Navigation Links
Scientists develop mathematical model to predict the immune response to influenza

Researchers at the University of Rochester have developed a mathematical model to predict immune responses to infection with influenza A viruses, including novel viruses such as the emergent 2009 influenza A (H1N1). This model examines the contributions of specific sets of immune cells in fighting influenza A virus. The model also helps predict when during the immune response to viral infection antiviral therapy would be most effective.

The project was conducted by investigators funded through the Modeling Immunity for Biodefense program, a program established in 2005 by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, to improve preparedness for emerging and re-emerging pathogens.

When an individual is infected by a virus, a network of immune cells becomes immediately engaged, taking up viral particles and presenting pieces of the virusantigensto specialized white blood cells, thereby initiating a virus-specific response. The responding cells include T cellswhich either directly attack and eliminate virus-infected cells or help other immune cells fight the virusas well as B cells, which produce antibodies that bind and neutralize the virus.

The mathematical model developed by the research team generates immune response scenarios reflecting multiple variables, including the pathogenicity of the virus, numbers of responding B and T cells and function of antigen-presenting cells, in the lungs and lymph nodes. Their model suggests that prolonged viral infection limits the production of T cells and inhibits antigen presentation to immune cells. Confirming previous findings, the mathematical model predicts that antiviral therapy is most effective in reducing the spread of the virus when given within two days after infection.

The research team tested the accuracy of their model in mice infected with influenza A virus. They next plan to apply the model to human populations and continue to improve the model as more data become available.

In addition to the investigators in Rochester, NIAID supports three additional laboratories across the United States as part of the Modeling Immunity for Biodefense program. These scientists are conducting immune modeling research with the goal of developing models to simulate host immune responses to infections or vaccination in order to better treat and prevent diseases affecting millions of people, such as seasonal flu and tuberculosis.


Contact: Julie Wu
NIH/National Institute of Allergy and Infectious Diseases

Related medicine news :

1. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
2. Scientists Probe Sepsis Deadly Secrets
3. Scientists puzzled by severe allergic reaction to cancer drug in the middle Southern US
4. Scientists Develop Natural Protection for Stored Foods
5. Scientists detect presence of marburg virus in african fruit bats
6. Scientists Spot Brains Free Will Center
7. Scientists ID Likely Culprit in Popcorn Lung
8. Scientists explain how insulin secreting cells maintain their glucose sensitivity
9. Scripps Research scientists shed new light on how antibodies fight HIV
10. Scientists, physicians present latest findings in personalized cancer treatment and prevention
11. Scientists demonstate link between genetic variant and effectiveness of smoking cessation meds
Post Your Comments:
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... A team ... ways to treat it. Surviving Mesothelioma has just posted the findings on the ... University Hospital Zurich analyzed the cases of 136 mesothelioma patients who were treated with ...
(Date:11/27/2015)... ... November 27, 2015 , ... ProSidebar: Fashion ... Cut Pro X. With ProSidebar: Fasion, video editors can easily add an informative ... a minimalist title opener. Utilize presets featuring self-animating drop zones, lines, bars, and ...
(Date:11/27/2015)... ... November 27, 2015 , ... The moment you ... for not only fulfilling the needs of advisers and clients but going above ... and providing top-tier customer service. However, there's always room for improvement, which is ...
(Date:11/27/2015)... San Francisco, California (PRWEB) , ... November 27, 2015 , ... ... 1969 Janis Joplin Ann Arbor Michigan boxing style concert posters. This is one of ... 1969 at the Canterbury House at the University of Michigan in Ann Arbor. The ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... Representative. As a franchise owner, Somu now offers travelers, value and care based ... packages, private cruise sales, as well as, cabin upgrades and special amenities such ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... Research and Markets ( ) has ... Market 2015-2019" report to their offering. ... report, the author the present scenario and growth prospects ... calculate the market size, the report considers revenue generated ... IUDs and copper IUDs. The report forecasts the global ...
(Date:11/26/2015)... Países Bajos, November 26, 2015 ... fotodinámica de Bremachlorin para el cáncer avanzado.   ... con la terapia fotodinámica de Bremachlorin para el cáncer ... enfoque combina la inmunoterapia con la terapia fotodinámica de ... Clinical Cancer Research . --> Clinical Cancer ...
(Date:11/26/2015)... Nederland, November 26, 2015 ... Een nieuwe aanpak combineert immunotherapie met Bremachlorin-photodynamische ... ) --> ...      (Photo: ) ... Universitair Medisch Centrum (LUMC) blijkt ...
Breaking Medicine Technology: