Navigation Links
Scientists discover the mechanisms and function of a type of mysterious immune cell
Date:9/2/2010

LA JOLLA, CA August 31, 2010 In two closely related studies, two teams of Scripps Research Institute scientists have discovered the underlying mechanisms that activate a type of immune cell in the skin and other organs. The findings may lead to the development of new therapies to treat inflammation, wounds, asthma, and malignant tumors.

The results of the two companion studies were published in the September 3, 2010 issue of the prestigious journal Science. Together, the new research sheds light on γδ (pronounced "gamma delta") T cells, an immune cell found within epithelial tissuesthe thin layer of cells that makes up the outermost layer of skin and organs like the intestines and lungs.

"These cells play unique and critical roles in recognition of damage or disease in epithelial tissues," said Scripps Research Professor Wendy Havran, who headed up one of the projects. "Our study identified a new costimulatory molecule for γδ T cells that directs the wound healing abilities of these cells."

The other team, led by Scripps Research Professor Ian Wilson, focused on the underlying mechanisms of γδ T cell costimulation, which until now have remained elusive.

"Our focus was to uncover the molecular details in the cell-signaling process of γδ T cells," said Wilson. "Using x-ray crystallography, we were able to get a three-dimensional view of a costimulatory receptor-ligand pair for γδ T cells. Our two studies, together, move the basic science and understanding of γδ T cells to a new level."

Coaxing Secrets from γδ T cells Before several recent studies of γδ T cells by scientists at Scripps Research and elsewhere, little had been learned about the activation mechanisms of γδ T cells in the nearly three decades since their discovery. Scientists found that these cells arise early in fetal development in the thymus, and from th
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... ... 28, 2015 , ... The Kentucky State Department of Workforce Investment Commissioner Beth ... are applying for, they are unable to pass the initial drug test and therefore ... policies in order to be able to hire long-term, skilled talent. (1) Will Wesch, ...
(Date:8/28/2015)... ... ... With the goal of furthering music education programs in schools, the “Music With ... in Mendon, IL on May 30th, 2015. Backed once again by Best Drug Rehabilitation, ... school districts of Mendon and its neighboring town of Quincy, IL. Best Drug Rehabilitation’s ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... FDA’s Position and Best Practices for Compliance, **Presented by FDAnews and GessNet**, ... chaired by internationally renowned expert Fubin Wu, has been specifically designed to ...
(Date:8/28/2015)... ... 28, 2015 , ... The 6th Annual Survivor in the City, Chicago ... yet another accolade to its cadre of widespread support—an official letter of support and ... of the medical community and the University of Illinois at Chicago’s Department of Neurosurgery, ...
(Date:8/28/2015)... ... 28, 2015 , ... Loved ones of a person suffering ... chemical dependency, may be able to find some hope in the latest video ... for addiction located in Western Michigan. Focusing on several different aspects of the ...
Breaking Medicine News(10 mins):Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:Best Drug Rehabilitation Interviews Country-Rock Duo Highway Run at the 2015 "Music With A Mission" Benefit Concert 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 2Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 3Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 4Health News:FDAnews Announces — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, Oct. 14-15 5Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 2Health News:Chicago Mayor Pens Official Support of Annual Survivor in the City Event Benefitting Brain Aneurysm Foundation 3Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 2Health News:Best Drug Rehabilitation Releases New Video Outlining Patients' Personal Recovery Stories 3
... be detected by his or her eye movement, and a ... Chris Harris, from the University of Plymouth, uses a computer- ... see how "flicks" of the eye are affected by various ... ,The scientist said: 'The way we control our eye ...
... alcohol, causes the fundamental ills of society. If we're looking ... for drugs, we should test them for stupidity, ignorance, greed ... ,Methamphetamine, a known stimulant, commonly used by college students, ... for use as a nasal decongestant, it has been very ...
... by the National Institute for Health and Clinical Excellence (NICE) ... identification, treatment and management of obsessive-compulsive disorder (OCD) and body ... ... starts in childhood or adolescence, and is characterized by the ...
... Young girls who get extra calcium from food tend to ... tablet supplements, a Finnish research team reports.// ,The team ... peak bone mass during the rapid-growth period of puberty in ... thus prevent osteoporosis in adulthood. , ,The study, published ...
... revealed that longer duration of breast-feeding is associated with ... in the mother.// Previous studies have already provided evidence ... mothers when compared to their counterparts. ,The study ... establish a relationship between lactation and Type 2 diabetes. ...
... might help increase the life span of people who are ... fourth leading cause of death from cancer //and is one ... results from the cancer vaccine trial show that it improved ... one year after diagnosis to 88 percent." It was also ...
Cached Medicine News:Health News:Dominant Discoveries and The Darker Side Of Methamphetamine Drug Addiction 2Health News:Calcium From Food Better Than From Supplements 2Health News:Breastfeeding To Reduce Risk Of Type 2 Diabetes 2
(Date:8/28/2015)... SAN FRANCISCO, Calif. , Aug. 28, 2015 /PRNewswire/ ... for the treatment of cancer, today announced the filing ... U.S. Securities and Exchange Commission (SEC) relating to a ... number of shares to be offered and the price ... CytomX intends to list its common stock under the ...
(Date:8/28/2015)... 2015 Research and Markets ... "Investigation Report on China,s Bevacizumab Market ,2010-2019" ... under the trade name of Avastin, bevacizumab injection is ... 2010, it was approved by CFDA to treat metastatic ... China all come from Roche and its ...
(Date:8/28/2015)... Utah , Aug. 28, 2015  Today, in ... Prevention,s (CDC) Contact Lens Health Week, 1-800 Contacts is ... has found that contact lens wearers who do not ... greatest risk for eye infections. Most ... their lenses, but a clean lens case is sometimes ...
Breaking Medicine Technology:CytomX Files Registration Statement for Proposed Initial Public Offering 2Investigation Report on China's Bevacizumab Market 2015-2019 21-800 Contacts Shares Tips on How to Clean Lens Cases 2
... YORK, March 26 Crystal Research Associates, LLC,announced ... Overview(R),(EIO(R)) on Bioniche Life Sciences Inc. (TSX: BNC). ... http://www.crystalra.com ., Bioniche is a Canadian biopharmaceutical ... life in both humans and animals worldwide through,innovative ...
... RGEN ) announced today that the Company ... the use of RG1068, synthetic human secretin, to,improve ... resonance,imaging (MRI). This Phase 3 study is a ... patients will receive an,unenhanced MRI followed by a ...
Cached Medicine Technology:Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Bioniche Life Sciences Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Bioniche Life Sciences Inc. 3Repligen Initiates Phase 3 Clinical Trial of RG1068 for Pancreatic MRI Imaging 2Repligen Initiates Phase 3 Clinical Trial of RG1068 for Pancreatic MRI Imaging 3Repligen Initiates Phase 3 Clinical Trial of RG1068 for Pancreatic MRI Imaging 4
... Philadelphia™ Collar and Stabilizer Plastazote® ... reinforcements. Hook-and-pile closure straps. Chin ... mandibular pieces may be interchanged ... easily to the standard Philadelphia ...
Bougie Urethrotomes for slitting the female urethra and for meatus stenosis in males...
Optical Mini Urethrotome for telescope 3.3 mm, 0...
... flexible cystoscope is being used more and more ... its outstanding optical quality and large working/irrigation channel, ... and therapy. The outstanding flexibility of the cystoscope ... patient. Being ...
Medicine Products: