Navigation Links
Scientists develop vaccine that attacks breast cancer in mice
Date:12/12/2011

Athens, Ga.Researchers from the University of Georgia and the Mayo Clinic in Arizona have developed a vaccine that dramatically reduces tumors in a mouse model that mimics 90 percent of human breast and pancreatic cancer casesincluding those that are resistant to common treatments.

The vaccine, described this week in the early edition of the journal Proceedings of the National Academy of Sciences, reveals a promising new strategy for treating cancers that share the same distinct carbohydrate signature, including ovarian and colorectal cancers.

"This vaccine elicits a very strong immune response," said study co-senior author Geert-Jan Boons, Franklin Professor of Chemistry and a researcher in the UGA Cancer Center and its Complex Carbohydrate Research Center. "It activates all three components of the immune system to reduce tumor size by an average of 80 percent."

When cells become cancerous, the sugars on their surface proteins undergo distinct changes that set them apart from healthy cells. For decades, scientists have tried to enable the immune system to recognize those differences to destroy cancer cells rather than normal cells. But since cancer cells originate within the body, the immune system generally doesn't recognize them as foreign and therefore doesn't mount an attack.

The researchers used unique mice developed by Sandra Gendler, Grohne Professor of Therapeutics for Cancer Research at the Mayo Clinic in Arizona and co-senior author on the study. Like humans, the mice develop tumors that overexpress a protein known as MUC1 on the surface of their cells. The tumor-associated MUC1 protein is adorned with a distinctive, shorter, set of carbohydrates that set it apart from healthy cells.

"This is the first time that a vaccine has been developed that trains the immune system to distinguish and kill cancer cells based on their different sugar structures on proteins such as MUC1," Gendler said. "We a
'/>"/>

Contact: Sam Fahmy
sfahmy@uga.edu
706-542-6049
University of Georgia
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Scientists discover new way to target cancer
2. Survey reveals scientists have trouble accessing human embryonic stem cell lines
3. Scientists capture single cancer molecules at work
4. Scientists identify strategies to conquer lifestyle and genetic factors related to chronic diseases
5. Scientists discover likely cause of most common involuntary movement disorder
6. Scientists ID Gene That Predicts Chances of Cold Sores
7. Scientists discover anti-inflammatory polyphenols in apple peels
8. Scientists identify key area that could sever communication between brain and heart in disease
9. Scientists identify defect in brain cell channel that may cause autism-like syndrome
10. Scientists Reveal Monarch Butterfly Genome
11. Scripps Research scientists identify new class of antimalarial compounds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists develop vaccine that attacks breast cancer in mice
(Date:3/28/2015)... New York (PRWEB) March 28, 2015 ... ) involving devices manufactured by C.R. Bard, Inc. ... underway in U.S. District Court, Southern District of ... Grand, is serving on the Plaintiffs’ Steering Committee. ... the Court has granted certain defendants named in ...
(Date:3/28/2015)... Centurion Service Group will be hosting a live on-site ... their Las Vegas warehouse, located at 4606 Andrews St. Suite ... of equipment from hospitals and surgery centers from around the ... , Buyers will find items of all types including anesthesia, ... said Erik Tivin, CEO of Centurion. , Among the sale’s ...
(Date:3/28/2015)... NV (PRWEB) March 28, 2015 Early ... patients with Type V AC joint injuries, according to ... presented today at the American Orthopaedic Society for Sports ... returned to duty faster when surgery was not performed. ... with 7 receiving surgical treatment and 17 receiving non-surgical ...
(Date:3/28/2015)... March 28, 2015 Healthpointe’s otolaryngologists, medical ... and throat disorders, are now offering a wide ... issue which is characterized by the presence of phantom ... 5 people, tinnitus is a prevalent symptom that can ... it is non-fatal, tinnitus can impede a person’s quality ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 Servpro ... , this week released a report about the link ... of asthma sufferers, and according to recent medical research, ... , According to the Environmental Protection Agency, people with ... reactions. Breathing in mold may trigger asthma attacks for ...
Breaking Medicine News(10 mins):Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 2Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 3Health News:Federal C.R. Bard Vaginal Mesh Lawsuits Move Forward, As Court Grants Defense Motion to Amend Responses to Master Complaint 4Health News:Medical Equipment Auction to Take Place in North Las Vegas 2Health News:For Type V AC Joint Injuries, Early Surgery May Not Be the Best Approach 2Health News:Healthpointe now Offering Tinnitus Treatments in Clinics throughout Southern California 2Health News:Water Damage Restoration Specialists Servpro of Paso Robles Release Report on Mold and Asthma 2Health News:Water Damage Restoration Specialists Servpro of Paso Robles Release Report on Mold and Asthma 3
... Benefit Susan G. Komen for the Cure; $6.3 Million Raised to ... ... and television,personalities, professional athletes and other celebrities are teaming up,with American Airlines this ... Airlines Celebrity Golf and Tennis Weekend,Oct. 4-7 at the Four Seasons Resort Aviara ...
... Congressman Chaka Fattah,(D- PA) responds to the ... "The numbers just don,t add up. This ... war, but he won,t support $35 million to ... health insurance is vital to their,well being. Today,s ...
... received a five year, $5 million renewal grant from ... to provide financial and career support for 39 doctoral ... pre-dissertation doctoral students. This grant seeks to address the ... workers by supporting future aging-focused faculty who will ...
... Oct. 3 Immucor, Inc. (Nasdaq:,BLUD), a global ... transfusion industry, today reported financial results for the,fiscal ... for the fiscal first quarter was a record ... same period last year. Of the $12.6 million ...
... faculty member Rachel Jones has been selected to be the ... 2007 Tribute to Nurses Award. , The New York Times ... of candidates nominated by patients and their families, students and ... in the Dec. 2 New York Times Magazine. , ...
... uses CT scans and is performed without anesthesia , , ... supports the effectiveness of an innovative form of colonoscopy ... a patient,s colon. , When it comes to ... colonoscopy" is just as effective as the traditional approach ...
Cached Medicine News:Health News:American Airlines 13th Annual Celebrity Golf and Tennis Weekend Will Raise Funds to Fight Breast Cancer 2Health News:American Airlines 13th Annual Celebrity Golf and Tennis Weekend Will Raise Funds to Fight Breast Cancer 3Health News:Hartford Foundation awards grant to address geriatric social work shortage 2Health News:Immucor Announces Record Fiscal First Quarter Revenues 2Health News:Immucor Announces Record Fiscal First Quarter Revenues 3Health News:Immucor Announces Record Fiscal First Quarter Revenues 4Health News:Immucor Announces Record Fiscal First Quarter Revenues 5Health News:Immucor Announces Record Fiscal First Quarter Revenues 6Health News:Immucor Announces Record Fiscal First Quarter Revenues 7Health News:Immucor Announces Record Fiscal First Quarter Revenues 8Health News:Rutgers College of Nursing faculty member Rachel Jones wins New York Times Nurse Award 2Health News:'Virtual' Colonoscopy an Effective Option: Study 2Health News:'Virtual' Colonoscopy an Effective Option: Study 3
(Date:3/27/2015)... Quebec , March 27, 2015  Valeant Pharmaceuticals ... today the closing of its previously announced registered offering ... (the "Offering"). Pursuant to the Offering, the ... $199.00 per share, for aggregate gross proceeds of approximately ... with the U.S. Securities and Exchange Commission a final ...
(Date:3/27/2015)... MARLBOROUGH, Mass. , March 27, 2015 ... ) and privately-held MirImmune LLC, today announced ... license agreement to RXi,s novel and proprietary ... cell-based cancer immunotherapies. The collaboration has the ... and patient friendly cancer treatments that could ...
(Date:3/27/2015)... , March 27, 2015  WebMD Health ... source of health information, today announced an ... National Action Plan for Combating Antibiotic-Resistant ... emphasized the urgency and importance of addressing ... and global health.    The WebMD ...
Breaking Medicine Technology:Valeant Pharmaceuticals Closes Offering Of $1.45 Billion Of Common Shares 2Valeant Pharmaceuticals Closes Offering Of $1.45 Billion Of Common Shares 3RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 2RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 3RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 4RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 5Exclusive: WebMD Interviews President Obama About Plan for Combating Antibiotic Resistance 2Exclusive: WebMD Interviews President Obama About Plan for Combating Antibiotic Resistance 3
... , MALVERN, Pa., Dec. 14 Fujirebio ... Company of the Year by the Eastern Technology Council at ... on Thursday, December 3, 2009. , The Eastern ... sciences trade association. Known as "The Academy Awards" of the ...
... , , WASHINGTON, Dec. 14 Following is ... Consumer Healthcare Products Association (CHPA), regarding today,s release of the ... , "Findings released today on this year,s Monitoring the Future ... and empower parents with the information they need to talk ...
Cached Medicine Technology:Fujirebio Diagnostics Named Life Sciences Company of the Year 2Statement From the Consumer Healthcare Products Association(CHPA) on Annual Monitoring the Future Survey on Drug Abuse 2Statement From the Consumer Healthcare Products Association(CHPA) on Annual Monitoring the Future Survey on Drug Abuse 3
... The many benefits of fibre bronchoscopy: The ... by which all other fibre bronchoscopes are ... bronchoscopes from PENTAX, including the FB-19TV, FB-18V ... slim FB-10V and the pediatric FB-8V, offer ...
... many benefits of fibre bronchoscopy: The HF-compatible ... which all other fibre bronchoscopes are measured., ... from PENTAX, including the FB-19TV, FB-18V and ... FB-10V and the pediatric FB-8V, offer much ...
... benefits of fibre bronchoscopy: The HF-compatible V ... all other fibre bronchoscopes are measured., ... PENTAX, including the FB-19TV, FB-18V and FB-15V ... and the pediatric FB-8V, offer much better ...
... fiberoptic bronchoscopes offers a ... with a slim outside ... allows for improved suction ... cytology brushes. The scope ...
Medicine Products: