Navigation Links
Scientists discover new drug target for squamous cell carcinoma
Date:5/19/2011

SEATTLE Researchers at Fred Hutchinson Cancer Research Center have discovered a new drug target for squamous cell carcinoma the second most common form of skin cancer. Scientists in the laboratory of Valeri Vasioukhin, Ph.D., have found that a protein called alpha-catenin acts as a tumor suppressor and they also have unlocked the mechanism by which this protein controls cell proliferation.

The findings by Vasioukhin and colleagues will be published May 24 in Science Signaling.

For the study, the researchers studied mice that were bred to lack a copy of the gene that makes the protein alpha-catenin in hair follicle stem cells. The researchers found that these mice developed a type of skin cancer called squamous cell carcinoma.

"The fact that alpha-catenin-deficient mice developed skin cancer led us to conclude that the loss of this protein is an important event in cancer development, and that alpha-catenin functions as a tumor suppressor," said Vasioukhin, an associate member of the Hutchinson Center's Human Biology Division. "We also found that unlike normal cells, alpha-catenin-mutant cells cannot stop dividing when they become very crowded in the Petri dish this characteristic is one of the hallmarks of cancer cells."

The researchers also teased out the mechanisms by which the protein suppresses tumor growth. They found that alpha-catenin controls the activity of a protein called Yap1, which, if activated, can cause cancer.

"We found that alpha-catenin controls cell proliferation by regulating Yap1, which is active in cells missing alpha-catenin. Therefore, Yap1 is likely to be an excellent target for the treatment of patients with squamous cell carcinoma," Vasioukhin said.

More than 700,000 new cases of squamous cell carcinoma are diagnosed each year. This form of skin cancer arises in the cells that make up most of the skin's upper layers (epidermis). Squamous cell malignancies may arise in many areas of the body including
'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Queens scientists teaming up to cure premature baby blindness
2. Scientists design new anti-flu virus proteins using computational methods
3. Scientists use genetically altered virus to get tumors to tattle on themselves
4. Scientists Find MRSA Germ in Supermarket Meats
5. Weizmann Institute scientists show: How adversity dulls our perceptions
6. McMaster scientists find protein’s bad guy role in prostate cancer
7. UCLA scientists discover way to amp up power of killer T cells
8. Yale and Rush University scientists receive Sanberg Awards from ASNTR
9. Scripps Research scientists show how shifts in temperature prime immune response
10. CIRM awards Scripps Research Institute scientists $3.5 million
11. Scientists afflict computers with schizophrenia to better understand the human brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... July 22, 2014 The European Bio ... market in Europe with analysis and forecast of revenue. ... grow from around $528.5 million in 2013 to $940.6 ... 2013 to 2018. , Browse through the TOC of ... idea of the in-depth analysis provided. , http://www.micromarketmonitor.com/market/europe-bio-stimulants-1315565884.html ...
(Date:7/22/2014)... Colorado Springs, CO (PRWEB) July 22, 2014 ... (ASTI), the leader in professional data archiving solutions, ... Cloud-Integrated Storage (CiS) data archiving solution. The ... cloud supporting the company’s focus on compliant data ... enforcement, and more. , The introduction of ...
(Date:7/22/2014)... the University of Murcia have studied the changes ... a personality trait that causes difficulties in inhibiting ... and leads to unplanned actions without considering the ... indicator for predicting the risk of behavioural problems. ... the University of Murcia analyses whether the connectivity ...
(Date:7/22/2014)... There’s an old adage that says ... new improvements and enhancements Global Eyeglasses has made, people ... lasting impressions while having what they need to sport ... , “We are offering new sports clip prescription sunglasses ... Sagar, CEO of Global Eyeglasses . , ...
(Date:7/22/2014)... York, NY (PRWEB) July 22, 2014 ... the Icahn School of Medicine at Mount Sinai have ... associated with the risk of developing schizophrenia, in the ... date, conducted with 80,000 people. The findings, published online ... may underlie schizophrenia, and could lead to new approaches ...
Breaking Medicine News(10 mins):Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 2Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 3Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 4Health News:Europe Bio Stimulants Market is Expected to Reach $940.6 Million in 2018 - New Report by MicroMarket Monitor 5Health News:Data Archiving Leader Alliance Storage Technologies Releases Enterprise Class Cloud-Integrated Storage Solution 2Health News:Data Archiving Leader Alliance Storage Technologies Releases Enterprise Class Cloud-Integrated Storage Solution 3Health News:Data Archiving Leader Alliance Storage Technologies Releases Enterprise Class Cloud-Integrated Storage Solution 4Health News:Children's impulsive behaviour is related to their brain connectivity 2Health News:Global Eyeglasses Adds New Products and Enhances Services 2Health News:Mount Sinai Scientists and International Team Shed New Light on Schizophrenia in Largest Genomic Study Published to Date 2Health News:Mount Sinai Scientists and International Team Shed New Light on Schizophrenia in Largest Genomic Study Published to Date 3Health News:Mount Sinai Scientists and International Team Shed New Light on Schizophrenia in Largest Genomic Study Published to Date 4
... in Afghanistan are increasingly suffering from war–related anxiety and ... ,Ontario’s ombudsman Andre Marin had undertaken a recent ... center for treatment of such traumatized children was caught ... bodies unwilling to take financial responsibilities. ,Mr. ...
... All India Institute of Medical Sciences (AIIMS) Director P. ... a former patient alleging// that the state-run hospital had ... undergoing treatment at its cardiac and neuro center. ... to Venugopal, Mayank Sharma, former senior financial advisor, Arti ...
... scientists have undertaken what is described as the biggest DNA ... mark the biggest single leap in the understanding of how ... to a new wave of tailored therapies and tests to ... ,A coalition of 50 groups, including 24 leading ...
... human interference may destroy much of Sundarbans in India and ... a new UNESCOreport.// ,"Sea-level rise is the greatest ... Asia. A 45 cm rise in global sea levels would ... mangroves," the report warned. ,The report, "Case Studies ...
... may be at far higher risk for eating disorders ... first population-based study of its kind, the// researchers found ... eating disorders. ,Researchers Ilan H. ... the Mailman School of Public Health and principal investigator, ...
... remains the most beneficial proven intervention for ischemic stroke, ... Guidelines for the Early Management of Adults with Ischemic ... intra-arterial administration of clot-busting drugs and mechanical removal of ... guidelines focus on the crucial first hours from the ...
Cached Medicine News:Health News:Collateral Damage-Children Of Canadian Soldiers Suffer 2Health News:Court Issues Notice to Venugopal Over Fund Irregularities 2Health News:UK Scientists to Reveal Genetic Secrets Behind Serious Illnesses 2Health News:Climate Change Threatens Sundarbans and World Heritage Sites 2Health News:Climate Change Threatens Sundarbans and World Heritage Sites 3Health News:Eating Disorders Highly Prevalent Among Gay and Bisexual Men 2Health News:Intravenous Delivery of Clot-busting Drug Still Best Intervention for Ischemic Stroke 2
(Date:7/22/2014)... , July 22, 2014 The steady ... is spreading to previously rep-friendly specialties, according to ... and marketing consulting firm ZS Associates.      ... 200 U.S. pharmaceutical sales teams. The report examines ... meet with the pharmaceutical sales reps who visit ...
(Date:7/22/2014)... 22, 2014 BioDelivery Sciences International, Inc. (BDSI) ... of Directors has appointed Charles J. (Chuck) Bramlage ... members of the Board.  Mr. Bramlage ... in marketing, sales and other commercial functions.  He is ... a development stage company that was recently acquired by ...
(Date:7/22/2014)... 22, 2014  UL (Underwriters Laboratories), a global ... Food and Drug Administration (FDA) has recognized two ... medical devices incorporating lithium or nickel-based batteries. The ... Household and Commercial Batteries, and UL 1642 - ... Consensus standards are standards recognized by the FDA ...
Breaking Medicine Technology:Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 2Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 3Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 4Even traditionally rep-friendly specialists will see fewer pharmaceutical sales reps this year, according to ZS Associates 5BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 2BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 3BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 4BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 5BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 6BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 7Two UL Battery Safety Standards Are now FDA Recognized Consensus Standards for Medical Devices 2
The only daily cleaner specially formulated with isopropyl alcohol to help dissolve lipids and oil-based make-up from contact lenses....
Clerz Plus helps retain moisture to relieve dryness and removes protein buildup from your lenses while you wear them for longer wear comfort....
Lens Plus rewetting drops for soft contact lenses....
... Renu Multiplus preservative free lubricating ... moisturize your eyes while you're ... gentle preservative free formula is ... be sensitive to preservatives and ...
Medicine Products: