Navigation Links
Scientists find key mechanism of childhood respiratory disease
Date:3/7/2011

GALVESTON, Texas Researchers have identified a critical part of the process by which one of the world's most common and dangerous early childhood infections, respiratory syncytial virus, causes disease.

The discovery could lead to badly needed new therapies for RSV, which in 2005 was estimated to have caused at least 3.4 million hospitalizations and 199,000 deaths among children under five worldwide.

By analyzing samples taken from infected infants and data from laboratory-mouse experiments, University of Texas Medical Branch at Galveston scientists determined that RSV interferes with airway cells' ability to produce enzymes that keep highly damaging molecules known as reactive oxygen species under control. The virus does this by preventing the activation of a single protein needed for the expression of a variety of detoxifying enzymes. Reactive oxygen species then accumulate, causing cell-killing oxidative stress and inflammation in both infected and uninfected airway cells a major factor in the damage done by RSV infection.

"The role of oxidative stress has been studied in everything from aging to asthma, but this is really the first study to implicate it in lung inflammation associated with viral infections," said Dr. Antonella Casola, an associate professor at UTMB Health and lead author of a paper on the research, published online March 4 in the "Articles in Press" section of the American Journal of Respiratory and Critical Care Medicine (http://ajrccm.atsjournals.org/articlesinpress.dtl). "We've been working on this project for a while starting in cells, then moving to animal models and finally getting results in patients so we're very excited about this paper."

The UTMB Health researchers followed up earlier studies in human cell cultures with experiments that showed a substantial reduction in the expression and activation of antioxidant enzy
'/>"/>

Contact: Jim Kelly
jpkelly@utmb.edu
409-772-8791
University of Texas Medical Branch at Galveston
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New weight loss discovery by Harvard scientists moves us closer to the Pill for obesity
2. Scientists Link 13 New Gene Regions to Heart Disease Risk
3. Scientists Use Stem Cells, Skin Cells to Create Brain Cells Lost to Alzheimers
4. New gene regions identified that predispose people to heart attacks, Stanford scientists say
5. Scientists Link Sets of Genetic Abnormalities to Autism Risk
6. Scientists Spot Another Gene Behind Type 2 Diabetes
7. Scientists reveal new insights into tendon injury
8. Top scientists unite to develop global scientific strategy Towards An HIV Cure
9. Scientists Say Newborn Mice Can Regrow Damaged Hearts
10. Neuroscientists find overlooked brain area is an important locus of depression
11. Scientists bioengineer a protein to fight leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Andover, NJ (PRWEB) July 30, 2014 Within weeks ... with excitement and promise. Each hopes this will be a time ... is reason for each to pause; it may not be as ... as 80% of students will switch their major at least once ... cost time and energy and the costs are exacerbated when switching ...
(Date:7/30/2014)... 30, 2014 Conducting Advanced Root ... Thinking Skills and Innovative Techniques to Improve the ... and FDAnews**, Sept. 17-18, 2014 – Raleigh, NC, ... #1 reason for 483 observations since 1997. , ... a successful CAPA program has never been more ...
(Date:7/30/2014)... Good Neighbor Community Services announced ... episode of Innovations with Ed Begley Jr, airing ... show times TBA. , In this segment, viewers ... vision to redefine the traditional approach to serving ... Through passion, innovation, determination, excellence, and collaboration, Good ...
(Date:7/30/2014)... 30, 2014 SF Cable, distributor of ... lowest prices on the internet with guaranteed customer satisfaction ... lengths and two colors. These lightning cords are MFI ... The high quality SF Cable Lightning to USB ... signal delivering faster charging and syncing. Compatible with the ...
(Date:7/30/2014)... Hamilton Facial Plastic Surgery is ... office on July 30th. After months of planning, Dr. ... the state-of-the-art suite, located only steps away from the ... for one-on-one patient comfort, shorter wait times, and generally ... Hamilton’s new office-suite will continue to provide the same ...
Breaking Medicine News(10 mins):Health News:Advice to College Freshman from Author Garrett Miller 2Health News:Advice to College Freshman from Author Garrett Miller 3Health News:FDAnews Workshop: Conducting Advanced Root Cause Analysis CAPA Investigations, Sept. 17-18, 2014, Raleigh, NC 2Health News:FDAnews Workshop: Conducting Advanced Root Cause Analysis CAPA Investigations, Sept. 17-18, 2014, Raleigh, NC 3Health News:FDAnews Workshop: Conducting Advanced Root Cause Analysis CAPA Investigations, Sept. 17-18, 2014, Raleigh, NC 4Health News:Good Neighbor Community Services to be Featured in an Upcoming Episode of Innovations With Ed Begley, Jr. 2Health News:SF Cable Delivers Certified Lightning Cable in Multiple Sizes and Colors 2Health News:Hamilton Facial Plastic Surgery Opens New Carmel Office 2
... As injectable fillers,become mainstream it is no surprise ... alternatives to prevent facial wrinkles. Dr. Arnold,Klein, world-renowned ... says, "Fillers such as Artefill, Radiesse and Sculptra,contain ... into,human tissue, all of these products can cause ...
... ARLINGTON, Va., May 8 Who says the best,times ... The HealthCentral Network, Inc. (http://www.HealthCentral.com ) has recently,brought ... prove that along,with wrinkles and the responsibility of caring ... bring a smile to the face of others., ...
... An international,organization dedicated to furthering the advancement ... (GSK) Consumer Healthcare executive today,during an awards ... Ernestine Harris,GSK Consumer Healthcare,s U.S. director of ... Star" by the Healthcare Businesswomen,s Association,(HBA). The ...
... with human immunodeficiency virus (HIV), which leads to acquired ... According to the most recent estimates, released in ... HIV/AIDS (UNAIDS) and the World Health Organization (WHO), an ... currently. Although the rates of infection appear to ...
... Hill-Rom Holdings,Inc., (NYSE: HRC ) invites ... H.,Soderberg, president and chief executive officer, Hill-Rom. He ... New York on Wednesday, May 21,at 8:30 a.m. ... the live presentation via the internet,link at ...
... ("MDAC") is proud to announce that it has retained ... build a significant enterprise in one or,more select medical ... MDAC team combines a strong set of capabilities and ... excited to be working,with them in identifying and executing ...
Cached Medicine News:Health News:Dr. Arnold Klein Warns of Dangers With Permanent and Longer Lasting Injectable Fillers 2Health News:The HealthCentral Network Signs Spunky 'Midlife Gals' for Comedic Relief on Alzheimer's, Skin Care Sites 2Health News:GSK's Ernestine Harris Honored as Industry 'Rising Star' by Healthcare Businesswomen's Association 2Health News:GSK's Ernestine Harris Honored as Industry 'Rising Star' by Healthcare Businesswomen's Association 3Health News:Do antidepressants enhance immune function? 2
(Date:7/30/2014)... , July 30, 2014  Cepheid (Nasdaq: ... group purchasing contract with Premier will end on ... Premier GPO will be able to continue their ... Baycare, HPA, MedAssets, Novation, and ROi, in addition ... directly with Cepheid. "Cepheid has always ...
(Date:7/30/2014)... , July 30, 2014  Unilife Corporation ("Unilife" ... a developer and supplier of injectable drug delivery ... manufacturing capacity, R&D, and facilities in response to ... its products and services. During the fourth quarter ... $16 million in capital expenditures and R&D above ...
(Date:7/30/2014)... Research and Markets has announced the addition of the ... report to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... lower CAGR in developed countries; however, it is expected to witness ... , India , and Brazil ... the hematology analyzers and reagents market is driven by factors such ...
Breaking Medicine Technology:Cepheid Updates Status Of Premier Group Purchasing Organization (GPO) Agreement 2Cepheid Updates Status Of Premier Group Purchasing Organization (GPO) Agreement 3Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 2Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 3Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 4Unilife Accelerates Investment to Meet Increasing Demand from New and Existing Customers 5Hematology Analyzers & Reagents Market - Forecasts to 2019 2
... flow while minimizing the pain ... the safety-engineered BD Microtainer Genie ... Lancet offers a full range ... capillary blood collection and protects ...
... Maximize blood flow and minimize pain ... the safety-engineered BD Microtainer Quikheel Lancet. ... surgical blade providing a precise and ... retracts into its casing, helping to ...
DAVINCI® performs all required steps primary tube sampling, reagent dispensing, microplate incubation, washing and optical reading....
The Minilyser offers a combination of three well proven instruments for fully automated processing of microplates. The Minilyser is the optimal fully automated ELISA and EIA equipment for laboratorie...
Medicine Products: