Navigation Links
Scientists find gene that modifies severity of cystic fibrosis lung disease
Date:3/3/2009

WINSTON-SALEM, N.C. Researchers at Wake Forest University Baptist Medical Center, and colleagues, have identified a gene that modifies the severity of lung disease in people with cystic fibrosis, a lethal genetic condition. The findings open the door to possible new targets for treatment, researchers say.

The study appeared online last week in advance of print publication in Nature. It is the first published study to search the entire genome looking for genes that modify the severity of cystic fibrosis lung disease.

"This is a good example of researchers with different expertise coming together and using the knowledge gained from mapping the human genome to make discoveries that improve our understanding of cystic fibrosis," said Carl Langefeld, Ph.D., a study co-author and Wake Forest University School of Medicine researcher. "It may also help in the identification of targets for drug development and the development of tools for the earlier diagnosis of individuals with cystic fibrosis who are susceptible to severe lung disease."

After analyzing the genetic makeup of nearly 3,000 cystic fibrosis patients, researchers found that small genetic differences in a gene called IFRD1 correlate with lung disease severity. While probing how the gene might alter the disease's course, researchers discovered the protein encoded by IFRD1 is particularly abundant in a type of white blood cell called neutrophils, and that it regulates their function. Part of the immune system, neutrophils are known to cause inflammatory damage to the airways of people with cystic fibrosis.

"Neutrophils appear to be particularly bad actors in cystic fibrosis," said senior investigator Christopher Karp, M.D., the director of Molecular Immunology at Cincinnati Children's Hospital Medical Center. "They are important to the immune system's response to bacterial infection. In cystic fibrosis, however, neutrophilic airway inflammation is dysregulated, ev
'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UCI scientists to study brain region linked to autism, schizophrenia
2. Singapore Offers Grants to Research Scientists to Start Labs Here
3. Scripps research scientists engineer new type of vaccination that provides instant immunity
4. Scientists Discover New Drug Targets for Crohns Disease
5. Scripps research scientists develop general-purpose method for detecting trace chemicals
6. Scientists Spot New Clue to Alzheimers
7. Scientists eavesdrop on the exciting conversations within cells
8. Scientists Find Gene for Tooth Enamel
9. Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu
10. Scientists May Have New Way to Fight the Flu
11. Scientists Gain Insight Into Blood Cancers Progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... Sunrise, FL (PRWEB) March 05, 2015 ... appear at this week’s Arnold Sports Festival and ... March 5-8. Metabolic Nutrition will host a display ... its all-new pre-workout E.S.P. and its highly-popular, class-leading fat ... free shaker cups, unique recipes that utilize its top-of-the-line ...
(Date:3/5/2015)... Think it’s tough to get kids to ... them to brush their teeth. That’s a finding from a ... Delta Dental(1) in conjunction with National Parenting Month in March. ... kids to brush their teeth is one of the most ... higher than getting children to eat vegetables regularly (42 percent) ...
(Date:3/5/2015)... DE (PRWEB) March 05, 2015 The ... false weight loss promises is alarming, with more and ... products without an actual prescription, making it easy for ... that simply take their money and endanger their health. ... questions before purchasing prescription online diet pills: , 1.    Where ...
(Date:3/5/2015)... The MTC 5-day Fundamental Implantology Course ... from a variety of dental disciplines, to offer implant ... "From the onset we wanted this course to be ... to the excellence of the lecturers and the sheer ... more than satisfied our aims." , Unlike large-scale ...
(Date:3/5/2015)... Plains, NY (PRWEB) March 05, 2015 Hope ... New York Sporting Clay Shoot to be held at Beretta ... May 15, 2015. All proceeds from the event will benefit ... a sense of self, restoring the family unit, and restoring ... The event will honor our nation’s heroes through a day ...
Breaking Medicine News(10 mins):Health News:Metabolic Nutrition Exhibiting at 2015 Arnold Sports Festival and Fitness EXPO This Week 2Health News:Delta Dental Survey Says Parents Have Harder Time Getting Kids to Brush than to Eat Vegetables 2Health News:Delta Dental Survey Says Parents Have Harder Time Getting Kids to Brush than to Eat Vegetables 3Health News:Diet Doc Announces Four Simple Questions that Dieters Must Ask Prior to Purchasing Online Diet Pills 2Health News:Diet Doc Announces Four Simple Questions that Dieters Must Ask Prior to Purchasing Online Diet Pills 3Health News:MIS Global Training Center (MTC) Launches its Fundamental Implantology Course for Doctors - with a Difference 2Health News:Hope For The Warriors Announces New York Clay Shoot to Benefit Military Families 2
... by the National Human Genome Research Institute (NHGRI), has ... shows promise in laboratory studies for treating a fatal ... ,These drugs belong to a class of farnesyltransferase inhibitors ... myeloid leukemia, neurofibromatosis and other conditions. It could also ...
... Brisk walks or running may reduce the risk of ovarian cancer, ... may reduce the risk of some other forms of cancer. ... a 70 % reduction in the risk of development of ovarian ... colon cancer was also less frequent among those who exercised. ...
... behaviors, like over speeding, more in company of same ... sex. ,The study was published on-line edition of ... ,The findings indicate that teen risky driving increases in ... But more important, the finding should remind teens-and the ...
... from University of Pennsylvania had identified a brain chemical ... abuse. The chemical called orexin is also involved in ... ,Research showed that the activation of ... that controls many vital functions such as eating, body ...
... couples trying to conceive that is, one in every six ... a problem with conception. ,With this being the clinical ... is increasing day by day. // In spite of ... to physical, mental and psychological trauma. Anxiety of patients regarding ...
... by AUT Professor of Nutrition Elaine Rush states that ... sugar as well as caffeine contributes to obesity. // ... containing sugar, added caffeine and guarana (which also contains ... more rapidly than lemonade. "These results could have huge ...
Cached Medicine News:Health News:Brain Chemical Identified For Drug Dependent Behavior 2Health News:Will anxiety regarding fertility treatment affect the chances of conception? 2Health News:Obesity Can Be Caused By Consumption Of Energy Drinks 2
(Date:3/5/2015)... 5, 2015  Sanomedics, Inc. (OTC: SIMH, SIMHD) ("Sanomedics" ... on developing, manufacturing, and acquiring cutting-edge technology, products and ... will be exhibiting at booth # 709 at the ... (NAPNAP) taking place on March 11-13, 2015 at Caesars ... The 36 th annual NAPNAP ...
(Date:3/5/2015)... , March 5, 2015   AMC ... management solutions recognized for improving the effectiveness and ... that Robert Anazagasty and Jared ... serve as Vice President, Strategic Client Development, and ... These additions support AMC Health,s commitment to accelerating ...
(Date:3/5/2015)...  Celsion Corporation (NASDAQ: CLSN ) ... conference call to discuss year-end 2014 financial results ... for ThermoDox®, its proprietary heat-activated liposomal encapsulation of ... and TheraSilence™, in immunotherapy and RNA delivery at ... To participate in the call, interested parties may ...
Breaking Medicine Technology:Sanomedics to Showcase the Caregiver at National Association of Pediatric Nurse Practitioners Conference 2Sanomedics to Showcase the Caregiver at National Association of Pediatric Nurse Practitioners Conference 3AMC Health Bolsters Sales Team with Robert Anazagasty and Jared Wilstead 2AMC Health Bolsters Sales Team with Robert Anazagasty and Jared Wilstead 3Celsion Corporation to Hold Year-End 2014 Financial Results Conference Call on Thursday, March 12, 2015 2
... WORCESTER, Mass. and TORONTO, Nov. 21, 2011 Generex ... that its wholly-owned subsidiary, Antigen Express, Inc. ( www.antigenexpress.com ... its study of a novel Ii-Key Hybrid-based HER-2/neu Peptide ... the 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium ...
... Calif., Nov. 21, 2011  BARRX Medical Inc., a leader ... with endoscopy to remove precancerous tissue from the gastrointestinal ... agreement to be acquired by Covidien.  Covidien is a ... leader in advanced energy-based devices.  Covidien ...
Cached Medicine Technology:Generex Subsidiary Antigen Express to Present AE37 Cancer Vaccine Phase 2 Clinical Data at 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium 2Generex Subsidiary Antigen Express to Present AE37 Cancer Vaccine Phase 2 Clinical Data at 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium 3Generex Subsidiary Antigen Express to Present AE37 Cancer Vaccine Phase 2 Clinical Data at 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium 4Generex Subsidiary Antigen Express to Present AE37 Cancer Vaccine Phase 2 Clinical Data at 34th Annual CTRC-AACR San Antonio Breast Cancer Symposium 5BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 2BARRX Medical, Inc. Announces Definitive Agreement to be Acquired by Covidien 3
The XTRI method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of triglycerides in serum and plasma....
For the quantitative in vitro determination of Triglycerides in serum and plasma....
CK-MB Control...
The CK method used on the Dimension clinical chemistry system is an in vitro diagnostic test intended for the quantitative determination of creatine kinase activity in serum and plasma...
Medicine Products: