Navigation Links
Scientists develop powerful new animal model for metastatic prostate cancer
Date:1/24/2014

Cold Spring Harbor, NY Prostate cancer is the most common form of cancer in men. Affecting about 1 in 6 men, it is the second deadliest cancer. Research has been stymied by imperfect animal models of the disease, which are costly, take considerable time to develop, and fail to mimic the most lethal aspects of the illness. Now, Cold Spring Harbor Laboratory (CSHL) scientists have developed a new method to rapidly create much better mouse models for metastatic prostate cancer. This discovery allows scientists to investigate the causes of the disease while at the same time testing new therapeutics to treat it.

The most widely used mouse models for prostate cancer rarely develop tumors that metastasize, making it almost impossible to study the terminal, lethal events in cancer progression. In work published today in Cancer Discovery, a CSHL team led by Associate Professor Lloyd Trotman report that they have developed a new mouse model that does generate metastases from primary prostate tumors. To create the model, called RapidCaP, scientists surgically deliver gene mutations directly into the prostate. A luminescent marker is also injected, which enables live monitoring of metastasis, tumor regression after treatment, and disease relapse.

Trotman and his team, which included collaborators from Weill Cornell Medical College, Mt. Sinai School of Medicine and the Dana-Farber Cancer Institute, used RapidCaP to generate mice that developed metastatic prostate cancer with classic hallmarks of this disease, including resistance to hormone therapy. However, PI 3-kinase activity, a well-known driver of prostate cancer, was notably absent from the metastasized tumors. In these deadly dispersed tumors, Trotman and his colleagues were surprised to find that a different cancer gene, called Myc, had taken over.

The team explored Myc's role in metastasis. They found that prostate tumors could be driven to metastasize simply by inc
'/>"/>

Contact: Jaclyn Jansen
jjansen@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. NIH scientists map gene changes driving tumors in common pediatric soft-tissue cancer
2. Scripps Florida scientists find regulator of amyloid plaque buildup in Alzheimers disease
3. NCCS scientists discover gene regulation is dependent on protein ANP32E
4. Scientists make your stomach turn bright green if you have an ulcer
5. Scientists reduce protein crystal damage, improve pharmaceutical development
6. It's All In The Climate: New Study from Research Scientists at Florida International University Predict
7. Surviving ovarian cancer: Rutgers scientists attack drug resistant cancer cells
8. Scientists discover that short-term energy deficits increase factors related to muscle degradation
9. CNIO scientists create the first large catalog of interactions between drugs and proteins
10. Over 70 new centers to train tomorrows engineers and scientists
11. Scientists Agree: Sleep Less, Get Fat
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists develop powerful new animal model for metastatic prostate cancer
(Date:9/21/2014)... (PRWEB) September 21, 2014 According to latest ... the highest birth rate since 1966 (10.5 births per 1,000 ... their early 40s has risen steadily by 2 percent per ... births to women aged 50 and over) also rose, the ... there were more than nine times as many first births ...
(Date:9/20/2014)... Recently, iFitDress.com, a well-known wedding dress manufacturer and ... dresses . In addition, the company has launched a special ... promotion is to benefit all of its big fans. Worldwide ... now. , Along with beautiful party dresses, the company ... recently released its new sexy short prom outfits and purple ...
(Date:9/20/2014)... (PRWEB) September 21, 2014 Diabetes ... Kenneth Pullman that is helping thousands of people learn ... symptoms without shots, pills, or prescriptions has caught the ... , “There are currently tens of millions of people ... 1 and Type 2 diabetes, and unfortunately, big pharma ...
(Date:9/20/2014)... Las Vegas, NV (PRWEB) September 21, 2014 ... and method created by fitness expert Craig Ballantyne that is ... boost their metabolism and blast away stubborn body fat using ... the attention of Shane Michaels, prompting an investigative review. ... equation isn’t always calories in vs. calories out for all ...
(Date:9/20/2014)... (PRWEB) September 20, 2014 The Villa ... Villa del Palmar Cabo San Lucas, Villa La Estancia ... to Hurricane Odile, with plans to welcome guests back ... As of Sept. 19, all members and guests of ... thanks to a coordinated effort with government authorities. ...
Breaking Medicine News(10 mins):Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 2Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 3Health News:Statistics Reveal That the Number of 'Older' First-Time Mothers Is Growing 4Health News:Beautiful Party Dresses For Autumn Unveiled By iFitDress.com 2Health News:Diabetes Protocol: Review Exposes Kenneth Pullman’s Breakthrough Discovery About Diabetes Management 2Health News:6 Minutes to Skinny: Review Exposes Craig Ballantyne’s Method to Jump Starting the Metabolism and Blasting Away Body Fat in Just 6 Minutes Per Day 2Health News:Villa Group Resorts in Cabo Largely Unharmed, Plan to Re-open Early October 2
... the practice of using duct tape a strong wide adhesive ... up on skin of hands or feet in schoolchildren. ... the popularly attested belief that duct tape is helpful in ... Contrary to popular belief the duct tape only works slightly ...
... rise in the number of tuberculosis cases in Britain, ... official figures reveal. ,The largest increase was ... 4,696 in 2004 to 5,310 in 2005, figures from ... of the Respiratory Diseases Department at the Agency, said: ...
... Arcelor Mittal, announcing Monday that he is to become the ... ,The move reverses a previous plan when former Arcelor chief ... combined group, shortly after Arcelor agreed to a 22 billion ... ,But in a new restructuring proposal issued with ...
... achieving a healthy mind as well as a health body. This ... ,The November issue of Mayo Clinic Women's HealthSource offers an ... its roots in in ancient India and is today broadly understood ... yoga have evolved over the centuries. While some focus more on ...
... major cause of death in the Intensive Care Unit (ICU) ... of central nervous system// and cardiovascular system. The study also ... patients who are out of the ICU but still in ... ,This study is published in the journal Critical Care. ...
... A new dryer that is capable of eliminating parasites that ... hair with a single half hour treatment is much more ... dryer capable of drying up lice and their eggs blows ... regular hair dryer has been christened Louse Buster by the ...
Cached Medicine News:Health News:TB Cases On The Rise Among British Asians 2Health News:Lice now dried to death by novel dryer 2
(Date:9/20/2014)... OTTAWA , Sept. 20, 2014 /CNW/ - The issue: ... voluntarily recalling all lots of its Mylan-Nitro Spray 0.4 mg/metered ... is part of the pump component. A ... delivery of nitroglycerin to the patient. This defect may lead ... fact they are unable to access it. Not receiving nitroglycerin ...
(Date:9/19/2014)... HILL, N.C. , Sept. 19, 2014 /PRNewswire/ ... role in forging relationships with key opinion leaders ... market and competition. Despite the critical nature of ... created many challenges, including altering the landscape for ... According to research, the oversight responsibility ...
(Date:9/19/2014)... , Sept. 19, 2014 Harwood Feffer LLP ... board of directors of PDL BioPharma, Inc. ("PDL" or ... the board has breached its fiduciary duties to shareholders ... September 16, 2014, the Company disclosed: "On September 11, ... accounting firm, Ernst & Young LLP ("EY"), that it ...
Breaking Medicine Technology:Advisory - Mylan Pharmaceuticals recalling nitroglycerin spray due to defective pump 2Role of Medical Science Liaisons Shifting in Healthcare Industry 2Harwood Feffer LLP Announces Investigation of PDL BioPharma, Inc. 2
...
LASIK Retreatment Forceps - Also available in Titanium...
To enter, dissect, elevate and smooth the flap. Combined features of Spatula, Dissector and Forceps. - Also available in Titanium...
The CGPL capsulotomy contact glass was designed by Riquin, Fankhauser et al. for the dissection of opacified posterior lens capsules and membranes in the pupillary and retropupillary space with the Y...
Medicine Products: