Navigation Links
Scientists find calcium is the initial trigger in our immune response to healing
Date:2/14/2013

For the first time scientists studying the cellular processes underlying the body's response to healing have revealed how a flash of calcium is the very first step in repairing damaged tissue. The findings, published in Current Biology, could lead to new therapies that speed up the healing process following injury or surgery.

Until recently, very little was known about how damaged tissue activates and attracts the first white blood cells to the wound the first stage in the healing process. However, researchers from the University of Bristol's School of Biochemistry in collaboration with a team from the University of Bath, have shown that the very first trigger in this process is a flash of calcium which spreads like a wave back from the wound edge through gap junctions that connect all the cells.

This flash of calcium signal goes on to activate an enzyme known as DUOX that synthesises hydrogen peroxide, which, in turn, attracts the first white blood cells to the wound. This white blood cell invasion, which is initiated during our inflammatory responses, is needed to kill off invading microbes and stop the onset of septicaemia following tissue damage.

The findings indicate that the wound-induced calcium flash represents the earliest identified signal following wounding and might therefore orchestrate the rapid recruitment of immune cells.

To assess the impact of a reduced calcium flash upon the inflammatory response the team used Drosophila (fruit fly) embryos because they are translucent which makes it easy to image the inflammatory response and because of their simple genetics. The team found that blocking the calcium flash inhibited H2O2 release at the wound site leading to a reduction in the number of immune cells migrating to the wound.

Paul Martin, Professor of Cell Biology and an expert in wound healing at the University, said: "White blood cells are a little like 'Jeckyll and Hyde' in that th
'/>"/>

Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-011-792-88086
University of Bristol
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Scientists should advance management of behavioral norms
2. Scientists advance the art of magic with a study of Penn and Tellers cups and balls illusion
3. CSHL scientists identify a new strategy for interfering with a potent cancer-causing gene
4. Scientists Find 24 New Genes Linked to Nearsightedness
5. NIH scientists discover promising target to block Staphylococcus infection
6. Scientists find key to growth of bad bacteria in inflammatory bowel disease
7. Scientists Explore How Zinc Fights Off Infection
8. Compound developed by scientists protects heart cells during and after attack
9. Scientists discover how chromosomes keep their loose ends loose
10. Meeting: Scientists to explore 60 topical issues related to human health and the environment
11. Scientists debate CDC recommendations during meningitis outbreak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... New York, NY (PRWEB) May 20, 2013 ... to protecting the rights of victims injured by defective ... South Dakota man who alleges that use of the ... The suit was filed on April 30, 2013, ... of Louisiana (Case No. 6:13-cv-0888), where it is one ...
(Date:5/20/2013)... (PRWEB) May 20, 2013 Mirena ... in the multidistrict litigation recently established in U.S. District ... reports. According to court records, the litigation’s first ... time appointments to Plaintiff’s leadership positions were discussed. ... in the Southern District of New York, all of ...
(Date:5/20/2013)... Salt Lake Community College’s Know Greater Heroes program ... winners for 2013. As part of the award, the ... is a leadership training program that involves SLCC athletes who ... eat right, be active, and avoid drugs and alcohol. , ... program each year, and visit more than 30 schools each ...
(Date:5/20/2013)... The judge overseeing pretrial proceedings in ... specifically for female lawyers to be included in a ... Group LLP acknowledges the judge’s request, noting that its ... providing information on Mirena side effects and how to ... the addition of some female lawyers to the committee. ...
(Date:5/20/2013)... 2013 While Huntington,s disease (HD) is currently ... disease-modifying therapies in development may slow or minimize ... depends upon the identification of reliable and sensitive ... these biomarkers may eventually be used as outcome ... helpful to monitor changes during the time prior ...
Breaking Medicine News(10 mins):Health News:Taking Actos for Two Years Caused Bladder Cancer, Alleges Lawsuit Filed by Parker Waichman LLP on Behalf of South Dakota Man 2Health News:Mirena IUD Lawsuit News: Bernstein Liebhard LLP Reports on First Status Conference in Federal Mirena Litigation 2Health News:Mirena IUD Lawsuit News: Bernstein Liebhard LLP Reports on First Status Conference in Federal Mirena Litigation 3Health News:SLCC Know Greater Heroes Program Named to Select 25 2Health News:SLCC Know Greater Heroes Program Named to Select 25 3Health News:Mirena IUD Lawsuit Update: Judge Calls for More Input from Female Lawyers, Notes Rottenstein Law Group LLP 2Health News:Leading researchers report on the elusive search for biomarkers in Huntington's disease 2Health News:Leading researchers report on the elusive search for biomarkers in Huntington's disease 3
... Cleaners Proven to Protect and Even Improve Health, ... homes is,increasingly contaminated and polluted, and now studies have ... not only allergy and asthma,symptoms but also a variety ... clots., Studies are emerging that prove poor indoor ...
... the type diagnosed in Sen. Edward Kennedy , , MONDAY, ... is showing promise against the same general type of ... reporting. , The vaccine, when given with chemotherapy, more ... tumors. Kennedy was diagnosed last month with a malignant ...
... The discovery of new genetic mutations involved in inflammatory ... these common conditions, two scientists told the annual conference ... 2 June). , Dr.Alexandra ... Netherlands, and Dr. Eleonora Festen, from the University of ...
... ST. PETERSBURG, Fla., June 2 The Advanced,Wound Management ... announced,today that its negative pressure wound therapy (NPWT) products ... areas included in the,first phase of the competitive bidding ... (CMS) in the U.S. The program, which is,scheduled to ...
... family of CCRCs with expansion into Alabama;,Community to ... June 2 ACTS Retirement-Life,Communities, a premier not-for-profit ... its acquisition of Carlton Cove, a,continuing care retirement ... renamed Magnolia Trace and become the 19th ACTS,continuing ...
... the body,s own tissues and organs, wreaking havoc and ... of these diseases are so obscure, no effective treatment ... Weizmann Institute scientists have developed a method that in ... diseases effectively without necessarily knowing their exact cause. Their ...
Cached Medicine News:Health News:Studies Find Poor Indoor Air Quality Can Lead to Major Health Problems 2Health News:Studies Find Poor Indoor Air Quality Can Lead to Major Health Problems 3Health News:Vaccine May Boost Survival of Brain Cancer Patients 2Health News:Vaccine May Boost Survival of Brain Cancer Patients 3Health News:Discovery of new family of genetic mutations involved in inflammatory intestinal disease 2Health News:Discovery of new family of genetic mutations involved in inflammatory intestinal disease 3Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 2Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 3Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 4Health News:Smith & Nephew Negative Pressure Wound Therapy Products To Be Available To Patients Through the Medicare Part B Competitive Bidding Process 5Health News:ACTS Retirement-Life Communities Completes Carlton Cove Acquisition 2Health News:Weizmann Institute scientists develop a new approach to treating autoimmune disease 2
(Date:5/20/2013)... , BERLIN and ... Arthroscopy Devices Market to 2018 ... Invasive Procedures to Drive Future Growth" looks at the ... six arthroscopy device market segments: arthroscopes, arthroscopy shavers, arthroscopy ... systems, and arthroscopy visualization systems. The report provides comprehensive ...
(Date:5/20/2013)... 2013  Rhythm announced today the presentation of results ... of gastroparesis symptoms among diabetic patients in the U.S. ... among patients with both type 1 and type 2 ... with the more common type 2 disease. ... Associate Professor of Medicine at Harvard Medical School and ...
(Date:5/20/2013)... May 20, 2013  AbbVie (NYSE: ... Phase 3 clinical study called SONAR (Study Of ... of the investigational compound atrasentan - when added to ... in patients with stage 2 to 4 chronic ... is a large, multinational, double-blind, placebo-controlled clinical study ...
Breaking Medicine Technology:Increasing Prevalence of Osteoarthritis and Preference for Minimally Invasive Procedures to Drive Arthroscopy Devices Market Growth 2Increasing Prevalence of Osteoarthritis and Preference for Minimally Invasive Procedures to Drive Arthroscopy Devices Market Growth 3Increasing Prevalence of Osteoarthritis and Preference for Minimally Invasive Procedures to Drive Arthroscopy Devices Market Growth 4Rhythm Announces Study Demonstrating High Prevalence of Diabetic Gastroparesis Symptoms in the U.S. 2Rhythm Announces Study Demonstrating High Prevalence of Diabetic Gastroparesis Symptoms in the U.S. 3Rhythm Announces Study Demonstrating High Prevalence of Diabetic Gastroparesis Symptoms in the U.S. 4AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy 2AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy 3AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy 4AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy 5AbbVie Initiates Phase 3 Study of Its Investigational Compound Atrasentan on Renal Outcomes in Patients with Diabetic Nephropathy 6
... Inc. (Nasdaq: MAPP ) today announced that the ... Stifel Nicolaus Healthcare Conference Thursday, September 8, at ... Sciences Conference Wednesday, September 21, at 9:30 a.m. ET in ... will be available on the Investor Relations section of MAP ...
... THOUSAND OAKS, Calif., Sept. 6, 2011 Amgen (NASDAQ: ... on Thursday, Sept. 8, 2011, at The New York Palace ... Time. Arvind Sood, vice president of Investor Relations at Amgen, ... from the Events Calendar on Amgen,s website, www.amgen.com , ...
Cached Medicine Technology:
... Use , The new Finnpipette Novus is so user-friendly ... a few minutes. With the intuitive instantly familiar menu ... pipetting functions you need quickly and easily. The large, ... full names of all functions. The easily accessible ...
... of a 384 Well Plate at Once , ... plates, you need a pipettor that can adapt ... you get with our 16-channel Impact pipettor., Available ... innovation was specifically designed to allow you to ...
... of a 384 Well Plate at Once , ... plates, you need a pipettor that can adapt ... you get with our 16-channel Impact pipettor., Available ... innovation was specifically designed to allow you to ...
... The Seal-Away CS and Alliance ... designed for the introduction of ... coronary sinus from a superior ... Jude Medical's outstanding peel-away introducer ...
Medicine Products: