Navigation Links
Scientists confirm new virus responsible for deaths of transplant recipients in Australia
Date:2/6/2008

February 6, 2008 In the first application of high throughput DNA sequencing technology to investigate an infectious disease outbreak, scientists from Columbia University Mailman School of Public Health, the Victorian Infectious Diseases Reference Laboratory (VIRDL) in Melbourne, Australia, the Centers for Disease Control and 454 Life Sciences link the discovery of a new arenavirus to the deaths of three transplant recipients who received organs from a single donor in Victoria, Australia in April 2007. The full findings are published in the March 2008 issue of the New England Journal of Medicine and are now online.

After failing to implicate an agent using other methods including culture, PCR and viral microarrays, RNA from the transplanted liver and kidneys was analyzed using rapid sequencing technology established by 454 Life Sciences and bioinformatics algorithms developed at Columbia. Examination of tens or thousands of sequences yielded 14 that resembled arenaviruses at the protein level. Thereafter, the team cultured the virus, characterized it by electron microscopy and developed specific molecular and antibody assays for infection. The presence of virus in multiple organs, IgM antibodies in the organ donor and increasing titer of antibody in a recipient were used to implicate the virus as the cause of disease. The arenavirus lymphocytic choriomeningitis virus (LCMV) has been implicated in a small number of cases of disease transmission by organ transplantation, however, the newly discovered virus, which may be a new strain of LCMV, is sufficiently different that it could not be detected using existing screening methods.

High throughput sequencing and methods for cloning nucleic acids of microbial agents directly from clinical samples offer powerful tools for pathogen surveillance and discovery, stated W. Ian Lipkin, MD, John Snow Professor of Epidemiology and Professor of Neurology and Pathology at Columbia University and director o
'/>"/>

Contact: Randee Sacks Levine
rs363@columbia.edu
212-305-8044
Columbia University's Mailman School of Public Health
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Bonn scientists simulate dinosaur digestion in the lab
2. Scripps scientists peg wind as the force behind fish booms and busts
3. Chemical signature of manic depression discovered by scientists
4. Bug guts map brings scientists closer to understanding different bugs role in the body
5. Scripps scientists find calcium channel blockers help normalize lysosomal storage disease cells
6. Global Consensus on Mercury: Scientists Defend Science Journalists
7. DuPont Hosts Meeting of Leading Plant Scientists to Improve World Agricultural Productivity
8. Novel vaccine concept developed by scientists at the Wistar Institute
9. Landmark Articles Published by QualityMetric Scientists Report Improvements in Short Form Health Status Measures and Establish Criteria for Future Development
10. CSHL scientists make progress in determining how the brain selectively interprets sound
11. UC scientists awarded $1.7 million for low back pain research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... known as the "Mississippi baby" an infant seemingly cured ... a prolonged remission of HIV infection in The New ... of HIV after more than two years of not taking ... HIV specialist and researchers involved in the case. ... this young child, the medical staff involved in the child,s ...
(Date:7/10/2014)... those students looking to bump up their grade point ... more time in a library or study hall, but ... shows that students who were members of the recreational ... freshman and sophomore years had higher GPAs than those ... students with memberships stayed in school longer. An increase ...
(Date:7/10/2014)... ROCHESTER, Minn. The benefits of medical imaging far ... ordered The Right Way, with The Right Radiation Dose. ... ratio and Mayo Clinic is leading a collaborative effort ... The commentary, published online in the Journal of ... Radiology, the Joint Commission, the Intersociety Accreditation Commission, and ...
(Date:7/10/2014)... illness and even death are likely to result if ... Now, however, a team of researchers based at The ... order of infection, the bacteria Streptococcus pneumoniae ... case of the flu. , The researchers discovered ... a bacterial virulence factor, might protect macrophagesa type of ...
(Date:7/10/2014)... A neuroscientist at Rutgers University-Newark says the human brain ... a finding that could provide a better understanding ... conditions that afflict an estimated 13.6 million Americans. , ... , Michael Cole, an assistant professor at the Center ... brain architecture of a person at rest is basically ...
Breaking Medicine News(10 mins):Health News:'Mississippi Baby' now has detectable HIV, researchers find 2Health News:'Mississippi Baby' now has detectable HIV, researchers find 3Health News:Want a higher GPA in college? Join a gym 2Health News:Mayo Clinic calls for standardization of safe imaging protocols for children 2Health News:Bacterial colonization prior to catching the flu may protect against severe illness 2Health News:Working to loosen the grip of severe mental illness 2
... Authentidate Holding Corp. (Nasdaq: ADAT ), ... workflow management services, today announced financial results for the ... Benjamin, President of Authentidate, stated, "Revenue growth slowed during ... conditions impacted our results. Although total revenues were ...
... of the most harmful forms of teen drug abuse with a hard-hitting ... ... Los Angeles, CA (PRWEB) February 12, 2009 -- Statistics show a dangerous ... office of the DEA announced this week that Phoenix high school students ...
... An investor group in Trinity,Biotech plc (Nasdaq: ... of,diagnostic products, is delighted that Jim Merselis has joined ... support for Mr. Merselis, the,group has scheduled a conference ... am PT) on Tuesday, February 17, 2009. , ...
... advancing the lives,of children and adults experiencing barriers to ... hit the slopes last weekend. Nearly,200 community members, volunteers ... a day of fun, competition and meeting new friends ... The event, at Trollhaugen in Dresser, ...
... SCAN Long Term Care and SCAN Health Plan Arizona, ... of Health Plans. "The new association intends to be ... here in Arizona," said Lescault. "As president I look ... the governor,s office in adjusting the state health budget ...
... CRANBURY, N.J., Feb. 12 Innophos Holdings, Inc. (Nasdaq: ... in North America, today announced the election of John ... is Executive Vice President and Chief Operating Officer of ... of highly engineered specialty chemicals, including polymer additives, catalysts ...
Cached Medicine News:Health News:Authentidate Holding Corp. Reports Fiscal 2009 Second Quarter Results 2Health News:Authentidate Holding Corp. Reports Fiscal 2009 Second Quarter Results 3Health News:Authentidate Holding Corp. Reports Fiscal 2009 Second Quarter Results 4Health News:Authentidate Holding Corp. Reports Fiscal 2009 Second Quarter Results 5Health News:Authentidate Holding Corp. Reports Fiscal 2009 Second Quarter Results 6Health News:Authentidate Holding Corp. Reports Fiscal 2009 Second Quarter Results 7Health News:Authentidate Holding Corp. Reports Fiscal 2009 Second Quarter Results 8Health News:Church of Scientology Fighting Teen Drug Abuse 2Health News:Second Annual Courage Cup Race Raises More Than $5,000 for Courage Center's Ski and Snowboard Program 2Health News:SCAN's Thomas Lescault Elected President of New Arizona Association of Health Plans 2Health News:Innophos Holdings, Inc. Elects John M. Steitz as New Independent Director 2
(Date:1/15/2014)... Jan. 15, 2014 MultiCell Technologies, Inc. (OTC Bulletin ... provisional patent application concerning composition of matter, biological targets, ... tumor cell death.  This patent application ... stranded RNA molecules (VSRNAs) which interfere with the basic ...
(Date:1/15/2014)... , Jan. 15, 2014  According to Millennium ... technology market intelligence, the United States ... (TEO) device markets will expand moderately through 2022, ... segments. In particular, increasing interest in drug-eluting beads ...
(Date:1/15/2014)... Quebec , Jan. 15, 2014  Valeant Pharmaceuticals International, ... announced that the applicable waiting period under the Hart-Scott-Rodino ... the previously announced tender offer by its indirect wholly-owned ... outstanding shares of common stock of Solta Medical, Inc. ...
Breaking Medicine Technology:MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
... Oct. 18, 2011 Phreesia, the patient check-in ... of electronic health records (EHR) software and solutions, ... Through this partnership, medical practices nationwide that use ... achieve a seamless patient check-in experience. The automated ...
... Melnik, President & CEO of PediaVisionJeff Mortensen, Vice President ... a revolutionary new vision screening device, which identifies vision ... October 20, Friday October 21 WHY: Spot is ... children across America.   Spot has an incredibly ...
Cached Medicine Technology:Phreesia and SOAPware Integrate to Improve Clinical Data and Streamline Workflow at Medical Practices 2Phreesia and SOAPware Integrate to Improve Clinical Data and Streamline Workflow at Medical Practices 3
Diagnosoft HARP is designed for rapid analysis of tagged cardiac MR images using the HARP technology, which is packaged into an intuitive, easy-to-use graphic user interface....
The MediLive ImageBox is the first, easy-to-use digital,recording device that integrates with the surgical microscope and video camera., ,It simplifies image capturing by burning the still imag...
With MediLive MindStream you can make, cut and edit digital videos, add commentaries and notes, and save them. MediLive MindStream - intuitive user interface and high-resolution monitor all in one....
... non-mydriatic fundus camera increases ... of fundus imaging. Compact, ... set the standard in ... a unique combination of ...
Medicine Products: