Navigation Links
Scientists discover a mechanism that can send cells on the road to cancer
Date:4/22/2008

ey hypothesized that the answer could be found in the activity of yet another protein, called Myc, which Dr. Tansey has spent much of his career studying. Myc is an oncoprotein: one that is important in a great many regulatory processes in the cell, and which, when overexpressed, can cause dysregulation that leads to cancer.

Prior work had shown that when E1A was present in a cell, the potentially dangerous Myc protein was stable -- it did not degrade naturally. In new experiments, Tansey and colleagues found that E1As stabilization of the Myc protein was accomplished not, as was suspected by some, by directly inhibiting its degradation in a cellular component called the proteosome, which destroys proteins. Rather, E1A stabilized Myc by promoting its binding with p400.

To recap the complex sequence of events: E1A, when present in a cell, binds to p400. That protein, in turn, forms a complex with Myc which accounts for Mycs stability in cells in which E1A is present. Close study showed that the piece of the E1A protein that was important for stabilizing Myc was the same piece that bound to p400, Dr. Tansey said. And just as E1A can pull the Rb protein away from E2F, initiating a cascade of pathologies potentially leading to oncogenesis, so does the ability of E1A to bind p400 -- and via that connection to engage Myc -- stabilize that oncoprotein and open the door to tumorigenesis.

We know now that the interaction of E1A and p400 is very important in terms of regulating cell growth in normal and cancer cells, Dr. Tansey said. So were taking a cue from the history of work on adenoviruses and were leaving E1A behind to concentrate on Myc and p400. For us, now, the next step is to learn more about the p400-Myc connection.


'/>"/>

Contact: Jim Bono
bono@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Scientists identify novel way to prevent cardiac fibrosis
2. Scientists Explore Human Gene Pool With Help From Microsoft Research
3. Scientists obtain anticancer medicines from the elecampe, a wild plant growing in the Mediterranean
4. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
5. With annual deaths from malaria on the rise: Scientists ask where is all the money going?
6. Stem cells and cancer: Scientists investigate a fine balancing act
7. Scientists Block Prostate Cancer Cells Spread
8. Scientists solve mystery of polyketide drug formation
9. Scientists Uncover How HIV Hides Inside Cells
10. Scientists: New technique identifies molecular biomarkers for disease
11. Princeton Professor David W. C. MacMillan Lectured WuXi PharmaTech Scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... technologies and development solutions for drugs, biologics and consumer health products, today welcomed ... accepted for review OPKO’s New Drug Application for a new treatment for chronic ...
(Date:8/3/2015)... ... 03, 2015 , ... The art of preparing and cooking food comes naturally ... a young age, Nasreen Zereshki was extremely eager to cook Persian cuisine. Now that ... from My Persian Kitchen with the world. , Since Americans tend to be undereducated ...
(Date:8/3/2015)... ... August 03, 2015 , ... The U.S. Food and Drug Administration ... is similar to deoxycholic acid, which occurs naturally in the body and helps absorb ... treat this area of the body. These are invasive procedures and very expensive for ...
(Date:8/3/2015)... ... ... Dignity Health named Dr. Norris A. Baldwin, Jr. the Facility Medical Director of ... The new facility is licensed under Dignity Health Arizona General Hospital , ... an excellent leader and will ensure our new freestanding emergency room delivers the highest ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... provider of medical information, risk management and investigative services, has introduced a ... toward focused, expert information solutions that improve business outcomes for its customers. ...
Breaking Medicine News(10 mins):Health News:Catalent’s OptiShell™ Technology is Delivery Platform for OPKO Health’s New Chronic Kidney Disease Treatment 2Health News:Catalent’s OptiShell™ Technology is Delivery Platform for OPKO Health’s New Chronic Kidney Disease Treatment 3Health News:Persian Cuisine: Colorful and Extremely Healthy 2Health News:Dr. Ava Shamban to Offer the New Double Chin Treatment Kybella 2Health News:Dr. Ava Shamban to Offer the New Double Chin Treatment Kybella 3Health News:Dignity Health Names Dr. Norris A. Baldwin, Jr. Facility Medical Director of New Freestanding Emergency Room 2Health News:Dignity Health Names Dr. Norris A. Baldwin, Jr. Facility Medical Director of New Freestanding Emergency Room 3Health News:EMSI Announces New Branding: Powerful Information. Improved Outcomes. 2
... Vietnam is badly hit by a rubella epidemic, with more ... seem to be worst affected//, said a Government health official. ... year has reached 6,000,’ said Pham Ngoc Dinh, deputy director ... ,One of the largest outbreaks has been in Ho Chi ...
... Rush University have developed ,the first knee replacement shaped ... from the U.S. Food and Drug Administration, and will ... // ,Dr. Aaron G. Rosenberg and Dr. Richard A. ... surgeons who sought to address shape-related differences of a ...
... research in the promising field of nanotechnology, scientists have ... test tubes//. These findings have the potential to revolutionize ... filled with anti-cancer drugs and injected into cancer patients, ... the tiniest tubes, scientists have made, are about 80 ...
... for providing information on dozens of diseases. The Best ... and jargon-free information. // ,Concerned about number ... leaving the GPs overwhelmed with visits from “cyberchondriacs” has ... ,It has sections on men's, women's and children's health ...
... content of beverages such as tea, coffee and soda may ... the decaf label that claims reduced or nil caffeine content. ... School of Medicine, is based on a dipstick analysis. The ... journal, Analytical Chemistry, a publication of the American Chemical Society. ...
... nurses along with a Palestinian doctor were accused of infecting ... 426 children with AIDS contaminated blood at a local hospital. ... But on Christmas their penalty were quashed. Till now fifty-one ... appealed and the court ordered a retrial, and scrapped the ...
Cached Medicine News:Health News:Shapelier Knee Replacements for Women 2Health News:Shapelier Knee Replacements for Women 3Health News:Shapelier Knee Replacements for Women 4Health News:Tiniest Nanoscale Test Tubes Corked; Holds Promise In Cancer Treatment 2Health News:Caffeine Content In Beverages To Be Identified By Home Test Kit 2
(Date:8/3/2015)... , August 3, 2015 ... announced today that it has acquired ... Inc. for $300 million. With the acquisition, Shire ... drops combining 0.6% povidone iodine (PVP-I) and 0.1% ... treatment of infectious conjunctivitis, an ocular surface condition ...
(Date:8/2/2015)... 2015  Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ... to discover and develop antisense therapies for cardiovascular, ... on a broad existing relationship between the two ... therapeutic areas using novel RNA-targeted treatments. It also ... antisense technology to diseases of the kidney. ...
(Date:8/2/2015)... Texas , Aug. 3, 2015  Lexicon ... that the pivotal TELESTAR Phase 3 clinical trial ... oral telotristat etiprate in treating cancer patients with ... the current standard of care. Telotristat etiprate was ... Prize-winning technology, and is the company,s first discovery ...
Breaking Medicine Technology:Shire Acquires Privately Held Foresight Biotherapeutics Inc., Boosting Ophthalmics Portfolio with Late-Stage Asset 2Shire Acquires Privately Held Foresight Biotherapeutics Inc., Boosting Ophthalmics Portfolio with Late-Stage Asset 3Shire Acquires Privately Held Foresight Biotherapeutics Inc., Boosting Ophthalmics Portfolio with Late-Stage Asset 4Shire Acquires Privately Held Foresight Biotherapeutics Inc., Boosting Ophthalmics Portfolio with Late-Stage Asset 5Shire Acquires Privately Held Foresight Biotherapeutics Inc., Boosting Ophthalmics Portfolio with Late-Stage Asset 6AstraZeneca and Isis Pharmaceuticals to Discover and Develop Antisense Drugs for Cardiovascular, Metabolic and Renal Diseases 2AstraZeneca and Isis Pharmaceuticals to Discover and Develop Antisense Drugs for Cardiovascular, Metabolic and Renal Diseases 3AstraZeneca and Isis Pharmaceuticals to Discover and Develop Antisense Drugs for Cardiovascular, Metabolic and Renal Diseases 4Lexicon Pharmaceuticals Reports Positive Top-Line Results For Pivotal Phase 3 Telotristat Etiprate Study In Cancer Patients With Carcinoid Syndrome 2Lexicon Pharmaceuticals Reports Positive Top-Line Results For Pivotal Phase 3 Telotristat Etiprate Study In Cancer Patients With Carcinoid Syndrome 3Lexicon Pharmaceuticals Reports Positive Top-Line Results For Pivotal Phase 3 Telotristat Etiprate Study In Cancer Patients With Carcinoid Syndrome 4Lexicon Pharmaceuticals Reports Positive Top-Line Results For Pivotal Phase 3 Telotristat Etiprate Study In Cancer Patients With Carcinoid Syndrome 5Lexicon Pharmaceuticals Reports Positive Top-Line Results For Pivotal Phase 3 Telotristat Etiprate Study In Cancer Patients With Carcinoid Syndrome 6
... 7, 2010 Where do you start when trying to ... ), an independent nonprofit that researches the best approaches to ... release of its 5th annual list of Top 10 ... free download with registration, the list features the ...
... Research Group (MRG), the global authority on medical technology ... the US clot management device market.   ... report provides important insight into the device-based treatments ... of medical device manufacturers in this field. The report ...
Cached Medicine Technology:ECRI Institute Releases 'Top 10 Health Technology Hazards for 2011' 2ECRI Institute Releases 'Top 10 Health Technology Hazards for 2011' 3Millennium Research Group to Release Their Latest US Clot Management Data 2
Invacare 5 Oxygen Concentrator with Sens O2, 230 VAC - Intl....
... Nine out of ten peptic ulcers ... can deliver improved patient care while the ... that fits the staffing requirements of waived ... Facilities: the most sensitive CLIA-waived rapid H. ...
... the Japanese market:, ,QuietLife 3 ... low-power-consumption, high-performance oxygen concentrator for home ... in an attractive, lightweight (26 kg) ... to meet the requirements of the ...
... Oxygen Concentrator is a low decibel, low ... oxygen for prescriptions up to 5 liters ... running concentrator at <40 dBA, this unit ... Concentrators are also an economical and safe ...
Medicine Products: