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Scientists discover how gold eases pain of arthritis
Date:10/22/2007

in the synovial tissue and fluid around the joints where arthritis occurs.

Pisetsky, working with colleagues at the University of Pittsburgh and the Karolinska Institute in Sweden, stimulated mouse and human immune system cells to secrete HMGB1, then treated them with gold salts. They found that the gold blocked the release of HMGB1 from the nucleus. That, in turn, should lessen the amount available to provoke the bodys immune system, weakening the inflammatory response.

Basically, keeping HMGB1 corralled inside the nucleus is a good thing, when it comes to arthritis, says Pisetsky.

Pisetsky says gold inhibits the release of HMGB1 by interfering with the activity of two helper molecules that ease HMGB1s release from the cell, interferon beta and nitric oxide.

The study will appear in the January, 2008 issue of the Journal of Leukocyte Biology, but a preprint is already online at the journals website at: http://tinyurl.com/3cd957.

Now that we have identified at least one of the ways gold can help arthritis sufferers, perhaps we can use that knowledge to build new and safer-acting, gold-based treatments, says Pisetsky, a senior author of the study.

Pisetsky is encouraged by the results but says additional studies need to be done to find out if the same mechanism is active in animals and people and not just in laboratory studies.


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Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

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