Navigation Links
Scientists decode secrets of a very common virus that can cause cancer
Date:12/15/2010

DURHAM, N.C. About 90 percent of people are infected at some time in their lives with Epstein-Barr virus (EBV), usually with no ill effects. But individuals with compromised immune systems, such as people with organ transplants or HIV infection, have a greater risk of cancer occurring because of this virus.

Scientists at the Duke Cancer Institute have discovered a pathway that infected cells use to root out EBV infections, a finding that has implications for understanding the human response to cancer-causing viruses in general.

"Using cell culture studies, we have uncovered a major pathway that the infected host cell activates to prevent an oncogenic virus from causing cancer," said senior author Micah Luftig, Ph.D., Assistant Professor of Molecular Genetics and Microbiology. "We proposed that the cell was sensing that the virus is trying to take over. When this oncogenic stress response is activated, it keeps the virus in check, and now we know why."

The Luftig group also learned how the Epstein-Barr virus overcomes the cell's response. "The findings may eventually yield therapies to benefit people who don't have good immune systems and who need protection from a threatening EBV infection," Luftig said.

This work appears in the Dec. 15 online issue of Cell Host and Microbe.

Very early in many people's lives, there is a huge expansion of immune system B cells infected with EBV. But thanks to the oncogenic stress response and a strong immune system, the majority of these infected cells are killed off and the person remains healthy. Luftig and his group, including lead authors Pavel Nikitin and Chris Yan, found two enzymes, called kinases, which were critical in mediating this oncogenic stress response and preventing unchecked B-cell cell growth, called immortalization.

When the scientists blocked the ATM and Chk2 kinases, unchecked growth resulted in 10 times more infected cells. This burgeoning c
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists Pinpoint Area of Brain That Fears Losing Money
2. Scientists Discover How HIV Is Transmitted Between Men
3. Prevention Is Key Research Goal for Premature Babies, Scientists Say
4. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
5. Scientists find donut-shaped structure of enzyme involved in energy metabolism
6. Neuroscientists reveal new links that regulate brain electrical activity
7. Two UCSF Scientists to Receive Prestigious Dementia Research Honor
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. Scientists Spot Genetic Fingerprints of Individual Cancers
10. Scientists Unravel Mysteries of Intelligence
11. MSU scientists develop more effective method of predicting lead-poisoning risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... Dr. Vu Ho, a Dallas based ... practice and med-spa with the addition of new Silk ... cosmetic treatments and services. , “Silk Peel is a ... Dr. Ho. “As a result it can address issues ... spots, discolorations or blemishes.” , Similar to microdermabrasion, ...
(Date:12/24/2014)... The report “Stivarga (Colorectal Cancer) – Forecast and ... landscape, unmet needs, current pipeline and commercial opportunities in ... is used in the treatment of colon or rectal ... prescribed to patients who suffer from advanced gastrointestinal stromal ... multi-kinase inhibitor and it blocks many enzymes which are ...
(Date:12/24/2014)... Dec. 24, 2014 (HealthDay News) -- The holidays can be ... set off by certain foods and drinks. "This is ... can trigger attacks of migraine," Dr. David Dodick, chair of ... the foundation. "It,s important to think through food and ... migraine attack," added Dodick, a professor of neurology at the ...
(Date:12/24/2014)... (HealthDay News) -- Researchers say they have used human ... eggs and sperm. While this had already been ... time that these types of cells -- called primordial ... stem cells, according to the team at the University ... germ cells is one of the earliest events during ...
(Date:12/24/2014)... 24, 2014 Gluten, a protein found ... who have an intolerance to gluten, causing side effects ... migraine headaches, joint pain and fatigue. For this reason, ... that deliver safe and fast weight loss while ... a gluten allergy reaction. These gluten free diet plans ...
Breaking Medicine News(10 mins):Health News:Dr. Vu Ho Expands Facial Plastic Surgery Practice to Include New Skin Care Treatment 2Health News:Stivarga Colorectal Cancer Treatment Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Stivarga Colorectal Cancer Treatment Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Expert Offers Tips for Preventing Holiday Migraines 2Health News:Diet Doc Adds Gluten Free Diet Plans to Their Stable of Specialized Weight Loss Programs 2Health News:Diet Doc Adds Gluten Free Diet Plans to Their Stable of Specialized Weight Loss Programs 3
... for the Cure Greater Atlanta Affiliate the First in a Nationwide ... , ATLANTA, May 4 In an effort to increase awareness ... Interactive and BrainJocks have joined ... an avid group of social media users who believe that "friends, ...
... N.C., May 4 Dr. Mehmet Oz on Oprah ... exercise" for people seeking to avoid drugs, surgery, and ... as Qigong, may eventually replace health insurance for many ... growing in popularity in the USA as a low-cost, ...
... May 4 Children hospitalized with concussions should ... in a follow-up exam before returning to regular ... The Children,s Hospital of Philadelphia. Rather than only ... signs after the initial treatment, the Children,s Hospital ...
... insurer reports ... call volume CLEVELAND, May 4 Medical Mutual ... intensifying swine flu outbreak in the United States.In response, the company has posted a message on its ... and member groups to the Centers for Disease Control ...
... Unrestricted Financial Lifeline for Americans Struggling With Serious ... Insurance Company of America (Guardian) supports National Stroke ... owners, benefits decision makers and employees to consider ... have on a person,s financial security.According to the ...
... American Academy of Dermatology introduces new "E" tool for detecting ... to brunch or backyard barbeques is a great way to ... American Academy of Dermatology (Academy) hopes more families will start ... skin cancer . To help detect the warning ...
Cached Medicine News:Health News:Response Mine Interactive and BrainJocks Launch 'Tweets for a Cause' to Support Local Non-Profits 2Health News:Medical Tai Chi (Qigong) - Chinese 'Miracle Exercise' Popular as U.S. Health Costs Rise 2Health News:Medical Tai Chi (Qigong) - Chinese 'Miracle Exercise' Popular as U.S. Health Costs Rise 3Health News:Children with Concussions Require Follow-up Care Before Returning to Play, Say Researchers 2Health News:Children with Concussions Require Follow-up Care Before Returning to Play, Say Researchers 3Health News:Medical Mutual of Ohio Offers Swine Flu Assistance to Customers 2Health News:Guardian Highlights Significance of Critical Illness Insurance During National Stroke Awareness Month 2Health News:Guardian Highlights Significance of Critical Illness Insurance During National Stroke Awareness Month 3Health News:Guardian Highlights Significance of Critical Illness Insurance During National Stroke Awareness Month 4Health News:Dermatologists Encourage People to Screen the One You Love for Skin Cancer 2Health News:Dermatologists Encourage People to Screen the One You Love for Skin Cancer 3Health News:Dermatologists Encourage People to Screen the One You Love for Skin Cancer 4Health News:Dermatologists Encourage People to Screen the One You Love for Skin Cancer 5
(Date:12/24/2014)... , Dec. 23, 2014 Echo ... medical device company focused on skin permeation, continuous ... Scott W. Hollander has been appointed ... Hollander has more than 20 years of experience ... industries, and most recently served as Vice President, ...
(Date:12/24/2014)... 2014 LifeScienceIndustryResearch.com adds ... Syringe Industry of 178 pages providing 10 ... library. The 2014 Market Research ... a professional and deep research report on ... the report introduces Disposable Syringe basic information ...
(Date:12/24/2014)... , Dec. 23, 2014  Lockton Dunning ... of Lockton Companies, announced the addition of Vice ... will join Lockton Dunning,s Pharmacy Consulting team, Excelsior ... of relevant industry experience to the position.  Most ... Market Sales at Diplomat Specialty Pharmacy, where she ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5Kim Foerster Joins Lockton Companies 2
... June 19 /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,(ASX: PXS; Nasdaq: PXSL) ... Food,and Drug Administration (FDA) have reached agreement on ... via the Special,Protocol Assessment process., The SPA ... trial protocol,intended to form the primary basis of ...
... KNDL ), a,leading global full-service clinical research organization ... present at the upcoming Drug,Information Association (DIA) 44th ... 2008, at the Boston Convention and Exhibition Center ... topics in the clinical,development industry, including EDC, biomarkers, ...
Cached Medicine Technology:Pharmaxis Concludes Special Protocol Assessment with FDA for Bronchitol Phase 3 Trial 2Pharmaxis Concludes Special Protocol Assessment with FDA for Bronchitol Phase 3 Trial 3Kendle Experts to Present at the Drug Information Association 44th Annual Meeting 2Kendle Experts to Present at the Drug Information Association 44th Annual Meeting 3
Lyphochek Urine Bone Markers Control is a bilevel human urine based control designed to monitor tests for urinary markers of osteoporosis management and bone resorption....
Lyphochek Maternal Serum Control is a trilevel product with analytes at clinically significant levels to monitor maternal serum analysis....
... Immunoassay Plus Control is a ... in today's busy immunoassay laboratory. ... this human serum based control ... separate control products for immunoassay ...
... NsD Nucleic Sample Detection Platform provides fully ... The new platform for molecular pathology ... (CE), with software features that deliver a ... Vidiera NsD has the capacity to run ...
Medicine Products: