Scientists discover how chromosomes keep their loose ... (We found that TRF2 uses a two-step mecha...)

Scientists discover how chromosomes keep their loose ends loose

Date:2/6/2013

We found that TRF2 uses a two-step mechanism to protect chromosome ends," said Keiji Okamoto, a postdoctoral fellow in Lazzerini Denchi's laboratory who was the lead author of the new study.

TRF2 is a complex protein with four functional domains (regions). Okamoto probed the specific functions of these four domains by creating artificial TRF2-like proteinsin which one or more functional domains were replaced with non-functional "dummy" domains. By studying how these artificial TRF2s functioned in cells, he could determine the separate functions of each individual domain.

Uncovering Distinct Roles

Two of these domains turned out to have distinct roles in suppressing the DNA damage response. "One domain, called TRFH, blocks localization of the DNA damage factor γH2AX, the initial step in the DNA response pathway," said Okamoto. It may do so by inducing a structural change in telomeres that hides it from the DNA damage machinery. A distinct region of TRF2, which Okamoto dubbed iDDR (inhibitor of the DNA damage response pathway), independently and actively suppresses the transduction of the DNA damage signal downstream of γH2AX.

Okamoto and colleagues found that the iDDR region works in part by recruiting an enzymatic activity associated with the tumor suppressor protein BRCA1. Defects in BRCA1 lead to DNA misrepairs, genomic instability and a sharp rise in cancer risk. (Certain BRCA1 mutations bring a greater than 50-percent lifetime risk of breast or ovarian cancer.) This new finding hints that BRCA1 defects may result in defects in telomere protection, too.

Lazzerini Denchi, Okamoto and their colleagues now plan to explore TRF2's functions and protein partners in further detail, in cell studies and in transgenic mice. "We want to address the BRCA1 connection more thoroughly, too, for example, to determine the importance of its association with telomeres in preventing tumors," Lazzerini Denchi said.

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

0

GOOD

Page: 1 2 3
Related medicine news :

1. Meeting: Scientists to explore 60 topical issues related to human health and the environment
2. Scientists debate CDC recommendations during meningitis outbreak
3. Scientists discover protein that allows safe recycling of iron from old red blood cells
4. MU scientists build harness for powerful radiation cancer therapy
5. Monell scientists identify elusive taste stem cells
6. American Association of Radon Scientists and Technologists (AARST) Releases Nation's First Standard for Mitigating Radon (Radioactivity) in Multifamily Buildings
7. Scientists Find Clue to Aging Reversal in Mice
8. Leading researchers warn of brain drain as scientists struggle to find funding
9. UNC scientists unveil a superbugs secret to antibiotic resistance
10. Scientists learn more about how inhibitory brain cells get excited
11. New target to stop cancers spread discovered by Georgia State scientists

Post Your Comments:

Related Image:

Scientists discover how chromosomes keep their loose ends loose

(Date:6/19/2013)... Mesothelioma Victims Center says, "According to the ... citizens, who will be diagnosed with a rare form ... will be US Navy Veterans. We can assure a ... of cancer, or their family members that we will ... mesothelioma compensation settlement attorneys, who actually do have a ...

(Date:6/19/2013)... Faith4Kidz is starting a new fundraising effrt ... would like help showing support for kids to learn how ... positive. Check out the website, http://www.gracenfaith.com to see ... red, white and blue stars as a symbol of our ... as well as the stars we should encourage our children ...

(Date:6/18/2013)... Exposed Skin Care has finally been released after much ... ages finally achieve the clear, beautiful skin they have always ... clearing system combines the power of science and nature to ... , After a quick review of Exposed ... the most effective available on the market to cure acne ...

(Date:6/18/2013)... South Africa (PRWEB) June 19, 2013 Looking ... disillusionment and monotony of everyday life? , IWALKAWAKE is ... awakening process. Written by Adam Botha, it focuses on harnessing ... , The book lays out a nine-step guide to ... a process that a person must go through to reach ...

(Date:6/18/2013)... York (PRWEB) June 19, 2013 The ... understanding and unprecedented access to the drug delivery partnering ... healthcare companies. , The report provides a detailed ... drug delivery partnering deals. The majority of deals are ... right or an option right to license the license ...

Breaking Medicine News(10 mins):Health News:Mesothelioma Victims Center Urges US Navy Veterans Diagnosed With Mesothelioma To Call Them For Instant Access To The Nation's Top Asbestos Lawyers-Better Compensation 2 Health News:Mesothelioma Victims Center Urges US Navy Veterans Diagnosed With Mesothelioma To Call Them For Instant Access To The Nation's Top Asbestos Lawyers-Better Compensation 3 Health News:Faith4Kidz Introduces Patriotic Hats to Benefit the "Grace in Faith Equals Peace" Mission 2 Health News:Exposed Skin Care Review Released by ExposedSkinCareReview.org 2 Health News:Exposed Skin Care Review Released by ExposedSkinCareReview.org 3 Health News:New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz 2 Health News:New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz 3 Health News:New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz 4

[0] Mesothelioma Victims Center Urges US Navy Veterans Diagnosed With Mesothelioma To Call Them For Instant Access To The Nation's Top Asbestos Lawyers-Better Compensation [0] Faith4Kidz Introduces Patriotic Hats to Benefit the "Grace in Faith Equals Peace" Mission [0] Exposed Skin Care Review Released by ExposedSkinCareReview.org [0] Learn How To Stop Sleepwalking Through Life in New Book 'IWALKAWAKE'[0] New Drug Delivery Partnering Terms and Agreements Market Study Report Available at MarketResearchReports.Biz

... The Institute for Health Freedom (IHF) is warning the ... government to plan for each American to use "an" ... or patient-consent provisions."Congress needs to add opt-out and patient-consent ... IHF president. "The bottom line is that if YOU ...

... Full Value,Committee announced today that it has filed ... materials and is commencing,distribution of those soliciting materials ... ) ("LCAV") to solicit consents to replace the ... highly qualified nominees. The Full,Value Committee,s director ...

... 9 Team Health Inc.,s,parent company, Team Finance LLC ... fiscal year and the fourth quarter ended,December 31, 2008. ... for uncollectibles ("revenue less provision"),for the fiscal year ended ... billion in the prior year. Same contract revenue less ...

... Powerful opioid drugs can pose risks even for patients, ... The U.S. Food and Drug Administration announced plans Monday ... painkillers by requiring manufacturers of certain opioid drugs to ... with the medications. , The FDA said it has ...

... genes can be used to reliably identify the four ... at Washington University School of Medicine in St. Louis ... potentially predict the most effective therapy for each breast ... all patients., "Unlike a widely used genomic test that ...

... adolescent use of prescription pain relievers has dropped, report ... of prescription painkillers among young adults increased from 4.1 ... government report released Monday shows. , However, the researchers ... (SAMHSA) also found that non-medical use of painkillers by ...

Economic Stimulus Bill Mandates Electronic Health Records for Every American by 2014 - With No Opt-out Provision The LCA-Vision Full Value Committee Commences Consent Solicitation to Elect New Board of Directors at LCA-Vision (Nasdaq: LCAV) and Sends Letter to Stockholders Team Finance LLC Announces Fiscal 2008 Financial Results FDA Seeks Better Regulation of Painkillers New genomic test can personalize breast cancer treatment Painkiller Abuse Increases Among Young Adults

(Date:6/18/2013)... , June 18, 2013 Decision Resources, ... firms for pharmaceutical and healthcare issues, announces that ... of the Middle East ... Tracker analyzes the challenges and opportunities to gaining ... international regions comprising 24 countries. The countries covered ...

(Date:6/18/2013)... , June 18, 2013 New-generation ... being highly portable and lightweight. Simultaneously, circuitry is ... the processing speed to which it performs at. ... medical electronics and military equipment, such as cameras ... Omnetics, micro-circular and nano-circular connectors include custom cable ...

(Date:6/18/2013)... And EMERYVILLE, Calif. , June ... final results today from a Phase 2/3 clinical ... demonstrating a statistically significant improvement in levodopa-induced dyskinesia ... week 8 versus placebo in the Unified Dyskinesia ... formulation of amantadine intended for once-nightly administration that ...

Breaking Medicine Technology:Decision Resources' Market Access Tracker Now Covers the Middle East and Africa 2 Decision Resources' Market Access Tracker Now Covers the Middle East and Africa 3 Omnetics Circular Connectors Offer Both Micro and Nano Interconnects for Highly Portable Electronic Systems, Meeting the Needs of Designers Looking for Size Reduction Options and Cable Flexibility 2 Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 2 Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 3 Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 4 Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 5 Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease 6

[0] Decision Resources' Market Access Tracker Now Covers the Middle East and Africa [0] Omnetics Circular Connectors Offer Both Micro and Nano Interconnects for Highly Portable Electronic Systems, Meeting the Needs of Designers Looking for Size Reduction Options and Cable Flexibility [0] Adamas Pharmaceuticals Presents Positive Phase 2/3 Results For ADS-5102 For The Treatment Of Levodopa-Induced Dyskinesia (LID) In Parkinson's Disease

... Therapeutics, Inc. (NASDAQ: ECTE ), a company ... wireless, transdermal continuous glucose monitoring system and its Prelude® ... Patrick T. Mooney, M.D., Chairman & CEO of Echo ... Conference. Dr. Mooney will make a presentation ...

... Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ) today ... operating officer, is scheduled to present a company overview ... York City on Wednesday, December 14th at 1:00 p.m. ... ) To access the live audio webcast ...

Cached Medicine Technology:

Echo Therapeutics to Present at the Oppenheimer Healthcare Conference Rigel to Present at Oppenheimer Annual Healthcare Conference

Lacrimal Cannula, Curved - Open End, 21gSize: 21g x 1-1/2"....

PremierEdge™ Implant Knives....

Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...

Medicine Products:

Lacrimal Cannula, Curved - Open End.PremierEdge™ Implant Knives Universal I/A handpiece - Titanium (Binkhorst Tip)Universal I/A handpiece - Titanium (Curved Tip, Size: 16g Outer Cannula)