Navigation Links
Scientists explain unique activity of TB drug pyrazinamide
Date:8/11/2011

WHAT:Pyrazinamide has been used in combination with other drugs as a first-line treatment for people with tuberculosis (TB) since the 1950s, but exactly how the drug works has not been well understood. Now, researchers have discovered a key reason why the drug effectively shortens the required duration of TB therapy. The finding potentially paves the way for the development of new drugs that can help eliminate TB in an infected individual even more rapidly. The study was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, and published online on August 11 in Science Express.

Unlike most first-line TB drugs, pyrazinamide does not directly kill Mycobacterium tuberculosis, the bacterium that causes TB, grown in a test tube; rather, the drug acts only on latent TB bacteria that exist in an acidic environment in the body. From previous studies, the investigators knew that shortly after pyrazinamide enters latent M. tuberculosis in the body, the drug converts to its active form, pyrazinoic acid (POA). But they did not know how POA then killed the bacteria, thereby shortening the normal 9- to 12-month course of therapy by several months.

In this study, the researchers learned that once formed, POA binds to a vital bacterial cell protein, ribosomal protein S1 (RpsA), blocking RpsA from decoding M. tuberculosis DNA to create other proteins that keep the bacteria alive in the body. The investigators note that their results explain the mechanism of this enigmatic TB drug, which could assist researchers attempting to develop improved TB drug treatment regimens.


'/>"/>

Contact: Nalini Padmanabhan
padmanabhannm@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1

Related medicine news :

1. BIDMC scientists receive Challenge Awards from Prostate Cancer Foundation
2. Scientists Take Navel-Gazing to New Level
3. Johns Hopkins scientists map genes for common form of brain cancer
4. Scientists May Have Found Missing Link to Common Brain Cancer
5. Have we met before? Scientists show why the brain has the answer
6. Scientists Warn of New Multidrug-Resistant Salmonella
7. Johns Hopkins scientists begin first-of-its-kind research to create blood platelets from stem cells
8. Scientists show swamp gas protects blood vessels from complications of diabetes
9. Scientists receive funding boost to further research into disease mechanisms of Alzheimer’s
10. Scientists ID Gene Linked to Syndrome Behind Elephant Man Disease
11. Scientists developing new therapy for HER2-positive breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... August 18, 2017 , ... Hernandez Insurance Agencies, ... communities throughout the greater DC region, is inaugurating a “New Leash On Life” ... animals and training them to be companions for veterans in need. , The ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... and financial planning assistance that serves communities throughout southern Florida, is working to ... provide scholarship assets to children from low income families. , The Take Stock ...
(Date:8/18/2017)... ... ... The Golseth Agency, a Texas based insurance management and financial planning assistance ... campaign organized to provide support to Christina Upchurch and her two children after the ... children returned from out of town to find her husband passed away and their ...
(Date:8/18/2017)... ... ... and Overseer at The House of Yahweh in Abilene, Texas, has released a new publication ... mother of the Savior whom the world calls “Mother Mary”. Yisrayl says when compared to ... this historical woman. , “The world bows, kisses the feet of, cries out to ...
(Date:8/18/2017)... ... August 18, 2017 , ... 800response, ... and monitoring solutions, announced today the launch of a redesigned corporate website, ... and aesthetic, fully responsive design, and an enhanced search directory for businesses and ...
Breaking Medicine News(10 mins):
(Date:8/8/2017)... Ltd. (NASDAQ/TASE: BLRX), a clinical-stage biopharmaceutical company focused on ... the second quarter ended June 30, 2017. ... to date: Continued ... lead project, BL-8040: Announced plans to ... stem cell mobilization treatment for autologous bone-marrow transplantation in ...
(Date:8/7/2017)... -- Diplomat Pharmacy, Inc. (NYSE: DPLO), the nation,s largest independent specialty ... 2017.  All comparisons, unless otherwise noted, are to the quarter ... Second Quarter 2017 Highlights include: ... of 3.5% Total prescriptions dispensed of 220,000, ... versus 7.6% Gross profit per prescription ...
(Date:8/2/2017)... 2, 2017 Fenita J. Caldwell ... a Pinnacle Lifetime Professional in the Field of ... at Turing Pharmaceuticals, AG. Her skills and areas ... building.                ... years of experience as a highly successful sales ...
Breaking Medicine Technology: