Navigation Links
Scientists deepen genetic understanding of eosinophilic esophagitis
Date:7/14/2014

WHAT:

Scientists funded by the National Institutes of Health (NIH) have identified genetic markers associated with eosinophilic esophagitis (EoE), an inflammatory disease characterized by high levels of immune cells called eosinophils in the esophagus. Their findings suggest that several genes are involved in the development of EoE, which can cause difficulty eating and often is associated with food allergies. The findings also may help explain why the disease specifically affects the esophagus. The work was supported in part by the Consortium of Food Allergy Research, which is funded by NIH's National Institute of Allergy and Infectious Diseases and National Institute of Diabetes and Digestive and Kidney Diseases.

A team led by researchers at Cincinnati Children's Hospital Medical Center searched the entire human genome for variations between 9,246 healthy people and 736 people with EoE. They confirmed previous results from a smaller study that linked variations in the region on chromosome 5 containing TSLP, a gene associated with allergic diseases, to a higher risk of developing EoE. They also identified variations in a region on chromosome 2 containing a gene called CAPN14, which produces an enzyme called calpain 14, that are associated with higher EoE risk. The researchers showed that CAPN14 is expressed, or "turned on," primarily in the esophagus. CAPN14 expression and calpain activity rose when scientists treated cultured esophageal cells with a molecule that induces allergic inflammation, suggesting that the enzyme is part of an anti-inflammatory response. People with EoE who carry the variant form of the gene may be unable to mount this response as effectively.

Further research is needed to determine if these findings might lead to identification of biomarkers to detect a person's risk of developing EoE. Understanding the factors underlying EoE may help guide development of new diagnostic and treatment strategies for the disease.


'/>"/>

Contact: Hillary Hoffman
hillary.hoffman@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. Scientists developed new technology for the diagnosis of cancer cells
2. USC scientists discover immune system component that resists sepsis in mice
3. Scientists find important piece in the brain tumor puzzle
4. Joslin scientists identify process that affects fat distribution and metabolic syndrome
5. Cancer Research UKs new funding scheme to nurture future world-leading scientists
6. Scientists find potential new use for cancer drug in gene therapy for blood disorders
7. Scientists about sequencing data: We drown in data but thirst for knowledge
8. NIH scientists take totally tubular journey through brain cells
9. Benaroya Research Institute scientists identify drivers of rheumatoid arthritis
10. NOAA scientists find mosquito control pesticide low risk to juvenile oysters, hard clams
11. MAD: Scientists shed light on braking mechanisms in cellular signaling
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... ... , ... "With 30 hand-drawn hand gesture animations, FCPX users can easily customize ... Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn pictures into ... Simply select a ProHand generator and drag it above media or text in the ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Research and Markets has announced ... Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality ... - Global Forecast to 2021" report to their ... global pharmaceutical excipients market is projected to reach USD ... in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... LOS ANGELES , June 23, 2016 /PRNewswire/ ... (NASDAQ: CAPR ), a biotechnology company ... first-in-class therapeutics, today announced that patient enrollment in ... progrEssion in Duchenne) has exceeded 50% of its ... its enrollment in the third quarter of 2016, ...
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
Breaking Medicine Technology: