Navigation Links
Scientists discover anti-inflammatory polyphenols in apple peels
Date:11/30/2011

Bethesda, MDHere's another reason why "an apple a day keeps the doctor away"according to new research findings published in the Journal of Leukocyte Biology (https://www.jleukbio.org), oral ingestion of apple polyphenols (antioxidants found in apple peels) can suppress T cell activation to prevent colitis in mice. This study is the first to show a role for T cells in polyphenol-mediated protection against an autoimmune disease and could lead to new therapies and treatments for people with disorders related to bowel inflammation, such as ulcerative colitis, Crohn's disease and colitis-associated colorectal cancer.

"Many people with colitis use some form of dietary supplement to complement conventional therapies, but most of the information on the health effects of complementary medicine remains anecdotal. Also, little is known about exactly how these therapies work, if they work at all," said David W. Pascual, Ph.D., a researcher involved in the work from the Department of Immunology and Infectious Diseases at Montana State University in Bozeman, Montana. "Our results show that a natural product found in apple peels can suppress colonic inflammation by antagonizing inflammatory T cells to enhance resistance against autoimmune disease."

To make this discovery, scientists used a chemically induced model of colitis with Dextran sulfate sodium (DSS), researchers administered an oral placebo to one group of mice, and the other group of mice was given an oral dose of apple polyphenols every day during the course of the disease. Results showed that mice treated orally with apple polyphenols were protected from colitis. Importantly, scientists also found that the treated mice had fewer activated T cells in their colons. In mice lacking T cells, apple polyphenols were unable to protect against colitis or suppress proinflammatory cytokine expression, indicating apple polyphenols protect against colitis via the suppression of T cell activation a
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists identify key area that could sever communication between brain and heart in disease
2. Scientists identify defect in brain cell channel that may cause autism-like syndrome
3. Scientists Reveal Monarch Butterfly Genome
4. Scripps Research scientists identify new class of antimalarial compounds
5. NIH-funded scientists identify potential malaria drug candidates
6. Scientists discover how to design drugs that could target particular nerve cells
7. Kessler Foundation scientists awarded grants to study cognition in MS
8. Opening the data bank -- scientists try to match new protein structures
9. Hospital for special surgery physician-scientists share advances in rheumatology research
10. Scientists identify genes that may signal long life in naked mole-rats
11. Gladstone scientists identify gene critical for cell responses to oxygen deprivation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... type of lung cancer, researchers have uncovered mutations in ... tumors. The new knowledge may expand treatments for patients ... are available or are in clinical trials. , Reporting ... Cancer Genome Atlas (TCGA), including researchers at Washington University ... and other institutions, studied tumors from 230 patients with ...
(Date:7/9/2014)... -- Researchers from The Miriam Hospital have ... (COPD) who are also depressed have difficulty sticking ... be particularly true for women, and screening and ... part of treatment. The study and its findings ... . , Chronic obstructive pulmonary disease is ...
(Date:7/9/2014)... KNOXVILLEAmphibian declines and extinctions around the world have ... chytridiomycosis, but new research from the National Institute ... another pathogen, ranavirus, may also contribute. , ... that ranavirus, which causes severe hemorrhage of internal ... populations of wood frogs if they are exposed ...
(Date:7/9/2014)... retrospective study conducted by researchers at Tufts University School ... with intellectual and developmental disabilities, the likelihood of having ... care increased. The findings, published in the July/August issue ... improve interventions designed to address the oral health of ... the dental records of 107 patients at one of ...
(Date:7/9/2014)... allergic diseases has risen dramatically in Western societies. One ... to microorganisms and have fewer infections than previous generations, ... study by researchers at Sahlgrenska Academy, University of Gothenburg, ... maturation of the immune system in relation to allergic ... of the Vstra Gtaland Region, half of them on ...
Breaking Medicine News(10 mins):Health News:Lung cancer study hints at new treatments 2Health News:Miriam Hospital study examines effect of depressed mood on pulmonary rehab completion 2Health News:Study predicts ranavirus as potential new culprit in amphibian extinctions 2Health News:Adults with special needs see gains, challenges with long term oral care 2Health News:Adults with special needs see gains, challenges with long term oral care 3
... APS Healthcare, a leading provider of specialty healthcare solutions, ... Services to deliver a unified total population health management ... the State consolidated its service providers from three to ... population that APS has been serving for the past ...
... PROSPECT, Ill., May 5 The National Association of ... May 5, 2009, examining the flagrant lawlessness of Web ... why this ,wild west, of an electronic marketplace is ... dead and injured patients," the paper asserts. The "State ...
... May 5 Tim Wentworth, group president, employer accounts, Medco ... to address the Bank of America/Merrill Lynch 2009 Health Care ... at the Palace Hotel in New York City, will begin ... officer, is also scheduled to attend.The presentation may be heard ...
... in one Minnesota city , , TUESDAY, May 5 (HealthDay ... known, another learning disability -- the inability to write ... new study suggests. , So-called written-language disorder is a ... epidemiologist at the Mayo Clinic and lead author of ...
... with elevated albumin levels were more likely to get ... News) -- A higher-than-normal level of the protein albumin ... clots in the deep veins of the lungs and ... (VTEs) include deep vein thrombosis (DVT), a clotting in ...
... NIH and Robert Wood Johnson Foundation-Sponsored Study Focuses on ... 5 Nearly 75 percent of children ages 3-6 ... getting enough exercise. A focus group study of child ... several reasons children are not getting as much physical ...
Cached Medicine News:Health News:Ohio Selects APS Healthcare to Manage Unified Population Health Management Program for State Employees 2Health News:NABP Position Paper Calls for Action Against Proliferation of Rogue Internet Drug Outlets 2Health News:NABP Position Paper Calls for Action Against Proliferation of Rogue Internet Drug Outlets 3Health News:Medco to Present at the Bank of America and Merrill Lynch 2009 Health Care Conference 2Health News:Writing Disorder May Be Common Among Kids 2Health News:Urine Test Predicts Vein Clot Risk 2Health News:Urine Test Predicts Vein Clot Risk 3Health News:ABCs and No Skinned Knees: Study Reveals Various Barriers to Physical Activity in Child Care 2Health News:ABCs and No Skinned Knees: Study Reveals Various Barriers to Physical Activity in Child Care 3
(Date:1/15/2014)... , Jan. 15, 2014 As health officials across the ... select Meijer pharmacies in Michigan will ... eligible patients, enabling Meijer pharmacists to administer tests and, in ... by a physician participating in the study. The ...
(Date:1/15/2014)...  Novation, the leading health care supply chain expertise, analytics ... (VAR) national contracts that expand its portfolio to provide ... costs. These include manufacturer product and service agreements, as ... ongoing IT consulting support. New Novation ...
(Date:1/15/2014)... 15, 2014 Massachusetts General Hospital (MGH), the ... ) announced today that they have launched a ... therapeutic targets and develop novel therapies for inflammatory ... millions worldwide. The MGH-Broad-Amgen collaboration brings together scientists ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4
... Highest Rate of TB Infection in U.S., SAN ... of tuberculosis (TB) in the U.S., with recurrent outbreaks ... recent study on,homelessness and TB by Harvard Medical School. ... San Francisco. To address this health care,crisis, St. Anthony,s ...
... Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today ... of the National Institutes of Health,has started ... for patients with,metastatic melanoma using systemic administration ... reovirus. The trial is,being carried out by ...
Cached Medicine Technology:National Healthcare for Homeless Day: August 13th, 2008 2U.S. NCI Starts Enrolment in Phase 2 Systemic Melanoma Clinical Trial with REOLYSIN(R) 2
Preclude Dura Substitute is the only non-biological membrane designed to "seal" around suture holes. 0.3 mm as nominal thickness....
... synthetic absorbable implant for the bridging of Dura ... is pliable, regardless of being used dry or ... must be taken, while implanting, to ensure that ... is oriented towards the cortex or the spinal ...
... is a non-absorbable dura ... purified polyesterurethane. Its microporous ... of fibroblast, supporting tissue ... minimizes suture channels, resulting ...
The Bovie IDS Series are the latest electrosurgical generators with fully digital implementation....
Medicine Products: