Navigation Links
Scientists discover the mechanisms and function of a type of mysterious immune cell
Date:9/2/2010

that go on between CAR, the ligand on the cell surface of damaged epithelial cells and its receptor JAML on γδ T cells. To do this, the scientists turned to a technique called x-ray crystallography, which involves making crystals of ordered arrays of protein and then blasting the frozen crystals with x-ray radiation. The atoms in the protein crystals cause the x-rays to diffract, and the scientists collect and analyze the pattern of diffraction to solve the atomic-level structure of the proteins.

Through this process, the Verdino et al. study determined the exact molecular details of how CAR on keratinocytes and JAML on γδ T cells interact. Furthermore, both studies revealed how the CAR-JAML interaction induces signaling events inside the γδ T cells that ultimately lead to proliferation and effector functions needed for wound repair.

But how did this basic-science finding translate into an animal model? The Witherden et al. study found that blocking the JAML interaction with CAR in mice led to defects in γδ T cell activation and subsequent wound healing. This confirmed that costimulatory signals from JAML are essential for γδ T cell responses to wounds.

"The best part of our combined effort," said Verdino, "is that we have put together a comprehensive picture of the role of JAML and CAR for γδ T cell function from various perspectives."

The Havran lab's next study, currently under way, will investigate a role for JAML and CAR interactions in activation of γδ T cells in humans. Chronic wounds are an increasing clinical problem for patients with diabetes, major burns, and pressure sores. The current studies suggest that JAML and CAR are potential targets for future treatments to stimulate faster wound healing in these patients.

"Identification of an epithelial γδ T cell specific activation molecule gives us a unique opportunity to manipula
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/30/2015)... ... June 30, 2015 , ... ... “Fireside Convalescent Care Center.” The video informs community members of Fireside’s Five-Star Medicare ... the need for those seeking care to be well informed and confident about ...
(Date:6/30/2015)... , ... June 30, 2015 , ... The LIV ... on fertility preservation and deciding the right age to pursue egg freezing. Statistics show ... the age of 35 — a 150 percent increase since the 1970s. , Sadly, ...
(Date:6/30/2015)... ... June 30, 2015 , ... Today, Grand Terrace Health Care ... Care Center.” Each year, Medicare ranks care centers around the country in an ... their needs. Grand Terrace prides itself on quality in each of Medicare’s evaluation ...
(Date:6/30/2015)... ... June 30, 2015 , ... According to a recent ... to 2013 while heroin-related deaths more than tripled in the same period—leading a majority ... Novus Medical Detox Center , a leading Florida-based drug treatment facility, asserts that these ...
(Date:6/30/2015)... , ... June 30, 2015 , ... ... announces today that they have been awarded the exclusive billing agreements with Jackson ... range of billing services encompassing their proprietary suite of billing process software functionality ...
Breaking Medicine News(10 mins):Health News:Fireside Convalescent Hospital Proves Itself as a Leading Care Center in New Video 2Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 2Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 3Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 4Health News:LIV Fertility Center Educating Women on the Critical Timing of Egg Freezing 5Health News:Grand Terrace Health Care Center Announces Five-Star Rating in YouTube Video 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 2Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 3Health News:Novus Medical Detox Center Urges Education and Action as New DEA Report Reveals Rising Heroin Use and Deaths 4Health News:ADVOCATE Wins Billing Agreements with Jackson Radiology Associates 2
... 1, 2010) Robotic surgical technology with its ... touch, even as they operate from a remote ... intersensory integration, and reports that surgical outcomes for ... compare favorably with traditional invasive surgery. Led by ...
... better than a "salt tax," study finds , MONDAY, ... to reduce U.S. sodium consumption by as little as ... of dollars, according to new research. , Cutting salt ... attacks and stroke. , "Per person on average it ...
... Mediterranean regimens all help the heart, study finds , ... three heart-healthy diets -- low-fat, low-carbohydrate, Mediterranean -- can ... to heart attack and stroke, an Israeli study indicates. ... though you experience only a moderate weight loss, if ...
... apt to enhance verbal skills, experts say, , MONDAY, ... their infants in front of supposedly brain-enhancing DVDs in ... be accomplishing nothing, new research shows. , What,s more, ... DVDs at an earlier age actually had lower levels ...
... , ... ... ... ...
... ... ... , , ... DALLAS , March ...
Cached Medicine News:Health News:Prostate cancer surgeons 'feel' with their eyes 2Health News:Prostate cancer surgeons 'feel' with their eyes 3Health News:Cutting Salt Could Prevent Almost 500,000 Heart Attacks 2Health News:Cutting Salt Could Prevent Almost 500,000 Heart Attacks 3Health News:Popular Diet Plans Can Unclog Arteries 2Health News:Watching Special Videos May Not Make Kids Brainier 2Health News:Watching Special Videos May Not Make Kids Brainier 3Health News:GNC Says 'Thank You' to Customers and Employees for Their $1.4 Million in Donations to the Sixth Annual St. Jude Children's Research Hospital(R) Thanks and Giving(R) Campaign 2Health News:GNC Says 'Thank You' to Customers and Employees for Their $1.4 Million in Donations to the Sixth Annual St. Jude Children's Research Hospital(R) Thanks and Giving(R) Campaign 3Health News:GNC Says 'Thank You' to Customers and Employees for Their $1.4 Million in Donations to the Sixth Annual St. Jude Children's Research Hospital(R) Thanks and Giving(R) Campaign 4Health News:GNC Says 'Thank You' to Customers and Employees for Their $1.4 Million in Donations to the Sixth Annual St. Jude Children's Research Hospital(R) Thanks and Giving(R) Campaign 5Health News:National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping? 2Health News:National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping? 3Health News:National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping? 4Health News:National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping? 5
(Date:6/30/2015)... , June 30, 2015 Pulse Light ... a survey to Rosacea sufferers as part of their ongoing ... Rosacea sufferers found effective for their Rosacea. The survey participants ... comprised 47% men and 53% women. The results ... participants did not consider or attempt to visit their GP ...
(Date:6/30/2015)... , June 30, 2015  Ardelyx, Inc. (NASDAQ: ... cardio-renal, gastrointestinal and metabolic diseases, today announced that the ... 14, 2015, from 8:00 a.m.- 1:00 pm EDT in ... The Ardelyx senior management team will present an ... compound, tenapanor, which has completed Phase 2b clinical trials ...
(Date:6/30/2015)... , BERKELEY, Kalifornien, und KOPENHAGEN, Dänemark, ... Biologics, Inc. , ein Weltmarktführer der klinischen ... anderen therapeutischen Proteinen, gab heute bekannt, dass ... der Produktionskapazität den Ausbau der nordamerikanischen Produktionsanlage ... mit der Ergänzung  einer Einweg-Anlage Bioreactor 6Pack™ ...
Breaking Medicine Technology:84% of Rosacea Sufferers Say NHS Treatments Were "Ineffective" New Survey Reveals 284% of Rosacea Sufferers Say NHS Treatments Were "Ineffective" New Survey Reveals 3Ardelyx to Host Inaugural R&D Investor Day in New York City on July 14, 2015 2CMC Biologics baut GMP-Produktionskapazität in den USA aus 2CMC Biologics baut GMP-Produktionskapazität in den USA aus 3
... Mass., Oct. 26, 2011 Idenix Pharmaceuticals, Inc. (NASDAQ: ... financial results for the third quarter of 2011 on Wednesday, ... Idenix management will host a conference call at 4:30 p.m. ... financial results for the third quarter of 2011 and provide ...
... MECHANICSBURG, Pa., Oct. 26, 2011 One out of three ... according to an Opinion Research/Select Medical telephone poll. Against that ... a statement today reminding the American public that influenza season ... chronic lung disease such as asthma or COPD (Chronic Obstructive ...
Cached Medicine Technology:Idenix to Host Conference Call Discussing Third Quarter and Nine Month 2011 Financial Results and Announces Presentations at the American Association for the Study of Liver Diseases Meeting (AASLD) 2Poll: One Out of Three U.S. Adults Not Planning to Get Flu Shot This Year 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: