Navigation Links
Scientists discover cells critical to childhood leukemia
Date:1/21/2010

Scientists at The Royal Melbourne Hospital and the University of Melbourne in Australia have discovered the cells that cause a common type of childhood leukaemia T cell Acute Lymphoblastic Leukaemia (T-ALL). Targeting of these cells may lead to improved treatments for this disease and help prevent relapse.

The team, led by Dr Matthew McCormack and Dr David Curtis of the Rotary Bone Marrow Research Laboratories and the University's Department of Medicine at The Royal Melbourne Hospital, made the discovery whilst studying mice prone to developing this leukaemia.

The results have been published online today by the prestigious international journal Science.

The team found that with irradiation treatment in animal models, over 99 per cent of cells in the thymus were killed, but these stem cell-like cells persisted and rapidly recovered. This suggests that these cells may survive therapy and be responsible for relapsed disease following treatment.

Currently, children with T-ALL are given extended therapy over two to three years in an attempt to stop a relapse. More targeted therapy on the thymus cells could reduce the length and toxicity of treatment and prevent relapse.

Dr McCormack, a leading international expert on childhood leukaemia, said: "The cellular origins of this leukaemia are not well understood. Our discovery that these cells are similar to normal stem cells explains why they are capable of surviving for long periods. It also explains why they are remarkably resistant to treatment."

Approximately 50 new cases of T-ALL are diagnosed every year in Australia, two thirds of these in children or adolescents. Adults also contract T-ALL, and the majority succumb to resistant or relapsed disease.

Dr Curtis, a Clinical Haematologist and head of the Leukaemia Research Program at The Royal Melbourne Hospital, said: "The identification of these cells provides an important target for the develop
'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... May 29, 2015 The third annual ... event, now closed to new registration, starts outside the ... This exciting competitive running event demonstrates the power of ... a public benefit – in this case, historic preservation. ... around the famed Ocean Drive and passes by many ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 Dot Hill can mark ... 91-year-old resident of Lake Prince Woods retirement community is ... in Virginia Beach, Virginia. , “It was great fun!”, she exclaimed. ... children didn’t want me to so they thought this would be ... stepped into a vertical wind tunnel,” she described. “I don’t ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 To compile ... research, choosing systems that have several awards for clinical ... on what systems stood out to them in terms ... inclusion as well. , The 50 Great Health Systems ... Adventist Health System (Altamonte Springs, Fla.) , Advocate Health ...
(Date:5/29/2015)... FL (PRWEB) May 29, 2015 ... Utah, recently partnered with Stratus Video ... which will facilitate better communication and timely ... (LEP) and hearing loss. Stratus’ video remote ... in-house translators, enabling staff to quickly access ...
(Date:5/29/2015)... New York, NY (PRWEB) May 29, 2015 ... mental wellness, as well as a number of specific ... integrative care, stigma reduction and mental health in the ... speak about mental health. The campaign also brings special ... inspiring those individuals to speak up and seek help ...
Breaking Medicine News(10 mins):Health News:The Newport 10 Miler at Fort Adams, an Outstanding Example of Event Marketing Helping in Preservation, is Now Completely Booked for 2015 2Health News:The Newport 10 Miler at Fort Adams, an Outstanding Example of Event Marketing Helping in Preservation, is Now Completely Booked for 2015 3Health News:Indoor Skydiving Brings Thrills to Seniors 2Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 2Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 3Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 2Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 3Health News:Stratus Video Interpreting Partners With Intermountain Healthcare to Provide On-Demand Interpretation Services for Patients With Limited English Proficiency (LEP) 4Health News:Mediaplanet Brings Activism to Those Living with Mental Illness in Bew “Mental Health Awareness” Campaign 2
... American Physical Society commends President Obama,s commitment to doubling ... implementing policies that will enhance science and math education; ... percent of the nation,s gross domestic product to investments ... that the U.S. develops effective solutions to challenges in ...
... Managing sick and concerned workers, navigating quarantine barriers ... impact areas facing epidemic-wary managersNEW YORK, April 28 ... spread and monitoring government advisories should prepare to ... epidemic or worst-case pandemic scenario, says New York ...
... TUESDAY, April 28 (HealthDay News) -- A computerized chest ... rooms with chest pains who have serious heart disease, ... in the study, computed tomography angiography (CTA) was 100 ... acute coronary syndrome, according to a report in the ...
... a ,crack in the facade, of the disorder, , , ... of two common genes can raise the risk for ... highlighting the complex genetic roots of the disorder. , ... region, responsible for complex social behavior and abstract thought, ...
... DURECT Corporation,s (Nasdaq: DRRX ) first quarter 2009 ... the conference call that will be broadcast live over the ... Time (1:30 pm Pacific Time).A live audio webcast of the ... http://www.durect.com and clicking "Investor Relations." ...
... 28 DATATRAK International, Inc. (Nasdaq: DATA ... eClinical solutions for the clinical trials industry, today reported ... become the newest member of the DATATRAK CRO Connect ... of CROs, CPI is able to expand its electronic ...
Cached Medicine News:Health News:APS commends President Obama's commitment to greater investment in science 2Health News:Swine Flu Plans Triggering Difficult Legal Questions, Says Noted Pillsbury Attorney 2Health News:Swine Flu Plans Triggering Difficult Legal Questions, Says Noted Pillsbury Attorney 3Health News:Computerized Scan Detects Heart Disease 2Health News:Computerized Scan Detects Heart Disease 3Health News:Research Highlights Genetic Risk for Autism 2Health News:Research Highlights Genetic Risk for Autism 3Health News:Research Highlights Genetic Risk for Autism 4Health News:German CRO clinicalprojects international GmbH Becomes Newest Member of DATATRAK's CRO Connect Program(TM) 2Health News:German CRO clinicalprojects international GmbH Becomes Newest Member of DATATRAK's CRO Connect Program(TM) 3Health News:German CRO clinicalprojects international GmbH Becomes Newest Member of DATATRAK's CRO Connect Program(TM) 4
(Date:5/29/2015)... May 29, 2015 A six-hour certification program on ... presented at the Cannabis World Congress & Business Exposition ... York, NY .  Taking place on Wednesday, June 17 ... of education at the leading event on the East Coast ... Led by Clover Leaf University, the first cannabis university to ...
(Date:5/29/2015)... Research and Markets ( http://www.researchandmarkets.com/research/hgs483/cardiovascular ) ... report "Cardiovascular Drug Delivery - Technologies, Markets ... Drug delivery to the cardiovascular system is different ... anatomy and physiology of the vascular system; it ... the body. Drugs can be introduced into the ...
(Date:5/29/2015)... Research and Markets ( ... "Surgical/Operating Microscopes Market by Application & End ... to their offering.      (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... poised to reach $806.6 million by 2020 from ... 12.3% from 2015 to 2020. , ,Major factors ...
Breaking Medicine Technology:Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 3Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 4Global Cardiovascular Drug Delivery Market 2015 - Technologies, Markets and Companies 2Global Cardiovascular Drug Delivery Market 2015 - Technologies, Markets and Companies 3Surgical/Operating Microscopes Market by Application & End User - Global Forecast to 2020 for the $806 Million Industry 2
... BD (Becton, Dickinson and Company) (NYSE: BDX ... revenues of $2.051 billion for the fourth fiscal quarter ended ... the prior-year period, or 4.0 percent on a foreign currency-neutral ... September 30, 2011, BD reported revenues of $7.829 billion, representing ...
... NEW YORK, Nov. 1, 2011 Keryx Biopharmaceuticals, Inc. ... on the acquisition, development and commercialization of medically important ... disease, today announced that a conference call will be ... EDT to discuss results for the third quarter ended ...
Cached Medicine Technology:BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 2BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 3BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 4BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 5BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 6BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 7BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 8BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 9BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 10BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 11BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 12BD Announces Results for 2011 Fourth Fiscal Quarter and Full Year 13Keryx Biopharmaceuticals, Inc. to Host Conference Call on Third Quarter 2011 Financial Results 2
Sterile squares of smooth foil for repair of the floor of the orbit and other plastic surgery. Available in large size....
Clear Base Stand Magnifiers are ideal for any visual task that requires high magnification....
Bausch & Lomb magnifiers incorporates precision optics and patented ergonomic designs for increased clarity and comfort during use....
Ultra Thin Sheet. Medpor Sheets are commonly used for orbital floor reconstruction and other craniofacial applications....
Medicine Products: