Navigation Links
Scientists discover genetic variant associated with prostate cancer in African Americans
Date:10/31/2007

Wednesday, October 31, 2007 Today researchers report a newly identified genetic variation that is linked to higher incidence of prostate cancer in African American men. This study, which emphasizes the importance of characterizing genetic markers associated with prostate cancer in high-risk populations, is published online in Genome Research (www.genome.org).

Prostate cancer is the second leading cause of cancer death in men and, according to the American Cancer Society, will claim the lives of more than 27,000 men in the United States this year. Among different populations, prostate cancer exhibits significant variation in incidence rates, with African American men exhibiting the highest rate worldwide.

Recent studies investigating genetic variations associated with susceptibility to prostate cancer have implicated a specific region of chromosome 8 as harboring potential markers for the disease. In the study published today, the research groups lead by Dr. Rick Kittles of the University of Chicago and Dr. John Carpten of the Translational Genomics Research Institute further analyzed the 8q24 region of chromosome 8 by comparing the genotypes of 490 African American men diagnosed with prostate cancer and 567 control subjects. This study took advantage of differences in genetic ancestry among the African American men in order to replicate and further localize a risk locus for prostate cancer, says Kittles.

Using this information, the researchers characterized new genetic markers which were significantly associated with prostate cancer. Since the prevalence of prostate cancer is almost two-fold higher among African Americans compared to European Americans, the use of ancestry informative markers for association with prostate cancer is quite powerful. We identified a novel prostate cancer risk locus that maps within a gene region on 8q24, Kittles says. This region contains an interesting candidate gene involved in DNA repair.

The data gathered in this study confirmed previous investigations, indicating that common genetic variants are linked to elevated prostate cancer risk, and found even stronger effects for several of the markers on 8q24 in African Americans. These results have important implications for diagnosis and therapy. The significance may be quite broad given the multiple genetic variants along 8q24 that impact risk, Kittles explains. It is likely that within the 8q24 region there is inherited predisposition to genetic instability and this is leading to increased cancer risk. By studying this region, we may be able to develop molecular targets for improved screening, early detection, and possibly treatment.


'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Related medicine news :

1. Nobel Prize for Medicine shared by Three scientists
2. Scientists plan human cloning clinic in the United States
3. Scientists crack mechanism of Leptin-Obesity Hormone
4. Scientists use plant hormones to fight cancer
5. American scientists alter gene makeup of babies
6. Expose on eating disorders!! Scientists trace “brain’s eating control center pathway”
7. Scientists found ancient Human Germ Killer
8. Scientists locate key hormone involved in appetite control
9. Scientists open the book of life
10. Electronic nose by Italian scientists
11. Scientists review SARS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... The ... MSC Cruises as part of the line’s 4th Annual MSC True Partnerships’ Awards. ... performing North American travel partners for the year based on overall business growth in ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... advance to the semi-final round of the 2017 Cupid's Cup Entrepreneurship Competition. Chaired ... its 12th year in 2017. The entrepreneurs will showcase their businesses on February ...
(Date:1/24/2017)... ... January 24, 2017 , ... West’s Health Advocate Solutions, ... Series of webinars will start January 31 with a session about understanding healthcare ... health and benefits topics, including employee engagement, pricing transparency, population health and wellness, ...
(Date:1/24/2017)... ... ... His message has been heard by more than 100,000 students and adults ... Joel Feldman, has reached his biggest national audience yet: the three million daily readers ... in circulation in the country, and he hopes it will help spread his message ...
(Date:1/24/2017)... Santa Margarita, CA (PRWEB) , ... January 24, 2017 , ... ... advancement platform for 21st century leadership, has named Hector M. Chavez, Manager, Employee & ... and diabetes treatment center - as its Hispanic Leader of the Month. City of ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... -- Trifecta Clinical , a leading global provider ... Ward to Vice President of Commercial Operations.  Rick ... the promotion of Ericka Atkinson to Vice ... joins Trifecta from Greenphire where he was Vice President ... positions within the healthcare industry throughout his career.  "Rick ...
(Date:1/24/2017)... Research and Markets has announced the addition of the "Implantable ... to 2025" report to their offering. ... The Global Implantable Medical Devices Market ... the next decade to reach approximately $54.28 billion by 2025 ... include 3D medical printing is expected to develop and find in ...
(Date:1/24/2017)... , and GAITHERSBURG, Md. , Jan. 24, ... ), a leader in the engineering and industrialization of biology ... planet, today announced that it has entered into a definitive ... GNVC ), a clinical-stage company and pioneer in the development ... to integrate and expand upon GenVec,s expertise in adenoviral vectors ...
Breaking Medicine Technology: