Navigation Links
Scientists explain unique activity of TB drug pyrazinamide
Date:8/11/2011

WHAT:Pyrazinamide has been used in combination with other drugs as a first-line treatment for people with tuberculosis (TB) since the 1950s, but exactly how the drug works has not been well understood. Now, researchers have discovered a key reason why the drug effectively shortens the required duration of TB therapy. The finding potentially paves the way for the development of new drugs that can help eliminate TB in an infected individual even more rapidly. The study was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and published online on August 11 in Science Express.

Unlike most first-line TB drugs, pyrazinamide does not directly kill Mycobacterium tuberculosis, the bacterium that causes TB, grown in a test tube; rather, the drug acts only on latent TB bacteria that exist in an acidic environment in the body. From previous studies, the investigators knew that shortly after pyrazinamide enters latent M. tuberculosis in the body, the drug converts to its active form, pyrazinoic acid (POA). But they did not know how POA then killed the bacteria, thereby shortening the normal 9- to 12-month course of therapy by several months.

In this study, the researchers learned that once formed, POA binds to a vital bacterial cell protein, ribosomal protein S1 (RpsA), blocking RpsA from decoding M. tuberculosis DNA to create other proteins that keep the bacteria alive in the body. The investigators note that their results explain the mechanism of this enigmatic TB drug, which could assist researchers attempting to develop improved TB drug treatment regimens.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. BIDMC scientists receive Challenge Awards from Prostate Cancer Foundation
2. Scientists Take Navel-Gazing to New Level
3. Johns Hopkins scientists map genes for common form of brain cancer
4. Scientists May Have Found Missing Link to Common Brain Cancer
5. Have we met before? Scientists show why the brain has the answer
6. Scientists Warn of New Multidrug-Resistant Salmonella
7. Johns Hopkins scientists begin first-of-its-kind research to create blood platelets from stem cells
8. Scientists show swamp gas protects blood vessels from complications of diabetes
9. Scientists receive funding boost to further research into disease mechanisms of Alzheimer’s
10. Scientists ID Gene Linked to Syndrome Behind Elephant Man Disease
11. Scientists developing new therapy for HER2-positive breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... Registration is now open for the 31st annual AIDS Walk ... Hatch Memorial Shell on the Esplanade. The event regularly draws thousands of participants, making it ... competitive, timed event fully sanctioned by the USA Track & Field Association. , The ...
(Date:5/3/2016)... ... 2016 , ... Elizabeth Murray has always loved walking one to two miles ... her shoulder and one on her arm. But she got to the point where ... valve prolapse. , The valves of the heart wouldn’t close properly resulting in mitral ...
(Date:5/3/2016)... ... 03, 2016 , ... Empyrean Benefit Solutions, Inc., the Hi-Touch ... center in La Vergne, Tennessee, near Nashville. The new center will complement Empyrean’s ... client services. , “Our Nashville-area center allows us to achieve several goals,” said ...
(Date:5/3/2016)... ... 03, 2016 , ... Ogawa World USA introduced the first of its kind ... exclusive Smart Application. The Smart 3D combines the best in technological advancement, design, and ... profile and specialized massage program, each user has a tailored experience unparalleled by any ...
(Date:5/3/2016)... ... May 03, 2016 , ... Dr. Poneh Ghasri, cosmetic dentist in ... both new and existing patients. Cosmetic dentistry allows patients to improve the aesthetics of ... smiles with some minor or more serious cosmetic flaws. These specials allow patients to ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... FLINT, Mich. , April 28, 2016 /PRNewswire/ ... transaction . Diplomat Pharmacy, Inc. (NYSE: DPLO), the ... it has signed a definitive agreement to acquire ... Advanced Specialty Pharmacy ("TNH"), a leading specialty pharmacy ... Van Nuys, California . In 2015, ...
(Date:4/28/2016)... Dr. ... und Stephen Schmidt werden Teil ... ein führender Anbieter cloudbasierter Softwarelösungen für den ... neue Führungskräfte zum Team Sicherheit und Pharmakovigilanz ... Erfahrungen mitbringen.  Dies wird die Geschäftseinheit Sicherheit ...
(Date:4/28/2016)... Dr. Vivek Ahuja , George ... phen Schmidt Join the Growing Organization ... for life sciences, today announced key new leaders have joined the ... a growing business.  This will bolster the company,s safety business unit ... ArisGlobal in the position of Vice President - Safety. George has ...
Breaking Medicine Technology: