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Scientists find donut-shaped structure of enzyme involved in energy metabolism
Date:2/16/2010

ation about the protein's donut shape. These techniques help researchers determine the structure and composition of the enzyme.

"The complementary methods of the X-ray crystallography, small-angle X-ray scattering, and centrifugation gave us a whole picture of the structure of the enzyme," Tanner said. "Knowing the structure of the enzyme helps us understand the function of the enzyme. Once we know an enzyme's structure, we can begin to interpret other important data, such as the enzyme's role in specific reactions, how its activity is controlled and how a drug could inhibit the enzyme."

The study, "Crystal structure of the bifunctional Proline utilization A flavoenzyme from Bradyrhizobium japonicum," was published in Proceedings of the National Academy of Sciences this month.


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Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert  

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