Navigation Links
Scientists find potential new clues for identifying breast cancer risk
Date:6/4/2013

New research provides critical insights into how normal breast precursor cells may be genetically vulnerable to develop into cancer. The research is published June 4th in the inaugural issue of Stem Cell Reports, an open-access journal from the International Society of Stem Cell Research (ISSCR) published by Cell Press. Scientists discovered that a particular class of normal breast precursor cells have extremely short chromosome ends (known as telomeres). As a result, these cells would be expected to be prone to acquiring mutations that lead to cancer if they managed to stay alive. These findings suggest new indicators for identifying women at higher risk for breast cancer and provide insights into potential new strategies to detect, treat, and prevent the disease.

Dr. David Gilley's laboratory at the Indiana University School of Medicine in Indianapolis and Dr. Connie Eaves' laboratory at the BC Cancer Agency's Terry Fox Laboratory in Vancouver, Canada, collaborated to determine how telomeres are regulated in different types of normal breast cells. Their studies revealed that a subset of normal breast precursor cells, called luminal progenitors, have dangerously short telomeres and display a correspondingly high level DNA damage response localized at their chromosome ends. This shows how a normal process of tissue development produces a cell type that is predisposed to acquire cancer-causing mutations.

"This is the first report of a particular normal human precursor cell type that shows such telomere malfunction," says Dr. Eaves. "The luminal progenitors we have found to possess this feature are thus now being brought into the spotlight as a likely stage where breast cancer may 'take off.'" Recent studies have implicated luminal progenitor cells in the development of breast cancers with a mutated BRCA1 gene.

The research highlights the importance of investigating different cell types in normal human tissues to understand the
'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. PolyU Scientists Help Identify Genes Causing Myopia
2. Scientists Gauge Radiation Dose From Trip to Mars
3. Scientists Spot Genes Tied to Success at School, College
4. German and Israeli scientists gain new insights into protein disposal
5. Scientists Cant Replicate Surprising Finding on Alzheimers Treatment
6. Scientists discover how rapamycin slows cell growth
7. Scientists Map the Fungi on Your Feet
8. UofL scientists uncover how grapefruits provide a secret weapon in medical drug delivery
9. Most scientists agree: Humans are causing climate change
10. Scientists Use Cloning Technique to Produce Human Stem Cells
11. Brain rewires itself after damage or injury, life scientists discover
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/3/2015)... ... ... ProScrub is a set of automated tools that allow Final Cut Pro ... without the use of keyframes. Utilize ProScrub's powerful sliders to determine the number ... to energetic video productions. ProScrub is a Final Cut Pro X ...
(Date:9/3/2015)... ... September 03, 2015 , ... AvePoint, the established leader ... Service Pack (SP) 4 – AvePoint’s solution for facilitating two-way collaboration and external ... 2015 Trend-Setting Product”. This is the fifth consecutive year an AvePoint product has ...
(Date:9/3/2015)... ... 2015 , ... Representatives with State Farm Agent EJ Roberts ... Gulf Babypalooza on September 19, 2015. , “We will be providing information to ... We will be discussing setting up college funds, offering information specific to their ...
(Date:9/3/2015)... ... September 03, 2015 , ... When looking at the types of people who have a ... two categories: those that have a weak appetite or those that have a fast metabolism. ... gain weight, CB-1 Weight Gainer gives three tips for slowing down metabolism. , The first ...
(Date:9/3/2015)... ... 03, 2015 , ... James Earl Jones will be hosting an upcoming VOICES ... Earl Jones will introduce a segment that discusses why it is important for the ... can be fostered in any working environment. , Employers are out billions of dollars ...
Breaking Medicine News(10 mins):Health News:FCPX Effects Developer Releases ProScrub for Final Cut Pro X 2Health News:AvePoint Perimeter Named a “KMWorld 2015 Trend-Setting Product” 2Health News:AvePoint Perimeter Named a “KMWorld 2015 Trend-Setting Product” 3Health News:AvePoint Perimeter Named a “KMWorld 2015 Trend-Setting Product” 4Health News:State Farm Agent EJ Roberts to Help Expecting Mothers at the Mississippi Gulf Babypalooza 2Health News:CB-1 Weight Gainer Gives Three Tips for Slowing Down Metabolism 2Health News:CB-1 Weight Gainer Gives Three Tips for Slowing Down Metabolism 3Health News:James Earl Jones Hosts a New "Voices In America" Piece on Making the Workplace Healthier 2
... 15, will mark the first national "Short Sleeve ... group, will be holding a,special show in Murray, ... 5 Monkeys,Salt Lake City singer- songwriter-pianist, and psoriasis ... to the combination awareness,event, fundraiser and party. More ...
... A free educational conference,focusing on women and neurological ... Ford Hospital - will take place from 8 a.m. ... 200 W. Big Beaver Rd. The conference will ... multiple sclerosis, epilepsy, Parkinson,s disease, dementia and,stroke. The ...
... see better, study finds , , FRIDAY, Sept. 14 (HealthDay News) -- ... eye." , British researchers say youngsters may not need to wear ... to treat the condition. , Instead, wearing the patch just three ... may do the trick to improve sight, the new study suggests. ...
... Saturday,September 15, will mark the first national "Short Sleeve ... will be holding a,special Chicagoland cookout to celebrate. From ... games and other fun at North Aurora Island Park ... will run,the combination awareness event, fundraiser and party. The ...
... N.C., Sept. 14 Inspiration can take on,different forms; ... person. Lulu.com has made,it possible for those with inspiring ... 11-year-old author with Autism. Heather Higgins published her ... ), and became one of Lulu,s,youngest authors. Her story ...
... 13 ,Exelixis, Inc. (Nasdaq: EXEL ) announced today ... of Exelixis, will present at the,Bank of America 2007 ... on Tuesday, September 18, 2007. The presentation will ... page under Investors on the Exelixis website at, http://www.exelixis.com ...
Cached Medicine News:Health News:Salt Lake City Psoriasis Event Saturday Will Celebrate First National Short Sleeve Day 2Health News:No Need for All-Day Patch to Treat 'Lazy Eye' 2Health News:No Need for All-Day Patch to Treat 'Lazy Eye' 3Health News:Chicagoland Psoriasis Event Saturday Will Celebrate First National Short Sleeve Day 2Health News:Inspiring Authors Tell Inspirational Stories: Special Writers Find Accepting Home at Lulu.com 2
(Date:9/2/2015)... , Sept. 2, 2015 About Chronic Lymphocytic ... malignant condition characterized by increased production of lymphocytes. It ... and then it can spread to other parts of ... stages because of the slow buildup of the cancerous ... spreads to the spleen, liver, and lymph nodes. The ...
(Date:9/2/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/l8z67c/pharmaceutical ) has ... China (Basel, Switzerland - November 26-27, 2015)" conference to ... detailed overview of the key areas of pharmaceutical regulatory affairs ... , Macau and ... All important aspects of gaining and maintaining a successful Marketing ...
(Date:9/2/2015)... DIAMONDHEAD, Miss. , Sept. 2, 2015   Gulf Coast ... tattoo removal services with the cutting-edge Astanza Duality laser in ... with unwanted ink erase their tattoo regret and take back control ... Mississippi but extends its services to Biloxi ... Coast region. "With tattoo regret being as prevalent as ...
Breaking Medicine Technology:Global Chronic Lymphocytic Leukemia Therapeutics Market 2015-2019 2Global Chronic Lymphocytic Leukemia Therapeutics Market 2015-2019 3Pharmaceutical Regulatory Affairs in China Seminar: Basel, Switzerland - November 26-27, 2015 2Gulf Coast Tattoo Removal Delivers Unrivaled Tattoo Removal Results To Biloxi And Gulfport With Astanza Duality 2
... 2011 ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ANX ... M. Culley, will present at the Rodman & Renshaw Annual ... p.m. Eastern time, in the Metropolitan East Salon at the ... can access a live audio webcast and slide presentation on ...
... Medical, Inc. today announced the full European launch of ... technology has an enhanced design to further promote clot ... ischemic stroke. The Trevo® Pro 4 system ... Medical and is used to remove thrombus in stroke ...
Cached Medicine Technology:Next Generation Trevo® System Launched in Europe - Trevo® Pro 2
... The Aladdin Companion is the most affordable, ... built-in handle and weighing only 18 pounds, ... or "on-the-go" video magnifier. The Companions easy-to-use ... of printed materials including books, magazines, newspapers ...
... The Classic is a ... designed for use by people ... the easy-to-use picture control selector, ... materials in high-contrast black text ...
The Miniviewer magnifies text or color images 5 to 15 times. MiniViewers superior magnification, light weight and portable design offer you the ultimate in flexibility....
... Minimate provides the ideal video magnification ... includes a simple-to-use camera attached to ... is mounted on a mini xY ... a carrying bag. Minimates versatility allows ...
Medicine Products: