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Scientists find key steps linking dietary fats and colon cancer tumor growth
Date:4/21/2014

Scientists have shown new genetic evidence that could strengthen the link between the role of dietary fats with colon cancer progression.

The study, led by Arizona State University researcher and physician Dr. Raymond DuBois, M.D., Ph.D., has identified a molecular culprit, called peroxisome proliferator-activated receptor delta (PPAR delta), which, when deleted in a mouse model of colon cancer, stopped key steps required for the initiation and progression of tumor growth.

"This study has shown without a doubt there is a new function for a key molecule, PPAR delta, in the initiation and progression of colon cancer," said DuBois, executive director of ASU's Biodesign Institute. "These results also provide a new rationale for developing therapeutics that could block PPAR delta to treat inflammatory bowel disease and colorectal cancer."

The study was published in the April 21 early online edition of the Proceedings of the National Academy of Sciences http://www.pnas.org/cgi/doi/10.1073/pnas.1324233111. The research team included DuBois' Laboratory of Inflammation and Cancer members Dingzhi Wang, Lingchen Fu, Lixia Guo at ASU's Biodesign Institute; Wei Ning, Rupesh Chaturvedi, and Keith Wilson of Vanderbilt Medical School; and Xiaofei Sun and Sudhansu Dey of Cincinnati Childern's Research Foundation.

The DuBois research team has been in pursuit of uncovering the links between inflammation and colon cancer for the past 2 decades. Colorectal cancer is the second leading cause of cancer deaths in the U.S.

Evidence for this link comes from data showing that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduced the risk of developing colorectal cancer by 40-50 percent. NSAIDs target an enzyme called cyclooxygenase 2 (COX-2), which carries out steps to produce the pro-inflammatory molecule prostaglandin E2 (PGE2), found at
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Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-258-8972
Arizona State University
Source:Eurekalert  

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