Navigation Links
Scientists develop the first model for investigating the origins of testicular cancer in humans
Date:8/3/2010

s gestation. The women gave consent in accordance with national guidelines. None of the terminations were related to foetal abnormalities.

Testicular tissue cannot be studied in a test tube because it does not survive and develop normally. So the researchers grafted the tissue under the skin of a naturally occurring strain of mice that do not reject tissue grafts because their immune systems do not work normally.

"We found that the testicular graft grows and develops normally over a six-week period; in particular, the foetal germ cells develop normally," said Prof Sharpe. "This means that we have developed a viable system in which we can now test what factors might interfere with this normal germ cell development and push it down the cancer path. For example, we are investigating if exposure to common environmental chemicals, to which human foetuses are exposed in the womb, can cause any such changes in the foetal testis grafts by treating the mouse hosts with these chemicals, an aspect that simply cannot be studied otherwise."

The mouse model may also enable the researchers to study disorders of sexual development (DSDs) in humans, which occur because of abnormal testis development. "DSDs can result from genetic abnormalities involving the sex chromosomes or genes involved in the development of the testes and several of these disorders, such as Frasier or Denys-Drash syndrome [2], are also associated with a high risk of TGCC," said Prof Sharpe. "In the future, it should be possible to modify our mouse model so that we can introduce genes that either promote or disrupt normal testicular development and so provide a living model of these conditions. This, in turn, should help us to develop treatments or early interventions for these disorders."


'/>"/>

Contact: Emma Mason
wordmason@mac.com
European Society of Human Reproduction and Embryology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2014)... One of the most recent dietary trends ... diet. Originally meant for sufferers of gluten intolerance and celiac ... who are looking to get healthier by simply consuming foods ... kind of information erroneous, it also exposes those same consumers ... a drastic change in their food consumption habits. ...
(Date:8/30/2014)... The new review published by Daily Gossip reveals that the ... wanted to make her guide accessible to sufferers from all ... to find in the form of an eBook, which is ... the new method shares all her tips and recommendations for ... review that the leaky gut syndrome can be an extremely ...
(Date:8/30/2014)... (PRWEB) August 30, 2014 August 28th, ... shoulder pain in our society and the toll that ... costs, it’s vital that continuing education for physical therapists ... to help physical therapists help others, Hands-On Seminars is ... , Three learning styles are available to ...
(Date:8/30/2014)... Ms. Meriwether’s striking beauty is not all that ... impressive resume to boost. Nana is best known for ... she’s also a two time All American UCLA volleyball player ... the 2008 Olympics and played professional volleyball as well. ... from Potomac, Maryland is a two-time, All American athlete; she ...
(Date:8/30/2014)... 2014 When a prominent bank reveals a ... on Wednesday, August 27th, when news began surfacing about the ... & Co and at least one other bank. But ... investigating attacks on seven prominent banks , everyone starts thinking ... and the buzz quickly goes viral. Bloomberg followed up ...
Breaking Medicine News(10 mins):Health News:“What is Gluten: Three Things You Need to Know Before Adopting a Gluten-Free Diet” Reveals What Readers Need to Know About the Benefits of a Strict Gluten Diet - Vinamy 2Health News:Leaky Gut Cure Review Reveals Unique Method to Stop Chronic Symptoms 2Health News:Leader in Manual Therapy Continuing Education Makes it Easier for Physical Therapists to Improve Results on Patients 2Health News:NJ Top Dentists Announces Cover Model for the Healthy Living: Top Dentists Issue 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 2Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 3Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 4Health News:Big Name Bank Hacks Highlight the Importance of Regular Testing and Effective Emergency Response 5
... 10 The Council for American Medical Innovation today ... Collins to head the National Institutes of Health (NIH). ... ) , , "Dr. Collins is ... pioneer in medical innovation," said Council President Dick Gephardt. ...
... July 10 Americans United for Life (AUL) announced today ... called to testify at the confirmation hearings for Judge Sonia ... AUL President Charmaine Yoest said "We are honored to have ... nomination of Judge Sotomayor to the highest court in the ...
... Germany, July 10 The supervisory board of Celesio ... per cent in pharmaceutical wholesaler Panpharma. This step into ... world-wide is part of Celesio,s growth strategy. Celesio doesn,t ... , Celesio spent about two years thoroughly analysing ...
... Healthy reaction to mental stress not seen in those with ... News) -- Anger and other forms of mental stress cause ... blood to the brain in healthy people, but this doesn,t ... finding of U.S. researchers who used ultrasound imaging to monitor ...
... months of protests, media coverage and online uproar, Oscar ... mental health organization, and Kipp Berdiansky, co-owner of the ... to discuss mental illness, the associated stigma and the ... Berdiansky and Jordan Zweigoron opened Psycho Donuts in March ...
... Aegis of Granada Hills has been named "Best Assisted Living Facility" ... annual Readers Choice Awards. This is the second year in a ... In voting, Aegis was a write-in candidate and received more ... area to gain top status. , , "We ...
Cached Medicine News:Health News:Council for American Medical Innovation Applauds Appointment of Geneticist Francis Collins to Head National Institutes of Health 2Health News:Americans United for Life President to Testify at Sotomayor Senate Judiciary Hearing 2Health News:Celesio Acquires Majority Stake in Number One Brazilian Pharmaceutical Wholesaler Panpharma 2Health News:Blood Rush to the Brain When Angry Is a Good Sign 2Health News:There Is No Way to Sugar Coat These Donuts 2
(Date:8/29/2014)... , Aug. 29, 2014  Abaxis, Inc. (NasdaqGS: ... blood instrumentation and consumables to the medical, research and ... Chairman and Chief Executive Officer, will present at the ... 2014 on Tuesday, September 9, 2014 at 12:30 p.m. ... Berkshire Place Hotel in New York City ...
(Date:8/29/2014)... , August 29, 2014 ... and collaboration software has announced a major new deal ... founded by renowned pathology expert, Dr. Marius Nap ... of the 26th European Congress of Pathology which is ... the ExCeL Arena, London where ...
(Date:8/29/2014)... ANDOVER, Mass. , Aug. ...  (NYSE: PHG ... at the  European Society of ... company is highlighting the full range of its cardiology solutions ... the care continuum from prevention and ...
Breaking Medicine Technology:Abaxis, Inc. to Present at CL King's 12th Annual Best Ideas Conference 2014 2Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 2Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 3Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 4Philips Spotlights New Cardiology Solutions and Unveils Ultrasound Technology at European Society of Cardiology Congress 2014 5
... Jan. 28, 2011 Drug safety remains front and ... the agency strives to improve the public,s perception of ... improving its reputation among consumers and recognizes that its ... important role in that effort. One issue ...
... Burg Simpson Eldredge Hersh & Jardine, P.C., one of the ... that shareholder, Seth. A. Katz, has been appointed by the ... the Plaintiffs, Steering Committee in the multidistrict litigation against DePuy Orthopaedics, ... Hip System. In August 2010, DePuy Orthopaedics, Inc., ...
Cached Medicine Technology:Navigating the Gray Areas of Post-Marketing Surveillance 2Burg Simpson Leads National Litigation Against DePuy Orthopaedics, Inc. 2
... contains primers and a FAM-labeled probe that ... gene. In addition, this ASR contains primers, ... internal control sequence. This ASR requires an ... Red reporter dyes such as the Cepheid ...
...
Reptilase-Time from Bothrops atrox...
Thrombin Activatable Fibrinolysis Inhibitor Assay Kit...
Medicine Products: