Navigation Links
Scientists eavesdrop on the exciting conversations within cells
Date:2/25/2009

Scientists have discovered the secrets of a sophisticated molecule that plays a role in many aspects of human health from fertility to blood pressure; digestion to mental health. This has opened up the potential for discovery of new drugs to treat an enormous variety of conditions.

In research supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Wellcome Trust a team from the University of Cambridge shows how a molecule the IP3 receptor arranges itself into clusters to help broadcast vital chemical messages around cells in the form of calcium. The work is published today (25 February) in Nature.

Team leader, Professor Colin Taylor said: "Almost everything a cell does is regulated by calcium, and we know there are many diseases in both humans and animals, such as stroke or an irregular heart beat, in which calcium regulation goes wrong. But the real puzzle is trying to understand how calcium which is amongst the simplest of all chemicals can manage to control lots of different things at the same time. What we have found is a crucial part of that puzzle.

"Imagine you're trying to find a dancing partner at a party. You might whisper the request to several people, or you might shout it out to everyone. Some of your handful of whispered requests might be ignored and some may have you heading for the dance floor. If you shout loud enough, everyone gets to decide whether to respond. It's rather similar with messages transmitted by calcium signals: they can evoke very different responses in cells depending on whether they are whispered or shouted."

The research published today shows that when cells are stimulated, their IP3 receptors receive instructions telling them to both gather into clusters and to open and allow calcium to pass. Furthermore, IP3 receptors behave very differently when they are alone as opposed to clustered, and these differences help determine whether the calcium
'/>"/>

Contact: Nancy Mendoza
press.office@bbsrc.ac.uk
01-793-413-355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Find Gene for Tooth Enamel
2. Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu
3. Scientists May Have New Way to Fight the Flu
4. Scientists Gain Insight Into Blood Cancers Progression
5. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
6. Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimers Disease
7. University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
8. Scientists uncover secrets of potential bioterror virus
9. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
10. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
11. Scientists Heartened at Prospect of End to Stem Cell Ban
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... 29, 2015 , ... "I have been a licensed physical ... specialize in manual therapy, and my invention will provide headache sufferers a solution ... muscle dysfunction throughout the body." , They developed THE RELIEVER to alleviates headaches, ...
(Date:8/29/2015)... ... August 29, 2015 , ... Next weekend is Labor Day weekend, ... officially ends on September 22nd this year). For IT security personnel, it should also ... which could prove far more costly than a simple headache. , Joe Caruso, founder ...
(Date:8/29/2015)... ... August 29, 2015 , ... Vascular Health Sciences ... sell Arterosil and Arterosil HP, and that all claims and counterclaims have been ... Sciences, LLC (VHS) in the United States District Court for the Southern District ...
(Date:8/28/2015)... ... , ... The Kentucky State Department of Workforce Investment Commissioner Beth Kuhn recently ... for, they are unable to pass the initial drug test and therefore unable to ... order to be able to hire long-term, skilled talent. (1) Will Wesch, Director of ...
(Date:8/28/2015)... ... August 28, 2015 , ... As reported by ... received FDA clearance for results that last for two years, the longest of ... for patients who are looking for a long-lasting, effective solution for their cellulite, according ...
Breaking Medicine News(10 mins):Health News:Inventors and InventHelp Clients Develops Tension Reliever (LGI-1951) 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 3
... to have a higher risk of developing late age-related ... to a report in the July issue of Archives ... Age-related macular degeneration (AMD) [a progressive eye disease that ... leading cause of blindness in the Western world, according ...
... an enzyme that inactivates two tumor-suppressing genes, ultimately triggering ... cells, researchers at The University of Texas M. D. ... the journal Cell. , "This is a completely new ... for clinical intervention," senior author Mien-Chie Hung, Ph.D., professor ...
... August 2007) could lead to a change of paradigm in ... resonance imaging (MRI) is substantially more accurate than mammography in ... now MRI was thought to be hardly suited for the ... at the University of Bonn have now come to a ...
... to rid the brain of the amyloid buildup that plagues ... the method outlined in a paper published online August 12 ... Center show how the bodys natural way of ridding the ... disease. Then the team demonstrated an experimental method in mice ...
... 2007 - In an Editorial, to be published ... http://intl.elsevierhealth.com/journals/joca/ ), published by Elsevier, a panel of ... nonsteroidal anti-inflammatory drugs (NSAIDs) must remain a significant ... osteoarthritis (OA). The Editorial summarizes the outcomes of ...
... to leaders of the U.S. House of Representatives Ways ... of the American College of Physicians (ACP) today expressed ... Act of 2007 (H.R. 3162). Representing 124,000 internal medicine ... medical specialty society in the United States. , ...
Cached Medicine News:Health News:Smoking may strongly increase long-term risk of eye disease 2Health News:Pathway links inflammation, angiogenesis and breast cancer 2Health News:Pathway links inflammation, angiogenesis and breast cancer 3Health News:MRI finds breast cancer before it becomes dangerous 2Health News:MRI finds breast cancer before it becomes dangerous 3Health News:Draining away brain's toxic protein to stop Alzheimer's 2Health News:Draining away brain's toxic protein to stop Alzheimer's 3Health News:Using coxibs and NSAIDs to treat osteoarthritis 2Health News:Support for Children's Health and Medicare Protection Act given to House leaders by ACP 2
(Date:8/28/2015)... Aug. 28, 2015 ... the addition of the "Investigation Report on ... offering. Originally discovered by Welfide (Mitsubishi ... Industries, Ltd) as an inflammatory drug, pranoprofen was ... Co., Ltd under the trade name of pranopulin ...
(Date:8/28/2015)... , Aug. 28, 2015 Patterson ... Inc. (Nasdaq: PDCO ), is now an ... announced acquisition of Patterson Medical by Madison Dearborn ... retain its name for a transition period before ... rehabilitation and sports medicine products.  With the focused ...
(Date:8/28/2015)... -- The scientific team of a new biotech ... leading academics in the field of aging Prof. Robert ... extension for model animals - 10 fold for nematodes) has ... diseases, primarily, around the stability and stress resistance of certain ... "Stability analysis of a model gene network links aging, stress ...
Breaking Medicine Technology:Investigation Report on China's Pranoprofen Market, 2010-2019 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 2Patterson Medical Positioned for Continued Growth as a Newly Independent Company 3Gero: Physics Meets Biology to Help Defeat Aging 2Gero: Physics Meets Biology to Help Defeat Aging 3
... 4, 2007 - Molecular Insight,Pharmaceuticals, Inc. (NASDAQ: ... the results of several preclinical studies at,the ... Nuclear Medicine (SNM) in,Washington, D.C. The presentations ... clinical-stage, targeted,radiotherapeutic candidate for the treatment of ...
... ZymoGenetics,Inc. today announced that interim findings were presented ... B-cell chronic,lymphocytic leukemia (B-CLL) at the American Society ... included intravenous,administration of higher doses than had been ... was well-tolerated and biologically,active at all dose levels ...
Cached Medicine Technology:Molecular Insight Pharmaceuticals, Inc. Presents Preclinical Data,at Society Of Nuclear Medicine 2007 Annual Meeting 2Molecular Insight Pharmaceuticals, Inc. Presents Preclinical Data,at Society Of Nuclear Medicine 2007 Annual Meeting 3Molecular Insight Pharmaceuticals, Inc. Presents Preclinical Data,at Society Of Nuclear Medicine 2007 Annual Meeting 4ZymoGenetics Reports Results From Atacicept Phase 1b Clinical Trial,in B-Cell Chronic Lymphocytic Leukemia 2ZymoGenetics Reports Results From Atacicept Phase 1b Clinical Trial,in B-Cell Chronic Lymphocytic Leukemia 3
The adult underbody blanket is conveniently positioned on the table before the patient arrives to the procedure suite....
The adult blanket provides full coverage for patients of all sizes. The generous size and versatility of these blankets include extra material for the shoulders and feet. The foot drape also reduces ...
The Bair Hugger outpatient blanket makes it easy to give your patients the benefit of prewarming and enhance patient comfort during outpatient procedures....
The full body blanket provides coverage to the entire patient....
Medicine Products: