Navigation Links
Scientists discover cells critical to childhood leukemia
Date:1/21/2010

Scientists at The Royal Melbourne Hospital and the University of Melbourne in Australia have discovered the cells that cause a common type of childhood leukaemia T cell Acute Lymphoblastic Leukaemia (T-ALL). Targeting of these cells may lead to improved treatments for this disease and help prevent relapse.

The team, led by Dr Matthew McCormack and Dr David Curtis of the Rotary Bone Marrow Research Laboratories and the University's Department of Medicine at The Royal Melbourne Hospital, made the discovery whilst studying mice prone to developing this leukaemia.

The results have been published online today by the prestigious international journal Science.

The team found that with irradiation treatment in animal models, over 99 per cent of cells in the thymus were killed, but these stem cell-like cells persisted and rapidly recovered. This suggests that these cells may survive therapy and be responsible for relapsed disease following treatment.

Currently, children with T-ALL are given extended therapy over two to three years in an attempt to stop a relapse. More targeted therapy on the thymus cells could reduce the length and toxicity of treatment and prevent relapse.

Dr McCormack, a leading international expert on childhood leukaemia, said: "The cellular origins of this leukaemia are not well understood. Our discovery that these cells are similar to normal stem cells explains why they are capable of surviving for long periods. It also explains why they are remarkably resistant to treatment."

Approximately 50 new cases of T-ALL are diagnosed every year in Australia, two thirds of these in children or adolescents. Adults also contract T-ALL, and the majority succumb to resistant or relapsed disease.

Dr Curtis, a Clinical Haematologist and head of the Leukaemia Research Program at The Royal Melbourne Hospital, said: "The identification of these cells provides an important target for the develop
'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method ... lean muscle by up to 30lbs in less than 12 ... HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... scientific diet formula that allows the body to pack on ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David ... Show to bestow a Juvent Sports Achievement award upon ... McKitrick. The award commemorated and congratulated McKitrick for her ... won her first amateur tournament in 1979 and most ...
(Date:1/22/2015)... 22, 2015 Carinsurancesavings.biz has released a new ... and dismemberment insurance . , Purchasing an accidental death ... very advantageous. This type of rider provides benefits if the ... be considered a lesser form of life insurance. , ...
(Date:1/22/2015)... Florida (PRWEB) January 22, 2015 IsoComforter, Inc. ... therapy machine with patented IsoTube design to treat specific body ... introduced the most progressive and easy to use patented cold ... post-operative and sports related orthopedic and muscle injuries. IsoComforter ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 JJsHouse.com is a ... dresses. Today, the business announces its latest collection of ... , “The most important issue is the wedding dress on ... thing in a woman’s life. Every bride wants to find ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... 5 The Chartis Group, a leading,healthcare advisory ... Pamela Damsky, James Karpook and Gregory Maddrey to ... leading healthcare,organizations in advancing their strategic, organizational and ... tremendous asset to our clients and our,firm. Greg, ...
... March,29 at 8:00 am, the Bowen Foundation for Autism ... Annapolis to raise money to fight autism. For a,registration ... 5K,waterfront course complete with activities for the whole family ... event go toward the Bowen,Foundation, an organization created to ...
... all NHS Hospital Trusts a study by researchers at The ... even by staff in uniform. , Researchers in the School ... and more must be done to find better ways of ... and stop smoking on site. , The study was ...
... to assist in healing, MEMPHIS, Tenn. and ... (NYSE: SNN , LSE: SN) Orthopaedic Trauma ... of the CAPTION(TM),Disposable Platelet Concentration System. The CAPTION ... concentrate (PRC) and eliminates,cross- contamination risks., The ...
... PLAINES, Ill., March 5 Since 1999,OurHealthNetwork.com ( ... custom-made foot orthotics. The company,s,team of board- certified ... two dozen different styles of custom orthotics that ... foot pain, but also cater to their,lifestyles and ...
... AIRM ) will report financial results for the ... the market on Wednesday, March 12,2008. The Company has ... 4:15 p.m. Eastern to discuss these results., Interested ... or (706) 643-0580 (international) or by accessing the web ...
Cached Medicine News:Health News:The Chartis Group Elects New Partners: Four Healthcare Industry Experts Promoted to Principal 2Health News:The Chartis Group Elects New Partners: Four Healthcare Industry Experts Promoted to Principal 3Health News:Inaugural Bowen Foundation Run/Walk to Fight Autism in Maryland Set for Saturday, March 29 2Health News:Hospitals still not smoke-free 2Health News:Smith & Nephew Introduces New Biologic to Speed Healing 2Health News:Smith & Nephew Introduces New Biologic to Speed Healing 3Health News:Unique Line of Custom-Made Orthotics for Sandals and Clogs Cater to Style-Minded Foot Pain Sufferers 2
(Date:1/23/2015)... DES MOINES, Iowa , Jan. 23, 2015  The Partnership to ... Iowa health care leaders and a new study ... prescription medications. The PFCD is a nationwide coalition working to educate ... The research released at the Capitol was focused on how the ...
(Date:1/23/2015)... and DUBLIN , Jan. 23, 2015 ... with KRS Global Biotechnology, Inc. for the compounding, packaging and ... for shipment in the United States . ... Outsourcing Facility capable of compounding naltrexone tablets in various strengths ...
(Date:1/23/2015)...  iMD Companies, Inc. (ICBU) has repositioned itself as a holding ... a foothold in the hydroponic, hemp and medical marijuana sectors. ... in the sector, and recently partnering with the Chippewa Tribe ... medical marijuana, iMD is committing to bring its vision to ...
Breaking Medicine Technology:New research shows Iowa health exchange would benefit from improvements 2New research shows Iowa health exchange would benefit from improvements 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 2Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 3Immune Therapeutics, Inc. Announces Agreement with KRS Global Biotechnology, Inc. 4iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2
... LOUIS, March 1, 2011 K-V Pharmaceutical Company (NYSE: KVa/KVb) ... million of senior secured notes due 2015 (the "Notes") in ... The Notes will be offered only to accredited investors pursuant ... amended (the "Securities Act").  The Notes have not been registered ...
... Medical Systems Ltd. (Nasdaq: DHRM ) ... the development, assembly, marketing and sale of medical ... announced that management will present at the following ... http://photos.prnewswire.com/prnh/20100422/CNTH001LOGO ) Rodman & Renshaw ...
Cached Medicine Technology:K-V Pharmaceutical Company Announces $200 Million Private Debt Offering 2K-V Pharmaceutical Company Announces $200 Million Private Debt Offering 3K-V Pharmaceutical Company Announces $200 Million Private Debt Offering 4K-V Pharmaceutical Company Announces $200 Million Private Debt Offering 5K-V Pharmaceutical Company Announces $200 Million Private Debt Offering 6K-V Pharmaceutical Company Announces $200 Million Private Debt Offering 7K-V Pharmaceutical Company Announces $200 Million Private Debt Offering 8Dehaier Medical Announces March Investor Presentations 2
... size AA required). Fast, Lightweight Strain Gage ... GN, dwt, mom, dwt, tael), Specific Gravity ... Auto Print. Optional hook (321-34532-03) available for ... ordered for AC Operation of ELB. External ...
... size AA required). Fast, Lightweight Strain Gage ... GN, dwt, mom, dwt, tael), Specific Gravity ... Auto Print. Optional hook (321-34532-03) available for ... ordered for AC Operation of ELB. External ...
... TOPLOAD 620/0.01G, BX620S. Digital stability control, ... measure, piece counting and percent measure ... including date and time data from ... external weights (selectable from 200g to ...
Guaranteed leak-proof , Teflon coating is impervious to corrosive materials , Shock-resistant , NBS tolerances of accuracy , Thermometers are 225 mm long with an immersion length of 35 mm ...
Medicine Products: