Navigation Links
Scientists discover new protein involved in lung cancer
Date:2/27/2014

Scientists from The University of Manchester part of the Manchester Cancer Research Centre (MCRC) - have discovered a new protein that is involved in cancer and inflammation in lung tissue.

The findings, published in the Journal of Biological Chemistry, could help in the development of new drugs to target lung cancer.

Lung cancer is the most common cause of cancer death in Greater Manchester, with around 930 men and 790 women dying from the disease every year in the area.

While there have been major advances in treatments and outcomes for some cancers over the past 60 years, lung cancer patients have enjoyed few of these improvements and new therapies have not made a difference to their survival.

The research by the Manchester team looked at glucocorticoids, the hormones that regulate inflammation and energy production in cells in the body. In lung cancer these hormones are known to play a role in controlling cell growth.

Glucocorticoids work through receptors, and this new research reveals how these receptors work. In particular, a newly discovered enzyme, known as Merm1, was discovered to be essential for glucocorticoids to work normally. Merm1 was found to be suppressed in lung inflammation, and in cancer.

Professor David Ray, Professor of Medicine and Endocrinology at The University of Manchester who led the research, said: "We know that resistance to glucocorticoids happens in various inflammatory diseases, as well as cancer, in lung tissue. We wanted to explore whether a protein, known as Merm1, was involved in this resistance and therefore involved in controlling the uncontrolled cell growth that is the hallmark of cancer."

The study showed Merm1 controls the binding between a glucocorticoid receptor and its target genes. This step is essential for the receptor to work, and to control cell growth, and division. More importantly, it revealed that inflammation, as seen in asthma or bronchitis, results in loss of Merm1.

Professor Ray said: "This work shows that targeting Merm1 could offer a new strategy in developing anti-inflammatory treatments.

Dr Toryn Poolman, from The University of Manchester and MCRC who also worked on the research, said: "The study has given us a new insight into the mechanisms at play in lung inflammation and lung cancer. We believe it could provide a new area to target drugs in lung cancer."


'/>"/>
Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related medicine news :

1. Scientists explore promising new option for first line of attack in lymphoma
2. Tel Aviv University scientists honored for proposals in melanoma research
3. Scientists call for screening mammography every 2 years for most women
4. NIH scientists find mechanism that helps HIV evade antibodies, stabilize key proteins
5. Scientists develop powerful new animal model for metastatic prostate cancer
6. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
7. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
8. NCCS scientists discover gene regulation is dependent on protein ANP32E
9. Scientists make your stomach turn bright green if you have an ulcer
10. Scientists reduce protein crystal damage, improve pharmaceutical development
11. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... was developed to enhance the health of felines. The formula is all-natural and is ... herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van ... Wellness at Work award to iHire in recognition of their exemplary accomplishments in worksite ... 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum ...
(Date:6/24/2016)... ... ... crisis. Her son James, eight, was out of control. Prone to extreme mood shifts and ... him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife on ... say he was going to kill them. If we were driving on the freeway, ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Any dentist who has made an implant supported denture ... of them do not even offer this as a viable ... costs involved. And those who ARE able to offer that ... cost that the majority of today,s patients would not be ... , founder of Dental Evolutions Inc. and inventor of Implanova ...
(Date:6/23/2016)...  In a startling report released today, National Safety Council ... a comprehensive, proven plan to eliminate prescription opioid overdoses. ... states are tackling the worst drug crisis in recorded U.S. history, ... Kentucky , New Mexico , ... the 28 failing states, three – Michigan , ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
Breaking Medicine Technology: