Navigation Links
Scientists discover key factor in controlling the breakdown of bone
Date:2/8/2009

. Ishii became interested in understanding what signals control immature osteoclast recruitment. He knew that cells can migrate to specific sites in the body in response to chemical mediators in the blood known as chemokines or chemoattractants. These molecules act like homing signals, telling cells that have certain receptors to move toward or away from certain tissues in the body.

Previously, Dr. Ishii had discovered that the chemoattractant sphingosine-1-phosphate (S1P), which is associated with the trafficking of immune cells into and out of the lymph nodes, also caused immature osteoclasts to mobilize.

"Because immature osteoclasts come from the same parent stem cell that gives rise to specific white blood cells already shown to respond to S1P," comments Dr. Ishii, "it seemed plausible that S1P could play a role in osteoclast migration."

Once at NIAID, Dr. Ishii worked with Dr. Germain's group to determine if S1P controlled immature osteoclast migration in live mice. Using a unique imaging technique, the researchers could see immature osteoclasts migrating away from the bones of the mice in response to S1P in the blood.

To confirm that S1P plays a direct role in bone metabolism, the research team compared the bone density in mice having the S1P receptor on their cells' surfaces with that of mice lacking the S1P receptor. They found that mice with functional S1P receptors had denser bones than mice lacking functional S1P receptors.

The researchers also tested a mouse model of postmenopausal osteoporosis to see if adding a synthetic S1P activator, known as FTY720, could help preserve bone. Postmenopausal mice given FTY720 had fewer immature osteoclasts on their bones and greater bone density when compared with untreated postmenopausal mice.

According to Dr. Ishii, these findings, combined with previous data, indicate that it may be possible to use combined therapies that target immature osteoclast migr
'/>"/>

Contact: Julie Wu
wujuli@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Team led by Scripps Scientists increases understanding of two types of blindness
2. CSHL scientists discover link between control of chromosome duplication and segregation
3. UCSB scientists make headway in understanding Alzheimers disease
4. Spanish scientists confirm extra virgin olive oil helps to combat breast cancer
5. UCLA scientists develop crystal ball for personalized cancer treatment
6. Weizmann Institute scientists create working artificial nerve networks
7. Scientists unmask genetic markers associated with psoriasis
8. Scientists and Investigators Cite Need for Radon Regulation to Prevent Lung Cancer- Call Current EPA Efforts Ineffective
9. Slices of living brain tissue are helping scientists identify new stroke therapies
10. Federal Members of Advisory Committee Block Vaccine-Autism Research, Defy Wishes of Its Own Scientists, Autism Community, and Congress
11. Canada-US scientists discover gene responsible for brains aging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... The report, “Heat Transfer Fluids Market by Type ... & Others), by Application (Oil & Gas, Chemical, CSP, ... & Forecasts to 2019” defines and segments the global ... of the global consumption in terms of volume and ... spread through 199 page sand in-depth TOC on"Heat Transfer ...
(Date:7/29/2014)... New York (PRWEB) July 29, 2014 ... mount in U.S. courts, Bernstein Liebhard LLP notes that ... medications in men with Type 2 diabetes. The research, ... Endocrinology & Metabolism on June 30th, involved 88 men ... had mild to moderate aging male symptoms and erectile ...
(Date:7/29/2014)... negotiations may depend on more than diplomacy. When it comes ... according to a new study. Researchers found ... for themselves than men with narrower faces. However, having ... require collaboration and compromise, the researchers found. "We negotiate ... not just the big things, like a car or a ...
(Date:7/29/2014)... Society of America (GSA) and the National Center ... PhD, of Columbia University as the 2014 recipient of ... Aging. , This award recognizes and honors the seminal ... field of creativity and aging shifted the conceptual focus ... potential. Cohen inspired individuals to approach longevity asking what ...
(Date:7/29/2014)... in boys with fragile X syndrome tend to ... study of the inherited disorder to date has ... everyday social and practical skills, including communication, socialization, ... getting dressed. In this study, socialization emerged as ... in that it did not decline as much ...
Breaking Medicine News(10 mins):Health News:Heat Transfer Fluids Market Expected to Grow 641,218.19 Tons by 2019 – New Report by MarketsandMarkets 2Health News:Heat Transfer Fluids Market Expected to Grow 641,218.19 Tons by 2019 – New Report by MarketsandMarkets 3Health News:Heat Transfer Fluids Market Expected to Grow 641,218.19 Tons by 2019 – New Report by MarketsandMarkets 4Health News:As Testosterone Lawsuits Mount, Bernstein Liebhard LLP Notes New Study Questioning Effectiveness of Low Testosterone Therapy in Diabetics 2Health News:As Testosterone Lawsuits Mount, Bernstein Liebhard LLP Notes New Study Questioning Effectiveness of Low Testosterone Therapy in Diabetics 3Health News:As Testosterone Lawsuits Mount, Bernstein Liebhard LLP Notes New Study Questioning Effectiveness of Low Testosterone Therapy in Diabetics 4Health News:Wider Face May Give You an Edge in Negotiations 2Health News:Charon to receive 2014 Gene D. Cohen Award 2Health News:Socialization relative strength in fragile X longitudinal study 2
... , THURSDAY, Jan. 27 (HealthDay News) -- Most ... at home, and quickly learn which types of brand-name fast ... In one experiment, the mothers of 67 children, aged 3 ... and listed foods high in sugar, fat and salt. The ...
... , THURSDAY, Jan. 27 (HealthDay News) -- Modern ... research suggests. An ancient human toolkit with hand axes, ... east Africa -- but not the Middle East -- was ... that the toolkit dates back 100,000 to 125,000 years, researchers ...
... Washington, DC, January 27, 2011 Screening patients in ... (MRSA) produces cost savings for the whole hospital, according ... published in the February issue of the American ... APIC - the Association for Professionals in Infection Control ...
... , THURSDAY, Jan. 27 (HealthDay News) -- Work-related ... has found. Israeli researchers gave hearing tests to 298 ... harmful noise and found that 99 of the workers had ... hearing problems tended to be older and to have been ...
... BEER SHEVA, ISRAEL January 27, 2011 -- A ... researchers indicates that physicians who give second opinions may ... factors. In the study, the researchers presented ... a national sample of orthopedic surgeons and neurologists. Some ...
... (RA) patients who failed to respond to methotrexate were ... an oral spleen tyrosine kinase (Syk) inhibitor that is ... and cartilage destruction. In the current study, RA patients ... In contrast to the prior study, however, fostamatinib was ...
Cached Medicine News:Health News:Kids Fed Unhealthy Foods Learn to Prefer Them 2Health News:Ancient Toolkit Holds Clues to Migration of Early Man 2Health News:Study finds MRSA screening saves hospitals money 2Health News:Ben-Gurion U. researchers determine that a first medical opinion can influence the second 2Health News:Fostamatinib proven to be safe but not effective 2
(Date:7/29/2014)... and TORONTO ... Acquisitions Corporation (OTCBB: ESAQ), an emerging pharmaceutical ... development of improved novel formulations and alternative ... announces expansion of its pharmaceutical development implementing ... direction includes large molecule drugs that will address ...
(Date:7/29/2014)... Mass., July 29, 2014 Cynosure, Inc. ... markets laser- and light-based aesthetic treatment systems for high-volume ... ended June 30, 2014. Second-quarter 2014 financial results incorporate ... on June 24, 2013. Second-Quarter ... increased 45% to $72.6 million , Non-GAAP net ...
(Date:7/29/2014)...  Novation, a VHA and UHC company, today ... features that automate key health care supply chain ... Association.  The new and enhanced ... Value Analysis, Item Master and Formulary – are ... most critical challenges brought on by health care ...
Breaking Medicine Technology:EastGate Acquisitions Announces Expansion of its Pharmaceutical Developments Implementing its Sub-Micron Platform Technology 2EastGate Acquisitions Announces Expansion of its Pharmaceutical Developments Implementing its Sub-Micron Platform Technology 3EastGate Acquisitions Announces Expansion of its Pharmaceutical Developments Implementing its Sub-Micron Platform Technology 4Cynosure Reports Second-Quarter 2014 Financial Results 2Cynosure Reports Second-Quarter 2014 Financial Results 3Cynosure Reports Second-Quarter 2014 Financial Results 4Cynosure Reports Second-Quarter 2014 Financial Results 5Cynosure Reports Second-Quarter 2014 Financial Results 6Cynosure Reports Second-Quarter 2014 Financial Results 7Cynosure Reports Second-Quarter 2014 Financial Results 8Cynosure Reports Second-Quarter 2014 Financial Results 9Cynosure Reports Second-Quarter 2014 Financial Results 10Cynosure Reports Second-Quarter 2014 Financial Results 11Cynosure Reports Second-Quarter 2014 Financial Results 12Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 2Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 3Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 4Breakthrough Novation Applications Empower Children's Hospital Association Members to Lower Costs, Increase Quality 5
... 2011 PediaVision today announced that Loma Linda ... the State of California to receive the revolutionary ... University,s Department of Ophthalmology is offering free vision ... the support of First 5 Riverside , ...
... small businesses struggle to afford health benefits, a ... Health Benefits regulations could include special interest protections that ... costs, the Pharmaceutical Care Management Association (PCMA) ... for thousands of small businesses throughout America. ...
Cached Medicine Technology:Loma Linda University Expands Vision Screening Program With Revolutionary New Screening Device, Spot 2Loma Linda University Expands Vision Screening Program With Revolutionary New Screening Device, Spot 3Loma Linda University Expands Vision Screening Program With Revolutionary New Screening Device, Spot 4Some Essential Benefits Rules Could Worry Small Businesses 2
... ENDOPATH EZ45 Endoscopic Linear Cutter has application ... surgical procedures for transection, resection, and/or creation ... staple line or tissue buttressing materials such ... reloaded seven times for a total of ...
... Linear Cutters provide a 45mm staple and ... the device suitable for many minimally invasive ... transection, resection, and/or creation of anastomoses in ... ,The LONG45A Endocutter has a shaft ...
ACUCLIP Endoscopic Right-Angle Multiple Clip Applier, 10 mm Shaft Diameter with 20, 8 mm Titanium Clips...
Insert only, Pilling-Weck medium clip size...
Medicine Products: