Navigation Links
Scientists discover new protein involved in lung cancer
Date:2/27/2014

Scientists from The University of Manchester part of the Manchester Cancer Research Centre (MCRC) - have discovered a new protein that is involved in cancer and inflammation in lung tissue.

The findings, published in the Journal of Biological Chemistry, could help in the development of new drugs to target lung cancer.

Lung cancer is the most common cause of cancer death in Greater Manchester, with around 930 men and 790 women dying from the disease every year in the area.

While there have been major advances in treatments and outcomes for some cancers over the past 60 years, lung cancer patients have enjoyed few of these improvements and new therapies have not made a difference to their survival.

The research by the Manchester team looked at glucocorticoids, the hormones that regulate inflammation and energy production in cells in the body. In lung cancer these hormones are known to play a role in controlling cell growth.

Glucocorticoids work through receptors, and this new research reveals how these receptors work. In particular, a newly discovered enzyme, known as Merm1, was discovered to be essential for glucocorticoids to work normally. Merm1 was found to be suppressed in lung inflammation, and in cancer.

Professor David Ray, Professor of Medicine and Endocrinology at The University of Manchester who led the research, said: "We know that resistance to glucocorticoids happens in various inflammatory diseases, as well as cancer, in lung tissue. We wanted to explore whether a protein, known as Merm1, was involved in this resistance and therefore involved in controlling the uncontrolled cell growth that is the hallmark of cancer."

The study showed Merm1 controls the binding between a glucocorticoid receptor and its target genes. This step is essential for the receptor to work, and to control cell growth, and division. More importantly, it revealed that inflammation, as seen in asthma or bronchitis, results in loss of Merm1.

Professor Ray said: "This work shows that targeting Merm1 could offer a new strategy in developing anti-inflammatory treatments.

Dr Toryn Poolman, from The University of Manchester and MCRC who also worked on the research, said: "The study has given us a new insight into the mechanisms at play in lung inflammation and lung cancer. We believe it could provide a new area to target drugs in lung cancer."


'/>"/>
Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related medicine news :

1. Scientists explore promising new option for first line of attack in lymphoma
2. Tel Aviv University scientists honored for proposals in melanoma research
3. Scientists call for screening mammography every 2 years for most women
4. NIH scientists find mechanism that helps HIV evade antibodies, stabilize key proteins
5. Scientists develop powerful new animal model for metastatic prostate cancer
6. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
7. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
8. NCCS scientists discover gene regulation is dependent on protein ANP32E
9. Scientists make your stomach turn bright green if you have an ulcer
10. Scientists reduce protein crystal damage, improve pharmaceutical development
11. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... 2017 , ... Permobil has just completed the acquisition of ... systems has a well-earned reputation for premium quality, with a focus on fit ... in the custom seating business, which enjoys strong demand, and it complements Permobil’s ...
(Date:1/16/2017)... (PRWEB) , ... January 16, 2017 , ... ... announce their recent partnership with an innovator in the wheelchair accessibility industry, ... motivate their dealer salespeople to sell wheelchair accessible vehicles. With this new incentive ...
(Date:1/16/2017)... ... January 16, 2017 , ... Date aired: January 9, 2017 ... Sharon Kleyne, America’s leading water educator, researcher and advocate welcomed health activist, author, ... Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health on ...
(Date:1/16/2017)... ... January 16, 2017 , ... In ... education and high-level training standards to an international multidisciplinary group of healthcare treatment ... As a way to further its mission at the grassroots level, iaedp launched ...
(Date:1/16/2017)... ... 16, 2017 , ... San Francisco dentist, Dr. Ben Amini , the ... device which is capable of taking digital impressions of teeth and gums. Conventional bite ... CAD CAM restorations , in terms of speed, efficiency and patient comfort. Increasingly, digital ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... --  The Harrington Discovery Institute at University ... has announced the 2017 recipients of Harrington Scholar-Innovator ... whose research shows promise to advance the standard ... – part of The Harrington Project for Discovery ... medicine: to advance early breakthroughs into the clinical ...
(Date:1/16/2017)... , January 16, 2017 According to the ... Controller, Multi Display , Smart Display, Graphic LCD Controller), Application (Industrial ... 2022", published by MarketsandMakets, the market is expected to grow from USD ... a CAGR of 9.68% between 2016 and 2022. ... ...
(Date:1/16/2017)... 16, 2017 The ... Type (Methyl, Ethyl, Hydroxyethyl, Hydroxypropyl, Carboxymethyl Cellulose), ... Surface Coatings & Paints), Region - Global ... market was valued at USD 4.51 Billion ... USD 6.41 Billion by 2021, at a ...
Breaking Medicine Technology: