Navigation Links
Scientists eavesdrop on the exciting conversations within cells
Date:2/25/2009

Scientists have discovered the secrets of a sophisticated molecule that plays a role in many aspects of human health from fertility to blood pressure; digestion to mental health. This has opened up the potential for discovery of new drugs to treat an enormous variety of conditions.

In research supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Wellcome Trust a team from the University of Cambridge shows how a molecule the IP3 receptor arranges itself into clusters to help broadcast vital chemical messages around cells in the form of calcium. The work is published today (25 February) in Nature.

Team leader, Professor Colin Taylor said: "Almost everything a cell does is regulated by calcium, and we know there are many diseases in both humans and animals, such as stroke or an irregular heart beat, in which calcium regulation goes wrong. But the real puzzle is trying to understand how calcium which is amongst the simplest of all chemicals can manage to control lots of different things at the same time. What we have found is a crucial part of that puzzle.

"Imagine you're trying to find a dancing partner at a party. You might whisper the request to several people, or you might shout it out to everyone. Some of your handful of whispered requests might be ignored and some may have you heading for the dance floor. If you shout loud enough, everyone gets to decide whether to respond. It's rather similar with messages transmitted by calcium signals: they can evoke very different responses in cells depending on whether they are whispered or shouted."

The research published today shows that when cells are stimulated, their IP3 receptors receive instructions telling them to both gather into clusters and to open and allow calcium to pass. Furthermore, IP3 receptors behave very differently when they are alone as opposed to clustered, and these differences help determine whether the calcium
'/>"/>

Contact: Nancy Mendoza
press.office@bbsrc.ac.uk
01-793-413-355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Find Gene for Tooth Enamel
2. Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu
3. Scientists May Have New Way to Fight the Flu
4. Scientists Gain Insight Into Blood Cancers Progression
5. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
6. Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimers Disease
7. University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
8. Scientists uncover secrets of potential bioterror virus
9. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
10. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
11. Scientists Heartened at Prospect of End to Stem Cell Ban
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... April 18, 2015 "I recognized the ... in healthcare facilities," said an inventor from Cincinnati, Ohio. ... system." , He developed the Slyde Door to offer ... in healthcare facilities. It provides convenient storage space for ... more stretchers available for patients. , This offers ...
(Date:4/18/2015)... 2015 Lowcostcarinsuranceprice.com has released a new ... on auto insurance prices . , Drivers ... vehicle theft may have to pay more for auto ... insurance policies can also offer protection against vehicle theft. ... compared online on a single website: http://lowcostcarinsuranceprice.com/ ...
(Date:4/18/2015)... April 18, 2015 In the past ... couple of changes. , "We had to run maintenance ... needed changes," said Jennifer Ramirez, the PR Director. "It ... to say that we are back on track after ... the process of changing phone systems which has not ...
(Date:4/18/2015)... “ ArcAngel ” was featured on NewsWatch as part of ... and coolest applications on the market for iOS, ... technology expert, conducted the app review and shared with viewers ... a turbulent world, people may find themselves in dangerous situations ... first move, but some situations can be avoided if there ...
(Date:4/17/2015)... John Evans, a Gardant affordable assisted living ... 2 p.m. to 3 p.m. on April 24. , ... in Pekin, Illinois, serves older adults of all incomes, ... maintain their independence. , Becky Baker will entertain guests ... served during the luau. , For more information, call ...
Breaking Medicine News(10 mins):Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2Health News:TheBeautyPlace.com Temporary Number Available 2Health News:A Personal Safety Application was Featured on NewsWatch Television 2Health News:John Evans Supportive Living Community Prepares for Party on the Patio 2
... Superior Side-Effect Profile Earns Vesicare Gold Standard Status Over, ... ... Decision Resources, WALTHAM, Mass., April 3, 2008 ... focusing on,pharmaceutical and healthcare issues, finds that a drug,s effect on ...
... 32 Dallas-area students will be participating in the American ... Program. The program is held in conjunction with the ... Anatole Hotel. , The students are from the High ... School, and the Business and Management Cluster School. The ...
... Medical Mutual of Ohio,announced the acquisition of Premier ... network headquartered in Columbia,South Carolina., PHS was ... Palmetto,Health., The acquisition expands Medical Mutual,s presence ... Carolina Care Plan, a Columbia-based health,plan that serves ...
... N.C., and SAN DIEGO, April 3, 2008 ... and development organization, and,Advanced Targeting Systems, Inc. ... a new strategic alliance focused on development,and ... for chronic,pain. Advanced Pain Therapeutics LLC (APT), ...
... ,MemorialCare is joining forces with its physician partners ... to the hard hits health care,providers have been ... Medi-Cal reimbursement cuts to physicians, as well as ... inpatient,services., In efforts to continue to build ...
... ANA, Calif., April 2, 2008 Grubb &,Ellis Healthcare ... in Lakeland, Fla., Located at 3035, 3037, 3131, ... complex is comprised of four identical buildings. Each,building has ... square feet. Built in 1996 and 1998 on approximately ...
Cached Medicine News:Health News:Astellas/GlaxoSmithKline's Vesicare Has Advantages Over Pfizer's Detrol LA/Detrusitol XL in Reducing Episodes of Urge Urinary Incontinence 2Health News:Cato Research Ltd. and Advanced Targeting Systems, Inc. Partner to Develop SP-SAP for Chronic Pain 2Health News:Cato Research Ltd. and Advanced Targeting Systems, Inc. Partner to Develop SP-SAP for Chronic Pain 3Health News:MemorialCare Joins Forces with Physician Partners to Advocate for a Balanced, Fiscally Responsible Healthcare System 2Health News:Grubb & Ellis Healthcare REIT Acquires Vista Professional Center in Lakeland, Fla. 2Health News:Grubb & Ellis Healthcare REIT Acquires Vista Professional Center in Lakeland, Fla. 3Health News:Grubb & Ellis Healthcare REIT Acquires Vista Professional Center in Lakeland, Fla. 4
(Date:4/17/2015)... 2015  AbbVie Inc. ("AbbVie") (NYSE / CHX / Euronext ... the expiration of its exchange offer to acquire all of ... 5 p.m., New York City time, ... 2015, AbbVie also voluntarily withdrew its initial Notification and Report ... provide the FTC with additional time to review the proposed ...
(Date:4/17/2015)... Inivata, a Cambridge, England -based ... the 2015 American Association for Cancer Research (AACR) Annual Meeting ... and a poster presentation. Michael Stocum , CEO ... nd . The presentation, entitled Monitoring the ... part of a session on Recent Advances in Diagnostics ...
(Date:4/17/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/lmsnqn/medical_equipment ... Equipment Rental and Leasing - Global Strategic Business Report" ... analyzes the worldwide markets for Medical Equipment Rental and ... analytics for the US, Japan , ... Annual estimates and forecasts are provided for ...
Breaking Medicine Technology:AbbVie Extends Exchange Offer to Acquire Pharmacyclics, Inc. 2AbbVie Extends Exchange Offer to Acquire Pharmacyclics, Inc. 3AbbVie Extends Exchange Offer to Acquire Pharmacyclics, Inc. 4Inivata Co-founder Nitzan Rosenfeld to Present at AACR Annual Meeting 2Medical Equipment Rental and Leasing Market 2015-2020 - Global Strategic Business Report - Healthcare Spending Slowdown Bodes Well for Medical Equipment Leasing 2
For the quantitative in vitro determination of Carbamazepine in human serum...
For the quantitative in vitro determination of Phenobarbital in human serum....
Determination of the Thrombin Time by STA Analyzers. Freeze-dried human thrombin (1.5NIH units/mL) with calcium....
Determination of Activated Partial Thromboplastin Time (APTT) by STA Analyzers. Cephalin reagent with particulate (silica) activator....
Medicine Products: