Navigation Links
Scientists develop powerful new animal model for metastatic prostate cancer
Date:1/24/2014

Cold Spring Harbor, NY Prostate cancer is the most common form of cancer in men. Affecting about 1 in 6 men, it is the second deadliest cancer. Research has been stymied by imperfect animal models of the disease, which are costly, take considerable time to develop, and fail to mimic the most lethal aspects of the illness. Now, Cold Spring Harbor Laboratory (CSHL) scientists have developed a new method to rapidly create much better mouse models for metastatic prostate cancer. This discovery allows scientists to investigate the causes of the disease while at the same time testing new therapeutics to treat it.

The most widely used mouse models for prostate cancer rarely develop tumors that metastasize, making it almost impossible to study the terminal, lethal events in cancer progression. In work published today in Cancer Discovery, a CSHL team led by Associate Professor Lloyd Trotman report that they have developed a new mouse model that does generate metastases from primary prostate tumors. To create the model, called RapidCaP, scientists surgically deliver gene mutations directly into the prostate. A luminescent marker is also injected, which enables live monitoring of metastasis, tumor regression after treatment, and disease relapse.

Trotman and his team, which included collaborators from Weill Cornell Medical College, Mt. Sinai School of Medicine and the Dana-Farber Cancer Institute, used RapidCaP to generate mice that developed metastatic prostate cancer with classic hallmarks of this disease, including resistance to hormone therapy. However, PI 3-kinase activity, a well-known driver of prostate cancer, was notably absent from the metastasized tumors. In these deadly dispersed tumors, Trotman and his colleagues were surprised to find that a different cancer gene, called Myc, had taken over.

The team explored Myc's role in metastasis. They found that prostate tumors could be driven to metastasize simply by increasing the amount of Myc protein. Trotman collaborated with Dana-Farber's Professor James Bradner to treat these very sick animals with a newly discovered drug called JQ1 that lowers the amount of Myc in cells. Their approach succeeded in shrinking the metastases, suggesting that the switch to Myc is required for maintenance of tumor cells that have metastasized throughout the body.

"The RapidCaP system has revealed a specific role for Myc as a druggable driver of metastasis in prostate cancer," says Trotman. "So there's hope that our model provides a fast and faithful test-bed for developing new approaches to cure the type of prostate cancer that today is incurable."


'/>"/>

Contact: Jaclyn Jansen
jjansen@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert  

Related medicine news :

1. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
2. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
3. NCCS scientists discover gene regulation is dependent on protein ANP32E
4. Scientists make your stomach turn bright green if you have an ulcer
5. Scientists reduce protein crystal damage, improve pharmaceutical development
6. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
7. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
8. Scientists discover that short-term energy deficits increase factors related to muscle degradation
9. CNIO scientists create the first large catalog of interactions between drugs and proteins
10. Over 70 new centers to train tomorrows engineers and scientists
11. Scientists Agree: Sleep Less, Get Fat
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists develop powerful new animal model for metastatic prostate cancer
(Date:8/22/2017)... (PRWEB) , ... August 22, 2017 , ... “To Walk ... radioman on a B17 bomber named Edward Koontz. “To Walk Away” is the creation ... Scranton, who has published over two hundred manuscripts in chemistry and religion, as well ...
(Date:8/22/2017)... ... 2017 , ... “Without Love’s Beauty and Pleasures Life Does ... faced while hoping for a better life. “Without Love’s Beauty and Pleasures Life ... spent 13 years working with deprived/neglected adolescents and almost 20 years working with ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Glimpses Of Light”: is ... world. “Glimpses Of Light” is the creation of published author, J.M. Shepherd, a writer, ... of answers to life’s perplexing mysteries. , Shepherd shares, “Love is one of the ...
(Date:8/22/2017)... ... August 22, 2017 , ... TopConsumerReviews.com recently gave a best-in-class 5-star ... . , As the stress of modern life continually makes more demands on time ... of artificial stimulants can trap people in vicious high/low cycles and can also cause ...
(Date:8/22/2017)... Hammond, Indiana (PRWEB) , ... August 22, 2017 , ... ... the Fourth of July, many communities have begun providing weekend displays, and numerous households ... for most humans, they can be downright terrifying for pets. , Kris Zambo, ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... 2017  AOTI Inc. announced today that its fully owned ... opened a New York City Office in Yonkers, New ... Topical Wound Oxygen (TWO 2 ) homecare therapy. This new East ... Health Care (ACHC) under the company,s DMEPOS accreditation for Home/Durable Medical ... Advanced Oxygen ...
(Date:8/10/2017)... Aug. 10, 2017  Physical Rehabilitation Network (PRN), acquired the ... Lakewood, Colorado . The reputable clinic will continue ... PT, DPT with his staff of four clinicians. Lipkin received ... and brings over 10 years of experience with a strong ... Belmar PT marks the 10th PRN clinic in and around the ...
(Date:8/7/2017)... 2017 Insightin Health, provider of data-driven ... engagement, announced the selection of Michael Wood ... effective as of February 2017. In this role, Wood ... for our clients. Wood brings with him more ... business analytics within the healthcare industry. Wood formerly ...
Breaking Medicine Technology: