Navigation Links
Scientists discover how to design drugs that could target particular nerve cells
Date:11/10/2011

The future of drug design lies in developing therapies that can target specific cellular processes without causing adverse reactions in other areas of the nervous system. Scientists at the Universities of Bristol and Lige in Belgium have discovered how to design drugs to target specific areas of the brain.

The research, led by Professor Neil Marrion at Bristol's School of Physiology and Pharmacology and published in this week's Proceedings of National Academy of Sciences USA (PNAS), will enable the design of more effective drug compounds to enhance nerve activity in specific nerves.

The team has been working on a subtype of ion channel called SK channels. Ion channels are proteins that act as pores in a cell membrane and help control the excitability of nerves.

Rather like an electrical circuit, ion channels work by allowing the flow of 'charged' potassium, sodium and calcium ions to enter or exit cell membranes through a network of pores formed by the channels, a subtype of which is the SK channel family.

The researchers have been using a natural toxin found in bee venom, called apamin, known for its ability to block different types of SK channel. SK channels enable a flow of potassium ions in and out of nerve cells that controls activity. The researchers have taken advantage of apamin being able to block one subtype of SK channel better than the others, to identify how three subtype SK channels [SK1-3] can be selectively blocked.

Neil Marrion, Professor of Neuroscience at the University, said: "The problem with developing drugs to target cellular processes has been that many cell types distributed throughout the body might all have the same ion channels. SK channels are also distributed throughout the brain, but it is becoming obvious that these channels might be made of more than one type of SK channel subunit. It is likely that different nerves have SK channels made from different subunits. Thi
'/>"/>

Contact: Caroline Clancy
caroline.clancy@bristol.ac.uk
44-011-792-88086
University of Bristol
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 17, 2014 The probability of prostate ... regular screening and examination, a healthy diet could decrease ... Epicure with the Chef MDs, renowned Chef ... Rusilko to prepare a delicious Fish Moilee. , Dr. ... that influence risk of prostate cancer, uncommonly found in ...
(Date:9/17/2014)... “North America Gynecological Devices Market Outlook ... North America Gynecological Devices market. The report provides ... units) and average prices (in US dollars) within ... Sterilization Devices (Transcervical Sterilization Devices (Micro-inserts) and Mechanical ... Endometrial Ablation Devices (Thermal Balloon, Hydrothermal Ablation ...
(Date:9/17/2014)... 2014 Stand Up for Heroes, New ... to the Theater at Madison Square Garden, Wednesday, Nov. ... Foundation (BWF) and New York Comedy Festival (NYCF), the ... veterans and their families. , The charitable event ... Oliver, Bruce Springsteen, Brian Williams and other surprise guests. ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 ... (NAPBS®) Background Screening Credentialing Council (BSCC) announced ... with the Background Screening Agency Accreditation Program ... as BSCC-Accredited. , S2Verify, LLC, 3600 ... year, U.S. employers, organizations and governmental agencies ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 2014 ... is a professional and in-depth research report on ... basic DEHP Plasticizer information, including its definition, classification, ... industry overview. This research covers the international market ... global industry analysis covering macroeconomic environment & economic ...
Breaking Medicine News(10 mins):Health News:Boost Prostate Health with Epicure with the Chef MDs 2Health News:Gynecological Devices Market in North America (US, Canada & Mexico) to 2020 New Report Available at MarketOptimizer.org 2Health News:Gynecological Devices Market in North America (US, Canada & Mexico) to 2020 New Report Available at MarketOptimizer.org 3Health News:Gynecological Devices Market in North America (US, Canada & Mexico) to 2020 New Report Available at MarketOptimizer.org 4Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 2Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 3Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 4Health News:Louis C.K., John Mulaney, John Oliver, Bruce Springsteen, Brian Williams & More to Perform at 8th Annual Stand Up for Heroes at Theater at Madison Square Garden, Nov. 5 5Health News:S2Verify Achieves Background Screening Credentialing Council Accreditation 2Health News:S2Verify Achieves Background Screening Credentialing Council Accreditation 3Health News:DEHP Plasticizer Industry & SiC Substrates Market Analysis For (NA, Asia, Europe & ROW) Research Now at DeepResearchReports.com 2Health News:DEHP Plasticizer Industry & SiC Substrates Market Analysis For (NA, Asia, Europe & ROW) Research Now at DeepResearchReports.com 3
... In Major Depression Treatment Is Growing, According to ... Pristiq and Effexor XR Need to Take Into ... Decision Resources, one of the world,s leading research ... issues, finds that Forest Laboratories, Lexapro is no ...
... Charts Help Patients Manage Their Daily and Weekly MedicationsLAWRENCE, ... to improve the healthcare industry as a whole, it,s ... a difference on a smaller scale.Goss, a medical technologist, ... more. "I feel good about what I do in ...
... China, May 12 /PRNewswire-Asia/ -- Winner Medical Group ... "Company") wholly-owned,subsidiary, Winner Industries (Shenzhen) Co., Ltd., "Winner ... announced the,establishment of a joint venture in Chengdu, ... West China. , Likang ...
... Guide Important Conversations and Get Families Closer to an ... expert consortium known as the Alzheimer,s Disease Screening Discussion ... proactively start a dialogue with loved ones, the potential ... possible Alzheimer,s disease (AD) symptoms. The goal of the ...
... What we see determines what we do; and ... vision are critical factors for better performance at school, ... http://www.newscom.com/cgi-bin/prnh/20090512/FL14726 )To help parents, caregivers and ... their best, the American Optometric Association (AOA) Sports Vision ...
... and SYDNEY, May 12 HeartWare International, Inc. (Nasdaq: ... scheduled to make an investor presentation at the Eighth Annual ... ET) on Tuesday, May 19, 2009. The conference is ... live webcast of the Company,s presentation at the conference will ...
Cached Medicine News:Health News:Lexapro Loses First-Line Position for the Treatment of Major Depression 2Health News:Lexapro Loses First-Line Position for the Treatment of Major Depression 3Health News:Healthcare Professional Is Working to Make a Difference, One Dose at a Time 2Health News:Winner Medical Establishes Joint Venture With West China Hospital in Chengdu, China 2Health News:Winner Medical Establishes Joint Venture With West China Hospital in Chengdu, China 3Health News:Winner Medical Establishes Joint Venture With West China Hospital in Chengdu, China 4Health News:Experts Urge Family Members and Friends to Seek Immediate Intervention for Their Loved Ones Who May Have Alzheimer's Disease (AD) 2Health News:Experts Urge Family Members and Friends to Seek Immediate Intervention for Their Loved Ones Who May Have Alzheimer's Disease (AD) 3Health News:Experts Urge Family Members and Friends to Seek Immediate Intervention for Their Loved Ones Who May Have Alzheimer's Disease (AD) 4Health News:Experts Urge Family Members and Friends to Seek Immediate Intervention for Their Loved Ones Who May Have Alzheimer's Disease (AD) 5Health News:New 'Healthy Eyes for Peak Performance' Brochure Offers Parents and Caregivers Advice, Insight on the Role of Vision in Children's Performance 2Health News:HeartWare to Present at Eighth Annual JMP Securities Research Conference 2
(Date:9/17/2014)... 2014  Millions of people suffer from neck and arm ... Recently the FDA approved the launch of a clinical ... device developed by Spinal Kinetics, which may offer relief to ... arm pain. Hospital for Special Surgery (HSS), the number one ... New York City and in the ...
(Date:9/17/2014)... Texas , Sept. 17, 2014  Lightbeam ... Direct Accountable Care Organization (Physician Direct ACO) to ... their physicians in providing better care while reducing ... Physician Direct Accountable Care Organization ... Network Services (OPNS). The OPNS mission is to ...
(Date:9/17/2014)... COLUMBUS, Ohio , Sept. 17, 2014 /PRNewswire/ ... Riverside Radiology and Interventional Associates announced today ... Systems to enhance its image sharing capabilities ... case of any network failures. In addition, the ... to help navigate disparate PACS systems to more ...
Breaking Medicine Technology:Cervical Disc Clinical Trial for People with Neck and Arm Pain Set to Begin at Hospital for Special Surgery 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 3Dicom Systems' Innovative Software Provides Enhanced Imaging Sharing Capabilities, as Well as Connection Reliability in the Case of Network Failure 2Dicom Systems' Innovative Software Provides Enhanced Imaging Sharing Capabilities, as Well as Connection Reliability in the Case of Network Failure 3
... N.J., Oct. 27 Watson Pharmaceuticals, Inc. (NYSE: ... Laboratories, Inc., filed a new drug application under Section ... (FFDCA) with the U.S. Food and Drug Administration (FDA) ... and 40 mg tablets.  Watson,s rosuvastatin zinc tablets are ...
... Oct. 27 Intrinsic Bioprobes today announced that ... issued US Patent 7,816,095 covering novel blood protein ... first of a series of patent applications that ... clinical utility. "The biomarkers were discovered ...
Cached Medicine Technology:Watson Confirms Crestor® Patent Challenge 2Intrinsic Bioprobes Announces Issuance of US Patent for Novel Biomarkers and Assays for Myocardial Infarction 2
... Bird and Cronin, Inc. ... of Patient Footwear, Orthopedic ... Care Products. Our products ... quality and available in ...
... Aspen® CTO combines highly effective immobilization of ... a level of comfort that makes it ... substantially progressive immobilization in going from a ... and then on to a four-post orthosis. ...
... Shoulder Immobilizer with Contoured ... Navy cotton sling with foam-padded ... body straps. Quick-release closure buckles. ... 35 covered abduction wedge to ...
The Humeral Stabilizing System is a terrific option for immobilization of stable humeral fractures, stablesupracondular fractures, and biceps/triceps repairs....
Medicine Products: