breaks' increase activity, educational performance in elementary schools 2Health News:'Brain Breaks' increase activity, educational performance in elementary schools 3Health News:Trevera, Inc adds Management Support to Services 2Health News:Trevera, Inc adds Management Support to Services 3Health News:Risperdal Lawsuit News: Fraud, Negligence Per Se Claims Dismissed from Florida Complaint, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuit News: Fraud, Negligence Per Se Claims Dismissed from Florida Complaint, Bernstein Liebhard LLP Reports 3
... be the greatest advance in waking up since coffee, ... wake up,in the morning feeling refreshed and ready to go, ... performance to spousal,relations and even driving ability. Fortunately, a unique ... a pill you take before,bedtime that will help you to ...
... specialty bio-therapeutics company developing high-value human,therapeutic proteins for commercialization, will hold its Annual ... Wednesday, April 9, 2008, Time: ... The National Club ... Toronto, Ontario Mr. ...
... look in your,medicine cabinet -- do you spot ... the nation,s dramatic increase in irresponsible,prescription drug use? ... 71 percent of prescription pain medication abusers,obtained the ... 13-year-olds,prescription drug abuse actually exceeds marijuana use., ...
... Awareness ... Month, PRINCETON, N.J., April 8, ... U.S. raising,awareness regarding the poor state of sexual health in America and urging,Americans ... and the Evolve tour is designed to address this head on by,inspiring a ...
... The appearance of a cold sore is,a sign that ... serious,illnesses emerge, according to John Sherman, ND, noted naturopathic,physician ... between 80% and 90% of the adult population have ... to Dr. Sherman, who,is the author of The Complete ...
... Moses and his,wife Ida thought they were doing everything ... multiple medical problems, Moses had an ugly,uncomfortable sore on ... go,away., Dr. Harris Greenberger, Director of Sound Foot ... and Stamford Hospitals in,Connecticut, diagnosed it as a diabetic ...
Cached Medicine News:Health News:Tired Mother Invents Pill to Wake You Up On Time 2Health News:Media Invitation - Annual General and Special Meeting of Shareholders of Haemacure 2Health News:Prescription Drug Abuse Threatens Availability of Pain Medication 2Health News:Video: Rubber Hits the Road as Trojan(R) Campaigns for Sexual Health in America to Evolve 2Health News:Video: Rubber Hits the Road as Trojan(R) Campaigns for Sexual Health in America to Evolve 3Health News:A Cold Sore Is Often A Warning Sign of Deeper Health Issues, Expert Says 2Health News:Living Cell Treatment Heals Diabetic Foot Sores Fast 2
(Date:9/23/2014)... Sept. 23, 2014 The Pennsylvania State Police will ... 27, as part of National Prescription Drug Take-Back Day. ... Take-Back Day is a national initiative, conducted ... aimed at encouraging the public to dispose of expired, ... abuse and theft. From 10 a.m. to ...
(Date:9/23/2014)... AVIV, Israel , Sept. 23, 2014 /PRNewswire/ ... ) ("Galmed"), a clinical-stage biopharmaceutical company focused on ... therapy for the treatment of liver diseases and ... and Drug Administration, or the FDA, approved its ... candidate, aramchol, for the treatment of Non-Alcoholic Steato-Hepatitis, ...
(Date:9/23/2014)...  Vesselon, Inc. today announced the appointment of Jurgen ... 15, 2014. Dr. Raths, appointment follows Vesselon,s engagement with ... market a private preferred Series A round to facilitate ... "Jurgen,s deep experience across multiple functional areas of ... Vesselon as we develop our device that can be ...
Breaking Medicine Technology:Galmed Pharmaceuticals Announces U.S. FDA Approval of Fast Track Designation of Aramchol for the Treatment of NASH 2Galmed Pharmaceuticals Announces U.S. FDA Approval of Fast Track Designation of Aramchol for the Treatment of NASH 3Vesselon Announces Jurgen Raths, MD to Serve on Board of Directors 2Vesselon Announces Jurgen Raths, MD to Serve on Board of Directors 3
... (NYSE: DGX ), the world,s leading provider of ... of Directors declared a quarterly cash dividend of $0.17 per ... of Quest Diagnostics common stock on April 3, 2012. ... is the world,s leading provider of diagnostic testing, information and ...
... For the first time, consumers shopping for over-the-counter ... system that appears on the skin, affecting as ... joint and tendon disease—will find a National Psoriasis ... experts deem effective in relieving disease symptoms. Learn ...
Cached Medicine Technology:National Psoriasis Foundation Launches "Seal of Recognition" for Psoriasis Products 2National Psoriasis Foundation Launches "Seal of Recognition" for Psoriasis Products 3
Solid steel construction for lifelong quality. Strong, smooth and quiet electro-mechanical up/down movement. Dual castor, locking wheels for use on carpet or tile flooring. Easy cleaning, deluxe lami...
Trial lens set +/- Cyl....
... Contemporary Soft Touch control panel with ... Pebble Gray, Noir Black, Colonial Blue and ... arms. Durable cast iron and steel construction ... smooth, quiet and reliable up/down chair movement. ...
Our Ophthalmic Diagnostic Sets offer everything an eye care specialist needs. Complete your set with your choice of ophthalmoscope, retinoscope, handle, and case....
Medicine Products: