Navigation Links
Scientists discover the mechanisms and function of a type of mysterious immune cell
Date:9/2/2010

that go on between CAR, the ligand on the cell surface of damaged epithelial cells and its receptor JAML on γδ T cells. To do this, the scientists turned to a technique called x-ray crystallography, which involves making crystals of ordered arrays of protein and then blasting the frozen crystals with x-ray radiation. The atoms in the protein crystals cause the x-rays to diffract, and the scientists collect and analyze the pattern of diffraction to solve the atomic-level structure of the proteins.

Through this process, the Verdino et al. study determined the exact molecular details of how CAR on keratinocytes and JAML on γδ T cells interact. Furthermore, both studies revealed how the CAR-JAML interaction induces signaling events inside the γδ T cells that ultimately lead to proliferation and effector functions needed for wound repair.

But how did this basic-science finding translate into an animal model? The Witherden et al. study found that blocking the JAML interaction with CAR in mice led to defects in γδ T cell activation and subsequent wound healing. This confirmed that costimulatory signals from JAML are essential for γδ T cell responses to wounds.

"The best part of our combined effort," said Verdino, "is that we have put together a comprehensive picture of the role of JAML and CAR for γδ T cell function from various perspectives."

The Havran lab's next study, currently under way, will investigate a role for JAML and CAR interactions in activation of γδ T cells in humans. Chronic wounds are an increasing clinical problem for patients with diabetes, major burns, and pressure sores. The current studies suggest that JAML and CAR are potential targets for future treatments to stimulate faster wound healing in these patients.

"Identification of an epithelial γδ T cell specific activation molecule gives us a unique opportunity to manipula
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... National (PRWEB) April 01, 2015 Every ... the S.A.D. (standard American diet) contains things banned in ... illness sky rockets every year. AlignLife Chiropractic & Natural ... patients but also their communities they can reduce the ... Throughout the year each AlignLife clinic offers workshops at ...
(Date:3/31/2015)... March 31, 2015 As the demand ... is pledging to have a mobile-friendly website online sometime ... part of Chunk Fitness’ continued commitment to bring the ... user base. All of the same great fitness information ... will be substantially easier to read while browsing on ...
(Date:3/31/2015)... Cosmetic Town, one of the most ... enduring adding news to its site while it redesigns ... plastic surgery and cosmetic medicine better use and navigate ... sections, the Cosmetic Town community is tingling at its ... Town site navigation, News and Blog section, will feature ...
(Date:3/31/2015)... In conjunction with the Asbestos ... the Mesothelioma Applied Research Foundation (Meso Foundation) announced ... complement its existing work in mesothelioma research, education, ... the Meso Foundation’s mission, we want to eliminate ... to asbestos, including mesothelioma,” said the Meso Foundation’s ...
(Date:3/31/2015)... In honor of National Disability Month, ... buying from a NMEDA QAP certified dealer. , ... nonprofit organization that provides consumer guidance and ensures ... of mobility equipment. The organization’s Quality Assurance Program ... adhere to the highest quality safety and customer ...
Breaking Medicine News(10 mins):Health News:Cosmetic Town is Now Transforming so Consumer can Better Navigate 2Health News:Mesothelioma Research Organization Announces New Prevention Program 2Health News:Mesothelioma Research Organization Announces New Prevention Program 3Health News:Advanced Driving Systems Celebrates National Disability Month 2
... with several aspects of physical and mental health by significantly ... been found// from recent studies that a strained relationship between ... process. This observation is believed to be due to a ... play a major role in wound healing) in the blood. ...
... citizens of Scotland to give up smoking on a voluntary basis. ... less trouble for the Government// that hopes to impose a public ... people who call up the smoking help line has infact increased ... is much more promising compared to the figures in 2003 where ...
... Bhopal gas leak tragedy was on Saturday 30 doctors of ... ,The doctors wanted a pay hike. The hospital gets around ... a trust, the BMHRC was set up as a super ... gas victims, it also treats private patients., ,The Essential ...
... to fund $142 million for cancer research facility in ... informed by its Premier Dalton McGuinty. The new research ... research activities in Ontario. The network will consist of ... they would discuss and work as a team in ...
... hormone injections (Leptin) taken twice daily by dieters help to maintain ... was headed by Dr Michael Rosenbaum of the Columbia University College ... light on the complex pathway that regulates metabolism and deposit fat. ... is to maintain the weight. ,A ...
... Men acquitted of a rape charge as he was suffering from ... is going to have her case against him in Canadian Supreme ... woman after a party when they were both in a drunken ... he was not aware or could remember of the act. Parasomnia ...
Cached Medicine News:Health News:Wound Healing Found To Be Slower In Couples Who Fight Often 2Health News:Leptin Injections Maintain Loss In Body Weight 2
(Date:3/31/2015)... , March 31, 2015  Frequentz Inc., a global ... a white paper to help the pharmaceutical industry understand ... Supply Chain Security Act (DSCSA). The white paper, "From ... the GS1 EPCIS Standard(s) and Implementation Plan ... the product tracing requirements that need to occur between ...
(Date:3/31/2015)... RESEARCH TRIANGLE PARK, N.C. , March 31, 2015 /PRNewswire/ ... Neeman International, will be attending the World Orphan Drug Congress ... India,s regulatory approval process and orphan drugs ... Advisory Board (DTAB) has recommended to the Ministry of Health ... a well-regulated country, marketing authorization can be obtained in ...
(Date:3/31/2015)... March 31, 2015  On May 2, 2015 ... in Santa Monica, CA ... Therapies for Malignant Pleural Mesothelioma (MPM), a rare ... asbestos and commonly affects the lining of the ... UCLA and the Pacific Mesothelioma Center (PMC). ...
Breaking Medicine Technology:Frequentz Releases White Paper Addressing DSCSA's Current & Future Impact 2Frequentz Releases White Paper Addressing DSCSA's Current & Future Impact 3Max Neeman to Discuss India's Orphan Drug Regulations at WOD 2015 2Cutting-Edge Research to Be Presented at 5th Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma in Santa Monica 2Cutting-Edge Research to Be Presented at 5th Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma in Santa Monica 3Cutting-Edge Research to Be Presented at 5th Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma in Santa Monica 4
... March 2, 2011 Warner Chilcott plc (Nasdaq: ... subsidiaries are seeking to refinance the Company,s existing credit ... (the "Existing Credit Agreement"), by entering into a new ... refinancing is expected to have the effect of extending ...
... take non-steroidal anti-inflammatory drugs three times a day for more ... erectile dysfunction compared to men who do not take those ... in The Journal of Urology . ... this observational study used electronic health records, an automated pharmacy ...
Cached Medicine Technology:Warner Chilcott Seeks to Refinance its Existing Credit Agreement 2Warner Chilcott Seeks to Refinance its Existing Credit Agreement 3Non-Steroidal Anti-Inflammatory Drugs Linked to Increased Risk of Erectile Dysfunction 2Non-Steroidal Anti-Inflammatory Drugs Linked to Increased Risk of Erectile Dysfunction 3
Fenestrated 14 mm blades. Wide extension of blade for protection of lids. Self-locking mechanism. Dull finish....
Solid 16 mm blades. Self-locking mechanism. Dull finish....
Infant model. Blades: 7 mm. Solid blades with locking mechanism. Dull finish....
Fenestrated 16 mm blades. Self-locking mechanism. Dull finish....
Medicine Products: