Navigation Links
Scientists decode 'software' instructions of aggressive leukemia cells
Date:10/29/2012

NEW YORK (Oct. 28, 2012) -- A team of national and international researchers, led by Weill Cornell Medical College scientists, have decoded the key "software" instructions that drive three of the most virulent forms of acute lymphoblastic leukemia (ALL). They discovered ALL's "software" is encoded with epigenetic marks, chemical modifications of DNA and surrounding proteins, allowing the research team to identify new potential biomarkers and therapeutic targets.

The research, published in Cancer Discovery, is the first study to show how these three different forms of white blood cell cancer are epigenetically programmed by several different molecules controlling cascading biological networks that manipulate normal gene function, directing cancer development and growth.

"Epigenetic programming is the software that is written on to human DNA, which can be viewed as its hard drive. This programming contains the instructions that determine how cells including leukemia cells function and cause disease," says the study's lead investigator, Dr. Ari Melnick, associate professor of medicine and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell Medical College.

"Finding the instructions that ultimately lead to cancer development, and to the especially bad outcome seen in patients with these different forms of ALL, is especially urgent. Epigenetic instructions are contained in many chemical layers. Our study is the first to integrate the decoding of many layers simultaneously, which has enabled us to unlock some of the mysteries explaining the malignant and aggressive behavior of these leukemias," says Dr. Melnick, who is also a hematologist-oncologist at NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

Abnormal Epigenetic Programming Leads to Poor Outcomes

The research team examined abnormalities in the "software" epigenetic programming that l
'/>"/>

Contact: Lauren Woods
law2014@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Canadian scientists discover cause of high cholesterol
2. Scientists step up hunt for bacterial genes tied to Lyme disease
3. Scientists to study the role genes play in treating TB
4. Kessler Foundation scientists awarded New Jersey grants for brain injury research
5. Scientists Focus on Factors Behind Asthma Attacks
6. Einstein-Montefiore scientists awarded 2 NCI Provocative Questions grants
7. Leading stem cell scientists to focus on diabetes, eye diseases at Cedars-Sinai symposium
8. Diets High in Fructose May Harm Liver in Some, Scientists Warn
9. Cardiff scientists bid to develop anthrax vaccine to counteract world bioterrorism threat
10. Scripps Research Institute scientists show protein linked to hunger also implicated in alcoholism
11. Scientists Spot 5 Genes That Help Shape Faces
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... (PRWEB) December 26, 2014 DW-InductionHeating.com (DaWei ... in designing, researching and developing, producing and marketing of ... of the business announces their new series of ... manager of the company, induction brazing refers ... a special filler material and heat. The manager says ...
(Date:12/25/2014)... The report “Nintedanib (Colorectal Cancer) – ... the current treatment landscape, unmet needs, current pipeline ... Stivarga is a drug which is used in ... Ingelheim is developing nintedanib (BIBF-1120), an orally available ... in the US, Europe, and Japan. The drug ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... When head lice hits a home or school, parents and ... of it while keeping it from taking over the house ... solution right in their neighborhood: Lice Troopers . Expanding ... spectrum head lice screening and treatment services to families and ... Brickell, Coconut Grove, Kendall, Pinecrest and South Miami. , The ...
(Date:12/25/2014)... early stage breast cancer patients who undergo chemotherapy and/or ... eventually develop leukemia as a result of their treatment, ... a review of more than 20,000 breast cancer cases ... the risk for developing treatment-related leukemia, though low, is ... frequency of bone marrow cancers such as leukemia is ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3
... advisory committee to the U.S. Food and Drug Administration recommended ... used without a prescription. The FDA does not have to ... does. There is no deadline for making a decision. // ... the ability to do both good and harm. Claritin, Allegra ...
... Hypertensive drugs in general have a common side effect- ... plagues people on a widely-used blood pressure medication.// ... treat high blood pressure, heart failure and other cardiac ... inhibitors are troubled by a cough. The side effect ...
... contains polyphenols in the form of flavonoids and its ... properties. Polyphenols protect the cells from damaging// physiological process ... Oxidation produces free radicals these are unstable ... increased amount of them can damage cells resulting in ...
... supplements of a fatty acid found in fish oil halves ... research has found that eating oily fish such as tuna ... caused by a particular type of irregular heartbeat. This study ... a therapy without side effects for heart patients. ...
... to a new study shows that women with ... 'good' cholesterol when they take oestrogen.// Previous research suggests ... heart disease. Now doctors at Forest University have discovered ... profile responds to HRT. ,An analysis of over ...
... An Australian psychiatrist has discovered that treating patients with ... Although antipsychotic drugs like risperidone have been shown to ... researchers have suspected for some time that oestrogen can ... version of the disease than men and it usually ...
Cached Medicine News:
(Date:12/24/2014)...  Novastem, a leader in regenerative medicine, announces ... study for ischemic stroke at Clinica Santa Clarita. ... account for 87 percent of all stroke cases. ... study, entitled "Internal Research Protocol in Combination Therapy ... and Intrathecal Administration of Neural Stem Cells in ...
(Date:12/24/2014)... China, Dec. 24, 2014 /PRNewswire/  -- Tianyin Pharmaceutical ... pharmaceutical company that specializes in the patented biopharmaceutical, ... active pharmaceutical ingredients (API) released unaudited preliminary financial ... 2015. Fiscal Year 2015 Ended September ... $9.7 million compared with $14.7 million in 1Q14 ...
(Date:12/24/2014)... -- The International Trade Commission (ITC) issued its final decision in ... a notice issued on December 23, the ITC ruled in ... humidifier was invalid. BMC President, James Xu ... excited with the ITC,s decision in this case. This victory ... the very beginning on the key patents in the case. ...
Breaking Medicine Technology:Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 3Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 2TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 3TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 4TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 5TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 6TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 7TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 8TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 9TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 10TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 11TPI Presents Unaudited Preliminary First Quarter Fiscal Year 2015 Financial Results 12ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2
... 8, 2007--The World Health Organization,has released new ... rising in,Pakistan. , So is this another ... pharmaceutical industry is denying important vaccines to,poor ... to London’s Guardian,newspaper, “parents of 24,000 children ...
... Outlines Development Plans - , ,OTTAWA, Canada – ... company specializing in developing,advanced products related to High ... results of,the Phase I/II Clinical Trial of its ... treatment of dyslipidemia and heart,disease. , ,Results showed, ...
Cached Medicine Technology:Why Is Polio Spreading in Pakistan? 2Liponex Inc. Reports Phase I/II Clinical Trial Data for CRD5 2Liponex Inc. Reports Phase I/II Clinical Trial Data for CRD5 3
... elitewas designed to improve patient compliance. Its ... sample collection options make this fecal occult ... and complete. Diet guidelines are explained in ... which foods and drugs are okay and ...
Inquire...
... The FSH Menopause Predictor Test ... for the detection of Follicle Stimulating ... confirmation of body hormone changes related ... changes of menopause. The FHS ...
... pylori Rapid Test Strip and Device are ... of antibodies to Helicobacter pylori (H. pylori) ... aid in the diagnosis of H. pylori ... and older. They are intended for health ...
Medicine Products: