Navigation Links
Scientists confirm new virus responsible for deaths of transplant recipients in Australia
Date:2/6/2008

February 6, 2008 In the first application of high throughput DNA sequencing technology to investigate an infectious disease outbreak, scientists from Columbia University Mailman School of Public Health, the Victorian Infectious Diseases Reference Laboratory (VIRDL) in Melbourne, Australia, the Centers for Disease Control and 454 Life Sciences link the discovery of a new arenavirus to the deaths of three transplant recipients who received organs from a single donor in Victoria, Australia in April 2007. The full findings are published in the March 2008 issue of the New England Journal of Medicine and are now online.

After failing to implicate an agent using other methods including culture, PCR and viral microarrays, RNA from the transplanted liver and kidneys was analyzed using rapid sequencing technology established by 454 Life Sciences and bioinformatics algorithms developed at Columbia. Examination of tens or thousands of sequences yielded 14 that resembled arenaviruses at the protein level. Thereafter, the team cultured the virus, characterized it by electron microscopy and developed specific molecular and antibody assays for infection. The presence of virus in multiple organs, IgM antibodies in the organ donor and increasing titer of antibody in a recipient were used to implicate the virus as the cause of disease. The arenavirus lymphocytic choriomeningitis virus (LCMV) has been implicated in a small number of cases of disease transmission by organ transplantation, however, the newly discovered virus, which may be a new strain of LCMV, is sufficiently different that it could not be detected using existing screening methods.

High throughput sequencing and methods for cloning nucleic acids of microbial agents directly from clinical samples offer powerful tools for pathogen surveillance and discovery, stated W. Ian Lipkin, MD, John Snow Professor of Epidemiology and Professor of Neurology and Pathology at Columbia University and director o
'/>"/>

Contact: Randee Sacks Levine
rs363@columbia.edu
212-305-8044
Columbia University's Mailman School of Public Health
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Bonn scientists simulate dinosaur digestion in the lab
2. Scripps scientists peg wind as the force behind fish booms and busts
3. Chemical signature of manic depression discovered by scientists
4. Bug guts map brings scientists closer to understanding different bugs role in the body
5. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
6. Global Consensus on Mercury: Scientists Defend Science Journalists
7. DuPont Hosts Meeting of Leading Plant Scientists to Improve World Agricultural Productivity
8. Novel vaccine concept developed by scientists at the Wistar Institute
9. Landmark Articles Published by QualityMetric Scientists Report Improvements in Short Form Health Status Measures and Establish Criteria for Future Development
10. CSHL scientists make progress in determining how the brain selectively interprets sound
11. UC scientists awarded $1.7 million for low back pain research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... Angeles, CA (PRWEB) , ... August 01, 2015 , ... Have you ever wondered what ... up when you hear the word “Karma.” , Vedic tradition, which gave birth to ... Karma is one of the central concepts of this tradition. According to the wisdom of ...
(Date:8/1/2015)... ... ... Calvary Hospital today announced that it is embarking on a yearlong restoration of ... this Torah – dating from 1880 – back to kosher status, so that it ... No. 515, from the town of Taus-Domazlice, is on permanent loan to Calvary from ...
(Date:8/1/2015)... ... August 01, 2015 , ... Brig and Lita Hart, icons of the network ... their Healthy Home mission with the HOPE Movement of EvolvHealth. In what has been ... companies have agreed to join their missions of purpose together to change the course ...
(Date:8/1/2015)... ... August 01, 2015 , ... On Tuesday, July 28th, ... who are thought to have been behind the attack on Anthem Inc. which resulted ... zero day exploits, watering hole attacks and spear phishing campaigns. , For ...
(Date:8/1/2015)... ... August 01, 2015 , ... BeverlyD, owner and founder of BeverlyD Luxe ... the very first small business donation to kick off the campaign for healing and ... Her legacy includes a complete line of raw, organic hair care products, as well ...
Breaking Medicine News(10 mins):Health News:Nithyananda Yoga Foundation to Conduct Global Webinar on Karma at No Charge on August 1st 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 2Health News:Calvary Hospital Announces Plans to Restore Historic Torah 3Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4Health News:March4thforWellBeing Foundation Kickoff 2
... from McMaster University in their clinical trial reported in ... such as amiodarone combined with beta blockers such as ... ventricular arrhythmia patients undergoing Implantable Cardioverter defibrillator (ICD). ICD ... treat fatal cases of ventricular arrhythmias, but these shocks ...
... some others see an endless hope. This is the secret ... another breast cancer survivor, who now has a success story ... is now trying to publish her autobiography and screen a ... determination the assistant news editor at Doordarshan television here displayed ...
... University says that regular exposure to a cacophony of sound ... tumor called as acoustic neuroma. //Eventually, people with this tumor ... this tumor on the cranial nerve that is responsible for ... ,The symptoms of this tumor are typically a loud ringing ...
... U.S. workers have been found to work under the ... by the Research Institute on Addictions (RIA) of the ... employed in different agencies were interviewed through telephone to ... impairment of work, over the past 12 months. The ...
... should avoid travelling to Turkey after seven confirmed cases of ... on Sunday // . ,Turkey is the sixth ... from poultry to people, the first human infections outside eastern ... from travelling to Turkey, especially to the eastern province of ...
... bacteria, previously known to exist in radioactive waste, hot ... found to reside inside the human stomach. // This ... gastrointestinal diseases and newer treatment strategies. ,The ... ago, has been largely blamed for causing peptic ulcers. ...
Cached Medicine News:Health News:Life Beyond Cancer - Delhi Woman Tells How 2Health News:Nearly 15% Of U.S. Workers Work Under The Influence Of Alcohol 2Health News:Russia warns against travel to Turkey, Iran closes border 2
(Date:7/30/2015)... Ohio, July 30, 2015 Mettler-Toledo International Inc. ... for 2015.  Provided below are the highlights: ... quarter compared with the prior year. Reported sales decreased ... the quarter. , Net earnings per diluted share ... the prior-year period. Adjusted EPS was $2.80 , ...
(Date:7/30/2015)... MOUNTAIN VIEW, Calif. , July 30, 2015 /PRNewswire/ ... that it will release its second quarter 2015 financial ... 6, 2015.   In conjunction with the release, the ... community at 5:00 p.m. Eastern Time on ... results of the quarter and other business developments. ...
(Date:7/30/2015)... , July 30, 2015  Tandem Diabetes Care®, ... company and manufacturer of the t:slim® and t:flex™ ... into non-exclusive Development Agreements with Dexcom, Inc. to ... pumps with the Dexcom G5 and G6 continuous ... next generation pump platform with Dexcom,s future CGM ...
Breaking Medicine Technology:Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 14IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 2Tandem Diabetes Care Announces Development Agreement with Dexcom for Integration of Future Generation CGM Systems 3
... Tarsa Therapeutics today announced that the Phase III ORACAL ... treatment of postmenopausal osteoporosis was successfully concluded and yielded ... used to support a New Drug Application (NDA) submission ... the fourth quarter of 2011, based on the study ...
... YORK, March 24, 2011 Reportlinker.com announces that ... its catalogue: RNAi Drug ... http://www.reportlinker.com/p0461653/RNAi-Drug-Delivery-Technologies-and-Global-Markets.html THIS ... to how the RNAi (ribonucleic acid interference) technologies market ...
Cached Medicine Technology:Tarsa Therapeutics Reports Positive Top-Line Results From Pivotal Phase III ORACAL Trial of its Oral Calcitonin in Treatment of Postmenopausal Osteoporosis 2Tarsa Therapeutics Reports Positive Top-Line Results From Pivotal Phase III ORACAL Trial of its Oral Calcitonin in Treatment of Postmenopausal Osteoporosis 3Tarsa Therapeutics Reports Positive Top-Line Results From Pivotal Phase III ORACAL Trial of its Oral Calcitonin in Treatment of Postmenopausal Osteoporosis 4Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 2Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 3Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 4Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 5Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 6Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 7Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 8Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 9Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 10Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 11Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 12Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 13Reportlinker Adds RNAi Drug Delivery: Technologies and Global Markets 14
... blood gas and electrolyte analyser with reusable ... upon our well established and successful Critical ... perform up to 50 tests form a ... , ,The OPTI R uses a combination ...
... Analysis Kit incorporates detection of T-wave alternans ... DMS Holter analysis tools. Premier 12 makes ... less than 10 seconds and provides visualization ... and validation. The TWA algorithm detects two ...
Velcro® Tracheostomy tube holders are available in Adult, pediatric, and infant sizes....
... Your patient will be more comfortable, ... tracheostomy tube stabilization more secure and to ... tying and untying of twill ties, consider ... adult and neonate/infant sizes, the narrow fastener ...
Medicine Products: