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Scientists discover distinct molecular subtype of prostate cancer
Date:5/20/2012

the finding of a SPOP mutation may be one of the breakthroughs oncologists have been seeking. "We have very limited information available to us now on the particular biology of the tumor that prostate cancer patients have, and how best to treat that cancer," he says. "But given the finding that SPOP mutations form a distinct kind of cancer, and if you low ball the incidence at about 10 percent of all tumors, that means, every year, 25,000 men in the U.S. will be diagnosed with tumors that have this mutation. That is a large number. Knowing what these mutations mean may give us huge clues about how the patient's cancer will progress and how they might be best treated in the future," Dr. Barbieri says.

"This prostate cancer subtype appears to contain abnormalities in cellular processes that are quite new to prostate cancer researchers, and should open up many future avenues for enhanced understanding of the disease," says Dr. Garraway. He adds, "our collaboration with the Rubin lab has been crucial to the success of this effort. Our groups bring nicely complementary expertise in disease biology, genomics and pathology."

"Going forward, we will attempt to define the specific biological roles of several new prostate cancer genes, and we will characterize new prostate cancer genomic alterations that are emerging through ongoing discovery efforts," Dr. Garraway says.


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Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

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