Navigation Links
Scientists discover tiny RNAs play a big role in controlling genes
Date:10/25/2007

New Haven, Conn.A study by researchers at the Yale Stem Cell Center for the first time demonstrates that piRNAs, a recently discovered class of tiny RNAs, play an important role in controlling gene function, it was reported this week in Nature.

Haifan Lin, director of the stem cell center and professor of cell biology at Yale School of Medicine, heads the laboratory that originally identified piRNAs. Derived mostly from so-called junk DNA, piRNAs had escaped the attention of generations of geneticists and molecular biologists until last year when Lins team discovered them in mammalian reproductive cells, and named them.

The labs current work suggests that piRNAs have crucial functions in controlling stem cell fate and other processes of tissue development.

In this study Lin and his Ph.D. student, Hang Yin, discovered more than 13,000 Piwi-associated piRNAs in fruit flies. One particular piRNA, they found, forms a complex with the protein known as Piwi, which then binds to chromatin, a strategic region in the genome that regulates the activity of the gene. Chromatins role is to package DNA so that it will fit into the cell, to strengthen the DNA to allow cell division, and to serve as a mechanism to control gene expression.

This is important in maintaining self-renewal of stem cells, Lin said. These small RNAs might provide new tools to harness the behavior of stem cells and other biological processes related to diseases.

This finding revealed a surprisingly important role for piRNAs, as well as junk DNA, in stem cell division, Lin said. It calls upon biologists to look for answers beyond the one percent of the genome with protein coding capacity to the vast land of junk DNA, which constitutes 99 percent of the genome.


'/>"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
Source:Eurekalert

Page: 1

Related medicine news :

1. Nobel Prize for Medicine shared by Three scientists
2. Scientists plan human cloning clinic in the United States
3. Scientists crack mechanism of Leptin-Obesity Hormone
4. Scientists use plant hormones to fight cancer
5. American scientists alter gene makeup of babies
6. Expose on eating disorders!! Scientists trace “brain’s eating control center pathway”
7. Scientists found ancient Human Germ Killer
8. Scientists locate key hormone involved in appetite control
9. Scientists open the book of life
10. Electronic nose by Italian scientists
11. Scientists review SARS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... NY (PRWEB) September 22, 2014 ... whom all of the federal mesh lawsuits ( ... Corp. have been consolidated for pretrial matters, issued ... Scientific Corp. Pelvic Repair System Products Liability Litigation ... of West Virginia; Case no. 2:12-md-02326)—requiring that four ...
(Date:9/22/2014)... -- All sexually active women should be screened ... infections: chlamydia and gonorrhea, according to new recommendations ... The task force noted this recommendation includes ... age and pregnant women. Most women with ... a result, many infections go undetected. If left ...
(Date:9/22/2014)... Steven Reinberg HealthDay Reporter ... are urging that all children aged 6 months and older ... Academy of Pediatrics updated their influenza vaccine recommendations to advise ... vaccine to build immunity. The AAP also wants parents of ... the nasal spray vaccine instead of the flu shot if ...
(Date:9/22/2014)... Hamilton, ON (September 22, 2014) McMaster scientists have ... a new class of antibiotics. , Although dozens ... looked at how a certain part of bacteria are ... stopping it. , The discovery is important as ... is making the cures for infections ineffective. The World ...
(Date:9/22/2014)... September 22, 2014 Quincy Bioscience, ... United States, promotes National Self-Improvement Month ... all individuals should have access to self-improvement resources, ... , The demand for products that preserve health ... ever before. For over six years, Quincy Bioscience ...
Breaking Medicine News(10 mins):Health News:Federal Court Sets Trial Date for Boston Scientific Vaginal Mesh Cases in Florida, the Rottenstein Law Group LLP Reports 2Health News:Screen Women for Chlamydia, Gonorrhea, Experts Say 2Health News:Pediatricians Urge Flu Vaccine for All Kids 6 Months and Older 2Health News:Pediatricians Urge Flu Vaccine for All Kids 6 Months and Older 3Health News:Quincy Bioscience Promotes National Self-Improvement Month 2
... Dramatically Cut Largest Source of Deadly Diesel Pollution in State ... 12 The California Air Resources Board today approved two ... of diesel pollution in the state and are the first ... Defense Fund (EDF). The Air Resource Board estimates that the ...
... national partners in effort to raise $5 million , ... National partners from the 17th annual Halloween Promotion benefiting ... celebrate raising more than $2.4 million to help the hospital ... , Companies represented at today,s recognition ceremony ...
... cells may make them more resilient during real attack, experts ... have long known that the creation of a "mini ... flow to arteries -- can actually reduce the damage from ... how that protective effect occurs, according to research from the ...
... PartsSource, the nation,s leading,supplier of replacement medical repair parts for ... in Ohio by the Case Western Reserve,University Weatherhead ... placed 14th on this year,s list with a growth rate ... eligible. , "The Weatherhead ...
... to bad treatment decisions, study shows , , FRIDAY, ... receive about the risk of their breast cancer ... whether to get chemotherapy more difficult, a new ... patients a bar chart, based on a standard ...
... A new report from the Institute of Medicine, THE ... ADMINISTRATION, examines why a commitment to global health is ... light of the current economic situation. The report ... goals the incoming administration should strive to meet, and ...
Cached Medicine News:Health News:California Rules to Cut Diesel Truck Pollution Called Most Sweeping in U.S. 2Health News:More Than $2.4 Million Raised by National Halloween Promotion Partners to Help St. Jude Fight Childhood Cancer 2Health News:Research Explains Benefit of 'Mini Heart Attack' 2Health News:Risk Info for Breast Cancer Patients Too Confusing 2
(Date:9/22/2014)... PLYMOUTH MEETING, Pa. , Sept. 22, 2014 ... ) announced today it has initiated a phase ... The trial will evaluate the safety, tolerability, and ... type 6 (HPV-6), which causes most aerodigestive cancers. ... tongue, nose, throat, vocal cords, and parts of ...
(Date:9/22/2014)... and NEW YORK , Sept. ... ACCP), has signed an exclusive, global license agreement ... and commercialization of its proprietary plasma fractionation process. ... team and its intention to strategically refocus and ... its plans to pursue a national listing for ...
(Date:9/22/2014)... Pa. , Sept. 22, 2014 ... a specialty biopharmaceutical company, today announced that its ... unsolicited, non-binding and conditional proposal from Endo International ... financial and legal advisors, has unanimously determined it ... of its existing merger agreement with QLT Inc. ...
Breaking Medicine Technology:Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 2Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 3Inovio Pharmaceuticals Expands HPV Immunotherapy Development to Aerodigestive Cancers 4Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 2Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 3Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 4Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 5Access Pharmaceuticals Announces Exclusive Global Plasma Therapeutics License, New Management And New Corporate Name 6Auxilium Provides Transaction Update 2Auxilium Provides Transaction Update 3Auxilium Provides Transaction Update 4Auxilium Provides Transaction Update 5Auxilium Provides Transaction Update 6
... SAN DIEGO, Feb. 6, 2012 Amylin Pharmaceuticals, Inc. (Nasdaq: ... quarter and year ended December 31, 2011. ... $164.9 million, which included net product sales of $160.9 million. ... 2011 was $17.6 million, compared to a non-GAAP operating income ...
... Feb. 6, 2012  Genomic Health, Inc. (Nasdaq: GHDX ... with the goal of improving the quality of diagnosis, communication ... with common and rare genetic conditions.   The subsidiary is expected ... first commercial service in 2013.  The new venture will be ...
Cached Medicine Technology:Amylin Pharmaceuticals Reports Fourth Quarter and Full Year 2011 Financial Results 2Amylin Pharmaceuticals Reports Fourth Quarter and Full Year 2011 Financial Results 3Amylin Pharmaceuticals Reports Fourth Quarter and Full Year 2011 Financial Results 4Amylin Pharmaceuticals Reports Fourth Quarter and Full Year 2011 Financial Results 5Amylin Pharmaceuticals Reports Fourth Quarter and Full Year 2011 Financial Results 6Amylin Pharmaceuticals Reports Fourth Quarter and Full Year 2011 Financial Results 7Amylin Pharmaceuticals Reports Fourth Quarter and Full Year 2011 Financial Results 8Amylin Pharmaceuticals Reports Fourth Quarter and Full Year 2011 Financial Results 9Genomic Health Announces Formation of New Genetics Subsidiary 2Genomic Health Announces Formation of New Genetics Subsidiary 3Genomic Health Announces Formation of New Genetics Subsidiary 4
... with a curvature of 12 ... of the retina. Instrument shaft ... For cutting membranes adherent to ... for cutting in small folds ...
Claes Shielded Retinotomy Scissors, Curved Vertical...
Claes Shielded Retinotomy Scissors, Vertical...
Indirect hemagglutination assay (IHA) for the detection and semi-quantitation of human antibodies to the bacteria of the genus Leptospira. Each kit contains test cells, control cells, and positive an...
Medicine Products: