Navigation Links
Scientists discover marker to identify, attack breast cancer stem cells
Date:5/16/2012

HOUSTON Breast cancer stem cells wear a cell surface protein that is part nametag and part bull's eye, identifying them as potent tumor-generating cells and flagging their vulnerability to a drug, researchers at The University of Texas MD Anderson Cancer Center report online in Journal of Clinical Investigation.

"We've discovered the first single marker for breast cancer stem cells and also found that it's targetable with a small molecule drug that inhibits an enzyme crucial to its synthesis," said co-senior author Michael Andreeff, M.D., Ph.D., professor in MD Anderson's Departments of Leukemia and Stem Cell Transplantation and Cellular Therapy.

Andreeff and colleagues are refining the drug as a potential targeted therapy for breast cancer stem cells, which are thought to be crucial to therapy resistance, disease progression and spread to other organs.

"It's been difficult to identify cancer stem cells in solid tumors," Andreeff said. "And nobody has managed to target these cells very well."

The marker is the cell surface protein ganglioside GD2. The drug is triptolide, an experimental drug that Andreeff has used in preclinical leukemia research. The team found triptolide blocks expression of GD3 synthase, which is essential to GD2production.

Triptolide stymied cancer growth in cell line experiments and resulted in smaller tumors and prolonged survival in mouse experiments. Drug development for human trials probably will take several years.

Cancer stem cells are similar to normal stem cells

Research in several types of cancer has shown cancer stem cells are a small subpopulation of cancer cells that are capable of long-term self-renewal and generation of new tumors. More recent research shows they resist treatment and promote metastasis.

Cancer stem cells are similar to normal stem cells that renew specialized tissues. The breast cancer findings grew out of Andreeff's long-
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... occurrence of allergic diseases has risen dramatically in Western ... less exposed to microorganisms and have fewer infections than ... , A study by researchers at Sahlgrenska Academy, University ... to examine maturation of the immune system in relation ... rural areas of the Vstra Gtaland Region, half of ...
(Date:7/8/2014)... UCLA Program in Memory Restoration has been awarded up ... Agency (DARPA) for a four -year project aiming to ... team of experts in neurosurgery, engineering, neurobiology, psychology and ... a memory prosthesis in the brain. , Memory is ... the brain encode information, store it and retrieve it. ...
(Date:7/8/2014)... hygiene rates were found to be three times higher ... there were no auditors present, according to a study ... The study, titled, "Quantification of the Hawthorne effect in ... a retrospective cohort study," published today on-line in the ... author Dr. Jocelyn Srigley, who did the study as ...
(Date:7/8/2014)... have increased risks of dying at a young age ... stroke, diabetes, and kidney and liver diseases, according to ... large studies of people from three countries. The study, ... part of the National Institutes of Health, found that ... dramatic reduction in life expectancy compared with people of ...
(Date:7/8/2014)... LOUIS Military physicians will soon pick up joysticks instead ... children with serious health threats. , James Gerard, M.D., a ... $541,807 grant from the Department of Defense Office of ... develop a video game that will train physicians on pediatric ... to use one of the most popular tools gaming ...
Breaking Medicine News(10 mins):Health News:DARPA awards UCLA $15 million to restore lost memory 2Health News:DARPA awards UCLA $15 million to restore lost memory 3Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 2Health News:Health-care worker hand hygiene rates increase three-fold when auditors visible 3Health News:NCI study finds extreme obesity may shorten life expectancy up to 14 years 2Health News:Save, don't kill: SLU pediatrician to develop educational video game for training military physician 2
... MONDAY, Dec. 19 (HealthDay News) -- When it comes to toys, ... for parents, who find themselves asking two crucial questions. The ... safe for my child? And the second, though not as ... media aimed at spurring a child,s development: Which of these toys ...
... EDITOR,S PICK: Potential concern about drugs in clinical trial ... derived naturally in the body from a major component ... [EETs]) are currently in clinical trials for the treatment ... researchers led by Dipak Panigrahy and Mark Kieran, ...
... COLUMBUS, Ohio -- Drinking enough alcohol to become intoxicated increases ... according to new research. But people without that trait ... when they,re sober. That trait is the ability to ... focus on the here and now, without thinking about the ...
... 19 (HealthDay News) -- Knee pain is common in middle-aged and ... of data collected from nearly 500 women, ages 44 to 57, ... older reported persistent, incident or intermittent knee pain. Forty-four percent ... percent said they had knee pain on most days of the ...
... Known for her poetry, letters, love affair and marriage ... legacy of unanswered questions about her lifelong chronic illness. ... her daughter, may have unraveled the mystery. Born in ... weakness, heart palpitations, intense response to heat and cold, ...
... better quality of life (QOL) and diminished cardiovascular disease ... adenotonsillectomy, according to new research published in the December ... Surgery . SDB is an increasingly common ... apnea syndrome (OSAS). Cardiovascular (CV) disease frequently has been ...
Cached Medicine News:Health News:Discerning Gift-Givers Look for Toys That Offer More Than Fun 2Health News:Discerning Gift-Givers Look for Toys That Offer More Than Fun 3Health News:Discerning Gift-Givers Look for Toys That Offer More Than Fun 4Health News:JCI online early table of contents: Dec. 19, 2011 2Health News:JCI online early table of contents: Dec. 19, 2011 3Health News:JCI online early table of contents: Dec. 19, 2011 4Health News:JCI online early table of contents: Dec. 19, 2011 5Health News:JCI online early table of contents: Dec. 19, 2011 6Health News:JCI online early table of contents: Dec. 19, 2011 7Health News:1 trait has huge impact on whether alcohol makes you aggressive 2Health News:1 trait has huge impact on whether alcohol makes you aggressive 3Health News:Knee Pain Plagues Many Women Over 50 2Health News:Elizabeth Barrett Browning's illness deciphered after 150 years 2Health News:Elizabeth Barrett Browning's illness deciphered after 150 years 3Health News:Effect of adenotonsillectomy in children with sleep-disordered breathing 2
(Date:1/14/2014)... 14, 2014 InformEx, North America,s ... chemistry, will hold the 30 th edition of its ... Convention Center from January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ... pharmaceutical, fine chemical and specialty chemical companies will take part ...
(Date:1/14/2014)... , Jan. 14, 2014 Animal Emergency Critical Care, a ... Leesburg, Virginia is the first in ... chamber. Dr. Susan M. Barnes , Medical ... Barnes and husband, Dr. Cole Taylor , are avid scuba ...
(Date:1/14/2014)... , January 14, 2014 ... Transfer Devices (CSTD) for hazardous drugs, today announced that it ... fourth straight year.   Equashield,s closed ... technicians, pharmacists, nurses and other medical professionals who ...
Breaking Medicine Technology:Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Equashield's Sales Grow by 60% in 2013 2
... 9 BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX ) today ... the Company,s Board of Directors. Dr. Sanders brings to ... and professor of medicine. , "We are pleased ... Zola P. Horovitz, Ph.D., Chairman of the Board of BioCryst ...
... , LONDON, Dec. 9 ... $1 billion in the European Union (EU), which includes total ... anticholinergics used for disease symptom relief. With the introduction of ... guidelines that call for using dopamine agonists as first-line therapy, ...
Cached Medicine Technology:BioCryst Pharmaceuticals Elects Charles A. Sanders to its Board of Directors 2BioCryst Pharmaceuticals Elects Charles A. Sanders to its Board of Directors 3BioCryst Pharmaceuticals Elects Charles A. Sanders to its Board of Directors 4Drug Candidates in Pipeline Offer Potential for Parkinson's Disease Therapeutics Market, Says Frost & Sullivan 2Drug Candidates in Pipeline Offer Potential for Parkinson's Disease Therapeutics Market, Says Frost & Sullivan 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: