Navigation Links
Scientists discover key factor in controlling the breakdown of bone
Date:2/8/2009

A new study demonstrates that a chemical mediator in the blood that influences immune cell migration also plays a key role in maintaining the balance between the build-up and breakdown of bones in the body. This mediator, which acts on cells that degrade bone, may provide a new target for scientists developing therapies and preventions for bone-degenerating diseases such as osteoporosis and rheumatoid arthritis.

The study comes from the laboratory of immunologist Ronald Germain, M.D., Ph.D., at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. A report describing the project, conceived by Masaru Ishii, M.D., Ph.D., a visiting fellow from Osaka University in Japan, appears online in Nature.

Bone is a dynamic tissue, constantly undergoing growth and degradation. Bone degeneration, also known as bone resorption, is caused by specialized cells called osteoclasts. Immature osteoclasts circulate within the blood and migrate to the surface of the bones, where they mature and start to degrade the bone matrix. Osteoclasts are the only cells known to degrade bone.

Normally bone resorption is balanced by the activity of bone-forming cells, called osteoblasts. In people with bone-destructive disorders such as osteoporosis, however, osteoclast activity outpaces osteoblast activity, leading to a loss of bone density.

"Most current therapies for bone-degrading diseases target mature osteoclasts," says NIAID Director Anthony S. Fauci, M.D. "Understanding how immature osteoclasts are recruited to the bone in the first place and targeting the signals that control that migration represents a potential new approach to treating and preventing debilitating joint and bone diseases." In the United States, approximately 1.5 million fractures per year are attributed to the bone-weakening effects of osteoporosis.

As a rheumatologist who treats people with bone diseases, Dr
'/>"/>

Contact: Julie Wu
wujuli@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Team led by Scripps Scientists increases understanding of two types of blindness
2. CSHL scientists discover link between control of chromosome duplication and segregation
3. UCSB scientists make headway in understanding Alzheimers disease
4. Spanish scientists confirm extra virgin olive oil helps to combat breast cancer
5. UCLA scientists develop crystal ball for personalized cancer treatment
6. Weizmann Institute scientists create working artificial nerve networks
7. Scientists unmask genetic markers associated with psoriasis
8. Scientists and Investigators Cite Need for Radon Regulation to Prevent Lung Cancer- Call Current EPA Efforts Ineffective
9. Slices of living brain tissue are helping scientists identify new stroke therapies
10. Federal Members of Advisory Committee Block Vaccine-Autism Research, Defy Wishes of Its Own Scientists, Autism Community, and Congress
11. Canada-US scientists discover gene responsible for brains aging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2015)... Scientists with Cardno ChemRisk, a scientific consulting firm, ... that may have raised the risk of mesothelioma for ... an article on the research. Click here to ... asbestos levels well above OSHA safety guidelines when they ... “Asbestos compliance sampling data associated with the construction, automotive ...
(Date:5/24/2015)... York (PRWEB) May 24, 2015 ... lawsuits ( http://www.testosteronelawsuithub.com/ ) has scheduled its next ... of the multidistrict litigation. According to court documents ... of Illinois, the Conference will be convened on ... Testosterone Replacement Therapy Product Liability Litigation - MDL ...
(Date:5/24/2015)... Indiana Fiber Network, LLC (IFN), the leading Indiana ... Inc. (MTA) has selected IFN as a fiber transport ... Sales Manager, fiber route diversity and network redundancy are ... MTA with the diverse fiber transport from their Merrillville ... voice carriers located at Henry Street in Indianapolis, IN. ...
(Date:5/24/2015)... May 24, 2015 ... CEO - The students were ... at the fourth annual A Day ... at Geneva National in Lake Geneva. ...     -Badger High School,         Jonathan Alfonso,         Bridget ...
(Date:5/23/2015)... Florida City, FL (PRWEB) May 23, 2015 ... together to build a new playground for Branches Florida City ... destroyed the former play space in 2010. , A large ... then new playground on May 23, 2010 in the middle ... families watched. The fire was later declared arson even though ...
Breaking Medicine News(10 mins):Health News:New Analysis Finds Too Many Employers Ignored OSHA Asbestos Guidelines, According to Surviving Mesothelioma 2Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Look Ahead to June Conference in Federal Multidistrict Litigation 2Health News:Testosterone Lawsuit Attorneys at Bernstein Liebhard LLP Look Ahead to June Conference in Federal Multidistrict Litigation 3Health News:Indiana Fiber Network, LLC Enables Midwest Telecom of America with Fiber Route Diversity 2Health News:Mercy Foundation Honors 16 Students for Making a Difference - Mercy Health System Javon Bea 2Health News:Five Years After Fire, Branches Rebuilds Playground 2
... to implement rigorous sunscreen standards and approve more effective ... , WASHINGTON, Nov. 20 ... experts from New York Presbyterian Hospital; the Skin Cancer ... LTD, and Ciba Corporation to call on the Food ...
... found hi-tech method improved compliance more than paper and pencil ... letting kids have their fingers do the texting will increase ... part of successful dieting. , As a first proof that ... Carolina study shows that kids aged 5 to 13 are ...
... 20 Innovation, makers of,PharmASSIST(R) pharmacy automation ... System in Dallas, Texas has implemented the ... nine pharmacy sites.,Parkland Health & Hospital System ... as their core workflow platform. For those ...
... 400 Student AIDS Activists and Partner Schools to Combat HIV/AIDS ... 20 On November 15th, Green Family Foundation (GFF) ( ... (KCA) Co-Founder and Global Ambassador Alicia Keys and KCA Co-Founder ... activists in the second annual KCA College Student AIDS Summit. ...
... Nutraceutical,International Corporation (Nasdaq: NUTR ) today reported ... 30, 2008. , Net ... compared,to $39.9 million for the same quarter of fiscal 2007. ... $1.5 million, or $0.14 diluted earnings per,share, compared to net ...
... FOR PALLIATIVE MEDICINE , , SAN DIEGO, Nov. 20 ... San Diego Hospice and The Institute for Palliative Medicine offers the following tips ... , 1. Take care of yourself , ... well rested and taking care of yourself first and foremost. , ...
Cached Medicine News:Health News:Panel Demands FDA Action to Address Dramatic Increases in Skin Cancer in U.S. 2Health News:Panel Demands FDA Action to Address Dramatic Increases in Skin Cancer in U.S. 3Health News:Texting Food Diaries Helps Kids Stick With Diets 2Health News:Texting Food Diaries Helps Kids Stick With Diets 3Health News:Parkland Health & Hospital System Rolls Out Innovation's PharmASSIST Technology Platform Across Nine Pharmacy Sites 2Health News:Green Family Foundation Sponsors Alicia Keys' Keep a Child Alive College Student AIDS Summit 2Health News:Green Family Foundation Sponsors Alicia Keys' Keep a Child Alive College Student AIDS Summit 3Health News:Nutraceutical Reports 2008 Fiscal Year End Results 2Health News:Nutraceutical Reports 2008 Fiscal Year End Results 3Health News:Nutraceutical Reports 2008 Fiscal Year End Results 4Health News:Nutraceutical Reports 2008 Fiscal Year End Results 5Health News:Nutraceutical Reports 2008 Fiscal Year End Results 6Health News:Nutraceutical Reports 2008 Fiscal Year End Results 7Health News:Ten Tips for Coping with Grief and Loss During the Holidays 2Health News:Ten Tips for Coping with Grief and Loss During the Holidays 3
(Date:5/22/2015)... , May 22, 2015  Research and ... its sixth Medical Affairs Roundtable on ... via a virtual roundtable to discuss "Medical Affairs, ... Best Practices, Medical Affairs Consortium provides Medical ... about the key challenges they face. The consortium ...
(Date:5/22/2015)... TORONTO , May 22 2015 /CNW/ - The Taskforce ... are very appreciative of all the hard work that the ... the past six months. This program recognizes the needs of ... receive at least $75,000 a year, tax free, with annual ... will be eligible for annual payments of $100,000 based on ...
(Date:5/22/2015)... OAKS, Calif. , May 22, 2015 ... announced the Company has commenced termination of ... of brodalumab with AstraZeneca (LON:AZN, STO:AZN and ... IL-17 inhibitor, is in development for patients ... axial spondyloarthritis.  The decision was based on ...
Breaking Medicine Technology:Best Practices Sixth Medical Affairs Consortium Roundtable to Focus on Health Economics & Outcomes Research 2Amgen to terminate participation in co-development and commercialization of brodalumab 2Amgen to terminate participation in co-development and commercialization of brodalumab 3Amgen to terminate participation in co-development and commercialization of brodalumab 4Amgen to terminate participation in co-development and commercialization of brodalumab 5
The versatility of multiple imaging frequencies and a smaller transducer face make this transducer is perfect for intercostal imaging....
Compact, bench-top analyser with minimal water volume requirements and easy waste management....
... AtheNA Multi-Lyte Test System* is a ... simultaneously perform multiple assays from a ... It offers a simple and streamlined ... providing improved clinical sensitivity and comparable ...
... Hamilton is precision, ergonomics, and ... hand fatigue with soft non-slip, contoured ... with smooth, light plunger spring action ... and sterilization without the need for ...
Medicine Products: