Navigation Links
Scientists explain how insulin secreting cells maintain their glucose sensitivity
Date:9/5/2007

Scientists at the leading Swedish medical university Karolinska Institutet have now disclosed the mystery how the insulin-secreting cells maintain an appropriate number of ATP sensing ion channel proteins on their surface. This mechanism, which is described in the latest number of Cell Metabolism, explains how the human body can keep the blood glucose concentration within the normal range and thereby avoid the development of diabetes.

Blood sugar absorbed from food has to timely enter muscles as energy supply as well as the liver and fat tissue for energy storage. Otherwise, diabetes occurs. Such glucose transport is precisely controlled by insulin, the bodys only hormone capable of lowering blood sugar. This hormone is released from insulin-secreting cells in the pancreas.

The ion channel proteins that are regulated by ATP and that transport potassium ions (KATP channels) are situated on the surface of the insulin-secreting cells to sense blood sugar and control sugar-stimulated insulin secretion. However, it has been a long-standing mystery how the insulin-secreting cells keep an appropriate number of KATP channels on their surface. Scientists at the the Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, have now disclosed a new traffic route whereby sugar promotes the insulin secretion controller KATP channel to march to its post.

Dogmatically, only two routes were believed to operate in insulin-secreting cells to deliver the macromolecules newly manufactured or modified inside cells to the cell surface where they

release or reside to function. One is referred to as a regulated insulin secretory pathway. The other is termed a constitutive pathway to renew cell surface lipids and proteins including KATP channels.

We have now found that the newly manufactured KATP channels in insulin-secreting cells reside in a non-insulin-containing structure, which contains the regulated secretory granule marker chromogranin, says Per-Olof Berggren. Such a structure moves to the cell surface subsequent to elevation of sugar concentration in a Ca2+- and protein kinase A-dependent fashion.

According to Professor Berggren the discovery is very important. This entirely new traffic route endows insulin-secreting cells with an efficient way to maintain an appropriate number of KATP channels on their surface and thereby being able to adequately keep the blood glucose concentration within the normal range thus avoiding the development of diabetes.


'/>"/>

Contact: Katarina Sternudd
katarina.sternudd@ki.se
46-852-483-895
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. Nobel Prize for Medicine shared by Three scientists
2. Scientists plan human cloning clinic in the United States
3. Scientists crack dengue fever puzzle
4. Scientists found ancient Human Germ Killer
5. Scientists locate key hormone involved in appetite control
6. Scientists open the book of life
7. Electronic nose by Italian scientists
8. Scientists review SARS
9. Scientists push to lower hidden sodium in food
10. Indian Scientists Make Wide-Ranging Analysis And Annotation Of X Chromosome
11. Scientists have found effective brain regions for deep brain stimulation for Parkinson’s
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... NY (PRWEB) , ... October 13, 2017 , ... Ellevate ... people in business to advocate for action towards gender equality at their inaugural Summit ... from around the globe, and reached a social audience of over 3 million. To ...
(Date:10/13/2017)... Fairfax, VA (PRWEB) , ... October 13, 2017 ... ... provider of DevOps and Agile Software Development, has been awarded a contract by ... (EATS) Blanket Purchase Agreement (BPA) aims to accelerate the enterprise use of Agile ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of Medical Informatics ... PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, D.C. AMIA’s ... of Morris F. Collen, a pioneer in the field of medical informatics, this prestigious ...
(Date:10/12/2017)... ... ... HMP , a leader in healthcare events and education, today announced that ... for ‘Best B-to-B Healthcare Website.’ Winners were announced during the Eddie & Ozzie Awards ... recognizes editorial and design excellence across a range of sectors. This year’s program included ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017  AllianceRx Walgreens Prime, ... formed by Walgreens and pharmacy benefit manager Prime Therapeutics ... new brand, which included the unveiling of new signage ... , as well as at a few other company-owned ... new brand to patients, some of whom will begin ...
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion ... notable awards. Ranked as number one in the South Florida ... time in Inc. 5000 yearly list, the national specialty pharmacy ... Armando Bardisa will soon be honored by SFBJ ... Set to receive his award in ...
(Date:9/22/2017)... 2017  As the latest Obamacare repeal effort moves ... (R-LA) and Lindsey Graham (R-SC) medical ... device industry is in an odd place.  The industry ... excise tax on medical device sales passed along with ... patients, increased visits and hospital customers with the funding ...
Breaking Medicine Technology: