Navigation Links
Scientists detail urgent research agenda to address chronic disease toll
Date:8/14/2014

Health care systems that keep HIV patients from dying early in low- and middle-income nations need urgently to be repurposed to treat the chronic diseases that many of these patients now have, experts say.

According to recommendations resulting from a multidisciplinary conference sponsored by the National Institutes of Health, scientists and physicians in low- and middle-income countries should build on existing HIV research to study and treat chronic conditions. Patients once condemned to death by AIDS now suffer from noncommunicable diseases such as tuberculosis, cancer, heart and lung disease, kidney disease, diabetes, mental illness and gastrointestinal disorders. These conditions can be related to the infection itself, the drugs used to treat it, or the simple process of aging.

Increasing rates of chronic diseases among persons with HIV, if unaddressed may set back or even reverse the impressive health gains achieved over the last decade, according to the authors of a new series of articles. Additionally, clinics in many rural areas of Africa, Asia and Latin America are increasingly under strain as they attempt to provide services beyond acute care to treat long-term HIV. To address these issues, global health experts recommend increasing research capacity with respect to HIV-noncommunicable disease burdens in developing countries.

An international group of researchers detailed the problem in a special issue of the Journal of Acquired Immune Deficiency Syndromes. In eight articles and two commentaries, the scientists lay out a research agenda to determine the scope of the noncommunicable disease problems and study the most efficient and cost-effective ways to tackle them. Estimates indicate that chronic illnesses have already overtaken infectious diseases as the main killers in the developing world, the authors report. These conditions can be simultaneous chronic diseases associated with HIV-related illness, whether HIV is being treated or not.

Research will play a critical role in providing the evidence, strategies and tools required to address this complex challenge, said the authors, who called for visionary scientific leadership, sustained investment and attention, and the breakdown of disciplinary silos.

"Just as the advent of widespread antiretroviral treatment demanded a seismic shift in global human capacity and health systems for the emergency response to HIV, emerging chronic conditions among those with HIV in lower- and middle-income countries will demand no less," said K. M. Venkat Narayan, M.D., of Emory University, Atlanta, one of the supplement's lead authors.

While the bulk of the supplement concerned circumstances in sub-Saharan Africa, two essays described similar challenges in low-resource settings in Asia, and in Latin America and the Caribbean. The authors suggested a number of complex health and implementation science topics in developing countries that merit further study, including:

  • The lessons learned from the integration of tuberculosis care into HIV treatment should be examined to develop optimal strategies to combat chronic diseases. .
  • Drug delivery systems now devoted to antiretroviral therapy (ART) and tuberculosis medicines could add essential and affordable drugs for noncommunicable disease management, improving the long-term survival and quality of life of those living with HIV, while potentially increasing ART adherence.
  • Virally triggered cancers associated with weakened immune systems are commonamong them anal cancer, liver cancer and Hodgkin diseasebut the epidemiology of HIV-associated cancers is not well studied.
  • ART is known to increase the risk of heart failure and other cardiopulmonary conditions in high-income countries but little is known about the impact in low-resource settings, where individuals may face additional risk factors such as air pollution.
  • Depression, alcohol abuse and nervous system disorders affecting memory, attention, decision-making and problem-solving are prevalent in people living with HIV but the diagnostic tools in low- and middle-income countries are inadequate.
  • Kidney disease whether caused by HIV-related infections or toxins from antiretroviral treatments is on the rise, and registries should be established to study occurrence and severity of side effects to ART.

There was also consensus that enhancement of HIV research and care platformsas well as expanded training for researchers and providers could strengthen health systems and improve the overall care of persons living with HIV/AIDS and larger populations.

"The papers in this supplement articulate an agenda from which we can begin to address the spectrum of research, training, effective implementation and evidence-based policy needed to confront this devastating new challenge of chronic illness among those living with HIV in developing countries," according. Roger I. Glass, director of NIH's Fogarty International Center, which supports international research.

The publication grew out of a 2013 conference of international experts held at the Center for Global Health Studies at the National Institutes of Health, jointly chaired by Dr. Sten Vermund of Vanderbilt University School of Medicine, Nashville, and Dr. K. M. Venkat Narayan of Emory University's Rollins School of Public Health. Attendees included representatives of nine NIH Institutes and Centers, as well as the World Health Organization, the U.S. Agency for International Development, the Centers for Disease Control and Prevention, the World Bank and the Office of the Global AIDS Coordinator at the U.S. Department of State. The meeting was hosted by the NIH Office of AIDS Research and the Fogarty International Center.


'/>"/>

Contact: Jeff Gray
Jeffrey.Gray@nih.gov
301-496-2075
NIH/Fogarty International Center
Source:Eurekalert  

Related medicine news :

1. Scientists make major breakthrough in understanding leukemia
2. Kessler Foundation scientists identify predictors of prospective memory deficit post TBI
3. Kessler Foundation scientists link environment & inclusion in adults with disabilities
4. CRI scientists pinpoint gene likely to promote childhood cancers
5. Scientists unlock key to blood vessel formation
6. Kessler Foundation scientists confirm effectiveness of cognitive rehabilitation in MS
7. Scientists unravel mystery of brain cell growth
8. Scientists Inch Closer Toward Using Stem Cells for Spinal Injuries
9. A*Star scientists make breakthroughs in ovarian cancer research
10. Scientists uncover stem cell behavior of human bowel for the first time
11. Scientists uncover key piece to cancer cell survival puzzle
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Scientists detail urgent research agenda to address chronic disease toll
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are recognized ... this recognition are considered among the top 2 percent of lawyers practicing within the ... this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, Burt ...
(Date:6/24/2016)... ... 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join ... wage raise to $12 an hour by 2020 and then adjusting it yearly to increase ... of the minimum wage, assure the wage floor does not erode again, and make future ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
(Date:6/24/2016)... ... 2016 , ... National recruitment firm Slone Partners is pleased to ... genomics experience, as Vice President of North American Capital Sales at HTG Molecular ... the sales team in the commercialization of the HTG EdgeSeq system and associated reagents ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
(Date:6/23/2016)... Research and Markets has announced the ... to 2022" report to their offering. ... patients with kidney failure, it replaces the function of kidneys ... blood and thus the treatment helps to keep the patient ... Increasing number of ESRD patients & substantial ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
Breaking Medicine Technology: