Navigation Links
Scientists develop the first model for investigating the origins of testicular cancer in humans
Date:8/3/2010

Scientists have developed a model that will enable them to investigate, for the first time, how human testes develop in baby boys while they are in the womb. Until now it has been impossible to study testicular development during pregnancy in humans and this discovery will enable researchers to understand the processes that can lead to the onset of testicular germ cell cancer (TGCC) in young adult life, and how factors, such as common environmental chemicals, might play a role.

The research was carried out by Dr Rod Mitchell, clinical research fellow at the UK's Medical Research Council's Human Reproductive Sciences Unit at the University of Edinburgh, and is published online in Europe's leading reproductive medicine journal Human Reproduction [1] today (Wednesday 4 August).

Principal Investigator at the unit, Professor Richard Sharpe said: "There is now overwhelming evidence that growth and development in foetal life play a fundamental role in determining the future risk of a wide range of common diseases in later life. Male reproductive disorders fall into this category, in particular testicular germ cell cancer, the commonest cancer of young men in their 20s and 30s. We know it originates because of abnormal foetal germ cell development and this then leads to tumour formation in young adulthood, but how and why things go wrong with development of some of the germ cells in foetal life is unknown and inaccessible for direct study for obvious reasons."

The types of TGCC that occur in humans do not occur in laboratory animals, probably because of differences between humans and animals in the timing and organisation of foetal germ cell development. Therefore, using animal models to study TGCC origins is not possible.

For this reason and because there was no other option available, the researchers obtained ethical approval to take testicular tissue from foetuses that had been aborted at nine weeks and between 14-18 week
'/>"/>

Contact: Emma Mason
wordmason@mac.com
European Society of Human Reproduction and Embryology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Autocarinsurancebest.com has released a new blog post explaining the ... . , Auto insurance quotes help many drivers find ... necessary to call an agent or visit an agency for ... single website: http://autocarinsurancebest.com/ . , Every business who relies ...
(Date:1/22/2015)... 2015 Joan Lunden, award-winning American journalist, ... the upcoming 32nd Annual Miami Breast Cancer Conference ... Resource®, LLC (PER®) , shares that “a fast-growing, virulent” ... if she had not followed up her clean mammogram ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 Recently, Weddingshe.com has ... catalog, and has announced its highest annual revenues in the ... on its popular glamorous wedding dresses. , According to the ... important wedding dress promotions for them in 2015. This point ...
(Date:1/22/2015)... 22, 2015 Payday lending practices in ... and cause financial distress to the states that permit ... Howard University’s Center on Race and Wealth. , While ... activity, payday loans at the same time substantially depress ...
(Date:1/22/2015)... 2015 JJsHouse.com is a famous dress online ... business announces its latest collection of wedding dresses , ... important issue is the wedding dress on your big day; ... woman’s life. Every bride wants to find the most suitable ...
Breaking Medicine News(10 mins):Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... Citrix, Dell, Intel, Intuit, Microsoft Corp., and Nuance; ... 14 Allscripts today announced the formation of ... partnering to educate 500,000 U.S. physicians about opportunities ... (ARRA) of 2009. The Act details President ...
... 20 Times Stronger,* Advanced Ribbon Dressing Features Hydrofiber(R) ... developer and marketer of innovative medical technologies for ... of AQUACEL(R) Ag Dressing with Strengthening Fiber, a ... Up to 20 times stronger than the original ...
... , inc. (Nasdaq: DSCM ), a ... pharmacy products, today announced that Dawn Lepore, chief ... Tracy Wright, chief finance officer, will be presenting ... http://www.newscom.com/cgi-bin/prnh/20070813/AQM043LOGO )The drugstore.com(TM) presentation will take place ...
... Nile Therapeutics, Inc. (Nasdaq: NLTX ), ... heart failure patients, today announced its first quarter financial results ... the US Food and Drug Administration (FDA) had placed all ... hold. In a letter sent to Nile, and in a ...
... include spring dedication at the Huntsville Botanical Garden ... the Huntsville Botanical Garden once again partnered to ... Garden of Hope spring dedication. The honorees, their ... community convened to celebrate life at this inspirational ...
... atrial fibrillation , , WEDNESDAY, May 13 (HealthDay News) -- ... fibrillation, a cause of stroke, even though blacks have ... blood pressure, new research shows. , About 2.2 ... which the two upper chambers, or atria, quiver chaotically ...
Cached Medicine News:Health News:Leading Healthcare Technology Companies Launch National Physician Education Program on Stimulus and Electronic Health Records 2Health News:Leading Healthcare Technology Companies Launch National Physician Education Program on Stimulus and Electronic Health Records 3Health News:Leading Healthcare Technology Companies Launch National Physician Education Program on Stimulus and Electronic Health Records 4Health News:Leading Healthcare Technology Companies Launch National Physician Education Program on Stimulus and Electronic Health Records 5Health News:Leading Healthcare Technology Companies Launch National Physician Education Program on Stimulus and Electronic Health Records 6Health News:Leading Healthcare Technology Companies Launch National Physician Education Program on Stimulus and Electronic Health Records 7Health News:Leading Healthcare Technology Companies Launch National Physician Education Program on Stimulus and Electronic Health Records 8Health News:Leading Healthcare Technology Companies Launch National Physician Education Program on Stimulus and Electronic Health Records 9Health News:Leading Healthcare Technology Companies Launch National Physician Education Program on Stimulus and Electronic Health Records 10Health News:ConvaTec Launches New AQUACEL(R) Ag Dressing with Strengthening Fiber 2Health News:ConvaTec Launches New AQUACEL(R) Ag Dressing with Strengthening Fiber 3Health News:ConvaTec Launches New AQUACEL(R) Ag Dressing with Strengthening Fiber 4Health News:ConvaTec Launches New AQUACEL(R) Ag Dressing with Strengthening Fiber 5Health News:drugstore.com, inc. to Present at the Upcoming JMP Securities Research Conference 2Health News:Nile Therapeutics Reports 2009 First Quarter Financial Results 2Health News:Nile Therapeutics Reports 2009 First Quarter Financial Results 3Health News:Nile Therapeutics Reports 2009 First Quarter Financial Results 4Health News:Courageous Cancer Survivors Honored at Intergraph(R) Garden of Hope 2Health News:Courageous Cancer Survivors Honored at Intergraph(R) Garden of Hope 3Health News:Courageous Cancer Survivors Honored at Intergraph(R) Garden of Hope 4Health News:Courageous Cancer Survivors Honored at Intergraph(R) Garden of Hope 5Health News:Courageous Cancer Survivors Honored at Intergraph(R) Garden of Hope 6Health News:Courageous Cancer Survivors Honored at Intergraph(R) Garden of Hope 7Health News:Risk Factor for Stroke More Common Among Whites 2
(Date:1/22/2015)... Jan. 22, 2015  BiOptix is pleased to announce the ... President of Chemistry and Biochemistry. Scott joins the company after ... and Amgen throughout the course of his nearly 20 ... "Scott is a nationally recognized thought leader in the ...
(Date:1/22/2015)... (NYSE: RMD ) today announced results for its ... $423.0 million, a 10 percent increase compared to the quarter ... constant currency basis). Net income was $91.2 million, an increase ... 2013. Diluted earnings per share for the quarter were $0.64, ...
(Date:1/22/2015)... OAKS, Calif. , Jan. 22, 2015  Amgen (NASDAQ: ... and full year 2014 financial results on Tuesday, Jan. 27, 2015, ... be followed by a conference call with the investment community at ... Robert A. Bradway , chairman and chief executive officer, and ...
Breaking Medicine Technology:BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2
The Marco Encore Chair continues the Marco tradition of useful features and unsurpassed quality. Its attractive, modern look blends beautifully with any office decore....
The Marco E-Z Tilt Chair combines the most simplified manual reclining motion with a new modern, sophisticated appearance....
... the Marco Keratometer I and ... instruments for objectively measuring corneal ... the added feature of internal ... or those who prefer to ...
... Bulb Direct has been ... Internet since 1996, and we ... 100% satisfaction guarantee. Check out ... and see our discount light ...
Medicine Products: