Navigation Links
Scientists discover the mechanisms and function of a type of mysterious immune cell
Date:9/2/2010

ere migrate to epithelial tissues.

Unlike the αβ ("alpha beta") T cells of the immune system (that are launched on a search-and-destroy mission when the skin suffers a cut or other damage), most γδ T cells do not circulate through the bloodstream. Instead, they are a major T cell component of the skin, lung, and intestine, where they take up residence and monitor the neighboring epithelial cells for damage and disease.

But do γδ T cells play other, perhaps more important biological roles in the body? This question was the focus of a Havran-led study eight years ago, which found that when skin is cut or damaged wound healing occurs faster with help from γδ T cells.

Following this study, Havran headed up two successful projects to discover exactly how the γδ T cells speed wound healing. Her team postulatedand showedthat the keratinocytes, the major type of epithelial cell in the epidermis, sense damage to the skin and then express an antigen (i.e. a molecule recognized by the immune system). This antigen is recognized by the γδ T cells, which then become activated and undergo a morphological change to become little round factories. These begin mass-producing a growth factor that binds to keratinocytes and other epithelial cells, helping them proliferate and leading to the closure of the wound. The γδ T cells also multiply to increase the wound-healing response.

Getting Down to the Basics of γδ T Cells

In the new studies, the Havran and Wilson labs combined their expertise to answer the question: Which molecules are important for the activation of γδ T cells?

Wilson came to the current study after more than 20 years of work on the structure and function of αβ T cells. In 1996, his research team was the first to solve the structure of the αβ T cell receptor.

"To become activated in your body, T
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2015)... As one of only 30 Illinois ... and Health Achievement and Recognition Program (SHARP) certification, ... by the Illinois Department of Labor to host this ... SHARP certification by the Occupational Safety and Health Administration’s ... continued to meet or exceed all of the necessary ...
(Date:5/2/2015)... NY (PRWEB) May 02, 2015 It’s ... a deadly natural disaster strikes anywhere on this planet, ... leverage human sympathy and compassion for their own personal ... States Computer Emergency Readiness Team) issued an alert ... “of potential email scams citing the earthquake in Nepal. ...
(Date:5/2/2015)... TX (PRWEB) May 02, 2015 ... skin laxity issues of the face, neck and ... new concept with real potential for the success ... by the ThermiHealth Clinical Advisory Council, ThermiGyn’s Women’s ... FACOG, FACS, ACGE, concluded that ThermiGyn’s temperature controlled ...
(Date:5/1/2015)... 2015 Pioneer Millworks, the largest reclaimed ... in their reclaimed wood products at the 27th annual ... Center in NYC this May. Their newest offerings, Vat ... anticipated texture and color to North America's platform for ... texture and color in the design world and we're ...
(Date:5/1/2015)... May 01, 2015 It’s raining bills on ... introducing proposals to expand federal support for telemedicine. ... ATA has been working with Congress,” said Jonathan Linkous, CEO ... how the nation is poised to embrace the use of ... more step in fulfilling ATA’s mission to improve quality, access, ...
Breaking Medicine News(10 mins):Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 2Health News:Essentra Specialty Tapes is Selected to Host Gov. Rauner and the Workers' Memorial Day Celebration 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 2Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 3Health News:Cyber Aftershocks from Nepal’s Earthquake Can Cripple Businesses Right Here at Home 4Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 2Health News:Study Demonstrates Efficacy of Temperature Controlled Radiofrequency for Vulvovaginal Laxity 3Health News:Intensely Textured Reclaimed Wood to be Unveiled at ICFF in NYC by Pioneer Millworks 2Health News:Intensely Textured Reclaimed Wood to be Unveiled at ICFF in NYC by Pioneer Millworks 3Health News:ATA: Congress Floods the Halls with Telemedicine Proposals 2
... 27 (HealthDay News) -- Disabled adults are at higher ... aren,t disabled, new research finds. Those with mental ... having experienced physical, sexual or "intimate partner" violence during ... Feb. 27 in The Lancet . For ...
... warranted for older men with prostate cancer and a short ... Feb. 27 Archives of Internal Medicine. ... said senior author on the study Cary Gross, M.D., associate ... men who are older and have less aggressive forms of ...
... HealthDay Reporter , MONDAY, Feb. 27 (HealthDay News) -- ... want to look out. That,s the message of a new ... are more likely to cut off pedestrians and ignore stop-sign ... habits, either. Other lab-based experiments done by the researchers found ...
... 27 (HealthDay News) -- A potentially dangerous heart rhythm problem ... physical decline in older people at risk for heart disease, ... in the Canadian Medical Association Journal , researchers analyzed ... 40 countries, aged 55 and older. All of the participants ...
... at Harbor-UCLA Medical Center (LA BioMed) recently announced that ... of the Center for Reproduction and Infertility at Women ... Center, as one of its three "Legends" this May. ... recognized contributions to medicine through research and innovative clinical ...
... that patients with chronic myeloid leukemia (CML) who have ... they switch to the targeted drug imatinib. Published early ... the American Cancer Society, the study indicates that imatinib ... Imatinib, a drug that blocks the protein made by ...
Cached Medicine News:Health News:Disabled Adults More Apt to Be Victims of Violence: Study 2Health News:Prostate cancer treatment overused in some older patients 2Health News:Are the Rich Really Different From You and Me? 2Health News:Are the Rich Really Different From You and Me? 3Health News:Irregular Heartbeat May Predict Mental Decline in Some 2Health News:Physician to be honored as 'Legend' 2Health News:Physician to be honored as 'Legend' 3
(Date:5/1/2015)... Corporation (NASDAQ: THOR ), a world leader in mechanical ... announced today that Marta Antonucci has joined Thoratec ... This new Europe -based position is responsible ... America , including Europe , ... , and reports directly to the Chief Executive Officer. Following the ...
(Date:5/1/2015)... 1, 2015  CytRx Corporation (CYTR), a biopharmaceutical ... reported financial results for the three months ended ... recent accomplishments and upcoming milestones for its clinical ... in the early months of 2015, including the ... of aldoxorubicin in patients with soft tissue sarcoma, ...
(Date:5/1/2015)... The Institute for Healthcare Advancement (IHA) is ... The IHA Health Literacy Awards aim to encourage, recognize ... practice of educating or empowering organizations to deliver clear ... three categories: innovative programs, published materials and research. This ... In the area of innovative programs, the ...
Breaking Medicine Technology:Thoratec Announces Addition To Senior Management Team 2Thoratec Announces Addition To Senior Management Team 3CytRx Reports First Quarter 2015 Financial Results 2CytRx Reports First Quarter 2015 Financial Results 3CytRx Reports First Quarter 2015 Financial Results 4CytRx Reports First Quarter 2015 Financial Results 5CytRx Reports First Quarter 2015 Financial Results 6CytRx Reports First Quarter 2015 Financial Results 7CytRx Reports First Quarter 2015 Financial Results 8CytRx Reports First Quarter 2015 Financial Results 9CytRx Reports First Quarter 2015 Financial Results 10CytRx Reports First Quarter 2015 Financial Results 11Institute for Healthcare Advancement Announces 2015 Award Winners 2
... SYDNEY, May 23, 2011 Starpharma Holdings Limited (ASX: ... major phase 2 clinical study that demonstrated efficacy of ... Key Points: VivaGel(R) ... BV VivaGel(R) expected to avoid many shortcomings of ...
... Advanced Life Sciences Holdings, Inc. ... its Annual Meeting of Shareholders, which was previously scheduled ... (Logo:   http://photos.prnewswire.com/prnh/20080218/ALSLOGO ) ... Sciences is a biopharmaceutical company engaged in the discovery, ...
Cached Medicine Technology:VivaGel(R) Demonstrates Efficacy in Bacterial Vaginosis 2VivaGel(R) Demonstrates Efficacy in Bacterial Vaginosis 3VivaGel(R) Demonstrates Efficacy in Bacterial Vaginosis 4VivaGel(R) Demonstrates Efficacy in Bacterial Vaginosis 5
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: