Navigation Links
Scientists discover new protein involved in lung cancer
Date:2/27/2014

Scientists from The University of Manchester part of the Manchester Cancer Research Centre (MCRC) - have discovered a new protein that is involved in cancer and inflammation in lung tissue.

The findings, published in the Journal of Biological Chemistry, could help in the development of new drugs to target lung cancer.

Lung cancer is the most common cause of cancer death in Greater Manchester, with around 930 men and 790 women dying from the disease every year in the area.

While there have been major advances in treatments and outcomes for some cancers over the past 60 years, lung cancer patients have enjoyed few of these improvements and new therapies have not made a difference to their survival.

The research by the Manchester team looked at glucocorticoids, the hormones that regulate inflammation and energy production in cells in the body. In lung cancer these hormones are known to play a role in controlling cell growth.

Glucocorticoids work through receptors, and this new research reveals how these receptors work. In particular, a newly discovered enzyme, known as Merm1, was discovered to be essential for glucocorticoids to work normally. Merm1 was found to be suppressed in lung inflammation, and in cancer.

Professor David Ray, Professor of Medicine and Endocrinology at The University of Manchester who led the research, said: "We know that resistance to glucocorticoids happens in various inflammatory diseases, as well as cancer, in lung tissue. We wanted to explore whether a protein, known as Merm1, was involved in this resistance and therefore involved in controlling the uncontrolled cell growth that is the hallmark of cancer."

The study showed Merm1 controls the binding between a glucocorticoid receptor and its target genes. This step is essential for the receptor to work, and to control cell growth, and division. More importantly, it revealed that inflammation, as seen in asthma or bronchitis, results in loss of Merm1.

Professor Ray said: "This work shows that targeting Merm1 could offer a new strategy in developing anti-inflammatory treatments.

Dr Toryn Poolman, from The University of Manchester and MCRC who also worked on the research, said: "The study has given us a new insight into the mechanisms at play in lung inflammation and lung cancer. We believe it could provide a new area to target drugs in lung cancer."


'/>"/>
Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related medicine news :

1. Scientists explore promising new option for first line of attack in lymphoma
2. Tel Aviv University scientists honored for proposals in melanoma research
3. Scientists call for screening mammography every 2 years for most women
4. NIH scientists find mechanism that helps HIV evade antibodies, stabilize key proteins
5. Scientists develop powerful new animal model for metastatic prostate cancer
6. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
7. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
8. NCCS scientists discover gene regulation is dependent on protein ANP32E
9. Scientists make your stomach turn bright green if you have an ulcer
10. Scientists reduce protein crystal damage, improve pharmaceutical development
11. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... , ... May 04, 2016 , ... ... Dr. Todd Rider's research and development of DRACO broad-spectrum antiviral therapeutics. DRACOs have ... campaign that starts on May 3, 2016 at http://igg.me/at/EndTheVirus and runs ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... ... and Continence Nurses (WOCN) Society™ and Canadian Association for Enterostomal Therapy (CAET) ... promotion, time saving and planning tools to attendees and exhibitors for the 2016 ...
(Date:5/4/2016)... ... May 04, 2016 , ... May kicked off with ... across the United States. Dermatologist Dr. Ellen Turner is encouraging her patients, as well ... and focus on skin safety and health now and in the future. , The ...
(Date:5/4/2016)... ... May 04, 2016 , ... Recognizing that lifestyle medicine is essential ... Verywell, have tapped David Katz, MD, MPH, president of the American College of ... to lifestyle medicine is especially gratifying,” said Katz. “There is so much opportunity to ...
(Date:5/4/2016)... ... May 04, 2016 , ... ... and compact tactical (6.7 inch) dual-light flashlights in models NSP-9842XL and NSR-9844XL ... (average retail starting at $59.95) uses 2 included CR-123 batteries to produce up ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... BROOMALL, Pa. , May 3, 2016 ... Attorney Jack Whelan and Delaware County ... NARCAN® (naloxone HCI) Nasal Spray in all ACME ... the U.S. Centers for Disease Control and Prevention (CDC), naloxone has ... 2014, when police officers in Delaware County ...
(Date:5/3/2016)... (NYSE: DPLO) announced today that it is celebrating Hepatitis Awareness Month with a campaign to ... personal story and encourage those at risk to get tested and begin the road to ... ... ... (PRNewsFoto/Diplomat Pharmacy, Inc.) ...
(Date:5/3/2016)... , May 3, 2016 Intec ... a clinical-stage biopharmaceutical company, today announced the appointment of ... Regulatory Affairs. "Ms. Strauss-Levy has 15 years ... has established an outstanding track record, having supported the ... regulatory approval processes in the United States ...
Breaking Medicine Technology: