Navigation Links
Scientists discover why newborns get sick so often
Date:10/31/2013

Bethesda, MDIf you think cold and flu season is tough, trying being an infant. A new research finding published in the November 2013 issue of the Journal of Leukocyte Biology sheds new light on why newborns appear to be so prone to getting sick with virusesthey are born without one of the key proteins needed to protect them. This protein, called "toll-like receptor 3" or "TLR3," is involved in the recognition of different viruses and mediates the immune response to them. Without this protein, newborn immune cells are not equipped to recognize and react appropriately to certain viruses, in particular, the herpes simplex virus known as HSV.

"This study helps to understand the molecular basis for the immaturity of the immune system of newborns, which we believe will contribute to development of therapeutic interventions to protect this vulnerable population group," said Lucija Slavica, a researcher involved in the work from the Department of Rheumatology and Inflammation Research at the University of Gothenburg in Gothenburg, Sweden.

To make this discovery, scientists compared cells from the cord blood of newborns with the same type of blood cells from adults. The cells from newborns did not contain the protein TLR3, which was present in adult cells. These cells rid the body of viral-infected cells, ultimately eliminating viral infections. When researchers treated both cell groups with a synthetic component mimicking a viral presence, the adult immune cells reacted by secreting substances involved in immune reaction against viruses (interferon-gamma) and killed cells infected with virus, while cells from newborns could not do this or were impaired in performing this function.

"This study adds to the growing body of research stemming from the Nobel-winning discovery in 2011 on how the immune system recognizes microbes by shedding light on how these pathways develop over time after birth," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "This report is particularly important - as any new parent can attest, infants are particularly susceptible to infections and understanding which pathways are not yet functional could lead to novel therapies."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Scientists modify Botox for the treatment of pain
2. UNC neuroscientists discover new mini-neural computer in the brain
3. New Genetic Error in Some Lung Cancers Identified by CU Scientists
4. CNIO scientists reduce progression of one of the most aggressive skin cancers in mice
5. Chicago Public High School Students to Rub Shoulders with Scientists from Around the World
6. NIH scientists pursue new therapies to improve rare disease drug development
7. NCI scientists identify targets for melanoma immunotherapy
8. Peering into Genetic Defects, CU Scientists Discover a New Metabolic Disease
9. What scientists can see in your pee
10. St. Jude Childrens Research Hospital scientists identify ALS disease mechanism
11. NIH-funded scientists describe genesis, evolution of H7N9 influenza virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2020)... (PRWEB) , ... January 24, 2020 , ... ... global consulting firm for the life sciences and food industries, is pleased to ... Specialist, at their head office and research site in Toronto, Canada. , Dr. ...
(Date:1/23/2020)... ... January 23, 2020 , ... A January 7 ... to get rid of them. The article quotes the president of the American Society ... are many. They can be caused by a person’s facial structure including an undefined ...
(Date:1/23/2020)... ... , ... Let’s face it; the holidays were a stressful time, a time ... secrets were revisited. It’s easy to understand why many folks prefer to duck out ... the holidays posed additional stress for which there is no “cookie-cutter” solution. , Dylan ...
(Date:1/23/2020)... (PRWEB) , ... January 23, 2020 , ... Park Avenue ... new website jschildhorn.com. Dr. Schildhorn is excited to bring this new digital portal for ... of Duke and attended medical school at Temple University. With over 12 years of ...
(Date:1/23/2020)... ... January 23, 2020 , ... ... SaaS vendor announced their partner agreement with Healthpac, a trusted medical billing ... offices and medical offices an expanded offering. Healthpac’s customers can now access ...
Breaking Medicine News(10 mins):
(Date:1/22/2020)... ... January 22, 2020 , ... ... technical services exclusively to the healthcare industry, announced today that Southern Illinois ... automation program for its Epic EHR. SIH is a prominent multi-hospital health system ...
(Date:1/12/2020)... , ... January 10, 2020 ... ... that Founder and CEO Remo Moomiaie-Qajar, MD has been selected to present ... company that has developed a vast platform with its proprietary Cargocyte™ next ...
(Date:1/12/2020)... ... January 12, 2020 , ... FutuRx, Israel’s leading ... JJDC, and Takeda Ventures, Inc, operating under a tender from the Israeli Innovation ... collaboration with Ramot at Tel-Aviv University and Glasgow University. , Epeius pharma ...
Breaking Medicine Technology: