Navigation Links
Scientists discover distinct molecular subtype of prostate cancer
Date:5/20/2012

cers containing the so-called "ETS" fusion genes, such as TMPRSS2-ERG.

"While there is still a need for increased discovery, it does appear that the overall genetic landscape of prostate cancer is taking shape, and better understanding of the biology and possible therapeutic avenues linked to these alterations has become a very high priority," says Dr. Levi Garraway, a senior associate member of the Broad Institute of MIT and Harvard, and assistant professor at the DanaFarber Cancer Institute and Harvard Medical School.

Dr. Rubin and Dr. Garraway are co-senior investigators for this study and for others that have preceded it in this unique examination of prostate cancer genes.

In February 2011, the collaborative groups published a study in Nature in which they used whole genome sequencing to discern global changes and patterns of abnormality in seven prostate tumors and compared them to normal tissue samples. They found that areas of the genome had been unexpectedly rearranged -- just as Dr. Rubin and his collaborators at the University of Michigan had in 2005 with the discovery of the common recurrent TMPRSS2-ERG gene rearrangement, created by the fusion of two different genes.

This current study looked at different drivers of cancer, which are mutations in specific genes. It focused on the 1-2 percent of DNA in the genome that codes for proteins, and, as such, is one of the largest "whole exome" sequencing studies published on prostate cancer to date, according to Dr. Garraway.

The impetus to search for genes in this way came about because of the observation that SPOP appeared to be mutated in some cases of prostate cancer, says Dr. Christopher Barbieri, a fifth year urology resident at Weill Cornell who spent a research year in Dr. Rubin's laboratory in the Department of Pathology and Laboratory Medicine.

Broad Institute researchers, led by Dr. Garraway and Dr. Sylvan Baca, completed an intensive exome sequenc
'/>"/>

Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Medicine team has found that targeted automated alerts ... infections in hospital patients with urinary catheters. In ... simplified, the rate of improvement dramatically increased. , ... need urinary catheters in the first place and ... catheters that have not been removed within a ...
(Date:8/22/2014)... (HealthDay News) -- Many Americans know little about how Ebola ... an outbreak in the United States, a new survey shows. ... that there will be a major Ebola outbreak in the ... immediate family member will get sick with the deadly virus ... of Public Health poll. However, those opinions don,t match ...
(Date:8/22/2014)... 22, 2014 Millennium Treatment Group, ... Lantana, FL, recently launched a new website. Patients, ... information can now find Millennium Treatment Group at ... went live at the beginning of July. Everything ... can be found on the website. There’s an ...
(Date:8/22/2014)... Las Vegas, NV (PRWEB) August 22, 2014 ... that teaches readers how they can use natural methods ... for years has caught the attention of Shane Michaels, ... only a condition that affects the skin, it can ... suffer from it,” reports Michaels. “The intense itching and ...
(Date:8/22/2014)... protein 11 (BIM) deletion in advanced non-small cell ... free survival (PFS) in epidermal growth factor receptor ... Asian patients. Also, BIM deletion independently predicts overall ... BIM protein can activate the programmed cell death ... BIM deletion has been detected in 12.8% of ...
Breaking Medicine News(10 mins):Health News:Penn study: Electronic alerts significantly reduce catheter-associated urinary tract infections 2Health News:Penn study: Electronic alerts significantly reduce catheter-associated urinary tract infections 3Health News:Many Americans Harbor Unfounded Fears About Ebola Outbreak: Survey 2Health News:Millennium Treatment Group Has a New Website 2Health News:Beat Eczema: Review Exposes Susan Clark’s Guide to Curing Eczema Naturally 2Health News:Deletion predicts survival in advanced non-small cell lung cancer 2
... maltreatment is associated with reductions in quality of life even ... that finds thaton averagevictims lose at least two years of ... professor Phaedra Corso and her colleagues at the Centers for ... people to assess the deficits in quality of life that ...
... Legendary music producer,and entertainment icon Quincy ... catastrophic earthquake that struck China and the ... recorded several public services,announcements for the American ... the,media ( http://www.redcross.org/QuincyJonesPSA )., (Photo: ...
... molecules fabricated in the laboratory have been shown to ... diabetes in animal models. The results of these studies ... Rangos Sr. Research Center at Childrens Hospital of Pittsburgh ... research study at Childrens Hospital, the scientists injected the ...
... N.C., May 28 Best Practices, LLC launched,this ... help,companies build more effective communication practices in the ... leading,pharmaceutical companies and interviews with district managers and ... on internal communication -- Percentage of time ...
... Sullivan was a born engineer. As a youngster, she ... with Tinker Toys. , Today, Sullivan, an assistant professor ... Merck Faculty Fellow, is applying her knowledge and talents ... materials for delivering healing drugs and gene therapies to ...
... PBM Holdings, Inc., a global,supplier of infant ... affiliate company, PBM (Guangzhou) Nutritionals Co., Ltd., has,donated ... PBM is,partnering with the Shanghai Bureau of Civil ... the Red Cross Society of China, to distribute ...
Cached Medicine News:Health News:Study: Child maltreatment victims lose 2 years of quality of life 2Health News:Study: Child maltreatment victims lose 2 years of quality of life 3Health News:Quincy Jones Lends Time and Talent to Support Red Cross Relief Efforts In China and Myanmar 2Health News:New vaccine approach prevents/reverses diabetes in lab study at Children's Hospital of Pittsburgh 2Health News:New vaccine approach prevents/reverses diabetes in lab study at Children's Hospital of Pittsburgh 3Health News:Research Study Shows That Pharmaceutical Field Sales Reps' Productivity Inhibited by Unnecessary Internal Communication 2Health News:Sullivan wins NSF Career Award for research on therapeutic drug carriers 2Health News:Sullivan wins NSF Career Award for research on therapeutic drug carriers 3Health News:PBM Companies Partner with the Red Cross to Donate Infant Formula to China Earthquake Victims 2
(Date:8/22/2014)... MC Medical, a subsidiary of Mitsubishi Corporation (MCM), ... OH medical device company, have formally agreed to ... visualization system in Japan . It is ... Japan in the latter half of 2015. ... product portfolio in endoscopic surgery market in Japan ...
(Date:8/22/2014)... , Cali ., Aug. 22, 2014 ... Papillomavirus Conference shows that a therapy being developed by Hera ... two that cause 70 percent of all cervical cancer. ... blocked the replication of HPV-16, HPV-18 and HPV-11 cells, according ... Broker , Ph.D., who presented the findings at the ...
(Date:8/22/2014)... 2014  Landauer, Inc. (NYSE: LDR ), ... and monitoring, outsourced medical physics services and high quality ... Saxelby , its President and Chief Executive Officer, will ... and as a member of the Board of Directors, ... replaced on an interim basis by Michael T. ...
Breaking Medicine Technology:MC Medical agrees to be the exclusive distributor of FloShield products in Japan 2Study shows Hera Therapeutics experimental compound shuts down human papillomavirus that causes most cervical cancer 2Landauer, Inc. Announces Executive Management Change 2
... 12, 2011 Aribex, Inc., the worldwide leader in ... Award from the internationally-known 2011 Edison Best New Product ... ceremony at the historic Capitale ballroom in New York ... recognized in the Science and Medical Handheld or Miniaturized ...
... Asante Solutions, Inc. (Asante), a medical device company focused ... mark for its Pearl Insulin Pump, the only insulin ... mark is a European proof of conformity that certifies ... Asante has begun discussions with potential distribution partners in ...
Cached Medicine Technology:NOMAD by Aribex Receives Edison Best New Product Award 2Asante Solutions, Inc. Receives CE Mark for Pearl™ Insulin Pump 2
... Instruments were developed in surgeon's desire to ... having an instrument with the strength to ... of the bending or breaking. Arthrotek Hand ... conform to the surgeon's hand. This new ...
This optimal design addresses low-cost, simple, non-invasive ankle distraction....
... BTA stat Test is an ... qualitative detection of bladder tumor ... with bladder cancer. This test ... aid in the management of ...
... TheraTears Liquid Gel is a thicker version ... or for those who need a longer-lasting ... Liquid Gel is so long-lasting, it is ... preserved gels, there never needs to be ...
Medicine Products: