Navigation Links
Scientists eavesdrop on the exciting conversations within cells
Date:2/25/2009

Scientists have discovered the secrets of a sophisticated molecule that plays a role in many aspects of human health from fertility to blood pressure; digestion to mental health. This has opened up the potential for discovery of new drugs to treat an enormous variety of conditions.

In research supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Wellcome Trust a team from the University of Cambridge shows how a molecule the IP3 receptor arranges itself into clusters to help broadcast vital chemical messages around cells in the form of calcium. The work is published today (25 February) in Nature.

Team leader, Professor Colin Taylor said: "Almost everything a cell does is regulated by calcium, and we know there are many diseases in both humans and animals, such as stroke or an irregular heart beat, in which calcium regulation goes wrong. But the real puzzle is trying to understand how calcium which is amongst the simplest of all chemicals can manage to control lots of different things at the same time. What we have found is a crucial part of that puzzle.

"Imagine you're trying to find a dancing partner at a party. You might whisper the request to several people, or you might shout it out to everyone. Some of your handful of whispered requests might be ignored and some may have you heading for the dance floor. If you shout loud enough, everyone gets to decide whether to respond. It's rather similar with messages transmitted by calcium signals: they can evoke very different responses in cells depending on whether they are whispered or shouted."

The research published today shows that when cells are stimulated, their IP3 receptors receive instructions telling them to both gather into clusters and to open and allow calcium to pass. Furthermore, IP3 receptors behave very differently when they are alone as opposed to clustered, and these differences help determine whether the calcium
'/>"/>

Contact: Nancy Mendoza
press.office@bbsrc.ac.uk
01-793-413-355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Find Gene for Tooth Enamel
2. Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu
3. Scientists May Have New Way to Fight the Flu
4. Scientists Gain Insight Into Blood Cancers Progression
5. Dallas Scientists Discover Statins May Falsely Indicate Thyroid Problems
6. Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimers Disease
7. University of Ottawa Heart Institute Scientists Unlock Mechanism That Turns on Weight-Loss Gene
8. Scientists uncover secrets of potential bioterror virus
9. Scientists uncover indicator that warns leukemia is progressing to more dangerous form
10. In Month of the Heart, Scientists Identify Better Way to Predict Heart-Disease Risk
11. Scientists Heartened at Prospect of End to Stem Cell Ban
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/6/2015)... , ... July 06, 2015 , ... ... that eliminates 100% of all acids, chemicals and impurities; it also properly mineralizes ... water because it contains harmful contaminants.  These harmful contaminants are a byproduct of ...
(Date:7/6/2015)... ... July 06, 2015 , ... Shortly after opening her second practice in ... of doctors working on a lien basis. Dr. Lim had previously worked with ... of two Cambodian refugees, Dr. Lim suffered with back pain herself throughout high school. ...
(Date:7/6/2015)... ... , ... Olive Fertility Centre is proud to announce that Olive medical director ... of the department of Family Practice. , “This award is a real honour,” says ... technology is changing so rapidly and we are also developing new models of patient-centred ...
(Date:7/6/2015)... CA (PRWEB) , ... July 06, 2015 , ... Seedstock ... deliver the keynote address at the 4th Annual Seedstock Sustainable Agriculture Conference – “Innovation ... year’s conference , held at the University of California-San Diego, will explore solutions ...
(Date:7/6/2015)... ... July 06, 2015 , ... With a new community ... with Livonia Save Our Youth and announced a new charity campaign to raise funds ... to alcohol and drug abuse. Livonia Save Our Youth is a coalition created especially ...
Breaking Medicine News(10 mins):Health News:Pristine Water Filters.com Offers The 1st Water Revival System That Re-Mineralizes Drinking Water and Eliminates All Impurities and Chemicals 2Health News:Respected Chiropractor Opens Office in Signal Hill/Cambodia Town and Joins Doctors on Liens 2Health News:Olive Fertility Centre Physician Honoured for Teaching 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 2Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 3Health News:Seedstock Names Go Green Agriculture Founder and CEO as 2015 Sustainable Agriculture Conference Keynote Speaker 4Health News:Bowker Insurance Group and Nonprofit Livonia Save Our Youth Initiate New Charity Campaign in Livonia, MI to Provide for The Health and Safety of The Communities’ Youth 2Health News:Bowker Insurance Group and Nonprofit Livonia Save Our Youth Initiate New Charity Campaign in Livonia, MI to Provide for The Health and Safety of The Communities’ Youth 3
... ... the most significant schedules of industry expert speakers ever assembled to address HIMSS 2010 ... (PRWEB) ... technology and outreach solutions, has developed one of the most significant schedules of industry ...
... ... the first to utilize cutting edge high definition technology for patients with visual impairments. ... (PRWEB) February 3, 2010 ... recent technological advancements in eye surgery. In addition to promising 20/20 vision, new corrective lens ...
... ... and age of specialization and compartmentalization, liberal arts and humanities degrees are ... individuals who desire a well-rounded, more classical education, a liberal arts or ... from communications and journalism to general arts and the humanities. A ...
... ... Dr. Nicole Detling Miller , U.S. Speedskating  Olympic team sports psychologist ... featured guest on The Colbert Report ,  yesterday, February 1st, ... supporter of U.S. Speedskating, having aired several TV segments highlighting his many ...
... ... Health Center Makes “America’s Best Nursing Homes” List , ... Tucson, Ariz. (Vocus) February 2, 2010 -- A ... “America’s Best Nursing Homes” by U.S. News and World Report. The designation will appear ...
... they get the news, study finds , TUESDAY, Feb. 2 ... unnerving enough to up a man,s odds for either suicide ... study results didn,t surprise us," said study co-author Dr. Lorelei ... School. "A cancer diagnosis is an acutely distressful event, and ...
Cached Medicine News:Health News:Sunquest Announces Significant Speaker Schedule for HIMSS 2010 2Health News:Sunquest Announces Significant Speaker Schedule for HIMSS 2010 3Health News:Sunquest Announces Significant Speaker Schedule for HIMSS 2010 4Health News:HD For More Than Your TV – New Technologies Offer Patients High Definition Vision At Any Age 2Health News:OnlineEducation.com Announces Expansion of Liberal Arts & Humanities to its Accredited Online Degree Programs 2Health News:OnlineEducation.com Announces Expansion of Liberal Arts & Humanities to its Accredited Online Degree Programs 3Health News:OnlineEducation.com Announces Expansion of Liberal Arts & Humanities to its Accredited Online Degree Programs 4Health News:Ashworth College Instructor Dr. Nicole Detling Miller Appears on 'Colbert Report' 2Health News:Ashworth College Instructor Dr. Nicole Detling Miller Appears on 'Colbert Report' 3Health News:Ashworth College Instructor Dr. Nicole Detling Miller Appears on 'Colbert Report' 4Health News:Ashworth College Instructor Dr. Nicole Detling Miller Appears on 'Colbert Report' 5Health News:U.S. News & World Report Ranks Sonora at Splendido Among Top in Nation 2Health News:Prostate Cancer Diagnosis Raises Suicide Risk 2Health News:Prostate Cancer Diagnosis Raises Suicide Risk 3
(Date:7/6/2015)... 6, 2015  Impax Laboratories, Inc. (NASDAQ: IPXL ... has resigned from the Company,s Board of Directors in ... a co-founder of Impax in 1995 and served as ... 2006 until April 2014. Logo - http://photos.prnewswire.com/prnh/20150310/180590LOGO ... President and Chief Executive Officer stated, "We wish to ...
(Date:7/6/2015)... BOSTON , July 6, 2015 ... Inc. (NASDAQ: ISIS ), announced today that ... Orphan Drug Designation to volanesorsen (ISIS-APOCIII Rx ) ... Syndrome (FCS).  FCS is a rare genetic disease ... of pancreatitis. In a Phase 2 study published ...
(Date:7/6/2015)... 6, 2015 /PRNewswire/ -- China Nepstar Chain Drugstore Ltd. (NYSE: ... retail drugstore chain in China ... announced that its board of directors has received a ... Simin Zhang , chairman of the board of ... Ltd., an investment vehicle wholly owned by Mr. Zhang(" ...
Breaking Medicine Technology:Impax Announces Resignation of Larry Hsu, Ph.D. from Board of Directors 2Impax Announces Resignation of Larry Hsu, Ph.D. from Board of Directors 3Impax Announces Resignation of Larry Hsu, Ph.D. from Board of Directors 4Impax Announces Resignation of Larry Hsu, Ph.D. from Board of Directors 5Akcea Therapeutics Receives Orphan Drug Designation from the US FDA for Volanesorsen (ISIS-APOCIII Rx) for the Treatment of Familial Chylomicronemia Syndrome 2Akcea Therapeutics Receives Orphan Drug Designation from the US FDA for Volanesorsen (ISIS-APOCIII Rx) for the Treatment of Familial Chylomicronemia Syndrome 3Akcea Therapeutics Receives Orphan Drug Designation from the US FDA for Volanesorsen (ISIS-APOCIII Rx) for the Treatment of Familial Chylomicronemia Syndrome 4Akcea Therapeutics Receives Orphan Drug Designation from the US FDA for Volanesorsen (ISIS-APOCIII Rx) for the Treatment of Familial Chylomicronemia Syndrome 5Akcea Therapeutics Receives Orphan Drug Designation from the US FDA for Volanesorsen (ISIS-APOCIII Rx) for the Treatment of Familial Chylomicronemia Syndrome 6China Nepstar Chain Drugstore Ltd. Announces Receipt of "Going Private" Proposal 2China Nepstar Chain Drugstore Ltd. Announces Receipt of "Going Private" Proposal 3China Nepstar Chain Drugstore Ltd. Announces Receipt of "Going Private" Proposal 4China Nepstar Chain Drugstore Ltd. Announces Receipt of "Going Private" Proposal 5China Nepstar Chain Drugstore Ltd. Announces Receipt of "Going Private" Proposal 6
... Mass., Oct. 20, 2011 Boston Scientific Corporation (NYSE: ... 30, 2011, as well as updated sales and earnings per share ... Third quarter and other highlights: ... per share and adjusted EPS of $0.15, both exceeding previous guidance ...
... 20, 2011 OncoSec Medical Incorporated (OTCBB: ONCS), which ... treatment of solid tumor cancers, announced today the submission ... Food and Drug Administration (FDA) for its patented ... generator and hand-held applicator. The Company has been developing ...
Cached Medicine Technology:Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 2Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 3Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 4Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 5Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 6Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 7Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 8Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 9Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 10Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 11Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 12Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 13Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 14Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 15Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 16Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 17Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 18Boston Scientific Exceeds Third Quarter EPS Guidance, Repurchases 30 Million Shares 19Device Master File for OncoSec Medical System Completed and Submitted to FDA 2Device Master File for OncoSec Medical System Completed and Submitted to FDA 3
The ImagingPlanet 55 mm surgical microscope video adapter: superior optical quality and precise engineering make this 55mm focal length adapter an excellent decision for use with your Leica surgical ...
The ImagingPlanet 55 mm Surgical Microscope Adapter. Superior optical quality and precise engineering make this 55mm focal length adapter an excellent decision for use with your Zeiss surgical micro...
Introducing Optronics DVMR, the first digital surgical documentation system designed for the microsurgical operating room environment. DVMR accepts images from a variety of high-resolution cameras fo...
Research Grade Microscope Camera from ImagingPlanet Research Microscopy Group, a superior imaging technology that delivers increased image resolution and precise color accuracy at an affordable pric...
Medicine Products: