Navigation Links
Scientists develop method to identify fleetingly ordered protein structures
Date:2/8/2011

LA JOLLA, CA February 8, 2011 - A team of scientists from The Scripps Research Institute and the University of California, San Diego (UCSD) have developed a novel technique to observe previously unknown details of how folded structures are formed from an intrinsically disordered protein. The insights could help scientists to better understand the mechanism of plaque formation in neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

The results of the study, which has broad implications for the field, were recently published in an advanced, online issue of the journal Nature Methods.

The new technique allows previously unheard-of rapid detectionin less than 0.001 secondsof transiently folded single-molecule structures from a class of often-amorphous molecules known as "intrinsically disordered proteins." The method also permits new types of observations of short-lived protein complexes.

"This exciting new technique allowed us to visualize multiple short-lived folded states," said Scripps Research Associate Professor Ashok Deniz, Ph.D., who led the study with UCSD Professor Alex Groisman, Ph.D., and Yann Gambin, Ph.D., of Scripps Research. "Further, better understanding of complexity during folding may offer more ways to regulate this interesting class of proteins."

The specific protein examined in the study was -synuclein, which is highly concentrated in neural tissue. The protein has been implicated in Parkinson's and Alzheimer's diseases, as it is found in high concentrations in aggregates from the brains of patients with these conditions.

Mixing It Up

Unlike typical proteins in the cell, intrinsically disordered proteins such as -synuclein do not adopt a stable globular form in isolation. Rather, intrinsically disordered proteins are like a messy, unfolded string of yarn, whereas typical globular proteins more closely resemble yarn neatly knit into compli
'/>"/>

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute
Source:Eurekalert

0

GOOD

Page: 1 2 3 4

Related medicine news :

1. Scripps Research scientists develop powerful new methodology for stabilizing proteins
2. Princeton scientists discover mechanism involved in breast cancers spread to bone
3. Scientists Discover Rare Vascular Disease
4. Scientists ID Genetic Clues to Parkinsons
5. Southampton scientists begin patient trials of new leukemia cancer vaccine
6. Scientists find key protein that suppresses prostate cancer growth in the laboratory
7. Victor Chang scientists unlock the gates on sudden cardiac death
8. Johns Hopkins scientists crack genetic code for form of pancreatic cancer
9. Scientists find industrial pollutants in Eastern Lake Erie carp
10. Scripps Research scientists find measles natural nemesis
11. Scientists Map Key Structure HIV Uses to Infect Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... May 24, 2013 Fit Yummy Mummy, ... busy mothers who are trying to get rid of ... and is ideal for women who want to combine ... http://HealthAvenger.com ’s Stan Stevenson, prompting an investigative review. ... that contains a wide variety of motivational strategies, nutritional ...
(Date:5/24/2013)... May 24, 2013 Residents of San ... boot camp classes. Fitness expert, and Certified Russian Kettlebell ... Kettlebell X Bootcamps in San Diego, California. The classes ... different class times offered. Initial sign-ups are available ... “I’ve been teaching Kettlebell for years. The bootcamps ...
(Date:5/24/2013)... New York, NY (PRWEB) May 24, 2013 ... nutrition school, is happy to announce that it has donated ... that supports the women held captive in Cleveland, Ohio. , ... Gina de Jesus, Michelle Knight, and Amanda Berry and her ... captive for a decade, we were shocked and horrified,” said ...
(Date:5/24/2013)... Ohio (PRWEB) May 24, 2013 DiscountHumidifiers.com, ... the launch of the new Broksonic line ... an array of color options with two styles to ... gives the appearance of a modern accent piece – ... silent operation and artful styling makes it an inconspicuous ...
(Date:5/24/2013)... 2013 General Data Company Inc., ... tracking and data management products and solutions, has ... Inc., (TBS) of Durham, North Carolina, a leading ... for the clinical and research pathology marketplace. TBS ... which provides specialty products and solutions to hospitals, ...
Breaking Medicine News(10 mins):Health News:Fit Yummy Mummy: Review Examining Holly Rigsby’s Fitness Program Released 2Health News:Integrative Nutrition Donates $10,000 to the Cleveland Courage Fund 2Health News:DiscountHumidifiers.com Announces the Launch of the New Broksonic Humidifiers to their Online Store 2Health News:General Data Acquires Triangle Biomedical Sciences 2Health News:General Data Acquires Triangle Biomedical Sciences 3
... , , NEW YORK, Aug. 10 ... exclusive commercialisation rights to Daxas((R)) in the United States in treatment of symptomatic ... plus significant milestones and royalties , Daxas filed for ... , Access to Forest Laboratories, 2,700-strong US sales force ...
... , , UNION ... ABAX ), a medical products company manufacturing point-of-care blood analysis ... the appointment of Brenton Hanlon to the position of vice ... Mr. Hanlon, a member of the Abaxis Board of Directors ...
... BETHESDA, Md., Aug. 10 /PRNewswire-Asia/ -- Chindex International, ... American provider of Western,healthcare products and services in the ... into two new exclusive, multi-year distribution,agreements for China with ... Biotest AG, based in Dreieich, Germany (SDAX: BIO3), ...
... ... selling author Mary Shomon , ... Joplin, MO (PRWEB) August 10, 2009 -- MyMedLab, Inc. today announced the ... Medicine" series. The author chosen to pilot the first release is nationally-known thyroid patient ...
... ... ... 2009 -- Tucson, Arizona is home to a dense Hispanic population. In recognition of ... spreading the word throughout the local Hispanic community that colorectal pre-screening can save lives., ...
... the place of amputation for bone and soft tissue sarcomas ... much or even any additional benefit to patients according to ... 2009 issue of Cancer , a peer-reviewed journal of ... rethink the pros and cons of limb-sparing surgery and amputation. ...
Cached Medicine News:Health News:Nycomed and Forest Laboratories to Collaborate on US Commercialisation of Daxas(R) in COPD 2Health News:Nycomed and Forest Laboratories to Collaborate on US Commercialisation of Daxas(R) in COPD 3Health News:Nycomed and Forest Laboratories to Collaborate on US Commercialisation of Daxas(R) in COPD 4Health News:Nycomed and Forest Laboratories to Collaborate on US Commercialisation of Daxas(R) in COPD 5Health News:ABAXIS Announces Appointment of Brenton Hanlon to Vice President of North American Medical Sales and Marketing 2Health News:ABAXIS Announces Appointment of Brenton Hanlon to Vice President of North American Medical Sales and Marketing 3Health News:Chindex International Announces Exclusive Distribution Agreements in China for Leading Clinical Chemistry and Aesthetic Laser Products 2Health News:Chindex International Announces Exclusive Distribution Agreements in China for Leading Clinical Chemistry and Aesthetic Laser Products 3Health News:Chindex International Announces Exclusive Distribution Agreements in China for Leading Clinical Chemistry and Aesthetic Laser Products 4Health News:MyMedLab Releases First Offer in Its Unique Personalized Medicine Series 2Health News:MyMedLab Releases First Offer in Its Unique Personalized Medicine Series 3Health News:Hispanics at High Risk for Colorectal Cancer 2Health News:Hispanics at High Risk for Colorectal Cancer 3Health News:Limb-sparing surgery may not provide better quality of life than amputation for bone cancer patients 2
(Date:5/24/2013)... -- Solta Medical, Inc. (NASDAQ: SLTM ), a ... Edward W. Knowlton has resigned as ... Dr. Knowlton is the founder of Thermage, the predecessor company ... 1996. "On behalf of the entire Board of ... to thank Ed for his tireless dedication to our company ...
(Date:5/24/2013)... LOS ANGELES , May 24, 2013  An ... gathered on Saturday, May 18, in Santa ... findings on new lung-sparing therapies for MPM, a rare ... and commonly affects the pleura, the lining of the ... Heart, Lung and Blood Institute, the 3rd Annual International ...
(Date:5/24/2013)... LOVELAND, Colo. , May 24, 2013  Heska Corporation ... veterinary diagnostic and specialty products, announced today that Dr. ... executive officer, and Jason Napolitano , executive ... Second Annual Marcum MicroCap Conference, which is being held May ... at the Grand Hyatt Hotel. The Company,s ...
Breaking Medicine Technology:Dr. Edward W. Knowlton Resigns as a Director of Solta Medical, Inc. 2International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 2International Mesothelioma Experts Present Promising New Research Findings at the 3rd Annual International Symposium on Lung-Sparing Therapies for Malignant Pleural Mesothelioma 3Heska Corporation To Present At The Second Annual Marcum LLP MicroCap Conference 2
... Scientific advances at The Scripps Research Institute ... Benlysta® (belimumab), approved today by the U.S. Food and Drug ... is the first in a new class of pharmaceuticals that ... "I am deeply gratified that our scientific findings have ...
... March 9, 2011 Gentiva Health Services, Inc. (Nasdaq: ... the Barclays Capital 2011 Global Healthcare Conference in Miami, Florida ... at the Barclays Capital High Yield Bond and Syndicated Loan ... March 24, 2011. The presentations will be available ...
Cached Medicine Technology:New Lupus Drug Results From Scripps Research Technology 2New Lupus Drug Results From Scripps Research Technology 3New Lupus Drug Results From Scripps Research Technology 4Gentiva® Health Services to Present at Upcoming Investor Conferences 2Gentiva® Health Services to Present at Upcoming Investor Conferences 3
Rees bayonet forceps, standard, 5-1/2", TC....
Medpor Encophthalmos Wedge mimics the contour of the orbital floor and provides volume to restore the orbit to its normal shape and size....
... Medpor Channel Implants, designed ... provide the surgeon with an ... orbital wall and floor blowout ... channels for placement of one ...
Medpor Complete Orbit are designed to replace non load bearing bony structures in the orbital area....
Medicine Products: