Navigation Links
Scientists discover why newborns get sick so often
Date:10/31/2013

Bethesda, MDIf you think cold and flu season is tough, trying being an infant. A new research finding published in the November 2013 issue of the Journal of Leukocyte Biology sheds new light on why newborns appear to be so prone to getting sick with virusesthey are born without one of the key proteins needed to protect them. This protein, called "toll-like receptor 3" or "TLR3," is involved in the recognition of different viruses and mediates the immune response to them. Without this protein, newborn immune cells are not equipped to recognize and react appropriately to certain viruses, in particular, the herpes simplex virus known as HSV.

"This study helps to understand the molecular basis for the immaturity of the immune system of newborns, which we believe will contribute to development of therapeutic interventions to protect this vulnerable population group," said Lucija Slavica, a researcher involved in the work from the Department of Rheumatology and Inflammation Research at the University of Gothenburg in Gothenburg, Sweden.

To make this discovery, scientists compared cells from the cord blood of newborns with the same type of blood cells from adults. The cells from newborns did not contain the protein TLR3, which was present in adult cells. These cells rid the body of viral-infected cells, ultimately eliminating viral infections. When researchers treated both cell groups with a synthetic component mimicking a viral presence, the adult immune cells reacted by secreting substances involved in immune reaction against viruses (interferon-gamma) and killed cells infected with virus, while cells from newborns could not do this or were impaired in performing this function.

"This study adds to the growing body of research stemming from the Nobel-winning discovery in 2011 on how the immune system recognizes microbes by shedding light on how these pathways develop over time after birth," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "This report is particularly important - as any new parent can attest, infants are particularly susceptible to infections and understanding which pathways are not yet functional could lead to novel therapies."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Scientists modify Botox for the treatment of pain
2. UNC neuroscientists discover new mini-neural computer in the brain
3. New Genetic Error in Some Lung Cancers Identified by CU Scientists
4. CNIO scientists reduce progression of one of the most aggressive skin cancers in mice
5. Chicago Public High School Students to Rub Shoulders with Scientists from Around the World
6. NIH scientists pursue new therapies to improve rare disease drug development
7. NCI scientists identify targets for melanoma immunotherapy
8. Peering into Genetic Defects, CU Scientists Discover a New Metabolic Disease
9. What scientists can see in your pee
10. St. Jude Childrens Research Hospital scientists identify ALS disease mechanism
11. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2020)... Neb. (PRWEB) , ... August 12, 2020 , ... ... that the company is under new ownership and looking to expand. , ... amazing, long-term staff members, but the franchise was underleveraged. As Caring Transitions, we ...
(Date:8/11/2020)... , ... August 11, 2020 , ... Help.org , ... has announced the Best Rehab Facilities in Greenville, for 2020. The informational guide ... and more. , According to recent studies , drug overdose is the ...
(Date:8/11/2020)... ... ... seen a drastic change in how things are done on a daily basis due to ... in public. Now, most states have made it compulsory as the need for authentic and ... in the U.S.A realized the shortage of PPE was inevitable. Dr. Rouhanian was no different ...
(Date:8/9/2020)... ... August 10, 2020 , ... Dr. Angela Abraham has ... of Optometry (NECO). Dr. Abraham will be leading the drive to foster a more ... on to the 13% Promise, a new initiative led by Black Eyecare Perspective and ...
(Date:8/7/2020)... ... August 07, 2020 , ... Alexandria Dental Health & ... Dr. Mojgan Mazhari, this well-respected practice offers advanced smile solutions to meet all ... among an exclusive group of dental practices with a large number of five-star ...
Breaking Medicine News(10 mins):
(Date:8/7/2020)... ... August 07, 2020 , ... ... is pleased to announce that it has partnered with Comprehensive Physical Therapy in ... central MA community since 1991 and has a strong reputation for providing high-quality ...
(Date:8/5/2020)... ... , ... Our pets mean the world to us, and lately with how much we’ve been ... joy, and comfort they bring. National Dog Day is coming up on Wednesday, August 26th, ... , Set aside some time to do what they love most, whether it’s going to ...
(Date:8/5/2020)... ... ... Fifty six percent of older adults think we need to invest more in Medicare ... according to a new survey by The Senior Citizens League (TSCL). “Boosting funding ... says Mary Johnson, a Medicare, and Social Security policy analyst for The Senior Citizens ...
Breaking Medicine Technology: