Navigation Links
Scientists find gene that modifies severity of cystic fibrosis lung disease
Date:3/3/2009

WINSTON-SALEM, N.C. Researchers at Wake Forest University Baptist Medical Center, and colleagues, have identified a gene that modifies the severity of lung disease in people with cystic fibrosis, a lethal genetic condition. The findings open the door to possible new targets for treatment, researchers say.

The study appeared online last week in advance of print publication in Nature. It is the first published study to search the entire genome looking for genes that modify the severity of cystic fibrosis lung disease.

"This is a good example of researchers with different expertise coming together and using the knowledge gained from mapping the human genome to make discoveries that improve our understanding of cystic fibrosis," said Carl Langefeld, Ph.D., a study co-author and Wake Forest University School of Medicine researcher. "It may also help in the identification of targets for drug development and the development of tools for the earlier diagnosis of individuals with cystic fibrosis who are susceptible to severe lung disease."

After analyzing the genetic makeup of nearly 3,000 cystic fibrosis patients, researchers found that small genetic differences in a gene called IFRD1 correlate with lung disease severity. While probing how the gene might alter the disease's course, researchers discovered the protein encoded by IFRD1 is particularly abundant in a type of white blood cell called neutrophils, and that it regulates their function. Part of the immune system, neutrophils are known to cause inflammatory damage to the airways of people with cystic fibrosis.

"Neutrophils appear to be particularly bad actors in cystic fibrosis," said senior investigator Christopher Karp, M.D., the director of Molecular Immunology at Cincinnati Children's Hospital Medical Center. "They are important to the immune system's response to bacterial infection. In cystic fibrosis, however, neutrophilic airway inflammation is dysregulated, ev
'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UCI scientists to study brain region linked to autism, schizophrenia
2. Singapore Offers Grants to Research Scientists to Start Labs Here
3. Scripps research scientists engineer new type of vaccination that provides instant immunity
4. Scientists Discover New Drug Targets for Crohns Disease
5. Scripps research scientists develop general-purpose method for detecting trace chemicals
6. Scientists Spot New Clue to Alzheimers
7. Scientists eavesdrop on the exciting conversations within cells
8. Scientists Find Gene for Tooth Enamel
9. Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu
10. Scientists May Have New Way to Fight the Flu
11. Scientists Gain Insight Into Blood Cancers Progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... 27, 2015 On June 5, Plan ... will partner with LifeSource to host Donate Your Break, ... place in a LifeSource donor coach outside of 116 ... p.m. , Demand for whole blood units is highest ... the summer months. LifeSource requires approximately 1,000 donations per ...
(Date:5/27/2015)... This is a professional and ... Omega-3 industry. The report provides a basic overview ... industry chain structure. The Omega-3 market analysis is ... competitive landscape analysis, and key regions development status. ... Company, Seadragon Marine Oils, Norwegian Fish Oil, Croda ...
(Date:5/27/2015)... (PRWEB) May 27, 2015 ... its SonarMD Platform, a first-of-its kind, cloud-based ... managing patients with chronic gastrointestinal disease. , ... MBA, the application allows physicians to monitor ... the ongoing use of electronic health assessment ...
(Date:5/27/2015)... 27, 2015 “Heroin has never been more ... overdoses are coming from,” says Harford County Sheriff Jeff Gahler, ... 8th. In the surging heroin related incidents in Baltimore, police ... education to prevent heroin addiction and subsequent abuse before it ... Drug Rehab Baltimore is a drug and alcohol rehab facility ...
(Date:5/27/2015)... Fernando Valley, CA (PRWEB) May 27, 2015 ... , Dr. Peyman Ghasri, is now offering discounts on facial ... every year after the age of 18. This lost collagen ... eyes, sunken cheeks, wrinkles and expression lines. Facial fillers are ... volume. Many people turn to facial fillers to create a ...
Breaking Medicine News(10 mins):Health News:Donate Your Break and Save Lives at the River North Blood Drive 2Health News:Omega-3 Market: Global 2015 Analysis & 2020 Forecasts on Market Size 2Health News:SonarMD™, LLC, Launches Game-Changing, IBD Population Health Management Platform 2Health News:The Price of Heroin in Baltimore Drops, Surging Use and Causing Rife Overdose Deaths 2Health News:The Price of Heroin in Baltimore Drops, Surging Use and Causing Rife Overdose Deaths 3Health News:Dermatologist, Dr. Peyman Ghasri, is Now Offering Discounts on Facial Fillers 2
... College at Dallas report that contact lenses, both ... materials are expected to reduce the possibility of ... available now. Based in part on these findings, ... hyper-oxygen transmissible contact lenses for 30-day continuous wear.// ...
... way to stop the hair loss associated with drug treatment ... alopecia (CIA), is a frequent side effect of cancer therapy ... time in their lives.// ,Currently, there is no effective ... way doctors can attempt to minimise hair loss is to ...
... have found the genetic mutation that is to blame ... many people.The breakthrough could lead to the development of drugs ... more than one in twelve people suffer from some form ... a history of problems such as panic disorders, agoraphobia and ...
... clues to the high failure rate of cloning and ... core of the nucleus.The discovery, announced at the annual ... Science in Washington, shows that DNA has an internal ... provides clues to how active genes and 'junk DNA' ...
... study, exercise can help older people avert a form ... standing up and walking an impossible one.Those who regularly ... lose abilities to perform activities of daily living. ... Texas, this report is the first to demonstrate that ...
... have developed a screening technique for persons suffering from ... investigations of skin lesions may allow doctors to identify ... particularly those of the colon. ,By looking ... in members of families with a history of HNPCC ...
Cached Medicine News:Health News:New contact lens materials 2Health News:Breakthrough in cancer therapy 2Health News:The anxiety gene, 2Health News:DNA and clones 2Health News:Arthritis risk reduced by exercise 2
(Date:5/27/2015)... 27, 2015   Madison Laser Tattoo Removal is ... Madison and the surrounding area to offer treatments ... Laser Tattoo Removal is dedicated to bringing a solution to ... . "I founded Madison Laser Tattoo Removal ... return their skin to its natural look," said Emily ...
(Date:5/27/2015)... OpportunityAnalyzer: Sepsis - Opportunity Analysis and Forecasts ... a series of diverse complications arising from the presence ... tissues, which cause a rapidly progressing hyperactive host immune ... 50% depending on disease severity. The syndrome places a ... global marketplace, which for the purposes of this report ...
(Date:5/27/2015)... 27, 2015 Protein purification involves the process ... in their physical properties. The objective of a protein ... functional protein with fewest contaminants. The global protein purification ... CAGR of around 5% to 6% during the forecast ... in the pharmaceutical and biotechnological fields, growing need to ...
Breaking Medicine Technology:Madison Laser Tattoo Removal Brings Superior Laser Tattoo Removal Services To Madison, WI With Astanza Duality 2OpportunityAnalyzer: Sepsis - Opportunity Analysis and Forecasts to 2021 2OpportunityAnalyzer: Sepsis - Opportunity Analysis and Forecasts to 2021 3OpportunityAnalyzer: Sepsis - Opportunity Analysis and Forecasts to 2021 4Protein Purification & Isolation Market by Technology by Product by Application & End User - Global Forecast to 2020 2Protein Purification & Isolation Market by Technology by Product by Application & End User - Global Forecast to 2020 3
... is specifically designed for use on cystoscopy ... MicroTouch LP attaches to tables on the ... user complete freedom to move the patient ... of position of the instrument or interference ...
... a 3-axis digital stepper designed to ... facilitate interactive treatment planning. ,Digital registration ... probe location and movement, and template ... Capture dramatically reduces volume study time ...
... MYDON is a long-pulsed Nd:YAG laser system ... be used to treat deep-lying, superficial as well ... also well-suited for epilation in patients with darker ... hair as well as for general improvement of ...
... triple-mode technology makes BURANE XL ... an array of aesthetic laser ... patented, controllable mode for coagulation, ... ablation procedures, and in particular ...
Medicine Products: