Navigation Links
Scientists decode TREX which could see new treatments for cancer realized
Date:8/14/2012

Decoded process could hold the key to future treatments for a wide range of chronic health problems including Motor Neuron Disease, myotonic dystrophy and a wide range of cancers, University of Sheffield scientists have revealed.

Experts from the University's Department of Molecular Biology and Biotechnology, collaborating with scientists from Harvard Medical School in the USA, have revealed how a complicated set of proteins called TREX act as a passport for the transfer of cell blueprints which create proteins that are essential for life.

The researchers believe their better understanding will mean they can ultimately fix problems in the process which cause fatal health conditions like Motor Neuron Disease, myotonic dystrophy and a wide range of cancers.

Professor Stuart Wilson, who led the groundbreaking project, said: "Protein production is an essential part of life for all organisms. This process involves reading the code in genes and converting this to a message which is ultimately decoded to make a protein.

"The message is made of a special molecule called mRNA. In all organisms from yeast through to man the mRNA is made in a compartment in the cell called the nucleus, but then has to be transported to a separate compartment, called the cytoplasm, where it is decoded to make a protein. This process of mRNA transport is essential for life and when it malfunctions in humans it can lead to diseases such as Motor Neuron Disease or cancer."

Researchers have shown how proteins called TREX provide a mark on the mRNA which acts as the passport which unlocks a transporter protein called Nxf1, allowing it to land on the mRNA and transport it to the cytoplasm to create proteins.

Professor Wilson added: "When a car is built in a factory, it goes through various stages of production with parts being added and, hopefully, quality control checks before it is driven out of the factory and into the salesroom.

"Similarly mRNA goes through various modifications in the nucleus, with bits added on and other sections removed. Only when the mRNA reaches the end of the production line in the nucleus and passes all the quality control checks is it given the passport which allows it to be transported to the cytoplasm and then used to make proteins.

"Until now, it has not been clear how the cell knows when the mRNA has reached the end of the production line in the nucleus and thus when it should be given a passport allowing passage to the cytoplasm. Now we have identified how the passport is issued, allowing the mRNA transport and the production of proteins in the cell which is essential for life."


'/>"/>
Contact: Paul Mannion
p.f.mannion@sheffield.ac.uk
01-142-229-851
University of Sheffield
Source:Eurekalert

Related medicine news :

1. Scientists devise new strategy to destroy multiple myeloma
2. Scientists ID New Gene Regions Linked to Type 2 Diabetes
3. Scientists discover how iron levels and a faulty gene cause bowel cancer
4. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
5. Scientists ID New Gene Linked to Vision Loss in Infants
6. Fruit flies light the way for A*STAR scientists to pinpoint genetic changes that spell cancer
7. NIH scientists identify likely predictors of hepatitis C severity
8. Scientists looking for noninvasive ways to detect lung cancer early
9. Increasing dopamine in frontal cortex decreases impulsive tendency, UCSF-Gallo scientists find
10. Scientists explore new class of synthetic vaccines
11. New method to find novel connections from gene to gene, drug to drug and between scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... New York, NY (PRWEB) , ... April 28, ... ... Shiel Medical Laboratory to expanded distribution of the GlycoMark test throughout the Northeast ... indicates recent hyperglycemia in patients with diabetes. The GlycoMark test provides a clinically ...
(Date:4/28/2017)... ... April 28, 2017 , ... Ushio America proudly ... offer an instant energy-saving solution for F32T8 fluorescent lamps on most instant-start and ... These 50,000 hour rated lamps utilize the existing electronic ballast, saving labor and ...
(Date:4/28/2017)... ... April 28, 2017 , ... Datta Endoscopic Back Surgery and ... revolutionary endoscopic practice under Dr. Datta. Patel is a Board Certified Anesthesiologist, with ... revolutionary eDiscSculpt Technique created and used by Datta Endoscopic is unlike traditional back ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... The Texas ... in recently to the labor and delivery team at Women’s Hospital at Renaissance in ... who give birth at the hospital and decide to donate. , “Women’s Hospital ...
(Date:4/28/2017)... , ... April 28, 2017 , ... ... hERG liability could substantially improve drug safety and minimize the cost of development. ... validating ion channel inhibition using cell lines and for cardiac toxicity using induced ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... April 20, 2017   ZappRx, Inc ., a digital ... prescribing process, today announced it closed $25 million in Series ... capital firm based in Seattle that ... Partners . The Series B round included participation from ... 2014, and GV (formerly Google Ventures). As part ...
(Date:4/20/2017)... -- Eyevensys, a private biotechnology company developing ... technology that enables the safe, local, sustained production of ... range of ophthalmic diseases, announces it has received approval ... (MHRA) to advance its technology into clinical development. ... The EyeCET platform ...
(Date:4/19/2017)... - CRH Medical Corporation (TSX: CRH) (NYSE MKT: CRHM) (the "Company"), announces that ... Conference 2017 at the Sheraton Hotel in Toronto, Ontario ... of the Company is scheduled to present on Tuesday, May 2 ... the Chairman of the Board, Tony Holler will also ... For more ...
Breaking Medicine Technology: