Navigation Links
Scientists find calcium is the initial trigger in our immune response to healing
Date:2/14/2013

For the first time scientists studying the cellular processes underlying the body's response to healing have revealed how a flash of calcium is the very first step in repairing damaged tissue. The findings, published in Current Biology, could lead to new therapies that speed up the healing process following injury or surgery.

Until recently, very little was known about how damaged tissue activates and attracts the first white blood cells to the wound the first stage in the healing process. However, researchers from the University of Bristol's School of Biochemistry in collaboration with a team from the University of Bath, have shown that the very first trigger in this process is a flash of calcium which spreads like a wave back from the wound edge through gap junctions that connect all the cells.

This flash of calcium signal goes on to activate an enzyme known as DUOX that synthesises hydrogen peroxide, which, in turn, attracts the first white blood cells to the wound. This white blood cell invasion, which is initiated during our inflammatory responses, is needed to kill off invading microbes and stop the onset of septicaemia following tissue damage.

The findings indicate that the wound-induced calcium flash represents the earliest identified signal following wounding and might therefore orchestrate the rapid recruitment of immune cells.

To assess the impact of a reduced calcium flash upon the inflammatory response the team used Drosophila (fruit fly) embryos because they are translucent which makes it easy to image the inflammatory response and because of their simple genetics. The team found that blocking the calcium flash inhibited H2O2 release at the wound site leading to a reduction in the number of immune cells migrating to the wound.

Paul Martin, Professor of Cell Biology and an expert in wound healing at the University, said: "White blood cells are a little like 'Jeckyll and Hyde' in that they help us heal but are also the reason behind why we scar so we really need to know how they are regulated at wounds in order to learn how to control their behaviours for future therapeutic intervention."

Will Razzell, the lead PhD researcher on this study, added: "We are more than ever understanding the pathways that lead to immune cell attraction to wounds. As calcium represents the immediate inflammatory signal, we now have a good foundation to investigate this complicated process further."


'/>"/>
Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-011-792-88086
University of Bristol
Source:Eurekalert

Related medicine news :

1. Scientists should advance management of behavioral norms
2. Scientists advance the art of magic with a study of Penn and Tellers cups and balls illusion
3. CSHL scientists identify a new strategy for interfering with a potent cancer-causing gene
4. Scientists Find 24 New Genes Linked to Nearsightedness
5. NIH scientists discover promising target to block Staphylococcus infection
6. Scientists find key to growth of bad bacteria in inflammatory bowel disease
7. Scientists Explore How Zinc Fights Off Infection
8. Compound developed by scientists protects heart cells during and after attack
9. Scientists discover how chromosomes keep their loose ends loose
10. Meeting: Scientists to explore 60 topical issues related to human health and the environment
11. Scientists debate CDC recommendations during meningitis outbreak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2017)... , ... August 21, 2017 , ... ... addition of two plastic surgery fellows for academic year 2017-2018, Christina M. Busuito, ... who have successfully completed residency in Plastic and Reconstructive Surgery. The candidate ...
(Date:8/21/2017)... California (PRWEB) , ... August 21, 2017 , ... Five ... money and awareness for Alzheimer’s Family Center. , Guests will be able to ... Newport Beach Plaza, Braised Lamb Shank with Fennel Dill Salad, Feta Cheese Sauce & ...
(Date:8/21/2017)... (PRWEB) , ... August 21, 2017 , ... The experts ... exactly are we supposed to get things done in a healthy way these days? ... they’re launching a crowdfunding campaign on August 28 to introduce Deskcise Pro™– the world’s ...
(Date:8/21/2017)... ... August 21, 2017 , ... San Diego physician and surgeon Dr. James ... has announced his candidacy for the 52nd Congressional District currently held by Representative Scott ... Coming to this country at age eleven after suffering homelessness and hardship in a ...
(Date:8/20/2017)... ANGELES, Calif. (PRWEB) , ... August 20, 2017 , ... A total solar eclipse ... darken for a few minutes as the moon moves between the sun and Earth. This ... , These four tips can help keep you safe on the road during the ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... -- Agragen, LLC, a Cincinnati -based ... and aquacultural feed sectors, announces a significant step ... AGR131.  This drug is designed to trap and ... patients suffering from inflammatory conditions such as rheumatoid ... Biological pharmaceuticals currently used ...
(Date:8/2/2017)... MEMPHIS, Tenn. and BENTON, Ky. , Aug. 2, 2017 /PRNewswire/ ... new member to its environmental services (ES) team to proactively reduce the risk of hospital-acquired ... is a UV disinfection robot that uses UVC light energy to kill deadly pathogens such ... ... Tru-D ...
(Date:8/1/2017)... , Aug. 1, 2017   CerSci Therapeutics , ... Dallas, Texas , has received notice from the ... Institutes of Health (NIH) that it has been awarded ... totaling over $650,000 in 2017 with an additional $1,000,000 ... Investigational New Drug application of their lead non-opioid drug ...
Breaking Medicine Technology: