Navigation Links
Scientists deepen genetic understanding of eosinophilic esophagitis
Date:7/14/2014

WHAT:

Scientists funded by the National Institutes of Health (NIH) have identified genetic markers associated with eosinophilic esophagitis (EoE), an inflammatory disease characterized by high levels of immune cells called eosinophils in the esophagus. Their findings suggest that several genes are involved in the development of EoE, which can cause difficulty eating and often is associated with food allergies. The findings also may help explain why the disease specifically affects the esophagus. The work was supported in part by the Consortium of Food Allergy Research, which is funded by NIH's National Institute of Allergy and Infectious Diseases and National Institute of Diabetes and Digestive and Kidney Diseases.

A team led by researchers at Cincinnati Children's Hospital Medical Center searched the entire human genome for variations between 9,246 healthy people and 736 people with EoE. They confirmed previous results from a smaller study that linked variations in the region on chromosome 5 containing TSLP, a gene associated with allergic diseases, to a higher risk of developing EoE. They also identified variations in a region on chromosome 2 containing a gene called CAPN14, which produces an enzyme called calpain 14, that are associated with higher EoE risk. The researchers showed that CAPN14 is expressed, or "turned on," primarily in the esophagus. CAPN14 expression and calpain activity rose when scientists treated cultured esophageal cells with a molecule that induces allergic inflammation, suggesting that the enzyme is part of an anti-inflammatory response. People with EoE who carry the variant form of the gene may be unable to mount this response as effectively.

Further research is needed to determine if these findings might lead to identification of biomarkers to detect a person's risk of developing EoE. Understanding the factors underlying EoE may help guide development of new diagnostic and treatment strategies for the disease.


'/>"/>

Contact: Hillary Hoffman
hillary.hoffman@nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Related medicine news :

1. Scientists developed new technology for the diagnosis of cancer cells
2. USC scientists discover immune system component that resists sepsis in mice
3. Scientists find important piece in the brain tumor puzzle
4. Joslin scientists identify process that affects fat distribution and metabolic syndrome
5. Cancer Research UKs new funding scheme to nurture future world-leading scientists
6. Scientists find potential new use for cancer drug in gene therapy for blood disorders
7. Scientists about sequencing data: We drown in data but thirst for knowledge
8. NIH scientists take totally tubular journey through brain cells
9. Benaroya Research Institute scientists identify drivers of rheumatoid arthritis
10. NOAA scientists find mosquito control pesticide low risk to juvenile oysters, hard clams
11. MAD: Scientists shed light on braking mechanisms in cellular signaling
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... People across ... in Genome magazine’s Code Talker Award, an essay contest in which patients and their ... award to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, affiliated ... Weintraub as a prominent plastic surgeon and the network’s newest partner. , ... most handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic ... Frederick area economy by obtaining investment capital for emerging technology companies. SCP ... that have already resulted in more than a million dollars of capital investment ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th Annual ... Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised funds ... been wounded in battle and their families. Venture Construction Group is a 2016 Silver ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... "Pharmaceutical Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, ... (Oral, Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is ... a CAGR of 6.1% in the forecast period 2016 ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... to 2022" report to their offering. ... financial data derived from varied research sources to present unique ... on the market during the next five years, including a ... markets, regional and country level analysis. The report provides a ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
Breaking Medicine Technology: