Navigation Links
Scientists discover how chromosomes keep their loose ends loose
Date:2/6/2013

We found that TRF2 uses a two-step mechanism to protect chromosome ends," said Keiji Okamoto, a postdoctoral fellow in Lazzerini Denchi's laboratory who was the lead author of the new study.

TRF2 is a complex protein with four functional domains (regions). Okamoto probed the specific functions of these four domains by creating artificial TRF2-like proteinsin which one or more functional domains were replaced with non-functional "dummy" domains. By studying how these artificial TRF2s functioned in cells, he could determine the separate functions of each individual domain.

Uncovering Distinct Roles

Two of these domains turned out to have distinct roles in suppressing the DNA damage response. "One domain, called TRFH, blocks localization of the DNA damage factor γH2AX, the initial step in the DNA response pathway," said Okamoto. It may do so by inducing a structural change in telomeres that hides it from the DNA damage machinery. A distinct region of TRF2, which Okamoto dubbed iDDR (inhibitor of the DNA damage response pathway), independently and actively suppresses the transduction of the DNA damage signal downstream of γH2AX.

Okamoto and colleagues found that the iDDR region works in part by recruiting an enzymatic activity associated with the tumor suppressor protein BRCA1. Defects in BRCA1 lead to DNA misrepairs, genomic instability and a sharp rise in cancer risk. (Certain BRCA1 mutations bring a greater than 50-percent lifetime risk of breast or ovarian cancer.) This new finding hints that BRCA1 defects may result in defects in telomere protection, too.

Lazzerini Denchi, Okamoto and their colleagues now plan to explore TRF2's functions and protein partners in further detail, in cell studies and in transgenic mice. "We want to address the BRCA1 connection more thoroughly, too, for example, to determine the importance of its association with telomeres in preventing tumors," Lazzerini Denchi said.

<
'/>"/>
Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Meeting: Scientists to explore 60 topical issues related to human health and the environment
2. Scientists debate CDC recommendations during meningitis outbreak
3. Scientists discover protein that allows safe recycling of iron from old red blood cells
4. MU scientists build harness for powerful radiation cancer therapy
5. Monell scientists identify elusive taste stem cells
6. American Association of Radon Scientists and Technologists (AARST) Releases Nation's First Standard for Mitigating Radon (Radioactivity) in Multifamily Buildings
7. Scientists Find Clue to Aging Reversal in Mice
8. Leading researchers warn of brain drain as scientists struggle to find funding
9. UNC scientists unveil a superbugs secret to antibiotic resistance
10. Scientists learn more about how inhibitory brain cells get excited
11. New target to stop cancers spread discovered by Georgia State scientists
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists discover how chromosomes keep their loose ends loose
(Date:7/9/2014)... that sudden, acute episodes of low back pain are ... air pressure, wind direction and precipitation. Findings published in ... the American College of Rheumatology (ACR), indicate that the ... wind speed or wind gusts, but was not clinically ... (WHO) nearly everyone experiences low back pain at some ...
(Date:7/9/2014)... Susan Wakulich was told she had an aneurysm, she figured ... her. , "I was devastated," said Wakulich, who is 56 ... this was a serious diagnosis. Then I met Dr. Bernard ... a less invasive procedure. It was something I didn,t even ... a multi-center U.S. clinical trial to evaluate the safety and ...
(Date:7/9/2014)... into the metabolism of stromal support cells and immune ... these cell types in the development of diseases ... and cancer. That was the conclusion of a review ... the leading journal Nature . , Prof. Peter ... call. The metabolism of cancer cells has been examined ...
(Date:7/9/2014)... from The Miriam Hospital have found that people ... also depressed have difficulty sticking to a pulmonary ... for women, and screening and brief treatment of ... The study and its findings are published in ... Chronic obstructive pulmonary disease is a common and ...
(Date:7/9/2014)... Montefiore Medical Center and the Albert ... present new findings at the Alzheimer,s Association International Conference ... Copenhagen, Denmark. Data from the four abstracts will focus ... to mild cognitive impairment and dementia. The research is ... in 1980 to examine healthy brain aging as well ...
Breaking Medicine News(10 mins):Health News:Low back pain? Don't blame the weather 2Health News:New type of stent could help some brain aneurysm patients 2Health News:Wake-up call for more research into cell metabolism 2Health News:Miriam Hospital study examines effect of depressed mood on pulmonary rehab completion 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 3
... of Nationwide Awareness Campaign - KENILWORTH, N.J., March ... SGP ), maker of the non-drowsy ... allergy sufferer and NASCAR driver Carl Edwards to ... News Release, go to: http://www.prnewswire.com/mnr/claritin/37512/ "Drowsy driving ...
... DENVER, March 18 St. Joseph,s Hospital in Marshfield, ... Medical Technologies, VersaRad CR radiography system. These units ... as for St. Joe,s Diagnostic Imaging services. St. Joseph,s ... of the Marshfield medical complex serving Wisconsin and the ...
... Northern California Chapter of the National MS SocietyMOUNTAIN VIEW, Calif., ... special donation program to coincide with MS Awareness ... a cure for multiple sclerosis. For each sale of a ... 2009, Presto Services Inc. will donate 5% of the retail ...
... TO ARMS 2009 EDITION" is a new documentary ... traces the controversial Anthrax Vaccine Immunization Program ( AVIP ... Through the personal invitation of Rick and Rozene ... Baristo Rd., Palm Springs, CA, the documentary feature had ...
... equipment to be acquired as part of purchaseMOUNTAIN VIEW, ... Los Gatos Town Council last evening, El Camino Hospital ... Camino Hospital had signed agreements that will allow an ... Los Gatos acquisition. The agreements will allow El ...
... March 17 Standard & Poor,s Rating Services (S&P) ... ,B, on Huntsman Corporation,s (NYSE: HUN ) ... that its operations are sound and that its liquidity ... Huntsman has met the challenging operating environment by ...
Cached Medicine News:Health News:Video: CLARITIN Partners with NASCAR Driver Carl Edwards to Educate Motorists on the Importance of Being Clear to Drive(SM) 2Health News:Video: CLARITIN Partners with NASCAR Driver Carl Edwards to Educate Motorists on the Importance of Being Clear to Drive(SM) 3Health News:Fischer Medical Announces Multi-System VersaRad Installation at St. Joseph's Hospital in Marshfield, WI 2Health News:Presto Announces Donation Program to Help Find the Cure for Multiple Sclerosis 2Health News:Presto Announces Donation Program to Help Find the Cure for Multiple Sclerosis 3Health News:Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs 2Health News:Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs 3Health News:Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs 4Health News:Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs 5Health News:Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs 6Health News:Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs 7Health News:Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs 8Health News:Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs 9Health News:Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs 10Health News:Parties in Los Gatos Hospital Acquisition Agree on Terms Allowing El Camino Hospital an Early Close of Escrow 2Health News:Parties in Los Gatos Hospital Acquisition Agree on Terms Allowing El Camino Hospital an Early Close of Escrow 3Health News:Huntsman Responds to S&P Action 2Health News:Huntsman Responds to S&P Action 3
(Date:1/15/2014)... Jan. 15, 2014 Massachusetts General Hospital (MGH), ... AMGN ) announced today that they have launched ... new therapeutic targets and develop novel therapies for ... affects millions worldwide. The MGH-Broad-Amgen collaboration brings together ...
(Date:1/15/2014)... Fla. , Jan. 15, 2014  In an unprecedented effort to ... TB in ambulances and other transport vehicles, an advanced and portable ... rescue personnel for the first time. In order ... with these deadly pathogens, West Palm Beach ...
(Date:1/15/2014)... TORONTO , Jan. 15, 2014  According to ... medical technology market intelligence, the United ... occlusion (TEO) device markets will expand moderately through ... fastest-growing segments. In particular, increasing interest in drug-eluting ...
Breaking Medicine Technology:Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Superbugs No Longer Ride In Rescue Vehicles 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3
... is pleased to announce the signing of a reseller ... CIVCO,s Body Pro-Lok to its customers. Introduced in 2008 ... worldwide, Body Pro-Lok excels as a modular base for ... (Logo: http://photos.prnewswire.com/prnh/20110419/AQ85801LOGO ) ...
... July 29, 2011 Argos Therapeutics, Inc. today announced that ... the U.S. Securities and Exchange Commission (SEC) relating to a ... All shares of the common stock to be sold in ... Lazard Capital Markets LLC and Canaccord Genuity Inc. are acting ...
Cached Medicine Technology:Varian Medical Systems to Offer CIVCO Medical Solutions' Body Pro-Lok™ for SBRT 2Argos Therapeutics Files Registration Statement for Proposed Initial Public Offering 2
Bone Curette, 180 mm...
Kevorkian Collector Endocervical Curette is a stainless-steel curette with rounded tip....
Kevorkian Endocervical Curette is a stainless-steel curette with a basket. It is narrow tipped for sampling without dilation....
...
Medicine Products: