Navigation Links
Scientists devise targeted therapy strategy for rare form of childhood cancer
Date:3/29/2011

BOSTON--By "distracting" cancer proteins from their usual activity, scientists at Dana-Farber Cancer Institute and Brigham and Women's Hospital have caused cells in a rare, lethal form of cancer to begin behaving like normal cells -- one of the longest-standing, and most rarely achieved, goals of cancer research. The study's findings are published online by the journal Cancer Research and will appear later in a print issue.

When the approach was tested in a child with an advanced case of the malignancy, known as NUT midline carcinoma (NMC), it slowed the course of the disease for several months. That result, in a cancer for which there are no other effective treatments, is a powerful impetus for making the new therapy available to patients in clinical trials, the authors assert.

"NUT midline carcinoma arises people of all ages, but predominantly in children and young adults," explained the study's senior co-author, James Bradner, MD, of Dana-Farber. "It usually originates in the chest, sometimes in the head or neck, and is often mistaken for other types of cancer. Traditional therapy involves surgery, radiation, and chemotherapy, but even in combination these approaches don't work well: most patients live only about nine and a half months after diagnosis. As we've learned more about the molecular basis of the disease, we've begun to be able to devise therapies against it."

The cause of the disease was discovered by Christopher French, MD, a senior author of the study from Brigham and Women's Hospital. It results from a "translocation" in which two genes from different chromosomes stick together and give rise to an abnormal, fused protein called BRD4-NUT. While Bradner and his colleagues have subsequently developed and studied compounds that target BRD4-NUT directly, the newly published study involves a more oblique approach.

Researchers discovered that BRD4-NUT causes cells to become cancerous by attaching to DNA's
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists devise targeted therapy strategy for rare form of childhood cancer
(Date:7/31/2015)... ... 01, 2015 , ... Super Bowl 50 will emanate from Levi’s Stadium in Santa ... year is the Super Bowl. In the two weeks that separate the conference championships and ... The 2016 Super Bowl game will mark the 50th time it has been held and ...
(Date:7/31/2015)... ... July 31, 2015 , ... The 2nd annual Ride to Fight On will ... October 3, 2015. The Ride to Fight On is a cycling fundraiser that benefits ... The West Clinic and The University of Tennessee Health Science Center. A health and ...
(Date:7/31/2015)... , ... July 31, 2015 , ... Coco Libre announced ... judges, media, and VIPs at the 2015 Vans US Open of Surfing, July 25 ... that can claim “no added sugar” on the market, is a natural choice given ...
(Date:7/31/2015)... ... 2015 , ... Well-known for its unique pastries and delicious confections, Pastry Palace, ... designs, making life just a little bit sweeter for newlyweds. A family-owned business, the ... orders one. , The bakery provides a full line of custom wedding cakes. Brides ...
(Date:7/31/2015)... ... 31, 2015 , ... Transfinder, a software company based in Schenectady, N.Y., achieved ... percent year-over-year for the first six months ended June 30, 2015 compared with the ... beat last year’s record-revenue mark of $10.4 million. , “We know what our customers ...
Breaking Medicine News(10 mins):Health News:Cheap 2016 Super Bowl Tickets at Levi's Stadium: Ticket Down Slashes Ticket Prices on Super Bowl 50 Tickets in Santa Clara, CA at Levi's Stadium 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:Coco Libre Brings Eco-conscious Hydration to Vans US Open of Surfing 2Health News:Pastry Palace of Las Vegas Announces It Is Now Offering Custom Wedding Cakes in Las Vegas 2Health News:Transfinder Closes First Half of 2015 with Record Revenue 2
... OTTAWA, May 19 /PRNewswire-FirstCall/ - MDS Nordion, a ... received information from its primary supplier, Atomic Energy ... the supply of medical isotopes, primarily molybdenum-99 (Mo-99) ... AECL has advised MDS Nordion that they anticipate ...
... and Chief Executive Officer Michael J. Ward has received ... support of Wounded Warrior Project (WWP).Ward, with a personal ... nation,s first Training and Rehabilitation Advocacy Center (TRACK), which ... to civilian lives. Ward,s personal donation is in addition ...
... Volcano,s Axsun Laser - At the Heart of OCTSAN ... (Nasdaq: VOLC ), a leader in the ... of coronary and peripheral artery disease, today highlights its ... Coherence Tomography (OCT) at the EuroPCR conference in Barcelona, ...
... Data from two presentations highlighting the use of ... severe chronic obstructive pulmonary disease (COPD) patients were ... American Thoracic Society in San Diego. In ... added to maintenance tiotropium, resulted in improved pulmonary ...
... line of universal CRT replacements for MRI, CT, ... other medical devices is now available from Medical ... can now extend equipment ROI and lower replacement ... medical grade displays to adapt and display the ...
... "Conversations from Penn State" will also air on the Big ... the face of modern warfare. "Emotionless warriors" and thought scans ... What are the medical and ethical ramifications of these innovations? ... Penn State . ...
Cached Medicine News:Health News:MDS Nordion Provides Update on AECL's Medical Isotope Supply Disruption 2Health News:MDS Nordion Provides Update on AECL's Medical Isotope Supply Disruption 3Health News:Michael Ward Cited for Support of Wounded Warrior Project 2Health News:Volcano Announces OCT Activities at EuroPCR 2009 2Health News:Volcano Announces OCT Activities at EuroPCR 2009 3Health News:Volcano Announces OCT Activities at EuroPCR 2009 4Health News:Perforomist(R) Inhalation Solution Data in Patients With Moderate to Severe COPD to Be Presented at the International Conference of the American Thoracic Society 2Health News:Perforomist(R) Inhalation Solution Data in Patients With Moderate to Severe COPD to Be Presented at the International Conference of the American Thoracic Society 3Health News:Perforomist(R) Inhalation Solution Data in Patients With Moderate to Severe COPD to Be Presented at the International Conference of the American Thoracic Society 4Health News:Perforomist(R) Inhalation Solution Data in Patients With Moderate to Severe COPD to Be Presented at the International Conference of the American Thoracic Society 5Health News:Perforomist(R) Inhalation Solution Data in Patients With Moderate to Severe COPD to Be Presented at the International Conference of the American Thoracic Society 6Health News:Perforomist(R) Inhalation Solution Data in Patients With Moderate to Severe COPD to Be Presented at the International Conference of the American Thoracic Society 7Health News:Universal CRT Replacement Gives New Life to Medical Equipment with Analog Video 2Health News:Universal CRT Replacement Gives New Life to Medical Equipment with Analog Video 3Health News:WPSU Debuts New Series; 1st Show Tackles Neuroscience and the Military 2
(Date:7/30/2015)... SAN DIEGO, July 30, 2015  ResMed Inc. (NYSE: ... ended June 30, 2015.  Revenue for the quarter was ... quarter ended June 30, 2014 (a 17 percent increase ... million, consistent with the quarter ended June 30, 2014. ... consistent with the quarter ended June 30, 2014.  ...
(Date:7/30/2015)... VANCOUVER , July 30, 2015  OncoGenex Pharmaceuticals, ... will report its second quarter 2015 financial results on ... conference call and live webcast at 4:30 p.m. Eastern ... development programs and a general corporate update. ... Investor Relations page of the OncoGenex website at ...
(Date:7/30/2015)... July 30, 2015  Cleveland Clinic President Wael ... address last month that industry is compelled to adopt ... gain the efficiencies—and develop the transformational innovations -- required ... comments were preceded by Doug Kohrs , past ... moderator, who stressed that industry must add "episode of ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16Orthopaedic Surgery Reimbursement Shifts to Episode of Care 2
... Mich., July 5, 2011 Allure Medical Spa released ... treatments and to help them visualize potential outcomes. "Many ... for the newest treatments," explains board certified cosmetic surgeon, ... a digital resource in the palm of their hands ...
... Spine, LLC, a medical device company focused on developing ... disc disease, today announced a 131% sales increase for ... and a 20% increase sequentially. These record results represent ... the company. RSB Spine Chief Executive Officer ...
Cached Medicine Technology:Cosmetic Surgery iPhone App Teaches and Amuses 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: