Navigation Links
Scientists discover a new way to enhance nerve growth following injury
Date:4/22/2014

New research published today out of the University of Calgary's Hotchkiss Brain Institute (HBI) uncovers a mechanism to promote growth in damaged nerve cells as a means to restore connections after injury. Dr. Doug Zochodne and his team have discovered a key molecule that directly regulates nerve cell growth in the damaged nervous system. His study was published in the prestigious journal Nature Communications, with lead authors Drs. Kim Christie and Anand Krishnan.

"We made the surprising discovery that a protein called Retinoblastoma (Rb) is present in adult neurons," explains Zochodne. "This protein appears to normally act as a brake preventing nerve growth. What we have shown is that by inactivating Rb, we can release the brake and coax nerves to grow much faster," says Zochodne, a professor in the Department of Clinical Neurosciences.

Zochodne and his team decided to look for Rb in nerve cells because of its known role in regulating cell growth elsewhere in the body.

"We know that cancer is characterized by excessive cell growth and we also know that Rb is often functioning abnormally in cancer," says Zochodne. "So if cancer is able to release this brake and increase cell growth, we thought we'd try to mimic this same action in nerve cells and encourage growth where we want it."

The researchers were able to shut down Rb for a short amount of time and did not observe any negative results, leading them to feel optimistic that this could one day be used as a safe treatment for patients suffering from nerve damage.

So far, Zochodne is only investigating this technique in the peripheral nervous system. Peripheral nerves connect the brain and spinal cord to the body and without them, there is no movement or sensation. Peripheral nerve damage can be incredibly debilitating, with patients experiencing symptoms like pain, tingling, numbness or difficulty coordinating hands, feet, arms or legs.

For example,
'/>"/>

Contact: Marta Cyperling
mcyperli@ucalgary.ca
403-210-3835
University of Calgary
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists find key steps linking dietary fats and colon cancer tumor growth
2. Stanford scientists identify source of most cases of invasive bladder cancer
3. Scientists discover brains anti-distraction system
4. Scientists find new way to fight malaria drug resistance
5. Stanford scientists develop playbook for reverse engineering tissue
6. Scientists unlock secrets of protein produced by disease-causing fungus
7. Kessler Foundation scientists receive Biogen Idec grant to study actual reality in MS
8. Scientists discover a number of novel genetic defects which cause oesophageal cancer
9. Scientists find potential target for treating mitochondrial disorders
10. Scientists describe gut bacteria that cause sepsis in preterm infants
11. Virginia Tech scientists out for blood when it comes to stopping malaria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... August 01, 2015 , ... BeverlyD, owner and founder of BeverlyD Luxe ... the very first small business donation to kick off the campaign for healing and ... Her legacy includes a complete line of raw, organic hair care products, as well ...
(Date:7/31/2015)... ... 2015 , ... When the weather turned hot and warm-season turfgrasses, such as ... called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) for short. Incidentally, both names ... new type of sod, Super-Sod is giving away red Adirondack chairs with the Leisure ...
(Date:7/31/2015)... ... July 31, 2015 , ... Recently touted by ... predictive health analytics , Jvion continues to disrupt the predictive analytic and ... that targets patient and population level illness to drive prevention and better health ...
(Date:7/31/2015)... Jacksonville, FL (PRWEB) , ... July 31, 2015 ... ... has announced an important workshop at its new True North Conference Center. The ... attend so that the Jacksonville community may be more aligned in the effort ...
(Date:7/31/2015)... , ... July 31, 2015 , ... According to the article published July ... the Pasadena courthouse was contained and extinguished by the city’s fire department before it caused ... building at the time of the fire, and it was a fire alarm system that ...
Breaking Medicine News(10 mins):Health News:March4thforWellBeing Foundation Kickoff 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Jvion Showcased as Leader in the Predictive Analytic Market 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 2Health News:Lakeview Health Links Sex Trafficking and Addiction in Special Jacksonville Educational Workshop 3Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 2Health News:Article on Recent Pasadena Courtroom Fire Highlights the Effectiveness of Fire Alarm Systems, Says Fire Protection Group Inc 3
... a sticky protein on the tip that makes them cling ... form of a coiled// , bungee cord-like structure which helps ... inside the body, researchers report in the journal PLoS Biology. ... of Washington in Seattle and ETH Zurich in Switzerland have ...
... hormones might rapidly worsen the formation of brain lesions ... ,According to the research led by Frank LaFerla, ... researchers from UC Irvine, with the collaboration from Lauren ... neurobiology and behaviour, managing stress and reduction of certain ...
... therapy has been proven to be more successful at ... some patients with early stage lung cancer// , according ... edition of the International Journal of Radiation Oncology * ... Society for Therapeutic Radiology and Oncology (ASTRO). ...
... Bryson of Inverness has criticized Advanced Cells Therapeutics, which provided ... the treatment is no// better than conventional treatments and her ... Two Newsnight programme Ms Bryson said, "I'm back to where ... I had so much hope it was going to work ...
... A woman student quit because she could take it no ... an angry student is on hunger strike. The Aligarh Muslim ... many of AMU's women students - they number a staggering ... that they are bringing a bad name to the university ...
... there is a significant rise in the number of deaths ... ,In 2005, the numbers were 177 in Argyll ... Scottish Executive figures reveal that there is a 20% increase ... on the rise with heroin-related deaths rising by 25%. ...
Cached Medicine News:Health News:Fimbriae Help Bacteria Stick Around Inside the Body 2Health News:Stress Could Have A Notable Effect In Quickening The Progression Of Alzheimer's disease 2Health News:Stress Could Have A Notable Effect In Quickening The Progression Of Alzheimer's disease 3Health News:Modern Radiation Therapy ups Lung Cancer Survival 2Health News:Sexual Harassment on the Rise in Aligarh Muslim University 2Health News:Sexual Harassment on the Rise in Aligarh Muslim University 3Health News:Alcohol-related deaths in Scotland on the rise 2
(Date:7/31/2015)... 31, 2015 Magnaquest, a ... data and cloud computing operators has signed a ... giant for Internet of Things (IoT) related initiative. ... on subscription model.      (Logo: ... striving for business innovations to make healthcare services ...
(Date:7/30/2015)... July 30, 2015 Mettler-Toledo International Inc. (NYSE: ... 2015.  Provided below are the highlights: , ... compared with the prior year. Reported sales decreased 4% ... quarter. , Net earnings per diluted share as ... prior-year period. Adjusted EPS was $2.80 , an ...
(Date:7/30/2015)... Calif. , July 30, 2015 IRIDEX ... will release its second quarter 2015 financial results after ...   In conjunction with the release, the Company will ... 5:00 p.m. Eastern Time on Thursday, ... the quarter and other business developments. Interested ...
Breaking Medicine Technology:Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 14IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2
The Valleylab Surgistat II generator provides exceptional performance, reliability, and safety benefits in a compact, easy to use unit....
Lorgnette pinhole occluder...
Maddox rod and occluder...
Black multi-pinhole occluder...
Medicine Products: