Navigation Links
Scientists describe gut bacteria that cause sepsis in preterm infants
Date:3/19/2014

Researchers studying intestinal bacteria in newborns have characterized the gut bacteria of premature infants who go on to develop sepsis, a serious and potentially life-threatening condition caused by bacteria in the bloodstream. Their findings suggest new strategies for the early detection and prevention of severe bloodstream infections. The research was funded by several components of the National Institutes of Health (NIH)the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Human Genome Research Institute (NHGRI), the National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the NIH Common Fundand other organizations.

Led by Phillip I. Tarr, M.D., and Barbara Warner, M.D., of Washington University in St. Louis, the investigators collected stool samples from 217 premature newborns who had been admitted to the neonatal intensive care unit (NICU) at St. Louis Children's Hospital soon after birth. Eleven of these infants developed sepsis between 13 and 82 days of age. Using the same blood samples that were used to diagnose the infection, the researchers genetically compared bacteria found in the affected infants' bloodstream to those found in their earlier stool samples. They also assessed whether sepsis-causing infections spread between infants by studying bacteria found in the stools of two comparison groups without the condition: 96 infants whose stays in the NICU overlapped with the sepsis cases, and 60 infants who stayed in the NICU at different times.

In seven of the 11 infants who developed sepsis, the researchers found genetic matches between bacteria in the initial stool samples and those in later blood samples, suggesting that bacteria from the gutrather than other parts of the bodyare responsible for these infections. From the comparison groups, genetic matches were found in four infants who were located near those who developed sepsis, suggesting that such bacteria can be transmitted between infants, though they do not always cause illness. These results pave the way for the evaluation of new sepsis prevention strategies, such as closer surveillance of premature infants to find strains of gut bacteria associated with sepsis, the study authors write.


'/>"/>

Contact: NIAID Office of Communications
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. Virginia Tech scientists out for blood when it comes to stopping malaria
2. U-M scientists slow development of Alzheimers trademark cell-killing plaques
3. NIH scientists track evolution of a superbug
4. In the lab, scientists coax E. coli to resist radiation damage
5. Let there be tissue-penetrating light: Scientists develop new nanoscale method to fight cancer
6. Scientists discover new protein involved in lung cancer
7. Scientists explore promising new option for first line of attack in lymphoma
8. Tel Aviv University scientists honored for proposals in melanoma research
9. Scientists call for screening mammography every 2 years for most women
10. NIH scientists find mechanism that helps HIV evade antibodies, stabilize key proteins
11. Scientists develop powerful new animal model for metastatic prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2017)... , ... April 21, 2017 , ... Providing broad access ... in opposition, but there is a better way to address this problem. , That ... of Pharmacy, Public Policy and Economics at the University of Southern California, who served ...
(Date:4/21/2017)... ... , ... Brady (NYSE:BRC), a global leader in industrial and safety ... vinyl label materials received certification for the BS5609 British Marine Standard. This internationally ... legible, for use on chemical drums shipped by sea. , “Achieving BS5609 ...
(Date:4/21/2017)... ... April 21, 2017 , ... The VIA Agency , ... for Theravent, Inc. , the makers of a revolutionary new device clinically ... is now working to expand distribution in anticipation of a national launch. VIA ...
(Date:4/21/2017)... , ... April 21, 2017 , ... ... announced an exciting new partnership with the highly regarded and well renowned Asian ... highly innovative, myTAP & myTAP PAP Nasal Pillow Mask, and will stabilize and ...
(Date:4/21/2017)... ... April 21, 2017 , ... BrightStar Care Salt Lake City, a home ... of Utah (APCUT) and has appointed Rex Wheeler as its new Director of Business ... our agency and our ability to provide quality care to the community,” said Tammara ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017  Cogentix Medical, ... focused on providing the Urology, Uro/Gyn and Gynecology ... that Ash Keswani has joined the Company as ... this newly created position, Mr. Keswani will report ... CEO. "Our organization is delighted that ...
(Date:4/20/2017)... April 20, 2017 Research and Markets has ... Innovation Driven by Rapidly Expanding Injectables Market and Increasing Usage of ... ... delivery technologies will rise from USD 20 Billion in 2015 to ... Drug Delivery Technologies - Innovation Driven by Rapidly Expanding Injectables Market ...
(Date:4/20/2017)... 2017 Eyevensys, a private biotechnology ... gene expression technology that enables the safe, local, sustained ... a wide range of ophthalmic diseases, announces it has ... Regulatory Agency (MHRA) to advance its technology into clinical ... The ...
Breaking Medicine Technology: