Navigation Links
Scientists decode TREX which could see new treatments for cancer realized
Date:8/14/2012

Decoded process could hold the key to future treatments for a wide range of chronic health problems including Motor Neuron Disease, myotonic dystrophy and a wide range of cancers, University of Sheffield scientists have revealed.

Experts from the University's Department of Molecular Biology and Biotechnology, collaborating with scientists from Harvard Medical School in the USA, have revealed how a complicated set of proteins called TREX act as a passport for the transfer of cell blueprints which create proteins that are essential for life.

The researchers believe their better understanding will mean they can ultimately fix problems in the process which cause fatal health conditions like Motor Neuron Disease, myotonic dystrophy and a wide range of cancers.

Professor Stuart Wilson, who led the groundbreaking project, said: "Protein production is an essential part of life for all organisms. This process involves reading the code in genes and converting this to a message which is ultimately decoded to make a protein.

"The message is made of a special molecule called mRNA. In all organisms from yeast through to man the mRNA is made in a compartment in the cell called the nucleus, but then has to be transported to a separate compartment, called the cytoplasm, where it is decoded to make a protein. This process of mRNA transport is essential for life and when it malfunctions in humans it can lead to diseases such as Motor Neuron Disease or cancer."

Researchers have shown how proteins called TREX provide a mark on the mRNA which acts as the passport which unlocks a transporter protein called Nxf1, allowing it to land on the mRNA and transport it to the cytoplasm to create proteins.

Professor Wilson added: "When a car is built in a factory, it goes through various stages of production with parts being added and, hopefully, quality control checks before it is driven out of the factory and into the salesroom.

"Similarly mRNA goes through various modifications in the nucleus, with bits added on and other sections removed. Only when the mRNA reaches the end of the production line in the nucleus and passes all the quality control checks is it given the passport which allows it to be transported to the cytoplasm and then used to make proteins.

"Until now, it has not been clear how the cell knows when the mRNA has reached the end of the production line in the nucleus and thus when it should be given a passport allowing passage to the cytoplasm. Now we have identified how the passport is issued, allowing the mRNA transport and the production of proteins in the cell which is essential for life."


'/>"/>
Contact: Paul Mannion
p.f.mannion@sheffield.ac.uk
01-142-229-851
University of Sheffield
Source:Eurekalert

Related medicine news :

1. Scientists devise new strategy to destroy multiple myeloma
2. Scientists ID New Gene Regions Linked to Type 2 Diabetes
3. Scientists discover how iron levels and a faulty gene cause bowel cancer
4. Scripps Florida scientists awarded nearly $1.5 million to develop new approaches to treat cancer
5. Scientists ID New Gene Linked to Vision Loss in Infants
6. Fruit flies light the way for A*STAR scientists to pinpoint genetic changes that spell cancer
7. NIH scientists identify likely predictors of hepatitis C severity
8. Scientists looking for noninvasive ways to detect lung cancer early
9. Increasing dopamine in frontal cortex decreases impulsive tendency, UCSF-Gallo scientists find
10. Scientists explore new class of synthetic vaccines
11. New method to find novel connections from gene to gene, drug to drug and between scientists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... ... May 03, 2016 , ... Finding the right way to address a patient’s condition before ... is now getting on board. , “You do the right thing, at the right time, ... goes down, not up,” said Leonard M. Fromer, MD, FAAFP, from Group Practice Forum. “Even ...
(Date:5/3/2016)... ... May 03, 2016 , ... The new web-based solution ... physician practices, to better grasp and implement HIPAA’s privacy, security, and data breach ... a well-defined, expert-created path to compliance. HIPAA Institute has positioned itself to be ...
(Date:5/3/2016)... ... May 03, 2016 , ... The American Medical Informatics ... Office of the National Coordinator for Health IT (ONC) with qualified support for ... including suspending and terminating certifications issued to Complete EHRs and Health IT Modules. ...
(Date:5/2/2016)... ... May 02, 2016 , ... Those who ... center can find some useful information in a new video released by Serenity ... video, which can be viewed on the Serenity Recovery YouTube channel, examines various ...
(Date:5/2/2016)... ... May 02, 2016 , ... As directed by its board of ... issues its full support to allow certified nurse practitioners (CNP) to practice to the ... worked under such supervision for three years and 3,600 hours. , In addition, HAP ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)...  Forté Elements, LLC (Forté) is excited to announce the launch of its Mediceutical ... needs of recovery for a variety of clinical conditions. Founded in 2013, Forté spent ... http://photos.prnewswire.com/prnh/20160502/362548 Logo -  http://photos.prnewswire.com/prnh/20160502/362547LOGO ... ... ...
(Date:5/3/2016)... , May 3, 2016 ... bekannt, dass sie einen entscheidenden Meilenstein durch ... Ein Aufruf zum Handeln, um Patientenresultate  bei ... trägt zu Fortschritten im Verständnis der Hepatischen ... ein Bewusstsein für Hepatische Enzephalopathie in der ...
(Date:5/2/2016)... Economies with Fastest Real GDP Annual Percentage Change, 2015  Real ... , Source: IMF and TechSci Research   According ... , Russia , India , ... fastest GDP growth during the first decade of the 21 st century. ... Brazil and Russia , along with policy uncertainty ...
Breaking Medicine Technology: