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Scientists find a key to maintaining our DNA
Date:3/18/2011

removed and backfilled, meaning more mistakes and errors are eliminated before the segments are joined. The end result is a more accurate copy of DNA.

The same situation occurs with the DNA repair process, as the body works to remove damaged pieces of DNA.

Unlike the current work, the majority of aging-related research zeroes in on specific agents that damage our DNA, called reactive oxygen species, and how to reduce them. The new research represents a small piece of the pie, but has the potential to be a very important one.

Bambara's team is investigating the newly identified acetylation regulatory process further to figure out how they might be able to intervene to augment the body's natural safeguarding of important genetic information. They are studying human and yeast cell systems to determine how proteins in cells work together to trigger acetylation, which adds a specific chemical to the proteins involved in DNA replication and repair. Researchers are manipulating cells in various ways, through damage or genetic alterations, to see if these changes activate or influence acetylation in any way.

Though they are far from identifying compounds or existing drugs to test, they do see this research having an impact in the future.

"The translational rate is becoming better and better. Today, the course between initial discovery and drug development is intrinsically faster. I could see having some sort of therapeutic that helps us live longer and healthier lives in 25 years," said Bambara.


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Contact: Emily Boynton
emily_boynton@urmc.rochester.edu
585-273-1757
University of Rochester Medical Center
Source:Eurekalert

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