Navigation Links
Scientists discover new drug target for squamous cell carcinoma
Date:5/19/2011

SEATTLE Researchers at Fred Hutchinson Cancer Research Center have discovered a new drug target for squamous cell carcinoma the second most common form of skin cancer. Scientists in the laboratory of Valeri Vasioukhin, Ph.D., have found that a protein called alpha-catenin acts as a tumor suppressor and they also have unlocked the mechanism by which this protein controls cell proliferation.

The findings by Vasioukhin and colleagues will be published May 24 in Science Signaling.

For the study, the researchers studied mice that were bred to lack a copy of the gene that makes the protein alpha-catenin in hair follicle stem cells. The researchers found that these mice developed a type of skin cancer called squamous cell carcinoma.

"The fact that alpha-catenin-deficient mice developed skin cancer led us to conclude that the loss of this protein is an important event in cancer development, and that alpha-catenin functions as a tumor suppressor," said Vasioukhin, an associate member of the Hutchinson Center's Human Biology Division. "We also found that unlike normal cells, alpha-catenin-mutant cells cannot stop dividing when they become very crowded in the Petri dish this characteristic is one of the hallmarks of cancer cells."

The researchers also teased out the mechanisms by which the protein suppresses tumor growth. They found that alpha-catenin controls the activity of a protein called Yap1, which, if activated, can cause cancer.

"We found that alpha-catenin controls cell proliferation by regulating Yap1, which is active in cells missing alpha-catenin. Therefore, Yap1 is likely to be an excellent target for the treatment of patients with squamous cell carcinoma," Vasioukhin said.

More than 700,000 new cases of squamous cell carcinoma are diagnosed each year. This form of skin cancer arises in the cells that make up most of the skin's upper layers (epidermis). Squamous cell malignancies may arise in many areas of the body including the mucous membranes and genitals, but are most common in areas frequently exposed to the sun, such as the rim of the ear, lower lip, face, scalp, neck, hands, arms and legs.


'/>"/>

Contact: Kristen Woodward
kwoodwar@fhcrc.org
206-667-5095
Fred Hutchinson Cancer Research Center
Source:Eurekalert

Related medicine news :

1. Queens scientists teaming up to cure premature baby blindness
2. Scientists design new anti-flu virus proteins using computational methods
3. Scientists use genetically altered virus to get tumors to tattle on themselves
4. Scientists Find MRSA Germ in Supermarket Meats
5. Weizmann Institute scientists show: How adversity dulls our perceptions
6. McMaster scientists find protein’s bad guy role in prostate cancer
7. UCLA scientists discover way to amp up power of killer T cells
8. Yale and Rush University scientists receive Sanberg Awards from ASNTR
9. Scripps Research scientists show how shifts in temperature prime immune response
10. CIRM awards Scripps Research Institute scientists $3.5 million
11. Scientists afflict computers with schizophrenia to better understand the human brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... "ProRandom is a set of camera tools that allow video ... in Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... of text with video footage. ProRandom works by using a virtual camera to create ...
(Date:1/23/2017)... ... January 23, 2017 , ... ... Society of Anesthesiologists® (ASA®), the Foundation for Anesthesia Education and Research (FAER), ... (AAOS) and the Cigna Foundation, encourages proposals supporting high quality research using ...
(Date:1/23/2017)... ... ... a story of love and redemption, hope and uncertainty as a girl makes her way ... at the Mill” is the creation of published author, Lois Kulp, who was born in ... County on Crow Hill. The inn, the mill and "Post Yokel" are within ...
(Date:1/23/2017)... , ... January 23, 2017 ... ... (SNP) has launched online education programs and resources at seafoodnutrition.org/programs and seafoodnutrition.org/resources ... benefits of a seafood-rich diet. These resources have been developed for use ...
(Date:1/23/2017)... ... ... “Some Infallible Characteristics of Christ”: a fascinating and entrancing novel exploring the gifts ... published author, Rev. Dr. Robert W. Thomas, the third of seven siblings. He was ... a pastor for over fifteen years. He is a graduate of N.C. College of ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... According to a new market research report ... Compliance, SCM), Component (Software, Service), Delivery (On premise, Cloud), End user ... MarketsandMarkets, the market is expected to reach USD 24.73 Billion by ... 13.3% during the forecast period. Continue ... ...
(Date:1/21/2017)... Jan. 20, 2017  Today, during a ... "PI3K Pathways in Immunology, Growth Disorders and ... INFI ) presented preclinical data ... that selectively inhibits phosphoinositide-3-kinase-gamma (PI3K-gamma). Preclinical data ... overcome resistance to checkpoint inhibition by remodeling ...
(Date:1/21/2017)... , Jan. 20, 2017  Faruqi & Faruqi, LLP, ... Inc. ("KemPharm" or the "Company") (NASDAQ: KMPH ) ... Company and certain officers and directors and underwriters of the ... seek the role of lead plaintiff. The lawsuit ... District Court for Johnson County on ...
Breaking Medicine Technology: