Navigation Links
Scientists decode TREX which could see new treatments for cancer realized
Date:8/14/2012

Decoded process could hold the key to future treatments for a wide range of chronic health problems including Motor Neuron Disease, myotonic dystrophy and a wide range of cancers, University of Sheffield scientists have revealed.

Experts from the University's Department of Molecular Biology and Biotechnology, collaborating with scientists from Harvard Medical School in the USA, have revealed how a complicated set of proteins called TREX act as a passport for the transfer of cell blueprints which create proteins that are essential for life.

The researchers believe their better understanding will mean they can ultimately fix problems in the process which cause fatal health conditions like Motor Neuron Disease, myotonic dystrophy and a wide range of cancers.

Professor Stuart Wilson, who led the groundbreaking project, said: "Protein production is an essential part of life for all organisms. This process involves reading the code in genes and converting this to a message which is ultimately decoded to make a protein.

"The message is made of a special molecule called mRNA. In all organisms from yeast through to man the mRNA is made in a compartment in the cell called the nucleus, but then has to be transported to a separate compartment, called the cytoplasm, where it is decoded to make a protein. This process of mRNA transport is essential for life and when it malfunctions in humans it can lead to diseases such as Motor Neuron Disease or cancer."

Researchers have shown how proteins called TREX provide a mark on the mRNA which acts as the passport which unlocks a transporter protein called Nxf1, allowing it to land on the mRNA and transport it to the cytoplasm to create proteins.

Professor Wilson added: "When a car is built in a factory, it goes through various stages of production with parts being added and, hopefully, quality control checks before it is driven out of the factory and into the salesroom.


'/>"/>
Contact: Paul Mannion
p.f.mannion@sheffield.ac.uk
01-142-229-851
University of Sheffield
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientists devise new strategy to destroy multiple myeloma
2. Scientists ID New Gene Regions Linked to Type 2 Diabetes
3. Scientists discover how iron levels and a faulty gene cause bowel cancer
4. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
5. Scientists ID New Gene Linked to Vision Loss in Infants
6. Fruit flies light the way for A*STAR scientists to pinpoint genetic changes that spell cancer
7. NIH scientists identify likely predictors of hepatitis C severity
8. Scientists looking for noninvasive ways to detect lung cancer early
9. Increasing dopamine in frontal cortex decreases impulsive tendency, UCSF-Gallo scientists find
10. Scientists explore new class of synthetic vaccines
11. New method to find novel connections from gene to gene, drug to drug and between scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... Florida Hospital is excited to continue its partnership ... care provider for the 2015 and 2016 season. As the ... and an athletic trainer for the team throughout each season. ... against the Cleveland Gladiators at Amalie Arena; the game starts ... to us as it gives us the opportunity, to provide ...
(Date:3/27/2015)... 27, 2015 The federal court overseeing ... the statin medication increases the risk that a patient ... Motion to Dismiss four individual cases that had been ... Order issued in the U.S. District Court, District of ... the dismissals were warranted because the plaintiffs in those ...
(Date:3/27/2015)... First Choice Emergency Room opened its ... located 12665 W Lake Houston Pkwy, Houston, Texas and is ... look forward to delivering the highest quality emergency medical care ... of First Choice Emergency Room Summerwood. , To ... to Summer Creek High School at First Choice Emergency Room’s ...
(Date:3/27/2015)... City, Mo (PRWEB) March 27, 2015 ... complications for patients undergoing percutaneous coronary intervention (PCI), ... studies have observed a “risk-treatment paradox,” in which ... gain from treatment are treated less often with ... Researchers at Saint Luke’s Mid America Heart Institute ...
(Date:3/27/2015)... 27, 2015 Top medical tourism firm, ... travel to the Dominican Republic to benefit from the ... is turning the medical tourism industry upside-down and becoming ... with trustworthy services becoming the central influence. , ... surgeon. Patients are not only attracted to low-cost surgical ...
Breaking Medicine News(10 mins):Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 2Health News:Florida Hospital Is Kicking off the 2015 Season as the Exclusive Health Care Provider for the Tampa Bay Storm 3Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 2Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 3Health News:First Choice Emergency Room Opens New Facility in Houston, Texas 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 3Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 2Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 3
... nutritional supplements ... in North ... Alliance,(CWA), experts in designing custom wellness programs for consumers and,corporations, ... announcement was made by biochemist, Lyle MacWilliam, author,of the recently ...
... many,people who have called and asked how they could help, ... with Tony Snow,s children,s education and,expenses., Jill Snow, Tony,s ... Kendall, Robbie and Kristi, as beneficiaries. Donations can,be made directly ... check,made payable to the "Tony Snow Family Trust" to:, ...
... ANGELES, July 14 The Cooperative of American,Physicians, ... exceeded 10,000 physicians., "Surpassing the 10,000 member ... CEO James L. Weidner. "The physicians who founded,CAP ... They believed that,physicians working together could find a ...
... with upbeat outlook, but same did not hold true for women ... had a lower risk of dying from heart disease turned out ... their conventional risk factors showed. , The death rate for men ... of those who listed themselves as being at average risk, said ...
... The Medical Device,Manufacturers Association (MDMA), a national trade ... the Board of Directors at the,MDMA Annual Meeting ... http://www.newscom.com/cgi-bin/prnh/20041004/MDMALOGO ), "I am honored to ... Manufacturers,Association," stated Root. "MDMA has a long history ...
... in heart and travels to the brain, heparin more risky, ... widely prescribed blood-thinning drug heparin is associated with an increased ... cardioembolic stroke, new research shows. , But another thinning ... in the same group of patients. , This finding led ...
Cached Medicine News:Health News:Vitalize(TM) Receives Top Multivitamin Rating 2Health News:Cooperative of American Physicians Membership Tops 10,000 2Health News:Optimism About Heart Risk Pays Off 2Health News:Vascular Solutions CEO Elected to MDMA Board of Directors 2Health News:Warfarin Safer Than Heparin for Some Strokes 2
(Date:3/27/2015)... YORK , March 27, 2015 Object ... the blind, visually impaired and elderly. The VelaSense ... these individuals to lead more independent, productive and fulfilling ... Technology which will allow users to identify objects from ... as well as create customized object databases for personal ...
(Date:3/27/2015)... 27, 2015 /PRNewswire/ - Medicure Inc. (the "Company") (TSXV:MPH, ... approved the grant of an aggregate of 236,070 options ... consultants of the Company pursuant to the Company,s Stock ... expire on the tenth anniversary of the date of ... anniversary of the date of grant and 50,000 are ...
(Date:3/27/2015)... LAKE CITY , March 27, 2015 Dynatronics ... J. Linder has been appointed to the Company,s Board ... created by the death in November 2014 of board member ... Rich Linder to our Board of Directors represents ... Cullimore, Jr. , chairman and president of Dynatronics.  "Rich is ...
Breaking Medicine Technology:VelaSense Object Recognition Technology for the Blind was unveiled at Baruch College's CCVIP 8th Annual Conference 2Dynatronics Announces Appointment of Richard J. Linder to Board of Directors 2
... , , , ... leading developer of medical device technology for the safe ... new Webinar program supporting its culture of safety initiative ... "A Culture of Safety in Pharmacy: Lessons Learned," features ...
... , MOUNTAIN VIEW, Calif., Dec. 29 VIVUS, Inc. (Nasdaq: ... therapies to address unmet needs in obesity, diabetes and sexual ... been submitted to the U.S. Food and Drug Administration (FDA) ... of obesity, including weight loss and maintenance of weight loss, ...
Cached Medicine Technology:Baxa Corporation to Sponsor Free Culture of Safety Webinar 2Baxa Corporation to Sponsor Free Culture of Safety Webinar 3VIVUS Submits Qnexa(R) New Drug Application to the FDA for the Treatment of Obesity 2VIVUS Submits Qnexa(R) New Drug Application to the FDA for the Treatment of Obesity 3VIVUS Submits Qnexa(R) New Drug Application to the FDA for the Treatment of Obesity 4VIVUS Submits Qnexa(R) New Drug Application to the FDA for the Treatment of Obesity 5
... Full frontal protection, our conventional ... shoulders by sturdy 2 webbed ... quick-acting snap hook fasteners. The ... custom fit the apron. Our ...
Unshielded...
... The Triage BNP Test is ... Blood test measuring B-type natriuretic peptide ... heart ventricles in response to ventricular ... hormonal marker of ventricular systolic and ...
... The MOST Options System is designed ... loss of the knee or hip ... and provides the potential for restoration ... beyond the requirements of a rotating ...
Medicine Products: