Navigation Links
Scientists discover how iron levels and a faulty gene cause bowel cancer
Date:8/9/2012

HIGH LEVELS of iron could raise the risk of bowel cancer by switching on a key pathway in people with faults in a critical anti-cancer gene, according to a study published in Cell Reports* today (Thursday).

Cancer Research UK scientists, based at the University of Birmingham and the Beatson Institute for Cancer Research in Glasgow, found bowel cancers were two to three times more likely to develop in mice with a faulty APC gene that were fed high amounts of iron compared to mice who still had a working APC gene.

In contrast, mice with a faulty APC gene fed a diet low in iron did not develop bowel cancer at all.

Study author Professor Owen Sansom, deputy director of the Cancer Research UK Beatson Institute for Cancer Research in Glasgow, said: "We've made a huge step in understanding how bowel cancer develops. The APC gene is faulty in around eight out of 10 bowel cancers but until now we haven't known how this causes the disease.

"It's clear that iron is playing a critical role in controlling the development of bowel cancer in people with a faulty APC gene. And, intriguingly, our study shows that even very high levels of iron in the diet don't cause cancer by itself, but rely on the APC gene."

Co-author Dr Chris Tselepis, a Cancer Research UK scientist at the University of Birmingham, said: "Our results also suggest that iron could be raising the risk of bowel cancer by increasing the number of cells in the bowel with APC faults. The more of these cells in the bowel, the greater the chance that one of these will become a starting point for cancer.

"We're now planning to develop treatments that reduce the amount of iron in the bowel and so could lower the risk of developing bowel cancer. We hope to start using these in trials in the next few years in people who are at a greater risk."

The study could also explain why foods such as red meat, which have high levels of iron, are linked to an increased risk of bowel cancer.

When the APC gene is deleted, two proteins are switched on that cause iron to build up in bowel cells. When this happens, a key cancer signalling pathway called wnt is switched on, causing cells to grow out of control.

In mice fed a diet with no iron, cells with a faulty APC gene were killed and bowel cancers did not develop. Mice with a fully functioning APC gene did not develop bowel cancers, even when fed a diet high in iron. In these bowel cells, the iron accumulation proteins are turned off and wnt signalling remains inactive.

Dr Julie Sharp, senior science information manager at Cancer Research UK, said: "Bowel cancer is the third most common cancer in the UK. These findings suggest a potentially effective way of reducing the chances of bowel cancer developing in people who are at high risk. Finding ways of 'mopping up' the iron that is in the bowel could have a real impact on the number of people who develop the disease.

"This research is a great example of scientists coming together and sharing their different expertise to find new ways of understanding and potentially preventing cancer."


'/>"/>

Contact: Simon Shears
simon.shears@cancer.org.uk
44-203-469-8054
Cancer Research UK
Source:Eurekalert

Related medicine news :

1. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
2. Scientists ID New Gene Linked to Vision Loss in Infants
3. Fruit flies light the way for A*STAR scientists to pinpoint genetic changes that spell cancer
4. NIH scientists identify likely predictors of hepatitis C severity
5. Scientists looking for noninvasive ways to detect lung cancer early
6. Increasing dopamine in frontal cortex decreases impulsive tendency, UCSF-Gallo scientists find
7. Scientists explore new class of synthetic vaccines
8. New method to find novel connections from gene to gene, drug to drug and between scientists
9. Scientists discover melanoma-driving genetic changes caused by sun damage
10. Scientists Map Genomes of One Mans Sperm
11. Scientists Say Blood Test May Help Predict Alzheimers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/26/2017)... ... ... Ballad of Cowboy Justin”: a charming tale of a brave cowboy who saves the ... published author, Leah Westbrook, a wife and mother who loves to spend time with ... tale about a young brave cowboy, Cowboy Justin, who saves the town from a ...
(Date:9/26/2017)... ... September 26, 2017 , ... “Childhood Memories of a Virginia Wanderer”: an ... help them relive their own youth. “Childhood Memories of a Virginia Wanderer” is the ... Navy for nine years. He received his BS from Idaho State University in ...
(Date:9/26/2017)... ... ... Tour Guide”: is the life story of the author and the exciting times this adventurer ... is an adventure tour guide and the subject of the book. , “Quickly slapping ... shocked faces. I played it off as a part of the adventure tour, an “added ...
(Date:9/26/2017)... ... ... Boobie and Ceebie”: a tool families can use to teach children about the love of ... G.S. White, a devoted follower of Jesus Chris who is married with one son. ... only for children but also to glorified God in everything he does.” --G.S. White , ...
(Date:9/25/2017)... ... September 26, 2017 , ... Your World Insurance Services, ... 2017 and began fulfilling a life-long wish of owner Stacy Boyle to give back ... recipient of help when I was in high school,” said Ms. Boyle. “My father ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)...  As the latest Obamacare repeal effort moves is ... (R-LA) and Lindsey Graham (R-SC) medical device ... industry is in an odd place.  The industry wants ... tax on medical device sales passed along with the ... increased visits and hospital customers with the funding to ...
(Date:9/19/2017)... ANN ARBOR, Mich. , Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical ... the precise destruction of targeted tissues, announced three leadership team developments today:   ... Josh Stopek, PhD ... ... Veteran medical device executive ...
(Date:9/18/2017)... Mich. , Sept. 18, 2017  PMD Healthcare ... Specialty Pharmacy of Kalamazoo, Mich. , ... hub service that expedites and streamlines patient and provider ... PD 2.0, and wellness management services.  ... device used to measure lung function for a variety ...
Breaking Medicine Technology: