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Scientists discover protein that allows safe recycling of iron from old red blood cells
Date:2/5/2013

d three other students from his lab joined Hamza in the research, along with researchers from Harvard, NIH and Utah.

This study's findings are the third major piece that Hamza and his Maryland lab have added to the puzzle of understanding how humans and other organisms safely move heme around in the body. In addition to their two studies showing the role of the HRG1, that Hamza showed in a 2011 Cell paper that in C. elegans there is a different, but related, protein called HRG3 that transports heme from the mother worm's intestine to her developing embryos.

According to Hamza, the HRG3-mediated pathway that worms use for transporting heme to developing oocytes also appears to be an excellent target for stopping the reproduction of hookworms and other parasites that feed on host red blood cell hemoglobin. Together these three findings could lead to new methods for treating two age-old scourges - parasitic worm infections, which affect more than a quarter of the world's population, and problems of iron metabolism and iron deficiency. The latter is the world's number one nutritional disorder. With the help of UMD's Office of Technology Commercialization and the university's Maryland Technology Enterprise Institute, Hamza has started a company, Rakta Therapeutics, Inc. that focuses on developing anti-parasitic drugs that specifically target the parasite's variation of HRG1 and HRG3 transporters.

Heme, Humans and Bloodless worms

In living organisms -- ranging from humans to baker's yeast -- iron enclosed in a heme cage is a critical molecule for health because it binds to oxygen and other gases needed for survival. However, because heme is toxic, scientists long ago started searching for the existence of proteins that could safely transport heme between cells and throughout the body.

However, identifying such proteins has been a very difficult task because organisms generate heme in a complicated eight-step process
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Contact: Lee Tune
ltune@umd.edu
301-405-4679
University of Maryland
Source:Eurekalert

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