Navigation Links
Scientists discover genetic variant associated with prostate cancer in African Americans
Date:10/31/2007

Wednesday, October 31, 2007 Today researchers report a newly identified genetic variation that is linked to higher incidence of prostate cancer in African American men. This study, which emphasizes the importance of characterizing genetic markers associated with prostate cancer in high-risk populations, is published online in Genome Research (www.genome.org).

Prostate cancer is the second leading cause of cancer death in men and, according to the American Cancer Society, will claim the lives of more than 27,000 men in the United States this year. Among different populations, prostate cancer exhibits significant variation in incidence rates, with African American men exhibiting the highest rate worldwide.

Recent studies investigating genetic variations associated with susceptibility to prostate cancer have implicated a specific region of chromosome 8 as harboring potential markers for the disease. In the study published today, the research groups lead by Dr. Rick Kittles of the University of Chicago and Dr. John Carpten of the Translational Genomics Research Institute further analyzed the 8q24 region of chromosome 8 by comparing the genotypes of 490 African American men diagnosed with prostate cancer and 567 control subjects. This study took advantage of differences in genetic ancestry among the African American men in order to replicate and further localize a risk locus for prostate cancer, says Kittles.

Using this information, the researchers characterized new genetic markers which were significantly associated with prostate cancer. Since the prevalence of prostate cancer is almost two-fold higher among African Americans compared to European Americans, the use of ancestry informative markers for association with prostate cancer is quite powerful. We identified a novel prostate cancer risk locus that maps within a gene region on 8q24, Kittles says. This region contains an interesting candidate gene involved in DNA repair.

The data gathered in this study confirmed previous investigations, indicating that common genetic variants are linked to elevated prostate cancer risk, and found even stronger effects for several of the markers on 8q24 in African Americans. These results have important implications for diagnosis and therapy. The significance may be quite broad given the multiple genetic variants along 8q24 that impact risk, Kittles explains. It is likely that within the 8q24 region there is inherited predisposition to genetic instability and this is leading to increased cancer risk. By studying this region, we may be able to develop molecular targets for improved screening, early detection, and possibly treatment.


'/>"/>

Contact: Peggy Calicchia
calicchi@cshl.edu
516-422-4012
Cold Spring Harbor Laboratory
Source:Eurekalert

Related medicine news :

1. Nobel Prize for Medicine shared by Three scientists
2. Scientists plan human cloning clinic in the United States
3. Scientists crack mechanism of Leptin-Obesity Hormone
4. Scientists use plant hormones to fight cancer
5. American scientists alter gene makeup of babies
6. Expose on eating disorders!! Scientists trace “brain’s eating control center pathway”
7. Scientists found ancient Human Germ Killer
8. Scientists locate key hormone involved in appetite control
9. Scientists open the book of life
10. Electronic nose by Italian scientists
11. Scientists review SARS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... A recent Bellwether Education Partners’ ... the field must first improve teacher preparation program design. It then asserts that ... that decades of input- and outcome-based research has failed to improve teacher education. ...
(Date:3/28/2017)... ... March 28, 2017 , ... India’s ... technology to directly address the resolution to globally reduce the harmful use of ... compound of FDA and TTB approved ingredients that when infused into alcohol, renders ...
(Date:3/28/2017)... WASHINGTON, DC (PRWEB) , ... March 28, 2017 ... ... call on elected representatives in state legislatures and Congress to protect parental rights ... the public health and safety in America. , The demonstration coincides with a ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... of all holidays (IBT World Travel Trends Report). As travelers visit both urban ... range in temperatures, and prolonged sun exposure. In response, the outdoor industry has ...
(Date:3/28/2017)... ... 2017 , ... Via Oncology, the leading provider of oncology ... public-facing tool for analyzing the costs of various drug regimens in cancer care. ... patients, providers, insurers and pharmaceutical companies about the estimated costs of treatment options. ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... DUBLIN , Mar 29, 2017 Research ... Global Market - Forecast to 2023" report to their offering. ... The ablation ... CAGR to reach $20,995.5 million by 2023. Ablation ... wide range of purposes, from cancerous or diseased tissue removal, to ...
(Date:3/29/2017)...  Spiral Therapeutics, Inc. today announced the signature ... for the worldwide exclusive rights to Bionure,s lead ... of otolaryngology for aggregate payments of up to ... provides Spiral with the option to license two ... Under the terms of the agreement, Spiral will ...
(Date:3/29/2017)... 2017   Royal Philips (NYSE: PHG, ... and PathAI, a company that develops artificial intelligence ... to develop solutions that improve the precision and ... diseases. The partnership aims to build deep learning ... artificial intelligence to be applied to massive pathology ...
Breaking Medicine Technology: